Amino acid dipepetide frequency for Perkinsus sp. BL_2016

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.732AlaAla: 8.732 ± 0.357
1.532AlaCys: 1.532 ± 0.109
4.029AlaAsp: 4.029 ± 0.145
4.445AlaGlu: 4.445 ± 0.171
3.3AlaPhe: 3.3 ± 0.125
5.183AlaGly: 5.183 ± 0.175
1.755AlaHis: 1.755 ± 0.096
4.716AlaIle: 4.716 ± 0.157
4.141AlaLys: 4.141 ± 0.151
7.552AlaLeu: 7.552 ± 0.251
1.845AlaMet: 1.845 ± 0.091
2.695AlaAsn: 2.695 ± 0.125
3.905AlaPro: 3.905 ± 0.192
2.922AlaGln: 2.922 ± 0.125
4.111AlaArg: 4.111 ± 0.158
6.672AlaSer: 6.672 ± 0.258
4.394AlaThr: 4.394 ± 0.172
5.818AlaVal: 5.818 ± 0.192
0.729AlaTrp: 0.729 ± 0.06
1.909AlaTyr: 1.909 ± 0.097
0.0AlaXaa: 0.0 ± 0.0
Cys
1.33CysAla: 1.33 ± 0.098
0.626CysCys: 0.626 ± 0.123
1.03CysAsp: 1.03 ± 0.072
0.862CysGlu: 0.862 ± 0.062
0.768CysPhe: 0.768 ± 0.056
1.137CysGly: 1.137 ± 0.08
0.451CysHis: 0.451 ± 0.041
0.995CysIle: 0.995 ± 0.07
0.626CysLys: 0.626 ± 0.059
1.592CysLeu: 1.592 ± 0.08
0.352CysMet: 0.352 ± 0.044
0.592CysAsn: 0.592 ± 0.051
1.017CysPro: 1.017 ± 0.081
0.545CysGln: 0.545 ± 0.049
1.017CysArg: 1.017 ± 0.063
1.519CysSer: 1.519 ± 0.093
0.987CysThr: 0.987 ± 0.064
1.137CysVal: 1.137 ± 0.082
0.215CysTrp: 0.215 ± 0.028
0.395CysTyr: 0.395 ± 0.042
0.0CysXaa: 0.0 ± 0.0
Asp
3.892AspAla: 3.892 ± 0.16
0.875AspCys: 0.875 ± 0.067
3.261AspAsp: 3.261 ± 0.186
4.222AspGlu: 4.222 ± 0.199
2.755AspPhe: 2.755 ± 0.115
3.184AspGly: 3.184 ± 0.124
1.176AspHis: 1.176 ± 0.076
3.016AspIle: 3.016 ± 0.123
2.364AspLys: 2.364 ± 0.107
5.402AspLeu: 5.402 ± 0.153
1.159AspMet: 1.159 ± 0.067
1.742AspAsn: 1.742 ± 0.098
2.677AspPro: 2.677 ± 0.114
1.905AspGln: 1.905 ± 0.102
2.823AspArg: 2.823 ± 0.123
4.72AspSer: 4.72 ± 0.174
2.266AspThr: 2.266 ± 0.115
3.501AspVal: 3.501 ± 0.144
0.747AspTrp: 0.747 ± 0.056
1.575AspTyr: 1.575 ± 0.086
0.0AspXaa: 0.0 ± 0.0
Glu
5.192GluAla: 5.192 ± 0.211
0.923GluCys: 0.923 ± 0.068
3.463GluAsp: 3.463 ± 0.14
4.857GluGlu: 4.857 ± 0.253
2.733GluPhe: 2.733 ± 0.105
3.424GluGly: 3.424 ± 0.129
1.309GluHis: 1.309 ± 0.065
4.265GluIle: 4.265 ± 0.142
3.677GluLys: 3.677 ± 0.176
5.887GluLeu: 5.887 ± 0.22
1.472GluMet: 1.472 ± 0.079
2.656GluAsn: 2.656 ± 0.114
2.21GluPro: 2.21 ± 0.089
2.008GluGln: 2.008 ± 0.101
3.527GluArg: 3.527 ± 0.173
4.965GluSer: 4.965 ± 0.168
3.493GluThr: 3.493 ± 0.13
3.72GluVal: 3.72 ± 0.143
0.708GluTrp: 0.708 ± 0.055
1.536GluTyr: 1.536 ± 0.094
0.0GluXaa: 0.0 ± 0.0
Phe
3.278PheAla: 3.278 ± 0.133
0.794PheCys: 0.794 ± 0.055
2.652PheAsp: 2.652 ± 0.115
2.643PheGlu: 2.643 ± 0.113
1.897PhePhe: 1.897 ± 0.099
3.016PheGly: 3.016 ± 0.14
0.91PheHis: 0.91 ± 0.068
2.407PheIle: 2.407 ± 0.099
2.218PheLys: 2.218 ± 0.12
3.948PheLeu: 3.948 ± 0.163
1.017PheMet: 1.017 ± 0.071
1.871PheAsn: 1.871 ± 0.112
2.137PhePro: 2.137 ± 0.108
1.33PheGln: 1.33 ± 0.068
2.27PheArg: 2.27 ± 0.096
3.75PheSer: 3.75 ± 0.119
2.36PheThr: 2.36 ± 0.115
3.081PheVal: 3.081 ± 0.121
0.545PheTrp: 0.545 ± 0.054
1.266PheTyr: 1.266 ± 0.078
0.0PheXaa: 0.0 ± 0.0
Gly
4.501GlyAla: 4.501 ± 0.175
1.141GlyCys: 1.141 ± 0.074
3.201GlyAsp: 3.201 ± 0.133
3.325GlyGlu: 3.325 ± 0.137
2.742GlyPhe: 2.742 ± 0.123
5.085GlyGly: 5.085 ± 0.198
1.596GlyHis: 1.596 ± 0.095
3.948GlyIle: 3.948 ± 0.148
3.643GlyLys: 3.643 ± 0.152
5.9GlyLeu: 5.9 ± 0.182
1.562GlyMet: 1.562 ± 0.106
2.759GlyAsn: 2.759 ± 0.114
2.274GlyPro: 2.274 ± 0.099
2.21GlyGln: 2.21 ± 0.11
3.647GlyArg: 3.647 ± 0.149
5.441GlySer: 5.441 ± 0.191
3.553GlyThr: 3.553 ± 0.14
4.432GlyVal: 4.432 ± 0.155
0.781GlyTrp: 0.781 ± 0.061
1.673GlyTyr: 1.673 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
1.626HisAla: 1.626 ± 0.1
0.451HisCys: 0.451 ± 0.044
1.098HisAsp: 1.098 ± 0.081
1.352HisGlu: 1.352 ± 0.076
1.034HisPhe: 1.034 ± 0.066
1.579HisGly: 1.579 ± 0.093
0.712HisHis: 0.712 ± 0.064
1.231HisIle: 1.231 ± 0.077
1.043HisLys: 1.043 ± 0.069
2.304HisLeu: 2.304 ± 0.114
0.549HisMet: 0.549 ± 0.049
0.798HisAsn: 0.798 ± 0.053
1.373HisPro: 1.373 ± 0.083
0.867HisGln: 0.867 ± 0.069
1.352HisArg: 1.352 ± 0.077
1.884HisSer: 1.884 ± 0.083
1.051HisThr: 1.051 ± 0.115
1.592HisVal: 1.592 ± 0.11
0.249HisTrp: 0.249 ± 0.035
0.657HisTyr: 0.657 ± 0.053
0.0HisXaa: 0.0 ± 0.0
Ile
4.287IleAla: 4.287 ± 0.171
1.043IleCys: 1.043 ± 0.069
3.652IleAsp: 3.652 ± 0.128
4.076IleGlu: 4.076 ± 0.151
2.51IlePhe: 2.51 ± 0.125
3.772IleGly: 3.772 ± 0.157
1.317IleHis: 1.317 ± 0.085
3.077IleIle: 3.077 ± 0.137
2.858IleLys: 2.858 ± 0.132
5.291IleLeu: 5.291 ± 0.168
1.038IleMet: 1.038 ± 0.061
2.236IleAsn: 2.236 ± 0.109
2.961IlePro: 2.961 ± 0.121
2.227IleGln: 2.227 ± 0.117
3.222IleArg: 3.222 ± 0.127
5.351IleSer: 5.351 ± 0.171
2.677IleThr: 2.677 ± 0.114
4.093IleVal: 4.093 ± 0.138
0.562IleTrp: 0.562 ± 0.047
1.412IleTyr: 1.412 ± 0.081
0.0IleXaa: 0.0 ± 0.0
Lys
4.265LysAla: 4.265 ± 0.171
0.777LysCys: 0.777 ± 0.064
2.45LysAsp: 2.45 ± 0.102
3.248LysGlu: 3.248 ± 0.151
2.193LysPhe: 2.193 ± 0.1
2.871LysGly: 2.871 ± 0.131
1.154LysHis: 1.154 ± 0.079
3.201LysIle: 3.201 ± 0.144
3.501LysLys: 3.501 ± 0.164
4.977LysLeu: 4.977 ± 0.168
1.356LysMet: 1.356 ± 0.087
2.283LysAsn: 2.283 ± 0.093
2.334LysPro: 2.334 ± 0.156
1.785LysGln: 1.785 ± 0.084
3.433LysArg: 3.433 ± 0.132
4.291LysSer: 4.291 ± 0.164
3.205LysThr: 3.205 ± 0.134
3.416LysVal: 3.416 ± 0.121
0.609LysTrp: 0.609 ± 0.053
1.716LysTyr: 1.716 ± 0.095
0.0LysXaa: 0.0 ± 0.0
Leu
7.488LeuAla: 7.488 ± 0.2
1.489LeuCys: 1.489 ± 0.084
4.737LeuAsp: 4.737 ± 0.162
5.956LeuGlu: 5.956 ± 0.204
4.055LeuPhe: 4.055 ± 0.155
5.574LeuGly: 5.574 ± 0.199
2.141LeuHis: 2.141 ± 0.091
5.149LeuIle: 5.149 ± 0.22
5.642LeuLys: 5.642 ± 0.202
9.234LeuLeu: 9.234 ± 0.28
2.381LeuMet: 2.381 ± 0.103
4.257LeuAsn: 4.257 ± 0.154
4.724LeuPro: 4.724 ± 0.155
3.621LeuGln: 3.621 ± 0.144
5.797LeuArg: 5.797 ± 0.172
8.157LeuSer: 8.157 ± 0.217
5.128LeuThr: 5.128 ± 0.165
6.475LeuVal: 6.475 ± 0.183
1.008LeuTrp: 1.008 ± 0.077
2.055LeuTyr: 2.055 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
1.97MetAla: 1.97 ± 0.102
0.421MetCys: 0.421 ± 0.042
1.347MetAsp: 1.347 ± 0.068
1.562MetGlu: 1.562 ± 0.085
0.815MetPhe: 0.815 ± 0.059
1.343MetGly: 1.343 ± 0.084
0.519MetHis: 0.519 ± 0.044
1.201MetIle: 1.201 ± 0.075
1.596MetLys: 1.596 ± 0.092
1.995MetLeu: 1.995 ± 0.095
0.618MetMet: 0.618 ± 0.045
1.06MetAsn: 1.06 ± 0.072
1.034MetPro: 1.034 ± 0.075
0.888MetGln: 0.888 ± 0.072
1.407MetArg: 1.407 ± 0.082
1.798MetSer: 1.798 ± 0.094
1.322MetThr: 1.322 ± 0.068
1.279MetVal: 1.279 ± 0.081
0.202MetTrp: 0.202 ± 0.031
0.566MetTyr: 0.566 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
2.811AsnAla: 2.811 ± 0.124
0.691AsnCys: 0.691 ± 0.065
2.06AsnAsp: 2.06 ± 0.109
2.347AsnGlu: 2.347 ± 0.117
1.867AsnPhe: 1.867 ± 0.094
2.677AsnGly: 2.677 ± 0.126
0.892AsnHis: 0.892 ± 0.064
2.321AsnIle: 2.321 ± 0.104
1.892AsnLys: 1.892 ± 0.108
3.982AsnLeu: 3.982 ± 0.186
0.82AsnMet: 0.82 ± 0.062
1.806AsnAsn: 1.806 ± 0.152
2.188AsnPro: 2.188 ± 0.116
1.39AsnGln: 1.39 ± 0.082
2.261AsnArg: 2.261 ± 0.11
3.587AsnSer: 3.587 ± 0.156
2.094AsnThr: 2.094 ± 0.099
2.587AsnVal: 2.587 ± 0.113
0.506AsnTrp: 0.506 ± 0.042
1.171AsnTyr: 1.171 ± 0.082
0.0AsnXaa: 0.0 ± 0.0
Pro
3.995ProAla: 3.995 ± 0.203
0.635ProCys: 0.635 ± 0.055
2.497ProAsp: 2.497 ± 0.101
3.034ProGlu: 3.034 ± 0.124
2.072ProPhe: 2.072 ± 0.107
2.793ProGly: 2.793 ± 0.139
0.974ProHis: 0.974 ± 0.072
2.493ProIle: 2.493 ± 0.106
2.175ProLys: 2.175 ± 0.129
4.287ProLeu: 4.287 ± 0.136
0.991ProMet: 0.991 ± 0.079
1.892ProAsn: 1.892 ± 0.103
3.265ProPro: 3.265 ± 0.207
1.918ProGln: 1.918 ± 0.113
2.798ProArg: 2.798 ± 0.142
4.707ProSer: 4.707 ± 0.183
2.738ProThr: 2.738 ± 0.149
3.506ProVal: 3.506 ± 0.205
0.541ProTrp: 0.541 ± 0.044
1.051ProTyr: 1.051 ± 0.071
0.0ProXaa: 0.0 ± 0.0
Gln
2.841GlnAla: 2.841 ± 0.126
0.532GlnCys: 0.532 ± 0.045
1.532GlnAsp: 1.532 ± 0.08
2.197GlnGlu: 2.197 ± 0.091
1.768GlnPhe: 1.768 ± 0.09
2.09GlnGly: 2.09 ± 0.099
0.85GlnHis: 0.85 ± 0.062
2.308GlnIle: 2.308 ± 0.114
1.832GlnLys: 1.832 ± 0.083
3.57GlnLeu: 3.57 ± 0.145
0.892GlnMet: 0.892 ± 0.062
1.296GlnAsn: 1.296 ± 0.085
1.532GlnPro: 1.532 ± 0.089
1.815GlnGln: 1.815 ± 0.138
2.09GlnArg: 2.09 ± 0.112
2.888GlnSer: 2.888 ± 0.137
1.849GlnThr: 1.849 ± 0.096
2.755GlnVal: 2.755 ± 0.118
0.442GlnTrp: 0.442 ± 0.047
1.056GlnTyr: 1.056 ± 0.095
0.0GlnXaa: 0.0 ± 0.0
Arg
4.115ArgAla: 4.115 ± 0.139
1.03ArgCys: 1.03 ± 0.073
2.918ArgAsp: 2.918 ± 0.142
3.308ArgGlu: 3.308 ± 0.137
2.42ArgPhe: 2.42 ± 0.092
3.506ArgGly: 3.506 ± 0.139
1.506ArgHis: 1.506 ± 0.088
3.497ArgIle: 3.497 ± 0.141
3.385ArgLys: 3.385 ± 0.15
5.767ArgLeu: 5.767 ± 0.174
1.446ArgMet: 1.446 ± 0.082
2.308ArgAsn: 2.308 ± 0.101
2.755ArgPro: 2.755 ± 0.147
2.291ArgGln: 2.291 ± 0.121
4.329ArgArg: 4.329 ± 0.223
4.432ArgSer: 4.432 ± 0.182
2.656ArgThr: 2.656 ± 0.118
3.78ArgVal: 3.78 ± 0.15
0.652ArgTrp: 0.652 ± 0.06
1.42ArgTyr: 1.42 ± 0.082
0.0ArgXaa: 0.0 ± 0.0
Ser
6.994SerAla: 6.994 ± 0.254
1.45SerCys: 1.45 ± 0.095
4.776SerAsp: 4.776 ± 0.179
5.128SerGlu: 5.128 ± 0.196
3.767SerPhe: 3.767 ± 0.147
5.758SerGly: 5.758 ± 0.18
1.875SerHis: 1.875 ± 0.1
4.806SerIle: 4.806 ± 0.173
4.308SerLys: 4.308 ± 0.141
7.891SerLeu: 7.891 ± 0.218
1.798SerMet: 1.798 ± 0.092
3.454SerAsn: 3.454 ± 0.139
4.119SerPro: 4.119 ± 0.176
2.905SerGln: 2.905 ± 0.105
4.626SerArg: 4.626 ± 0.159
9.732SerSer: 9.732 ± 0.58
4.999SerThr: 4.999 ± 0.245
6.26SerVal: 6.26 ± 0.209
0.961SerTrp: 0.961 ± 0.065
1.691SerTyr: 1.691 ± 0.091
0.0SerXaa: 0.0 ± 0.0
Thr
4.72ThrAla: 4.72 ± 0.16
0.978ThrCys: 0.978 ± 0.067
2.6ThrAsp: 2.6 ± 0.107
3.137ThrGlu: 3.137 ± 0.127
2.115ThrPhe: 2.115 ± 0.1
3.772ThrGly: 3.772 ± 0.14
1.287ThrHis: 1.287 ± 0.107
3.004ThrIle: 3.004 ± 0.129
2.433ThrLys: 2.433 ± 0.099
5.235ThrLeu: 5.235 ± 0.16
1.09ThrMet: 1.09 ± 0.063
2.021ThrAsn: 2.021 ± 0.091
2.819ThrPro: 2.819 ± 0.115
1.691ThrGln: 1.691 ± 0.107
2.832ThrArg: 2.832 ± 0.117
5.025ThrSer: 5.025 ± 0.309
3.51ThrThr: 3.51 ± 0.27
3.969ThrVal: 3.969 ± 0.137
0.592ThrTrp: 0.592 ± 0.056
1.249ThrTyr: 1.249 ± 0.085
0.0ThrXaa: 0.0 ± 0.0
Val
5.823ValAla: 5.823 ± 0.216
1.128ValCys: 1.128 ± 0.082
3.943ValAsp: 3.943 ± 0.137
4.304ValGlu: 4.304 ± 0.162
2.922ValPhe: 2.922 ± 0.127
4.175ValGly: 4.175 ± 0.136
1.536ValHis: 1.536 ± 0.093
3.857ValIle: 3.857 ± 0.126
3.669ValLys: 3.669 ± 0.124
6.574ValLeu: 6.574 ± 0.191
1.626ValMet: 1.626 ± 0.092
2.605ValAsn: 2.605 ± 0.108
3.458ValPro: 3.458 ± 0.131
2.587ValGln: 2.587 ± 0.123
3.643ValArg: 3.643 ± 0.129
5.501ValSer: 5.501 ± 0.203
3.72ValThr: 3.72 ± 0.164
5.209ValVal: 5.209 ± 0.186
0.759ValTrp: 0.759 ± 0.059
1.794ValTyr: 1.794 ± 0.095
0.0ValXaa: 0.0 ± 0.0
Trp
0.678TrpAla: 0.678 ± 0.052
0.185TrpCys: 0.185 ± 0.028
0.592TrpAsp: 0.592 ± 0.053
0.639TrpGlu: 0.639 ± 0.051
0.468TrpPhe: 0.468 ± 0.045
0.515TrpGly: 0.515 ± 0.059
0.185TrpHis: 0.185 ± 0.026
0.721TrpIle: 0.721 ± 0.062
0.759TrpLys: 0.759 ± 0.063
1.171TrpLeu: 1.171 ± 0.076
0.33TrpMet: 0.33 ± 0.034
0.639TrpAsn: 0.639 ± 0.055
0.416TrpPro: 0.416 ± 0.044
0.412TrpGln: 0.412 ± 0.046
0.845TrpArg: 0.845 ± 0.064
0.897TrpSer: 0.897 ± 0.067
0.837TrpThr: 0.837 ± 0.069
0.579TrpVal: 0.579 ± 0.051
0.202TrpTrp: 0.202 ± 0.032
0.3TrpTyr: 0.3 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.849TyrAla: 1.849 ± 0.092
0.493TyrCys: 0.493 ± 0.055
1.425TyrAsp: 1.425 ± 0.092
1.382TyrGlu: 1.382 ± 0.075
1.189TyrPhe: 1.189 ± 0.078
1.961TyrGly: 1.961 ± 0.105
0.657TyrHis: 0.657 ± 0.056
1.446TyrIle: 1.446 ± 0.087
1.3TyrLys: 1.3 ± 0.075
2.51TyrLeu: 2.51 ± 0.125
0.601TyrMet: 0.601 ± 0.049
0.987TyrAsn: 0.987 ± 0.08
1.163TyrPro: 1.163 ± 0.072
0.815TyrGln: 0.815 ± 0.059
1.493TyrArg: 1.493 ± 0.077
1.982TyrSer: 1.982 ± 0.1
1.24TyrThr: 1.24 ± 0.084
1.639TyrVal: 1.639 ± 0.091
0.36TyrTrp: 0.36 ± 0.041
0.751TyrTyr: 0.751 ± 0.059
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 691 proteins (233055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski