Amino acid dipepetide frequency for Oceanospirillum linum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.732AlaAla: 8.732 ± 0.127	0.977AlaCys: 0.977 ± 0.033	5.537AlaAsp: 5.537 ± 0.079	6.641AlaGlu: 6.641 ± 0.092	3.438AlaPhe: 3.438 ± 0.066	7.219AlaGly: 7.219 ± 0.098	1.751AlaHis: 1.751 ± 0.037	5.307AlaIle: 5.307 ± 0.072	4.132AlaLys: 4.132 ± 0.068	10.754AlaLeu: 10.754 ± 0.13	2.717AlaMet: 2.717 ± 0.051	2.85AlaAsn: 2.85 ± 0.054	3.167AlaPro: 3.167 ± 0.064	3.996AlaGln: 3.996 ± 0.074	4.665AlaArg: 4.665 ± 0.068	5.568AlaSer: 5.568 ± 0.079	4.169AlaThr: 4.169 ± 0.075	6.343AlaVal: 6.343 ± 0.09	0.996AlaTrp: 0.996 ± 0.033	2.306AlaTyr: 2.306 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	0.808CysAla: 0.808 ± 0.028	0.147CysCys: 0.147 ± 0.013	0.594CysAsp: 0.594 ± 0.028	0.543CysGlu: 0.543 ± 0.023	0.417CysPhe: 0.417 ± 0.019	0.789CysGly: 0.789 ± 0.03	0.365CysHis: 0.365 ± 0.022	0.522CysIle: 0.522 ± 0.024	0.356CysLys: 0.356 ± 0.02	0.974CysLeu: 0.974 ± 0.027	0.221CysMet: 0.221 ± 0.015	0.314CysAsn: 0.314 ± 0.019	0.454CysPro: 0.454 ± 0.022	0.51CysGln: 0.51 ± 0.019	0.53CysArg: 0.53 ± 0.024	0.671CysSer: 0.671 ± 0.025	0.446CysThr: 0.446 ± 0.021	0.608CysVal: 0.608 ± 0.028	0.13CysTrp: 0.13 ± 0.01	0.326CysTyr: 0.326 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.868AspAla: 4.868 ± 0.07	0.504AspCys: 0.504 ± 0.022	3.176AspAsp: 3.176 ± 0.074	3.972AspGlu: 3.972 ± 0.068	2.281AspPhe: 2.281 ± 0.055	3.854AspGly: 3.854 ± 0.077	1.337AspHis: 1.337 ± 0.036	3.723AspIle: 3.723 ± 0.059	2.711AspLys: 2.711 ± 0.05	6.109AspLeu: 6.109 ± 0.085	1.371AspMet: 1.371 ± 0.035	2.093AspAsn: 2.093 ± 0.055	2.274AspPro: 2.274 ± 0.05	2.902AspGln: 2.902 ± 0.056	2.926AspArg: 2.926 ± 0.044	3.298AspSer: 3.298 ± 0.064	2.898AspThr: 2.898 ± 0.061	3.701AspVal: 3.701 ± 0.068	0.825AspTrp: 0.825 ± 0.028	1.85AspTyr: 1.85 ± 0.044	0.0AspXaa: 0.0 ± 0.0
Glu	6.421GluAla: 6.421 ± 0.097	0.478GluCys: 0.478 ± 0.025	3.055GluAsp: 3.055 ± 0.06	4.126GluGlu: 4.126 ± 0.086	2.18GluPhe: 2.18 ± 0.046	4.224GluGly: 4.224 ± 0.063	1.621GluHis: 1.621 ± 0.041	3.831GluIle: 3.831 ± 0.059	3.529GluLys: 3.529 ± 0.06	7.27GluLeu: 7.27 ± 0.086	1.694GluMet: 1.694 ± 0.042	2.379GluAsn: 2.379 ± 0.041	2.374GluPro: 2.374 ± 0.053	4.449GluGln: 4.449 ± 0.079	3.954GluArg: 3.954 ± 0.069	3.853GluSer: 3.853 ± 0.066	3.352GluThr: 3.352 ± 0.059	4.267GluVal: 4.267 ± 0.076	0.741GluTrp: 0.741 ± 0.028	1.635GluTyr: 1.635 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.398PheAla: 3.398 ± 0.06	0.504PheCys: 0.504 ± 0.024	2.529PheAsp: 2.529 ± 0.049	2.355PheGlu: 2.355 ± 0.046	1.631PhePhe: 1.631 ± 0.045	2.962PheGly: 2.962 ± 0.058	0.776PheHis: 0.776 ± 0.025	2.427PheIle: 2.427 ± 0.055	1.688PheLys: 1.688 ± 0.041	3.408PheLeu: 3.408 ± 0.07	1.061PheMet: 1.061 ± 0.032	1.604PheAsn: 1.604 ± 0.035	1.399PhePro: 1.399 ± 0.034	1.35PheGln: 1.35 ± 0.03	1.833PheArg: 1.833 ± 0.04	3.141PheSer: 3.141 ± 0.062	2.115PheThr: 2.115 ± 0.055	2.463PheVal: 2.463 ± 0.053	0.558PheTrp: 0.558 ± 0.024	1.259PheTyr: 1.259 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.626GlyAla: 5.626 ± 0.092	0.923GlyCys: 0.923 ± 0.03	3.961GlyAsp: 3.961 ± 0.079	4.476GlyGlu: 4.476 ± 0.063	3.401GlyPhe: 3.401 ± 0.059	4.951GlyGly: 4.951 ± 0.096	1.756GlyHis: 1.756 ± 0.044	4.539GlyIle: 4.539 ± 0.077	3.706GlyLys: 3.706 ± 0.059	7.756GlyLeu: 7.756 ± 0.104	2.188GlyMet: 2.188 ± 0.045	2.362GlyAsn: 2.362 ± 0.053	1.817GlyPro: 1.817 ± 0.054	3.236GlyGln: 3.236 ± 0.062	3.844GlyArg: 3.844 ± 0.064	4.349GlySer: 4.349 ± 0.074	3.461GlyThr: 3.461 ± 0.057	5.305GlyVal: 5.305 ± 0.076	1.008GlyTrp: 1.008 ± 0.036	2.465GlyTyr: 2.465 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	1.663HisAla: 1.663 ± 0.043	0.294HisCys: 0.294 ± 0.016	1.107HisAsp: 1.107 ± 0.037	1.268HisGlu: 1.268 ± 0.035	1.112HisPhe: 1.112 ± 0.036	1.538HisGly: 1.538 ± 0.047	0.729HisHis: 0.729 ± 0.034	1.302HisIle: 1.302 ± 0.037	1.034HisLys: 1.034 ± 0.033	2.586HisLeu: 2.586 ± 0.055	0.499HisMet: 0.499 ± 0.018	0.828HisAsn: 0.828 ± 0.023	1.304HisPro: 1.304 ± 0.037	1.255HisGln: 1.255 ± 0.034	1.295HisArg: 1.295 ± 0.036	1.363HisSer: 1.363 ± 0.039	1.08HisThr: 1.08 ± 0.035	1.102HisVal: 1.102 ± 0.035	0.431HisTrp: 0.431 ± 0.02	0.859HisTyr: 0.859 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.92IleAla: 5.92 ± 0.079	0.649IleCys: 0.649 ± 0.025	3.58IleAsp: 3.58 ± 0.064	4.099IleGlu: 4.099 ± 0.062	1.98IlePhe: 1.98 ± 0.055	4.274IleGly: 4.274 ± 0.077	1.192IleHis: 1.192 ± 0.035	3.014IleIle: 3.014 ± 0.062	2.561IleLys: 2.561 ± 0.047	5.205IleLeu: 5.205 ± 0.082	1.27IleMet: 1.27 ± 0.038	2.491IleAsn: 2.491 ± 0.054	2.733IlePro: 2.733 ± 0.051	2.32IleGln: 2.32 ± 0.045	3.539IleArg: 3.539 ± 0.059	4.497IleSer: 4.497 ± 0.065	3.483IleThr: 3.483 ± 0.063	3.462IleVal: 3.462 ± 0.069	0.615IleTrp: 0.615 ± 0.025	1.497IleTyr: 1.497 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.83LysAla: 4.83 ± 0.077	0.254LysCys: 0.254 ± 0.016	2.54LysAsp: 2.54 ± 0.05	3.294LysGlu: 3.294 ± 0.062	1.089LysPhe: 1.089 ± 0.029	3.32LysGly: 3.32 ± 0.063	1.088LysHis: 1.088 ± 0.036	2.527LysIle: 2.527 ± 0.058	2.666LysLys: 2.666 ± 0.063	4.661LysLeu: 4.661 ± 0.07	1.167LysMet: 1.167 ± 0.035	1.751LysAsn: 1.751 ± 0.042	2.365LysPro: 2.365 ± 0.057	2.38LysGln: 2.38 ± 0.054	2.688LysArg: 2.688 ± 0.058	2.724LysSer: 2.724 ± 0.048	2.66LysThr: 2.66 ± 0.054	3.299LysVal: 3.299 ± 0.049	0.412LysTrp: 0.412 ± 0.021	0.994LysTyr: 0.994 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	10.438LeuAla: 10.438 ± 0.114	0.969LeuCys: 0.969 ± 0.032	6.104LeuAsp: 6.104 ± 0.092	6.743LeuGlu: 6.743 ± 0.093	4.126LeuPhe: 4.126 ± 0.076	7.106LeuGly: 7.106 ± 0.101	2.18LeuHis: 2.18 ± 0.05	6.469LeuIle: 6.469 ± 0.094	5.726LeuLys: 5.726 ± 0.083	11.445LeuLeu: 11.445 ± 0.155	3.081LeuMet: 3.081 ± 0.062	4.624LeuAsn: 4.624 ± 0.064	5.281LeuPro: 5.281 ± 0.08	4.729LeuGln: 4.729 ± 0.076	5.119LeuArg: 5.119 ± 0.071	8.151LeuSer: 8.151 ± 0.095	6.054LeuThr: 6.054 ± 0.083	7.042LeuVal: 7.042 ± 0.094	1.188LeuTrp: 1.188 ± 0.035	2.6LeuTyr: 2.6 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.828MetAla: 2.828 ± 0.056	0.165MetCys: 0.165 ± 0.013	1.376MetAsp: 1.376 ± 0.038	1.324MetGlu: 1.324 ± 0.036	0.8MetPhe: 0.8 ± 0.03	1.919MetGly: 1.919 ± 0.047	0.553MetHis: 0.553 ± 0.027	1.536MetIle: 1.536 ± 0.041	1.28MetLys: 1.28 ± 0.034	2.874MetLeu: 2.874 ± 0.055	0.792MetMet: 0.792 ± 0.029	0.994MetAsn: 0.994 ± 0.028	1.328MetPro: 1.328 ± 0.038	1.334MetGln: 1.334 ± 0.034	1.288MetArg: 1.288 ± 0.037	1.927MetSer: 1.927 ± 0.041	1.67MetThr: 1.67 ± 0.043	1.77MetVal: 1.77 ± 0.042	0.171MetTrp: 0.171 ± 0.014	0.438MetTyr: 0.438 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.202AsnAla: 3.202 ± 0.058	0.347AsnCys: 0.347 ± 0.019	1.9AsnAsp: 1.9 ± 0.048	1.988AsnGlu: 1.988 ± 0.042	1.26AsnPhe: 1.26 ± 0.039	2.581AsnGly: 2.581 ± 0.057	0.87AsnHis: 0.87 ± 0.03	2.282AsnIle: 2.282 ± 0.047	1.722AsnLys: 1.722 ± 0.041	3.721AsnLeu: 3.721 ± 0.064	0.818AsnMet: 0.818 ± 0.025	1.353AsnAsn: 1.353 ± 0.039	2.183AsnPro: 2.183 ± 0.052	1.824AsnGln: 1.824 ± 0.05	2.199AsnArg: 2.199 ± 0.042	2.16AsnSer: 2.16 ± 0.056	2.053AsnThr: 2.053 ± 0.048	1.976AsnVal: 1.976 ± 0.044	0.554AsnTrp: 0.554 ± 0.026	1.003AsnTyr: 1.003 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.768ProAla: 3.768 ± 0.064	0.341ProCys: 0.341 ± 0.019	3.16ProAsp: 3.16 ± 0.057	4.278ProGlu: 4.278 ± 0.075	1.697ProPhe: 1.697 ± 0.045	2.902ProGly: 2.902 ± 0.06	0.896ProHis: 0.896 ± 0.034	2.025ProIle: 2.025 ± 0.048	1.796ProLys: 1.796 ± 0.044	4.394ProLeu: 4.394 ± 0.072	1.109ProMet: 1.109 ± 0.033	1.308ProAsn: 1.308 ± 0.039	1.41ProPro: 1.41 ± 0.045	1.694ProGln: 1.694 ± 0.041	1.511ProArg: 1.511 ± 0.047	2.422ProSer: 2.422 ± 0.05	1.854ProThr: 1.854 ± 0.036	3.956ProVal: 3.956 ± 0.063	0.542ProTrp: 0.542 ± 0.022	1.217ProTyr: 1.217 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.857GlnAla: 4.857 ± 0.082	0.347GlnCys: 0.347 ± 0.02	2.187GlnAsp: 2.187 ± 0.045	2.852GlnGlu: 2.852 ± 0.054	1.563GlnPhe: 1.563 ± 0.04	3.232GlnGly: 3.232 ± 0.052	1.179GlnHis: 1.179 ± 0.031	2.657GlnIle: 2.657 ± 0.06	2.304GlnLys: 2.304 ± 0.047	5.851GlnLeu: 5.851 ± 0.102	1.213GlnMet: 1.213 ± 0.034	1.558GlnAsn: 1.558 ± 0.04	2.279GlnPro: 2.279 ± 0.049	3.522GlnGln: 3.522 ± 0.092	2.71GlnArg: 2.71 ± 0.06	2.93GlnSer: 2.93 ± 0.055	2.291GlnThr: 2.291 ± 0.053	3.545GlnVal: 3.545 ± 0.064	0.714GlnTrp: 0.714 ± 0.026	1.166GlnTyr: 1.166 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	3.982ArgAla: 3.982 ± 0.07	0.527ArgCys: 0.527 ± 0.023	2.78ArgAsp: 2.78 ± 0.056	3.377ArgGlu: 3.377 ± 0.071	2.513ArgPhe: 2.513 ± 0.05	2.869ArgGly: 2.869 ± 0.06	1.466ArgHis: 1.466 ± 0.038	3.478ArgIle: 3.478 ± 0.06	2.615ArgLys: 2.615 ± 0.052	6.218ArgLeu: 6.218 ± 0.09	1.544ArgMet: 1.544 ± 0.04	2.035ArgAsn: 2.035 ± 0.047	2.022ArgPro: 2.022 ± 0.05	2.957ArgGln: 2.957 ± 0.06	2.894ArgArg: 2.894 ± 0.062	3.236ArgSer: 3.236 ± 0.058	2.365ArgThr: 2.365 ± 0.046	3.448ArgVal: 3.448 ± 0.065	0.808ArgTrp: 0.808 ± 0.031	1.956ArgTyr: 1.956 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.892SerAla: 5.892 ± 0.075	0.599SerCys: 0.599 ± 0.026	3.98SerAsp: 3.98 ± 0.068	4.399SerGlu: 4.399 ± 0.076	2.656SerPhe: 2.656 ± 0.051	5.684SerGly: 5.684 ± 0.069	1.524SerHis: 1.524 ± 0.041	3.623SerIle: 3.623 ± 0.072	2.514SerLys: 2.514 ± 0.049	7.066SerLeu: 7.066 ± 0.087	1.6SerMet: 1.6 ± 0.035	2.06SerAsn: 2.06 ± 0.05	2.567SerPro: 2.567 ± 0.048	2.945SerGln: 2.945 ± 0.065	3.476SerArg: 3.476 ± 0.066	4.093SerSer: 4.093 ± 0.079	2.899SerThr: 2.899 ± 0.052	4.626SerVal: 4.626 ± 0.072	0.809SerTrp: 0.809 ± 0.033	1.807SerTyr: 1.807 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	4.776ThrAla: 4.776 ± 0.081	0.489ThrCys: 0.489 ± 0.024	3.184ThrAsp: 3.184 ± 0.065	3.462ThrGlu: 3.462 ± 0.061	1.815ThrPhe: 1.815 ± 0.039	4.512ThrGly: 4.512 ± 0.079	1.088ThrHis: 1.088 ± 0.033	2.583ThrIle: 2.583 ± 0.059	1.603ThrLys: 1.603 ± 0.042	6.498ThrLeu: 6.498 ± 0.087	1.013ThrMet: 1.013 ± 0.033	1.463ThrAsn: 1.463 ± 0.043	2.865ThrPro: 2.865 ± 0.056	2.314ThrGln: 2.314 ± 0.053	2.537ThrArg: 2.537 ± 0.051	3.02ThrSer: 3.02 ± 0.058	2.5ThrThr: 2.5 ± 0.058	3.565ThrVal: 3.565 ± 0.064	0.478ThrTrp: 0.478 ± 0.022	1.28ThrTyr: 1.28 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	6.372ValAla: 6.372 ± 0.089	0.719ValCys: 0.719 ± 0.025	3.833ValAsp: 3.833 ± 0.067	4.225ValGlu: 4.225 ± 0.067	2.704ValPhe: 2.704 ± 0.053	4.377ValGly: 4.377 ± 0.07	1.314ValHis: 1.314 ± 0.036	4.536ValIle: 4.536 ± 0.084	3.138ValLys: 3.138 ± 0.059	7.211ValLeu: 7.211 ± 0.1	2.02ValMet: 2.02 ± 0.049	2.633ValAsn: 2.633 ± 0.048	2.565ValPro: 2.565 ± 0.048	2.53ValGln: 2.53 ± 0.05	3.429ValArg: 3.429 ± 0.064	4.878ValSer: 4.878 ± 0.076	3.919ValThr: 3.919 ± 0.071	5.153ValVal: 5.153 ± 0.088	0.716ValTrp: 0.716 ± 0.026	1.722ValTyr: 1.722 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.797TrpAla: 0.797 ± 0.029	0.151TrpCys: 0.151 ± 0.012	0.549TrpAsp: 0.549 ± 0.023	0.501TrpGlu: 0.501 ± 0.023	0.578TrpPhe: 0.578 ± 0.027	0.794TrpGly: 0.794 ± 0.03	0.313TrpHis: 0.313 ± 0.02	0.649TrpIle: 0.649 ± 0.025	0.479TrpLys: 0.479 ± 0.02	1.974TrpLeu: 1.974 ± 0.053	0.367TrpMet: 0.367 ± 0.019	0.412TrpAsn: 0.412 ± 0.024	0.533TrpPro: 0.533 ± 0.025	1.029TrpGln: 1.029 ± 0.033	0.713TrpArg: 0.713 ± 0.029	0.74TrpSer: 0.74 ± 0.029	0.382TrpThr: 0.382 ± 0.021	0.853TrpVal: 0.853 ± 0.026	0.149TrpTrp: 0.149 ± 0.011	0.331TrpTyr: 0.331 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.087TyrAla: 2.087 ± 0.045	0.341TyrCys: 0.341 ± 0.018	1.539TyrAsp: 1.539 ± 0.038	1.51TyrGlu: 1.51 ± 0.034	1.221TyrPhe: 1.221 ± 0.036	2.025TyrGly: 2.025 ± 0.048	0.651TyrHis: 0.651 ± 0.023	1.354TyrIle: 1.354 ± 0.039	1.149TyrLys: 1.149 ± 0.038	3.201TyrLeu: 3.201 ± 0.05	0.621TyrMet: 0.621 ± 0.027	0.882TyrAsn: 0.882 ± 0.029	1.357TyrPro: 1.357 ± 0.036	1.68TyrGln: 1.68 ± 0.042	1.939TyrArg: 1.939 ± 0.049	1.799TyrSer: 1.799 ± 0.048	1.394TyrThr: 1.394 ± 0.045	1.51TyrVal: 1.51 ± 0.031	0.451TyrTrp: 0.451 ± 0.022	0.855TyrTyr: 0.855 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3358 proteins (1056198 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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