Amino acid dipepetide frequency for Cryptococcus amylolentus CBS 6039

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.047AlaAla: 9.047 ± 0.071	0.88AlaCys: 0.88 ± 0.017	4.014AlaAsp: 4.014 ± 0.03	5.357AlaGlu: 5.357 ± 0.044	3.045AlaPhe: 3.045 ± 0.026	6.426AlaGly: 6.426 ± 0.045	1.894AlaHis: 1.894 ± 0.024	3.908AlaIle: 3.908 ± 0.031	4.356AlaLys: 4.356 ± 0.032	8.12AlaLeu: 8.12 ± 0.047	1.881AlaMet: 1.881 ± 0.019	2.61AlaAsn: 2.61 ± 0.026	6.197AlaPro: 6.197 ± 0.057	3.534AlaGln: 3.534 ± 0.031	5.001AlaArg: 5.001 ± 0.039	8.378AlaSer: 8.378 ± 0.058	5.043AlaThr: 5.043 ± 0.04	5.262AlaVal: 5.262 ± 0.033	1.133AlaTrp: 1.133 ± 0.017	2.146AlaTyr: 2.146 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.773CysAla: 0.773 ± 0.013	0.201CysCys: 0.201 ± 0.007	0.493CysAsp: 0.493 ± 0.012	0.511CysGlu: 0.511 ± 0.011	0.425CysPhe: 0.425 ± 0.011	0.763CysGly: 0.763 ± 0.014	0.263CysHis: 0.263 ± 0.008	0.534CysIle: 0.534 ± 0.011	0.423CysLys: 0.423 ± 0.01	1.1CysLeu: 1.1 ± 0.017	0.227CysMet: 0.227 ± 0.008	0.302CysAsn: 0.302 ± 0.01	0.606CysPro: 0.606 ± 0.013	0.372CysGln: 0.372 ± 0.009	0.589CysArg: 0.589 ± 0.012	0.761CysSer: 0.761 ± 0.013	0.584CysThr: 0.584 ± 0.012	0.684CysVal: 0.684 ± 0.012	0.179CysTrp: 0.179 ± 0.006	0.286CysTyr: 0.286 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.444AspAla: 4.444 ± 0.033	0.507AspCys: 0.507 ± 0.011	4.326AspAsp: 4.326 ± 0.046	4.822AspGlu: 4.822 ± 0.046	1.875AspPhe: 1.875 ± 0.021	4.261AspGly: 4.261 ± 0.031	1.158AspHis: 1.158 ± 0.015	2.718AspIle: 2.718 ± 0.028	2.477AspLys: 2.477 ± 0.027	4.9AspLeu: 4.9 ± 0.035	1.233AspMet: 1.233 ± 0.018	1.553AspAsn: 1.553 ± 0.018	3.319AspPro: 3.319 ± 0.029	1.815AspGln: 1.815 ± 0.02	2.869AspArg: 2.869 ± 0.029	3.837AspSer: 3.837 ± 0.029	2.656AspThr: 2.656 ± 0.027	3.737AspVal: 3.737 ± 0.031	0.886AspTrp: 0.886 ± 0.013	1.455AspTyr: 1.455 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	5.609GluAla: 5.609 ± 0.039	0.54GluCys: 0.54 ± 0.012	4.569GluAsp: 4.569 ± 0.041	7.116GluGlu: 7.116 ± 0.067	1.666GluPhe: 1.666 ± 0.019	5.318GluGly: 5.318 ± 0.039	1.292GluHis: 1.292 ± 0.017	2.71GluIle: 2.71 ± 0.03	4.138GluLys: 4.138 ± 0.041	4.976GluLeu: 4.976 ± 0.036	1.591GluMet: 1.591 ± 0.021	1.868GluAsn: 1.868 ± 0.019	2.759GluPro: 2.759 ± 0.029	2.44GluGln: 2.44 ± 0.026	4.439GluArg: 4.439 ± 0.04	4.376GluSer: 4.376 ± 0.029	3.16GluThr: 3.16 ± 0.029	3.97GluVal: 3.97 ± 0.031	1.008GluTrp: 1.008 ± 0.015	1.533GluTyr: 1.533 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	2.882PheAla: 2.882 ± 0.026	0.458PheCys: 0.458 ± 0.011	2.009PheAsp: 2.009 ± 0.022	1.99PheGlu: 1.99 ± 0.024	1.456PhePhe: 1.456 ± 0.02	2.78PheGly: 2.78 ± 0.031	0.807PheHis: 0.807 ± 0.015	1.543PheIle: 1.543 ± 0.019	1.405PheLys: 1.405 ± 0.02	3.058PheLeu: 3.058 ± 0.031	0.694PheMet: 0.694 ± 0.011	1.187PheAsn: 1.187 ± 0.016	1.972PhePro: 1.972 ± 0.02	1.135PheGln: 1.135 ± 0.014	1.695PheArg: 1.695 ± 0.018	2.863PheSer: 2.863 ± 0.03	2.003PheThr: 2.003 ± 0.02	2.183PheVal: 2.183 ± 0.024	0.553PheTrp: 0.553 ± 0.013	0.952PheTyr: 0.952 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	5.732GlyAla: 5.732 ± 0.042	0.752GlyCys: 0.752 ± 0.014	3.914GlyAsp: 3.914 ± 0.032	4.947GlyGlu: 4.947 ± 0.037	2.515GlyPhe: 2.515 ± 0.024	7.242GlyGly: 7.242 ± 0.076	1.66GlyHis: 1.66 ± 0.02	3.19GlyIle: 3.19 ± 0.028	4.425GlyLys: 4.425 ± 0.033	6.333GlyLeu: 6.333 ± 0.039	1.855GlyMet: 1.855 ± 0.025	2.278GlyAsn: 2.278 ± 0.023	3.434GlyPro: 3.434 ± 0.031	2.963GlyGln: 2.963 ± 0.032	4.461GlyArg: 4.461 ± 0.041	6.164GlySer: 6.164 ± 0.052	3.845GlyThr: 3.845 ± 0.031	4.86GlyVal: 4.86 ± 0.04	1.395GlyTrp: 1.395 ± 0.018	2.096GlyTyr: 2.096 ± 0.031	0.0GlyXaa: 0.0 ± 0.0
His	1.879HisAla: 1.879 ± 0.02	0.254HisCys: 0.254 ± 0.007	1.171HisAsp: 1.171 ± 0.016	1.194HisGlu: 1.194 ± 0.015	0.818HisPhe: 0.818 ± 0.015	1.522HisGly: 1.522 ± 0.018	0.909HisHis: 0.909 ± 0.016	1.132HisIle: 1.132 ± 0.017	0.898HisLys: 0.898 ± 0.015	2.456HisLeu: 2.456 ± 0.027	0.434HisMet: 0.434 ± 0.01	0.74HisAsn: 0.74 ± 0.012	2.135HisPro: 2.135 ± 0.028	0.971HisGln: 0.971 ± 0.015	1.433HisArg: 1.433 ± 0.02	1.971HisSer: 1.971 ± 0.023	1.339HisThr: 1.339 ± 0.017	1.372HisVal: 1.372 ± 0.017	0.275HisTrp: 0.275 ± 0.007	0.63HisTyr: 0.63 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.841IleAla: 3.841 ± 0.029	0.578IleCys: 0.578 ± 0.01	2.635IleAsp: 2.635 ± 0.026	2.545IleGlu: 2.545 ± 0.024	1.683IlePhe: 1.683 ± 0.025	2.926IleGly: 2.926 ± 0.031	1.127IleHis: 1.127 ± 0.015	2.245IleIle: 2.245 ± 0.025	2.107IleLys: 2.107 ± 0.026	4.099IleLeu: 4.099 ± 0.041	0.911IleMet: 0.911 ± 0.013	1.542IleAsn: 1.542 ± 0.02	3.162IlePro: 3.162 ± 0.026	1.582IleGln: 1.582 ± 0.018	2.395IleArg: 2.395 ± 0.026	3.678IleSer: 3.678 ± 0.027	2.614IleThr: 2.614 ± 0.025	2.934IleVal: 2.934 ± 0.028	0.661IleTrp: 0.661 ± 0.012	1.173IleTyr: 1.173 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.742LysAla: 4.742 ± 0.038	0.418LysCys: 0.418 ± 0.01	2.782LysAsp: 2.782 ± 0.025	4.005LysGlu: 4.005 ± 0.042	1.273LysPhe: 1.273 ± 0.016	3.77LysGly: 3.77 ± 0.032	1.033LysHis: 1.033 ± 0.013	2.054LysIle: 2.054 ± 0.022	3.872LysLys: 3.872 ± 0.046	3.796LysLeu: 3.796 ± 0.032	1.032LysMet: 1.032 ± 0.013	1.459LysAsn: 1.459 ± 0.02	2.854LysPro: 2.854 ± 0.029	1.729LysGln: 1.729 ± 0.021	3.588LysArg: 3.588 ± 0.035	3.618LysSer: 3.618 ± 0.032	2.713LysThr: 2.713 ± 0.026	3.087LysVal: 3.087 ± 0.028	0.72LysTrp: 0.72 ± 0.013	1.159LysTyr: 1.159 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	8.099LeuAla: 8.099 ± 0.053	1.022LeuCys: 1.022 ± 0.016	4.877LeuAsp: 4.877 ± 0.039	5.388LeuGlu: 5.388 ± 0.044	3.185LeuPhe: 3.185 ± 0.026	6.262LeuGly: 6.262 ± 0.04	2.199LeuHis: 2.199 ± 0.022	3.761LeuIle: 3.761 ± 0.032	4.09LeuLys: 4.09 ± 0.033	8.43LeuLeu: 8.43 ± 0.065	1.638LeuMet: 1.638 ± 0.021	2.784LeuAsn: 2.784 ± 0.026	6.745LeuPro: 6.745 ± 0.046	3.356LeuGln: 3.356 ± 0.029	5.307LeuArg: 5.307 ± 0.038	8.125LeuSer: 8.125 ± 0.045	4.769LeuThr: 4.769 ± 0.036	5.368LeuVal: 5.368 ± 0.038	1.101LeuTrp: 1.101 ± 0.016	2.211LeuTyr: 2.211 ± 0.027	0.0LeuXaa: 0.0 ± 0.0
Met	1.954MetAla: 1.954 ± 0.019	0.213MetCys: 0.213 ± 0.006	1.225MetAsp: 1.225 ± 0.017	1.284MetGlu: 1.284 ± 0.017	0.698MetPhe: 0.698 ± 0.013	1.742MetGly: 1.742 ± 0.026	0.315MetHis: 0.315 ± 0.008	0.861MetIle: 0.861 ± 0.015	0.924MetLys: 0.924 ± 0.015	1.731MetLeu: 1.731 ± 0.02	0.578MetMet: 0.578 ± 0.012	0.622MetAsn: 0.622 ± 0.012	1.39MetPro: 1.39 ± 0.019	0.652MetGln: 0.652 ± 0.01	1.25MetArg: 1.25 ± 0.017	2.21MetSer: 2.21 ± 0.019	1.232MetThr: 1.232 ± 0.015	1.271MetVal: 1.271 ± 0.017	0.271MetTrp: 0.271 ± 0.007	0.476MetTyr: 0.476 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.866AsnAla: 2.866 ± 0.026	0.309AsnCys: 0.309 ± 0.009	1.666AsnAsp: 1.666 ± 0.02	1.692AsnGlu: 1.692 ± 0.018	1.078AsnPhe: 1.078 ± 0.016	2.584AsnGly: 2.584 ± 0.022	0.743AsnHis: 0.743 ± 0.013	1.549AsnIle: 1.549 ± 0.02	1.446AsnLys: 1.446 ± 0.018	2.905AsnLeu: 2.905 ± 0.025	0.671AsnMet: 0.671 ± 0.011	1.127AsnAsn: 1.127 ± 0.017	2.32AsnPro: 2.32 ± 0.022	1.111AsnGln: 1.111 ± 0.017	1.581AsnArg: 1.581 ± 0.019	2.318AsnSer: 2.318 ± 0.025	1.885AsnThr: 1.885 ± 0.023	2.101AsnVal: 2.101 ± 0.022	0.424AsnTrp: 0.424 ± 0.01	0.823AsnTyr: 0.823 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	6.368ProAla: 6.368 ± 0.054	0.437ProCys: 0.437 ± 0.011	3.024ProAsp: 3.024 ± 0.025	3.821ProGlu: 3.821 ± 0.031	2.182ProPhe: 2.182 ± 0.023	4.027ProGly: 4.027 ± 0.035	1.675ProHis: 1.675 ± 0.024	2.829ProIle: 2.829 ± 0.025	2.848ProLys: 2.848 ± 0.028	5.777ProLeu: 5.777 ± 0.04	1.053ProMet: 1.053 ± 0.016	2.122ProAsn: 2.122 ± 0.022	7.249ProPro: 7.249 ± 0.082	2.663ProGln: 2.663 ± 0.032	3.657ProArg: 3.657 ± 0.034	8.586ProSer: 8.586 ± 0.068	4.782ProThr: 4.782 ± 0.044	3.895ProVal: 3.895 ± 0.032	0.649ProTrp: 0.649 ± 0.013	1.606ProTyr: 1.606 ± 0.021	0.0ProXaa: 0.0 ± 0.0
Gln	3.647GlnAla: 3.647 ± 0.029	0.345GlnCys: 0.345 ± 0.009	1.856GlnAsp: 1.856 ± 0.023	2.4GlnGlu: 2.4 ± 0.02	1.004GlnPhe: 1.004 ± 0.015	2.728GlnGly: 2.728 ± 0.029	0.952GlnHis: 0.952 ± 0.016	1.613GlnIle: 1.613 ± 0.018	1.745GlnLys: 1.745 ± 0.023	3.119GlnLeu: 3.119 ± 0.03	0.858GlnMet: 0.858 ± 0.014	1.249GlnAsn: 1.249 ± 0.016	2.685GlnPro: 2.685 ± 0.031	2.299GlnGln: 2.299 ± 0.048	2.372GlnArg: 2.372 ± 0.026	3.248GlnSer: 3.248 ± 0.03	2.241GlnThr: 2.241 ± 0.022	2.205GlnVal: 2.205 ± 0.022	0.52GlnTrp: 0.52 ± 0.011	1.045GlnTyr: 1.045 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	4.928ArgAla: 4.928 ± 0.037	0.563ArgCys: 0.563 ± 0.012	3.183ArgAsp: 3.183 ± 0.029	4.116ArgGlu: 4.116 ± 0.039	1.836ArgPhe: 1.836 ± 0.02	4.143ArgGly: 4.143 ± 0.041	1.484ArgHis: 1.484 ± 0.018	2.475ArgIle: 2.475 ± 0.025	3.374ArgLys: 3.374 ± 0.036	5.266ArgLeu: 5.266 ± 0.037	1.339ArgMet: 1.339 ± 0.017	1.785ArgAsn: 1.785 ± 0.019	3.88ArgPro: 3.88 ± 0.037	2.489ArgGln: 2.489 ± 0.021	4.976ArgArg: 4.976 ± 0.049	4.849ArgSer: 4.849 ± 0.043	3.019ArgThr: 3.019 ± 0.027	3.4ArgVal: 3.4 ± 0.029	0.897ArgTrp: 0.897 ± 0.015	1.503ArgTyr: 1.503 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	7.902SerAla: 7.902 ± 0.058	0.748SerCys: 0.748 ± 0.012	4.271SerAsp: 4.271 ± 0.036	4.306SerGlu: 4.306 ± 0.03	3.048SerPhe: 3.048 ± 0.026	6.174SerGly: 6.174 ± 0.049	2.243SerHis: 2.243 ± 0.024	3.844SerIle: 3.844 ± 0.03	3.706SerLys: 3.706 ± 0.031	8.077SerLeu: 8.077 ± 0.049	1.616SerMet: 1.616 ± 0.019	2.764SerAsn: 2.764 ± 0.024	7.166SerPro: 7.166 ± 0.074	3.349SerGln: 3.349 ± 0.03	5.183SerArg: 5.183 ± 0.045	11.47SerSer: 11.47 ± 0.118	6.277SerThr: 6.277 ± 0.053	4.795SerVal: 4.795 ± 0.035	1.074SerTrp: 1.074 ± 0.016	2.106SerTyr: 2.106 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	5.131ThrAla: 5.131 ± 0.042	0.628ThrCys: 0.628 ± 0.014	2.612ThrAsp: 2.612 ± 0.024	2.804ThrGlu: 2.804 ± 0.024	2.148ThrPhe: 2.148 ± 0.023	3.936ThrGly: 3.936 ± 0.036	1.349ThrHis: 1.349 ± 0.016	2.75ThrIle: 2.75 ± 0.023	2.412ThrLys: 2.412 ± 0.026	5.355ThrLeu: 5.355 ± 0.038	1.046ThrMet: 1.046 ± 0.015	1.742ThrAsn: 1.742 ± 0.02	5.284ThrPro: 5.284 ± 0.045	1.932ThrGln: 1.932 ± 0.025	2.985ThrArg: 2.985 ± 0.027	5.996ThrSer: 5.996 ± 0.052	3.893ThrThr: 3.893 ± 0.032	3.423ThrVal: 3.423 ± 0.029	0.734ThrTrp: 0.734 ± 0.013	1.482ThrTyr: 1.482 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.134ValAla: 5.134 ± 0.032	0.728ValCys: 0.728 ± 0.012	3.719ValAsp: 3.719 ± 0.03	4.34ValGlu: 4.34 ± 0.04	2.222ValPhe: 2.222 ± 0.024	4.418ValGly: 4.418 ± 0.033	1.399ValHis: 1.399 ± 0.019	2.828ValIle: 2.828 ± 0.031	3.252ValLys: 3.252 ± 0.029	5.554ValLeu: 5.554 ± 0.04	1.335ValMet: 1.335 ± 0.017	2.0ValAsn: 2.0 ± 0.022	3.896ValPro: 3.896 ± 0.029	2.255ValGln: 2.255 ± 0.027	3.386ValArg: 3.386 ± 0.027	4.689ValSer: 4.689 ± 0.036	3.193ValThr: 3.193 ± 0.029	4.346ValVal: 4.346 ± 0.039	0.959ValTrp: 0.959 ± 0.016	1.652ValTyr: 1.652 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.143TrpAla: 1.143 ± 0.017	0.171TrpCys: 0.171 ± 0.005	0.93TrpAsp: 0.93 ± 0.016	0.98TrpGlu: 0.98 ± 0.017	0.473TrpPhe: 0.473 ± 0.012	1.065TrpGly: 1.065 ± 0.019	0.306TrpHis: 0.306 ± 0.008	0.636TrpIle: 0.636 ± 0.011	0.785TrpLys: 0.785 ± 0.012	1.23TrpLeu: 1.23 ± 0.02	0.369TrpMet: 0.369 ± 0.01	0.507TrpAsn: 0.507 ± 0.011	0.595TrpPro: 0.595 ± 0.012	0.514TrpGln: 0.514 ± 0.01	0.925TrpArg: 0.925 ± 0.016	1.086TrpSer: 1.086 ± 0.017	0.803TrpThr: 0.803 ± 0.013	0.918TrpVal: 0.918 ± 0.014	0.314TrpTrp: 0.314 ± 0.009	0.378TrpTyr: 0.378 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.11TyrAla: 2.11 ± 0.02	0.325TyrCys: 0.325 ± 0.009	1.573TyrAsp: 1.573 ± 0.02	1.46TyrGlu: 1.46 ± 0.02	0.997TyrPhe: 0.997 ± 0.016	1.973TyrGly: 1.973 ± 0.026	0.725TyrHis: 0.725 ± 0.012	1.26TyrIle: 1.26 ± 0.016	1.018TyrLys: 1.018 ± 0.014	2.435TyrLeu: 2.435 ± 0.026	0.534TyrMet: 0.534 ± 0.01	0.958TyrAsn: 0.958 ± 0.014	1.603TyrPro: 1.603 ± 0.022	0.972TyrGln: 0.972 ± 0.016	1.411TyrArg: 1.411 ± 0.017	1.897TyrSer: 1.897 ± 0.022	1.592TyrThr: 1.592 ± 0.018	1.497TyrVal: 1.497 ± 0.018	0.374TyrTrp: 0.374 ± 0.009	0.793TyrTyr: 0.793 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 9877 proteins (4861164 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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