Amino acid dipepetide frequency for Maritimibacter sp. 55A14

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.592AlaAla: 19.592 ± 0.211
1.241AlaCys: 1.241 ± 0.032
7.276AlaAsp: 7.276 ± 0.086
9.499AlaGlu: 9.499 ± 0.109
4.328AlaPhe: 4.328 ± 0.065
12.266AlaGly: 12.266 ± 0.119
2.718AlaHis: 2.718 ± 0.042
5.532AlaIle: 5.532 ± 0.076
3.029AlaLys: 3.029 ± 0.063
14.743AlaLeu: 14.743 ± 0.156
3.751AlaMet: 3.751 ± 0.063
2.384AlaAsn: 2.384 ± 0.05
6.633AlaPro: 6.633 ± 0.097
4.122AlaGln: 4.122 ± 0.067
11.308AlaArg: 11.308 ± 0.134
5.024AlaSer: 5.024 ± 0.065
5.778AlaThr: 5.778 ± 0.073
8.829AlaVal: 8.829 ± 0.114
1.581AlaTrp: 1.581 ± 0.039
2.458AlaTyr: 2.458 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.243CysAla: 1.243 ± 0.033
0.131CysCys: 0.131 ± 0.011
0.646CysAsp: 0.646 ± 0.025
0.505CysGlu: 0.505 ± 0.024
0.343CysPhe: 0.343 ± 0.019
1.042CysGly: 1.042 ± 0.034
0.283CysHis: 0.283 ± 0.017
0.393CysIle: 0.393 ± 0.021
0.191CysLys: 0.191 ± 0.012
0.937CysLeu: 0.937 ± 0.031
0.181CysMet: 0.181 ± 0.013
0.227CysAsn: 0.227 ± 0.016
0.595CysPro: 0.595 ± 0.024
0.221CysGln: 0.221 ± 0.015
0.683CysArg: 0.683 ± 0.026
0.454CysSer: 0.454 ± 0.022
0.508CysThr: 0.508 ± 0.026
0.687CysVal: 0.687 ± 0.025
0.146CysTrp: 0.146 ± 0.011
0.23CysTyr: 0.23 ± 0.015
0.0CysXaa: 0.0 ± 0.0
Asp
7.939AspAla: 7.939 ± 0.089
0.637AspCys: 0.637 ± 0.025
3.15AspAsp: 3.15 ± 0.06
3.459AspGlu: 3.459 ± 0.057
2.323AspPhe: 2.323 ± 0.055
5.755AspGly: 5.755 ± 0.084
1.349AspHis: 1.349 ± 0.039
2.94AspIle: 2.94 ± 0.057
1.386AspLys: 1.386 ± 0.036
6.207AspLeu: 6.207 ± 0.093
1.678AspMet: 1.678 ± 0.038
1.06AspAsn: 1.06 ± 0.033
3.837AspPro: 3.837 ± 0.064
1.48AspGln: 1.48 ± 0.041
4.866AspArg: 4.866 ± 0.069
1.95AspSer: 1.95 ± 0.045
2.788AspThr: 2.788 ± 0.058
3.93AspVal: 3.93 ± 0.057
1.304AspTrp: 1.304 ± 0.035
1.492AspTyr: 1.492 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
9.093GluAla: 9.093 ± 0.102
0.399GluCys: 0.399 ± 0.02
3.417GluAsp: 3.417 ± 0.059
3.712GluGlu: 3.712 ± 0.07
1.903GluPhe: 1.903 ± 0.045
5.043GluGly: 5.043 ± 0.073
1.261GluHis: 1.261 ± 0.036
3.875GluIle: 3.875 ± 0.069
2.086GluLys: 2.086 ± 0.05
5.39GluLeu: 5.39 ± 0.081
1.967GluMet: 1.967 ± 0.041
1.603GluAsn: 1.603 ± 0.043
2.84GluPro: 2.84 ± 0.057
1.671GluGln: 1.671 ± 0.04
5.023GluArg: 5.023 ± 0.071
2.296GluSer: 2.296 ± 0.044
4.015GluThr: 4.015 ± 0.066
4.263GluVal: 4.263 ± 0.057
0.745GluTrp: 0.745 ± 0.032
1.04GluTyr: 1.04 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
4.485PheAla: 4.485 ± 0.06
0.453PheCys: 0.453 ± 0.02
2.661PheAsp: 2.661 ± 0.048
2.271PheGlu: 2.271 ± 0.047
1.417PhePhe: 1.417 ± 0.039
3.599PheGly: 3.599 ± 0.053
0.792PheHis: 0.792 ± 0.03
1.578PheIle: 1.578 ± 0.044
0.758PheLys: 0.758 ± 0.029
3.442PheLeu: 3.442 ± 0.065
0.811PheMet: 0.811 ± 0.025
0.934PheAsn: 0.934 ± 0.031
1.545PhePro: 1.545 ± 0.034
0.902PheGln: 0.902 ± 0.026
2.54PheArg: 2.54 ± 0.052
1.932PheSer: 1.932 ± 0.047
2.076PheThr: 2.076 ± 0.04
2.563PheVal: 2.563 ± 0.053
0.613PheTrp: 0.613 ± 0.021
0.866PheTyr: 0.866 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
11.192GlyAla: 11.192 ± 0.118
0.934GlyCys: 0.934 ± 0.033
4.781GlyAsp: 4.781 ± 0.074
4.883GlyGlu: 4.883 ± 0.075
3.759GlyPhe: 3.759 ± 0.06
8.011GlyGly: 8.011 ± 0.098
2.102GlyHis: 2.102 ± 0.049
4.258GlyIle: 4.258 ± 0.068
2.842GlyLys: 2.842 ± 0.058
9.707GlyLeu: 9.707 ± 0.099
2.69GlyMet: 2.69 ± 0.055
1.976GlyAsn: 1.976 ± 0.044
4.098GlyPro: 4.098 ± 0.071
2.768GlyGln: 2.768 ± 0.049
7.138GlyArg: 7.138 ± 0.087
3.966GlySer: 3.966 ± 0.06
4.619GlyThr: 4.619 ± 0.071
6.484GlyVal: 6.484 ± 0.084
1.614GlyTrp: 1.614 ± 0.039
2.284GlyTyr: 2.284 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
2.553HisAla: 2.553 ± 0.046
0.293HisCys: 0.293 ± 0.017
1.359HisAsp: 1.359 ± 0.035
1.134HisGlu: 1.134 ± 0.03
0.879HisPhe: 0.879 ± 0.025
2.097HisGly: 2.097 ± 0.051
0.555HisHis: 0.555 ± 0.023
0.903HisIle: 0.903 ± 0.029
0.485HisLys: 0.485 ± 0.022
2.202HisLeu: 2.202 ± 0.047
0.575HisMet: 0.575 ± 0.025
0.428HisAsn: 0.428 ± 0.021
1.442HisPro: 1.442 ± 0.042
0.498HisGln: 0.498 ± 0.024
1.64HisArg: 1.64 ± 0.041
0.919HisSer: 0.919 ± 0.031
0.825HisThr: 0.825 ± 0.027
1.727HisVal: 1.727 ± 0.038
0.383HisTrp: 0.383 ± 0.019
0.577HisTyr: 0.577 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.865IleAla: 6.865 ± 0.078
0.603IleCys: 0.603 ± 0.024
3.24IleAsp: 3.24 ± 0.056
3.274IleGlu: 3.274 ± 0.059
1.741IlePhe: 1.741 ± 0.043
4.655IleGly: 4.655 ± 0.074
0.931IleHis: 0.931 ± 0.029
1.773IleIle: 1.773 ± 0.047
1.057IleLys: 1.057 ± 0.034
4.435IleLeu: 4.435 ± 0.071
0.997IleMet: 0.997 ± 0.03
1.157IleAsn: 1.157 ± 0.039
2.129IlePro: 2.129 ± 0.049
0.991IleGln: 0.991 ± 0.03
3.584IleArg: 3.584 ± 0.058
2.593IleSer: 2.593 ± 0.047
2.522IleThr: 2.522 ± 0.051
3.594IleVal: 3.594 ± 0.056
0.689IleTrp: 0.689 ± 0.027
1.052IleTyr: 1.052 ± 0.034
0.0IleXaa: 0.0 ± 0.0
Lys
3.363LysAla: 3.363 ± 0.059
0.181LysCys: 0.181 ± 0.012
1.426LysAsp: 1.426 ± 0.037
1.309LysGlu: 1.309 ± 0.041
0.768LysPhe: 0.768 ± 0.028
2.341LysGly: 2.341 ± 0.046
0.538LysHis: 0.538 ± 0.026
1.37LysIle: 1.37 ± 0.04
0.97LysLys: 0.97 ± 0.034
2.687LysLeu: 2.687 ± 0.054
0.694LysMet: 0.694 ± 0.027
0.647LysAsn: 0.647 ± 0.022
1.672LysPro: 1.672 ± 0.04
0.688LysGln: 0.688 ± 0.029
2.122LysArg: 2.122 ± 0.048
1.549LysSer: 1.549 ± 0.039
1.723LysThr: 1.723 ± 0.041
1.989LysVal: 1.989 ± 0.05
0.355LysTrp: 0.355 ± 0.017
0.556LysTyr: 0.556 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
14.045LeuAla: 14.045 ± 0.147
1.059LeuCys: 1.059 ± 0.032
6.408LeuAsp: 6.408 ± 0.092
6.096LeuGlu: 6.096 ± 0.087
3.249LeuPhe: 3.249 ± 0.066
8.834LeuGly: 8.834 ± 0.105
2.033LeuHis: 2.033 ± 0.05
4.805LeuIle: 4.805 ± 0.081
2.886LeuLys: 2.886 ± 0.05
8.998LeuLeu: 8.998 ± 0.123
2.579LeuMet: 2.579 ± 0.045
2.414LeuAsn: 2.414 ± 0.049
5.536LeuPro: 5.536 ± 0.079
2.273LeuGln: 2.273 ± 0.043
7.873LeuArg: 7.873 ± 0.09
6.009LeuSer: 6.009 ± 0.087
5.665LeuThr: 5.665 ± 0.07
7.052LeuVal: 7.052 ± 0.079
1.299LeuTrp: 1.299 ± 0.042
1.942LeuTyr: 1.942 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
3.567MetAla: 3.567 ± 0.06
0.191MetCys: 0.191 ± 0.013
1.387MetAsp: 1.387 ± 0.045
1.491MetGlu: 1.491 ± 0.039
0.727MetPhe: 0.727 ± 0.03
2.144MetGly: 2.144 ± 0.051
0.482MetHis: 0.482 ± 0.02
1.409MetIle: 1.409 ± 0.04
0.937MetLys: 0.937 ± 0.035
2.574MetLeu: 2.574 ± 0.056
0.731MetMet: 0.731 ± 0.031
0.729MetAsn: 0.729 ± 0.024
1.536MetPro: 1.536 ± 0.037
0.909MetGln: 0.909 ± 0.029
2.11MetArg: 2.11 ± 0.052
1.676MetSer: 1.676 ± 0.044
1.961MetThr: 1.961 ± 0.045
1.801MetVal: 1.801 ± 0.04
0.248MetTrp: 0.248 ± 0.014
0.314MetTyr: 0.314 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
2.923AsnAla: 2.923 ± 0.05
0.253AsnCys: 0.253 ± 0.016
1.173AsnAsp: 1.173 ± 0.036
1.081AsnGlu: 1.081 ± 0.03
0.85AsnPhe: 0.85 ± 0.033
2.088AsnGly: 2.088 ± 0.049
0.489AsnHis: 0.489 ± 0.02
1.154AsnIle: 1.154 ± 0.032
0.507AsnLys: 0.507 ± 0.022
2.258AsnLeu: 2.258 ± 0.044
0.598AsnMet: 0.598 ± 0.024
0.554AsnAsn: 0.554 ± 0.026
1.739AsnPro: 1.739 ± 0.039
0.563AsnGln: 0.563 ± 0.023
1.705AsnArg: 1.705 ± 0.039
1.01AsnSer: 1.01 ± 0.03
1.129AsnThr: 1.129 ± 0.035
1.71AsnVal: 1.71 ± 0.044
0.407AsnTrp: 0.407 ± 0.019
0.555AsnTyr: 0.555 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
6.527ProAla: 6.527 ± 0.092
0.432ProCys: 0.432 ± 0.02
4.198ProAsp: 4.198 ± 0.068
4.548ProGlu: 4.548 ± 0.071
1.92ProPhe: 1.92 ± 0.042
5.352ProGly: 5.352 ± 0.085
1.108ProHis: 1.108 ± 0.029
1.932ProIle: 1.932 ± 0.043
1.4ProLys: 1.4 ± 0.039
4.776ProLeu: 4.776 ± 0.074
1.277ProMet: 1.277 ± 0.034
1.137ProAsn: 1.137 ± 0.034
2.623ProPro: 2.623 ± 0.058
1.578ProGln: 1.578 ± 0.039
3.392ProArg: 3.392 ± 0.063
2.195ProSer: 2.195 ± 0.041
2.0ProThr: 2.0 ± 0.043
4.579ProVal: 4.579 ± 0.072
0.732ProTrp: 0.732 ± 0.028
1.115ProTyr: 1.115 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
3.718GlnAla: 3.718 ± 0.069
0.22GlnCys: 0.22 ± 0.015
1.438GlnAsp: 1.438 ± 0.035
1.513GlnGlu: 1.513 ± 0.036
0.921GlnPhe: 0.921 ± 0.031
2.321GlnGly: 2.321 ± 0.044
0.509GlnHis: 0.509 ± 0.023
1.719GlnIle: 1.719 ± 0.04
0.853GlnLys: 0.853 ± 0.032
2.316GlnLeu: 2.316 ± 0.04
0.946GlnMet: 0.946 ± 0.03
0.722GlnAsn: 0.722 ± 0.028
1.417GlnPro: 1.417 ± 0.038
0.873GlnGln: 0.873 ± 0.03
2.052GlnArg: 2.052 ± 0.041
1.532GlnSer: 1.532 ± 0.035
1.485GlnThr: 1.485 ± 0.034
2.094GlnVal: 2.094 ± 0.048
0.353GlnTrp: 0.353 ± 0.019
0.506GlnTyr: 0.506 ± 0.022
0.0GlnXaa: 0.0 ± 0.0
Arg
10.041ArgAla: 10.041 ± 0.124
0.585ArgCys: 0.585 ± 0.023
4.989ArgAsp: 4.989 ± 0.065
4.483ArgGlu: 4.483 ± 0.074
2.964ArgPhe: 2.964 ± 0.059
5.628ArgGly: 5.628 ± 0.076
1.883ArgHis: 1.883 ± 0.051
4.286ArgIle: 4.286 ± 0.058
2.316ArgLys: 2.316 ± 0.046
8.688ArgLeu: 8.688 ± 0.108
2.216ArgMet: 2.216 ± 0.044
1.845ArgAsn: 1.845 ± 0.04
3.987ArgPro: 3.987 ± 0.061
2.324ArgGln: 2.324 ± 0.048
6.566ArgArg: 6.566 ± 0.103
3.404ArgSer: 3.404 ± 0.056
3.285ArgThr: 3.285 ± 0.051
5.293ArgVal: 5.293 ± 0.07
1.094ArgTrp: 1.094 ± 0.034
1.677ArgTyr: 1.677 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.605SerAla: 5.605 ± 0.074
0.419SerCys: 0.419 ± 0.022
2.917SerAsp: 2.917 ± 0.049
2.615SerGlu: 2.615 ± 0.051
2.022SerPhe: 2.022 ± 0.043
5.139SerGly: 5.139 ± 0.083
1.032SerHis: 1.032 ± 0.031
2.101SerIle: 2.101 ± 0.049
1.196SerLys: 1.196 ± 0.036
4.48SerLeu: 4.48 ± 0.08
1.223SerMet: 1.223 ± 0.036
1.152SerAsn: 1.152 ± 0.035
2.392SerPro: 2.392 ± 0.054
1.298SerGln: 1.298 ± 0.033
3.422SerArg: 3.422 ± 0.056
2.069SerSer: 2.069 ± 0.05
2.187SerThr: 2.187 ± 0.056
3.564SerVal: 3.564 ± 0.065
0.594SerTrp: 0.594 ± 0.025
1.241SerTyr: 1.241 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
6.171ThrAla: 6.171 ± 0.074
0.499ThrCys: 0.499 ± 0.021
2.987ThrAsp: 2.987 ± 0.05
3.008ThrGlu: 3.008 ± 0.051
1.69ThrPhe: 1.69 ± 0.039
5.665ThrGly: 5.665 ± 0.072
1.112ThrHis: 1.112 ± 0.031
2.396ThrIle: 2.396 ± 0.046
1.163ThrLys: 1.163 ± 0.037
5.614ThrLeu: 5.614 ± 0.079
1.104ThrMet: 1.104 ± 0.034
1.085ThrAsn: 1.085 ± 0.034
3.304ThrPro: 3.304 ± 0.059
1.304ThrGln: 1.304 ± 0.038
3.876ThrArg: 3.876 ± 0.058
2.314ThrSer: 2.314 ± 0.055
2.477ThrThr: 2.477 ± 0.055
4.012ThrVal: 4.012 ± 0.064
0.635ThrTrp: 0.635 ± 0.023
1.086ThrTyr: 1.086 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.167ValAla: 9.167 ± 0.106
0.694ValCys: 0.694 ± 0.025
3.816ValAsp: 3.816 ± 0.067
4.834ValGlu: 4.834 ± 0.072
3.002ValPhe: 3.002 ± 0.054
5.068ValGly: 5.068 ± 0.077
1.392ValHis: 1.392 ± 0.04
3.91ValIle: 3.91 ± 0.071
1.914ValLys: 1.914 ± 0.039
7.63ValLeu: 7.63 ± 0.089
2.029ValMet: 2.029 ± 0.041
1.777ValAsn: 1.777 ± 0.044
3.642ValPro: 3.642 ± 0.057
1.891ValGln: 1.891 ± 0.048
4.584ValArg: 4.584 ± 0.07
3.976ValSer: 3.976 ± 0.071
4.683ValThr: 4.683 ± 0.07
5.4ValVal: 5.4 ± 0.074
1.037ValTrp: 1.037 ± 0.031
1.459ValTyr: 1.459 ± 0.042
0.0ValXaa: 0.0 ± 0.0
Trp
1.47TrpAla: 1.47 ± 0.042
0.161TrpCys: 0.161 ± 0.014
0.748TrpAsp: 0.748 ± 0.03
0.722TrpGlu: 0.722 ± 0.028
0.583TrpPhe: 0.583 ± 0.021
1.019TrpGly: 1.019 ± 0.033
0.375TrpHis: 0.375 ± 0.019
0.698TrpIle: 0.698 ± 0.024
0.465TrpLys: 0.465 ± 0.018
1.77TrpLeu: 1.77 ± 0.041
0.392TrpMet: 0.392 ± 0.017
0.398TrpAsn: 0.398 ± 0.019
0.819TrpPro: 0.819 ± 0.029
0.571TrpGln: 0.571 ± 0.021
1.308TrpArg: 1.308 ± 0.035
0.772TrpSer: 0.772 ± 0.028
0.773TrpThr: 0.773 ± 0.028
0.884TrpVal: 0.884 ± 0.032
0.242TrpTrp: 0.242 ± 0.013
0.288TrpTyr: 0.288 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.532TyrAla: 2.532 ± 0.049
0.261TyrCys: 0.261 ± 0.015
1.512TyrAsp: 1.512 ± 0.037
1.206TyrGlu: 1.206 ± 0.036
0.848TyrPhe: 0.848 ± 0.025
2.038TyrGly: 2.038 ± 0.043
0.532TyrHis: 0.532 ± 0.022
0.85TyrIle: 0.85 ± 0.027
0.509TyrLys: 0.509 ± 0.021
2.201TyrLeu: 2.201 ± 0.048
0.483TyrMet: 0.483 ± 0.021
0.518TyrAsn: 0.518 ± 0.023
1.036TyrPro: 1.036 ± 0.03
0.585TyrGln: 0.585 ± 0.024
1.762TyrArg: 1.762 ± 0.036
1.028TyrSer: 1.028 ± 0.03
1.001TyrThr: 1.001 ± 0.027
1.45TyrVal: 1.45 ± 0.036
0.387TyrTrp: 0.387 ± 0.019
0.565TyrTyr: 0.565 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3708 proteins (1118195 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski