Amino acid dipepetide frequency for Collinsella sp. BA40

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.43AlaAla: 16.43 ± 0.267
2.297AlaCys: 2.297 ± 0.08
7.422AlaAsp: 7.422 ± 0.132
7.444AlaGlu: 7.444 ± 0.14
4.331AlaPhe: 4.331 ± 0.086
10.242AlaGly: 10.242 ± 0.176
2.251AlaHis: 2.251 ± 0.067
5.75AlaIle: 5.75 ± 0.123
3.873AlaLys: 3.873 ± 0.117
11.98AlaLeu: 11.98 ± 0.184
3.138AlaMet: 3.138 ± 0.079
2.923AlaAsn: 2.923 ± 0.077
5.213AlaPro: 5.213 ± 0.133
3.613AlaGln: 3.613 ± 0.087
8.405AlaArg: 8.405 ± 0.17
7.38AlaSer: 7.38 ± 0.159
5.587AlaThr: 5.587 ± 0.116
8.898AlaVal: 8.898 ± 0.147
1.323AlaTrp: 1.323 ± 0.06
3.242AlaTyr: 3.242 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
1.852CysAla: 1.852 ± 0.067
0.274CysCys: 0.274 ± 0.024
1.134CysAsp: 1.134 ± 0.048
1.009CysGlu: 1.009 ± 0.047
0.508CysPhe: 0.508 ± 0.033
1.727CysGly: 1.727 ± 0.058
0.295CysHis: 0.295 ± 0.025
0.725CysIle: 0.725 ± 0.036
0.398CysLys: 0.398 ± 0.028
1.104CysLeu: 1.104 ± 0.046
0.361CysMet: 0.361 ± 0.028
0.339CysAsn: 0.339 ± 0.024
0.727CysPro: 0.727 ± 0.045
0.306CysGln: 0.306 ± 0.025
0.869CysArg: 0.869 ± 0.041
0.86CysSer: 0.86 ± 0.045
0.838CysThr: 0.838 ± 0.043
1.084CysVal: 1.084 ± 0.051
0.156CysTrp: 0.156 ± 0.018
0.364CysTyr: 0.364 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
9.066AspAla: 9.066 ± 0.161
0.812AspCys: 0.812 ± 0.042
3.97AspAsp: 3.97 ± 0.098
5.439AspGlu: 5.439 ± 0.094
2.378AspPhe: 2.378 ± 0.066
5.997AspGly: 5.997 ± 0.122
1.073AspHis: 1.073 ± 0.05
3.426AspIle: 3.426 ± 0.088
1.832AspLys: 1.832 ± 0.068
5.614AspLeu: 5.614 ± 0.111
1.728AspMet: 1.728 ± 0.061
1.454AspAsn: 1.454 ± 0.057
3.236AspPro: 3.236 ± 0.07
1.436AspGln: 1.436 ± 0.061
3.821AspArg: 3.821 ± 0.084
2.802AspSer: 2.802 ± 0.071
2.986AspThr: 2.986 ± 0.071
5.224AspVal: 5.224 ± 0.102
0.641AspTrp: 0.641 ± 0.035
1.876AspTyr: 1.876 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
7.724GluAla: 7.724 ± 0.136
0.782GluCys: 0.782 ± 0.043
3.711GluAsp: 3.711 ± 0.085
4.388GluGlu: 4.388 ± 0.114
2.113GluPhe: 2.113 ± 0.069
5.04GluGly: 5.04 ± 0.094
1.782GluHis: 1.782 ± 0.061
2.826GluIle: 2.826 ± 0.085
2.323GluLys: 2.323 ± 0.081
7.302GluLeu: 7.302 ± 0.144
1.83GluMet: 1.83 ± 0.063
1.881GluAsn: 1.881 ± 0.061
2.77GluPro: 2.77 ± 0.09
2.502GluGln: 2.502 ± 0.067
5.728GluArg: 5.728 ± 0.109
3.172GluSer: 3.172 ± 0.079
2.962GluThr: 2.962 ± 0.071
4.839GluVal: 4.839 ± 0.104
0.611GluTrp: 0.611 ± 0.033
1.736GluTyr: 1.736 ± 0.063
0.0GluXaa: 0.0 ± 0.0
Phe
4.12PheAla: 4.12 ± 0.097
0.598PheCys: 0.598 ± 0.029
3.063PheAsp: 3.063 ± 0.077
2.373PheGlu: 2.373 ± 0.077
1.392PhePhe: 1.392 ± 0.064
3.216PheGly: 3.216 ± 0.087
0.698PheHis: 0.698 ± 0.038
1.765PheIle: 1.765 ± 0.049
1.233PheLys: 1.233 ± 0.049
2.846PheLeu: 2.846 ± 0.077
0.959PheMet: 0.959 ± 0.044
1.097PheAsn: 1.097 ± 0.047
1.195PhePro: 1.195 ± 0.049
0.873PheGln: 0.873 ± 0.037
1.684PheArg: 1.684 ± 0.064
2.446PheSer: 2.446 ± 0.064
2.172PheThr: 2.172 ± 0.069
2.802PheVal: 2.802 ± 0.072
0.37PheTrp: 0.37 ± 0.028
0.992PheTyr: 0.992 ± 0.045
0.0PheXaa: 0.0 ± 0.0
Gly
9.539GlyAla: 9.539 ± 0.171
1.548GlyCys: 1.548 ± 0.057
4.872GlyAsp: 4.872 ± 0.103
5.165GlyGlu: 5.165 ± 0.101
3.258GlyPhe: 3.258 ± 0.092
6.363GlyGly: 6.363 ± 0.151
1.478GlyHis: 1.478 ± 0.06
4.883GlyIle: 4.883 ± 0.108
3.507GlyLys: 3.507 ± 0.096
7.079GlyLeu: 7.079 ± 0.125
2.54GlyMet: 2.54 ± 0.084
2.288GlyAsn: 2.288 ± 0.067
2.299GlyPro: 2.299 ± 0.071
2.025GlyGln: 2.025 ± 0.069
5.242GlyArg: 5.242 ± 0.11
5.353GlySer: 5.353 ± 0.116
4.723GlyThr: 4.723 ± 0.103
6.748GlyVal: 6.748 ± 0.114
1.049GlyTrp: 1.049 ± 0.048
2.573GlyTyr: 2.573 ± 0.073
0.0GlyXaa: 0.0 ± 0.0
His
2.284HisAla: 2.284 ± 0.077
0.241HisCys: 0.241 ± 0.022
1.373HisAsp: 1.373 ± 0.055
1.386HisGlu: 1.386 ± 0.061
0.593HisPhe: 0.593 ± 0.036
1.868HisGly: 1.868 ± 0.066
0.455HisHis: 0.455 ± 0.029
1.053HisIle: 1.053 ± 0.048
0.471HisLys: 0.471 ± 0.031
1.568HisLeu: 1.568 ± 0.045
0.48HisMet: 0.48 ± 0.028
0.453HisAsn: 0.453 ± 0.028
1.095HisPro: 1.095 ± 0.047
0.445HisGln: 0.445 ± 0.029
1.22HisArg: 1.22 ± 0.047
0.845HisSer: 0.845 ± 0.037
0.948HisThr: 0.948 ± 0.045
1.675HisVal: 1.675 ± 0.053
0.179HisTrp: 0.179 ± 0.016
0.504HisTyr: 0.504 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.406IleAla: 6.406 ± 0.132
0.815IleCys: 0.815 ± 0.039
4.186IleAsp: 4.186 ± 0.098
4.013IleGlu: 4.013 ± 0.081
1.511IlePhe: 1.511 ± 0.067
3.702IleGly: 3.702 ± 0.096
0.812IleHis: 0.812 ± 0.038
2.343IleIle: 2.343 ± 0.092
1.815IleLys: 1.815 ± 0.064
3.698IleLeu: 3.698 ± 0.097
1.237IleMet: 1.237 ± 0.057
1.476IleAsn: 1.476 ± 0.053
2.351IlePro: 2.351 ± 0.063
1.211IleGln: 1.211 ± 0.047
2.564IleArg: 2.564 ± 0.065
3.05IleSer: 3.05 ± 0.072
2.682IleThr: 2.682 ± 0.078
4.28IleVal: 4.28 ± 0.105
0.436IleTrp: 0.436 ± 0.03
1.154IleTyr: 1.154 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
3.615LysAla: 3.615 ± 0.128
0.309LysCys: 0.309 ± 0.024
2.084LysAsp: 2.084 ± 0.083
1.887LysGlu: 1.887 ± 0.07
0.92LysPhe: 0.92 ± 0.046
2.595LysGly: 2.595 ± 0.081
0.641LysHis: 0.641 ± 0.04
1.855LysIle: 1.855 ± 0.069
1.935LysLys: 1.935 ± 0.076
3.311LysLeu: 3.311 ± 0.089
0.95LysMet: 0.95 ± 0.04
1.29LysAsn: 1.29 ± 0.049
1.811LysPro: 1.811 ± 0.067
1.184LysGln: 1.184 ± 0.051
2.711LysArg: 2.711 ± 0.074
1.854LysSer: 1.854 ± 0.077
2.341LysThr: 2.341 ± 0.083
2.564LysVal: 2.564 ± 0.091
0.263LysTrp: 0.263 ± 0.023
0.841LysTyr: 0.841 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
11.829LeuAla: 11.829 ± 0.195
1.196LeuCys: 1.196 ± 0.051
6.649LeuAsp: 6.649 ± 0.114
5.809LeuGlu: 5.809 ± 0.106
3.277LeuPhe: 3.277 ± 0.081
7.462LeuGly: 7.462 ± 0.129
1.618LeuHis: 1.618 ± 0.057
3.958LeuIle: 3.958 ± 0.097
3.146LeuLys: 3.146 ± 0.093
8.042LeuLeu: 8.042 ± 0.163
2.467LeuMet: 2.467 ± 0.061
2.316LeuAsn: 2.316 ± 0.066
4.28LeuPro: 4.28 ± 0.087
2.31LeuGln: 2.31 ± 0.06
5.316LeuArg: 5.316 ± 0.121
6.025LeuSer: 6.025 ± 0.13
4.677LeuThr: 4.677 ± 0.103
7.659LeuVal: 7.659 ± 0.137
0.819LeuTrp: 0.819 ± 0.046
2.34LeuTyr: 2.34 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
3.306MetAla: 3.306 ± 0.08
0.32MetCys: 0.32 ± 0.023
1.631MetAsp: 1.631 ± 0.057
1.425MetGlu: 1.425 ± 0.045
0.804MetPhe: 0.804 ± 0.046
2.456MetGly: 2.456 ± 0.071
0.523MetHis: 0.523 ± 0.03
1.13MetIle: 1.13 ± 0.047
1.02MetLys: 1.02 ± 0.045
2.525MetLeu: 2.525 ± 0.07
0.652MetMet: 0.652 ± 0.039
0.937MetAsn: 0.937 ± 0.04
1.364MetPro: 1.364 ± 0.058
0.852MetGln: 0.852 ± 0.043
1.878MetArg: 1.878 ± 0.071
1.565MetSer: 1.565 ± 0.055
1.406MetThr: 1.406 ± 0.052
2.034MetVal: 2.034 ± 0.065
0.217MetTrp: 0.217 ± 0.02
0.556MetTyr: 0.556 ± 0.034
0.0MetXaa: 0.0 ± 0.0
Asn
3.115AsnAla: 3.115 ± 0.075
0.306AsnCys: 0.306 ± 0.023
1.662AsnAsp: 1.662 ± 0.062
1.819AsnGlu: 1.819 ± 0.066
0.828AsnPhe: 0.828 ± 0.037
2.461AsnGly: 2.461 ± 0.087
0.519AsnHis: 0.519 ± 0.034
1.498AsnIle: 1.498 ± 0.062
1.139AsnLys: 1.139 ± 0.056
2.509AsnLeu: 2.509 ± 0.073
0.731AsnMet: 0.731 ± 0.037
0.876AsnAsn: 0.876 ± 0.05
1.717AsnPro: 1.717 ± 0.054
0.692AsnGln: 0.692 ± 0.038
1.631AsnArg: 1.631 ± 0.055
1.235AsnSer: 1.235 ± 0.052
1.421AsnThr: 1.421 ± 0.053
2.238AsnVal: 2.238 ± 0.064
0.296AsnTrp: 0.296 ± 0.022
0.762AsnTyr: 0.762 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
5.708ProAla: 5.708 ± 0.149
0.563ProCys: 0.563 ± 0.033
2.791ProAsp: 2.791 ± 0.067
3.389ProGlu: 3.389 ± 0.092
1.666ProPhe: 1.666 ± 0.06
3.578ProGly: 3.578 ± 0.086
0.966ProHis: 0.966 ± 0.048
1.852ProIle: 1.852 ± 0.06
1.404ProLys: 1.404 ± 0.055
3.573ProLeu: 3.573 ± 0.094
0.996ProMet: 0.996 ± 0.043
1.169ProAsn: 1.169 ± 0.05
1.064ProPro: 1.064 ± 0.053
1.554ProGln: 1.554 ± 0.063
2.529ProArg: 2.529 ± 0.073
2.792ProSer: 2.792 ± 0.082
2.06ProThr: 2.06 ± 0.056
3.993ProVal: 3.993 ± 0.092
0.545ProTrp: 0.545 ± 0.032
1.392ProTyr: 1.392 ± 0.052
0.0ProXaa: 0.0 ± 0.0
Gln
3.361GlnAla: 3.361 ± 0.08
0.212GlnCys: 0.212 ± 0.02
1.434GlnAsp: 1.434 ± 0.053
1.589GlnGlu: 1.589 ± 0.061
0.917GlnPhe: 0.917 ± 0.047
2.222GlnGly: 2.222 ± 0.065
0.514GlnHis: 0.514 ± 0.033
1.64GlnIle: 1.64 ± 0.058
0.998GlnLys: 0.998 ± 0.037
2.844GlnLeu: 2.844 ± 0.069
0.847GlnMet: 0.847 ± 0.042
0.79GlnAsn: 0.79 ± 0.04
1.311GlnPro: 1.311 ± 0.067
1.233GlnGln: 1.233 ± 0.058
2.065GlnArg: 2.065 ± 0.066
1.336GlnSer: 1.336 ± 0.046
1.428GlnThr: 1.428 ± 0.056
2.305GlnVal: 2.305 ± 0.078
0.28GlnTrp: 0.28 ± 0.025
0.646GlnTyr: 0.646 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
7.934ArgAla: 7.934 ± 0.141
0.994ArgCys: 0.994 ± 0.052
4.09ArgAsp: 4.09 ± 0.09
4.771ArgGlu: 4.771 ± 0.121
2.522ArgPhe: 2.522 ± 0.07
4.674ArgGly: 4.674 ± 0.101
1.134ArgHis: 1.134 ± 0.048
3.527ArgIle: 3.527 ± 0.091
1.995ArgLys: 1.995 ± 0.074
5.649ArgLeu: 5.649 ± 0.136
1.99ArgMet: 1.99 ± 0.059
1.539ArgAsn: 1.539 ± 0.058
2.697ArgPro: 2.697 ± 0.083
1.614ArgGln: 1.614 ± 0.057
4.963ArgArg: 4.963 ± 0.141
3.612ArgSer: 3.612 ± 0.093
3.175ArgThr: 3.175 ± 0.083
5.224ArgVal: 5.224 ± 0.099
0.635ArgTrp: 0.635 ± 0.033
1.999ArgTyr: 1.999 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
6.531SerAla: 6.531 ± 0.118
0.9SerCys: 0.9 ± 0.048
3.308SerAsp: 3.308 ± 0.076
3.33SerGlu: 3.33 ± 0.079
2.507SerPhe: 2.507 ± 0.072
5.265SerGly: 5.265 ± 0.103
1.162SerHis: 1.162 ± 0.052
3.192SerIle: 3.192 ± 0.086
2.043SerLys: 2.043 ± 0.068
5.414SerLeu: 5.414 ± 0.136
1.624SerMet: 1.624 ± 0.059
1.655SerAsn: 1.655 ± 0.055
2.279SerPro: 2.279 ± 0.077
1.594SerGln: 1.594 ± 0.059
3.472SerArg: 3.472 ± 0.099
3.698SerSer: 3.698 ± 0.096
3.159SerThr: 3.159 ± 0.093
4.554SerVal: 4.554 ± 0.106
0.733SerTrp: 0.733 ± 0.038
1.925SerTyr: 1.925 ± 0.061
0.0SerXaa: 0.0 ± 0.0
Thr
5.62ThrAla: 5.62 ± 0.102
0.856ThrCys: 0.856 ± 0.044
3.008ThrAsp: 3.008 ± 0.084
2.676ThrGlu: 2.676 ± 0.066
2.132ThrPhe: 2.132 ± 0.068
4.869ThrGly: 4.869 ± 0.112
1.06ThrHis: 1.06 ± 0.04
2.735ThrIle: 2.735 ± 0.08
1.76ThrLys: 1.76 ± 0.06
4.756ThrLeu: 4.756 ± 0.098
1.327ThrMet: 1.327 ± 0.045
1.314ThrAsn: 1.314 ± 0.049
2.82ThrPro: 2.82 ± 0.074
1.421ThrGln: 1.421 ± 0.054
2.849ThrArg: 2.849 ± 0.078
3.142ThrSer: 3.142 ± 0.082
2.713ThrThr: 2.713 ± 0.094
4.699ThrVal: 4.699 ± 0.102
0.613ThrTrp: 0.613 ± 0.032
1.59ThrTyr: 1.59 ± 0.062
0.0ThrXaa: 0.0 ± 0.0
Val
9.364ValAla: 9.364 ± 0.155
1.351ValCys: 1.351 ± 0.052
5.808ValAsp: 5.808 ± 0.101
5.603ValGlu: 5.603 ± 0.108
2.888ValPhe: 2.888 ± 0.082
5.598ValGly: 5.598 ± 0.126
1.386ValHis: 1.386 ± 0.053
3.855ValIle: 3.855 ± 0.094
2.702ValLys: 2.702 ± 0.088
7.626ValLeu: 7.626 ± 0.118
1.872ValMet: 1.872 ± 0.064
2.345ValAsn: 2.345 ± 0.067
3.735ValPro: 3.735 ± 0.079
1.938ValGln: 1.938 ± 0.061
5.156ValArg: 5.156 ± 0.118
5.13ValSer: 5.13 ± 0.101
4.385ValThr: 4.385 ± 0.096
6.768ValVal: 6.768 ± 0.129
0.725ValTrp: 0.725 ± 0.038
2.106ValTyr: 2.106 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.885TrpAla: 0.885 ± 0.035
0.156TrpCys: 0.156 ± 0.017
0.641TrpAsp: 0.641 ± 0.041
0.611TrpGlu: 0.611 ± 0.031
0.383TrpPhe: 0.383 ± 0.028
0.839TrpGly: 0.839 ± 0.048
0.243TrpHis: 0.243 ± 0.021
0.482TrpIle: 0.482 ± 0.027
0.42TrpLys: 0.42 ± 0.035
1.127TrpLeu: 1.127 ± 0.049
0.318TrpMet: 0.318 ± 0.024
0.442TrpAsn: 0.442 ± 0.029
0.376TrpPro: 0.376 ± 0.025
0.357TrpGln: 0.357 ± 0.024
0.657TrpArg: 0.657 ± 0.035
0.607TrpSer: 0.607 ± 0.033
0.609TrpThr: 0.609 ± 0.041
0.687TrpVal: 0.687 ± 0.033
0.164TrpTrp: 0.164 ± 0.017
0.304TrpTyr: 0.304 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.056TyrAla: 3.056 ± 0.08
0.396TyrCys: 0.396 ± 0.026
1.975TyrAsp: 1.975 ± 0.072
1.896TyrGlu: 1.896 ± 0.056
0.965TyrPhe: 0.965 ± 0.037
2.362TyrGly: 2.362 ± 0.07
0.53TyrHis: 0.53 ± 0.03
1.246TyrIle: 1.246 ± 0.045
0.95TyrLys: 0.95 ± 0.047
2.625TyrLeu: 2.625 ± 0.078
0.552TyrMet: 0.552 ± 0.034
0.873TyrAsn: 0.873 ± 0.045
1.244TyrPro: 1.244 ± 0.056
0.81TyrGln: 0.81 ± 0.036
1.977TyrArg: 1.977 ± 0.063
1.439TyrSer: 1.439 ± 0.056
1.69TyrThr: 1.69 ± 0.064
2.065TyrVal: 2.065 ± 0.062
0.252TyrTrp: 0.252 ± 0.023
0.828TyrTyr: 0.828 ± 0.044
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1521 proteins (543261 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski