Amino acid dipepetide frequency for Tetzosporium hominis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.967AlaAla: 6.967 ± 0.136
0.527AlaCys: 0.527 ± 0.026
3.92AlaAsp: 3.92 ± 0.077
5.408AlaGlu: 5.408 ± 0.099
3.682AlaPhe: 3.682 ± 0.077
5.719AlaGly: 5.719 ± 0.088
1.604AlaHis: 1.604 ± 0.045
6.394AlaIle: 6.394 ± 0.092
4.758AlaLys: 4.758 ± 0.072
8.404AlaLeu: 8.404 ± 0.109
2.264AlaMet: 2.264 ± 0.054
2.533AlaAsn: 2.533 ± 0.066
2.391AlaPro: 2.391 ± 0.065
2.599AlaGln: 2.599 ± 0.056
3.259AlaArg: 3.259 ± 0.07
4.48AlaSer: 4.48 ± 0.086
4.497AlaThr: 4.497 ± 0.083
6.065AlaVal: 6.065 ± 0.096
0.729AlaTrp: 0.729 ± 0.029
2.573AlaTyr: 2.573 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.412CysAla: 0.412 ± 0.028
0.057CysCys: 0.057 ± 0.008
0.319CysAsp: 0.319 ± 0.023
0.392CysGlu: 0.392 ± 0.024
0.228CysPhe: 0.228 ± 0.017
0.562CysGly: 0.562 ± 0.028
0.196CysHis: 0.196 ± 0.016
0.339CysIle: 0.339 ± 0.021
0.276CysLys: 0.276 ± 0.018
0.457CysLeu: 0.457 ± 0.021
0.139CysMet: 0.139 ± 0.011
0.212CysAsn: 0.212 ± 0.016
0.335CysPro: 0.335 ± 0.021
0.207CysGln: 0.207 ± 0.017
0.279CysArg: 0.279 ± 0.02
0.399CysSer: 0.399 ± 0.024
0.347CysThr: 0.347 ± 0.024
0.38CysVal: 0.38 ± 0.023
0.052CysTrp: 0.052 ± 0.008
0.176CysTyr: 0.176 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.311AspAla: 4.311 ± 0.078
0.345AspCys: 0.345 ± 0.022
2.512AspAsp: 2.512 ± 0.057
4.481AspGlu: 4.481 ± 0.078
2.556AspPhe: 2.556 ± 0.057
3.547AspGly: 3.547 ± 0.075
1.166AspHis: 1.166 ± 0.047
3.597AspIle: 3.597 ± 0.081
2.618AspLys: 2.618 ± 0.062
5.078AspLeu: 5.078 ± 0.07
1.405AspMet: 1.405 ± 0.046
1.552AspAsn: 1.552 ± 0.042
2.076AspPro: 2.076 ± 0.049
2.165AspGln: 2.165 ± 0.054
2.516AspArg: 2.516 ± 0.06
2.824AspSer: 2.824 ± 0.062
2.807AspThr: 2.807 ± 0.064
4.248AspVal: 4.248 ± 0.077
0.655AspTrp: 0.655 ± 0.029
2.254AspTyr: 2.254 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
6.151GluAla: 6.151 ± 0.097
0.328GluCys: 0.328 ± 0.024
4.181GluAsp: 4.181 ± 0.09
7.376GluGlu: 7.376 ± 0.119
2.794GluPhe: 2.794 ± 0.067
4.578GluGly: 4.578 ± 0.078
1.561GluHis: 1.561 ± 0.043
4.898GluIle: 4.898 ± 0.097
5.334GluLys: 5.334 ± 0.096
8.053GluLeu: 8.053 ± 0.105
2.337GluMet: 2.337 ± 0.057
2.961GluAsn: 2.961 ± 0.069
2.262GluPro: 2.262 ± 0.059
4.299GluGln: 4.299 ± 0.088
4.039GluArg: 4.039 ± 0.083
3.744GluSer: 3.744 ± 0.069
4.492GluThr: 4.492 ± 0.075
5.574GluVal: 5.574 ± 0.093
0.995GluTrp: 0.995 ± 0.037
1.919GluTyr: 1.919 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
3.365PheAla: 3.365 ± 0.07
0.257PheCys: 0.257 ± 0.016
2.496PheAsp: 2.496 ± 0.056
3.241PheGlu: 3.241 ± 0.061
2.161PhePhe: 2.161 ± 0.063
3.333PheGly: 3.333 ± 0.068
0.918PheHis: 0.918 ± 0.039
3.283PheIle: 3.283 ± 0.066
1.985PheLys: 1.985 ± 0.052
4.313PheLeu: 4.313 ± 0.091
1.201PheMet: 1.201 ± 0.042
1.522PheAsn: 1.522 ± 0.049
1.654PhePro: 1.654 ± 0.043
1.64PheGln: 1.64 ± 0.05
1.678PheArg: 1.678 ± 0.047
3.046PheSer: 3.046 ± 0.069
2.824PheThr: 2.824 ± 0.068
3.395PheVal: 3.395 ± 0.074
0.463PheTrp: 0.463 ± 0.03
1.706PheTyr: 1.706 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
5.287GlyAla: 5.287 ± 0.105
0.497GlyCys: 0.497 ± 0.026
3.536GlyAsp: 3.536 ± 0.083
4.619GlyGlu: 4.619 ± 0.089
3.238GlyPhe: 3.238 ± 0.062
4.783GlyGly: 4.783 ± 0.114
1.531GlyHis: 1.531 ± 0.047
5.458GlyIle: 5.458 ± 0.09
4.423GlyLys: 4.423 ± 0.082
6.442GlyLeu: 6.442 ± 0.099
2.072GlyMet: 2.072 ± 0.057
2.424GlyAsn: 2.424 ± 0.069
1.803GlyPro: 1.803 ± 0.049
2.474GlyGln: 2.474 ± 0.067
2.902GlyArg: 2.902 ± 0.063
3.847GlySer: 3.847 ± 0.077
4.451GlyThr: 4.451 ± 0.093
5.095GlyVal: 5.095 ± 0.09
0.797GlyTrp: 0.797 ± 0.034
2.72GlyTyr: 2.72 ± 0.057
0.0GlyXaa: 0.0 ± 0.0
His
1.564HisAla: 1.564 ± 0.05
0.177HisCys: 0.177 ± 0.015
1.141HisAsp: 1.141 ± 0.045
1.475HisGlu: 1.475 ± 0.048
1.094HisPhe: 1.094 ± 0.038
1.421HisGly: 1.421 ± 0.042
0.69HisHis: 0.69 ± 0.037
1.397HisIle: 1.397 ± 0.046
0.917HisLys: 0.917 ± 0.03
2.294HisLeu: 2.294 ± 0.055
0.534HisMet: 0.534 ± 0.023
0.629HisAsn: 0.629 ± 0.027
1.309HisPro: 1.309 ± 0.048
1.031HisGln: 1.031 ± 0.04
0.943HisArg: 0.943 ± 0.034
1.222HisSer: 1.222 ± 0.04
1.102HisThr: 1.102 ± 0.036
1.698HisVal: 1.698 ± 0.048
0.201HisTrp: 0.201 ± 0.016
0.935HisTyr: 0.935 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.936IleAla: 5.936 ± 0.089
0.461IleCys: 0.461 ± 0.024
4.053IleAsp: 4.053 ± 0.072
5.747IleGlu: 5.747 ± 0.1
2.63IlePhe: 2.63 ± 0.06
5.534IleGly: 5.534 ± 0.097
1.556IleHis: 1.556 ± 0.041
4.363IleIle: 4.363 ± 0.078
3.159IleLys: 3.159 ± 0.07
6.291IleLeu: 6.291 ± 0.093
1.486IleMet: 1.486 ± 0.046
2.308IleAsn: 2.308 ± 0.06
3.161IlePro: 3.161 ± 0.077
2.983IleGln: 2.983 ± 0.06
3.267IleArg: 3.267 ± 0.065
4.199IleSer: 4.199 ± 0.077
3.943IleThr: 3.943 ± 0.067
5.465IleVal: 5.465 ± 0.103
0.569IleTrp: 0.569 ± 0.027
2.185IleTyr: 2.185 ± 0.056
0.001IleXaa: 0.001 ± 0.001
Lys
4.296LysAla: 4.296 ± 0.073
0.222LysCys: 0.222 ± 0.016
3.159LysAsp: 3.159 ± 0.078
5.643LysGlu: 5.643 ± 0.104
1.787LysPhe: 1.787 ± 0.048
3.721LysGly: 3.721 ± 0.081
1.187LysHis: 1.187 ± 0.041
3.362LysIle: 3.362 ± 0.068
4.486LysLys: 4.486 ± 0.083
5.266LysLeu: 5.266 ± 0.081
1.792LysMet: 1.792 ± 0.051
2.283LysAsn: 2.283 ± 0.06
2.059LysPro: 2.059 ± 0.057
3.121LysGln: 3.121 ± 0.073
3.274LysArg: 3.274 ± 0.067
3.236LysSer: 3.236 ± 0.08
3.353LysThr: 3.353 ± 0.068
4.065LysVal: 4.065 ± 0.071
0.77LysTrp: 0.77 ± 0.034
1.567LysTyr: 1.567 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
8.525LeuAla: 8.525 ± 0.123
0.489LeuCys: 0.489 ± 0.024
5.136LeuAsp: 5.136 ± 0.082
7.294LeuGlu: 7.294 ± 0.104
4.654LeuPhe: 4.654 ± 0.098
6.454LeuGly: 6.454 ± 0.106
2.239LeuHis: 2.239 ± 0.062
6.455LeuIle: 6.455 ± 0.108
5.508LeuLys: 5.508 ± 0.086
10.329LeuLeu: 10.329 ± 0.148
2.464LeuMet: 2.464 ± 0.057
3.345LeuAsn: 3.345 ± 0.063
4.174LeuPro: 4.174 ± 0.063
4.135LeuGln: 4.135 ± 0.083
3.959LeuArg: 3.959 ± 0.073
6.491LeuSer: 6.491 ± 0.099
5.987LeuThr: 5.987 ± 0.082
7.281LeuVal: 7.281 ± 0.103
0.843LeuTrp: 0.843 ± 0.033
3.228LeuTyr: 3.228 ± 0.068
0.0LeuXaa: 0.0 ± 0.0
Met
2.16MetAla: 2.16 ± 0.05
0.138MetCys: 0.138 ± 0.013
1.495MetAsp: 1.495 ± 0.045
2.056MetGlu: 2.056 ± 0.044
0.952MetPhe: 0.952 ± 0.036
1.73MetGly: 1.73 ± 0.05
0.491MetHis: 0.491 ± 0.023
1.889MetIle: 1.889 ± 0.051
2.385MetLys: 2.385 ± 0.051
2.38MetLeu: 2.38 ± 0.06
0.862MetMet: 0.862 ± 0.032
1.446MetAsn: 1.446 ± 0.046
1.021MetPro: 1.021 ± 0.032
1.026MetGln: 1.026 ± 0.035
1.196MetArg: 1.196 ± 0.039
1.529MetSer: 1.529 ± 0.047
2.001MetThr: 2.001 ± 0.052
1.637MetVal: 1.637 ± 0.043
0.184MetTrp: 0.184 ± 0.014
0.7MetTyr: 0.7 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
2.625AsnAla: 2.625 ± 0.069
0.229AsnCys: 0.229 ± 0.019
1.876AsnAsp: 1.876 ± 0.049
2.964AsnGlu: 2.964 ± 0.061
1.44AsnPhe: 1.44 ± 0.047
2.772AsnGly: 2.772 ± 0.065
0.825AsnHis: 0.825 ± 0.037
2.138AsnIle: 2.138 ± 0.059
2.01AsnLys: 2.01 ± 0.058
3.303AsnLeu: 3.303 ± 0.065
1.034AsnMet: 1.034 ± 0.035
1.268AsnAsn: 1.268 ± 0.05
1.887AsnPro: 1.887 ± 0.048
1.72AsnGln: 1.72 ± 0.051
1.909AsnArg: 1.909 ± 0.047
1.877AsnSer: 1.877 ± 0.051
1.801AsnThr: 1.801 ± 0.043
2.5AsnVal: 2.5 ± 0.059
0.482AsnTrp: 0.482 ± 0.024
1.406AsnTyr: 1.406 ± 0.044
0.0AsnXaa: 0.0 ± 0.0
Pro
2.644ProAla: 2.644 ± 0.064
0.182ProCys: 0.182 ± 0.017
2.096ProAsp: 2.096 ± 0.055
3.372ProGlu: 3.372 ± 0.081
1.995ProPhe: 1.995 ± 0.056
2.419ProGly: 2.419 ± 0.064
0.872ProHis: 0.872 ± 0.03
2.65ProIle: 2.65 ± 0.054
1.984ProLys: 1.984 ± 0.05
3.622ProLeu: 3.622 ± 0.078
0.903ProMet: 0.903 ± 0.034
1.501ProAsn: 1.501 ± 0.045
1.025ProPro: 1.025 ± 0.041
1.4ProGln: 1.4 ± 0.041
1.255ProArg: 1.255 ± 0.045
2.314ProSer: 2.314 ± 0.053
2.236ProThr: 2.236 ± 0.053
3.317ProVal: 3.317 ± 0.063
0.367ProTrp: 0.367 ± 0.021
1.422ProTyr: 1.422 ± 0.041
0.0ProXaa: 0.0 ± 0.0
Gln
3.597GlnAla: 3.597 ± 0.074
0.168GlnCys: 0.168 ± 0.016
2.137GlnAsp: 2.137 ± 0.055
3.135GlnGlu: 3.135 ± 0.068
1.841GlnPhe: 1.841 ± 0.051
2.54GlnGly: 2.54 ± 0.079
0.966GlnHis: 0.966 ± 0.037
2.551GlnIle: 2.551 ± 0.064
2.532GlnLys: 2.532 ± 0.062
4.827GlnLeu: 4.827 ± 0.088
1.192GlnMet: 1.192 ± 0.034
1.492GlnAsn: 1.492 ± 0.046
1.572GlnPro: 1.572 ± 0.049
2.786GlnGln: 2.786 ± 0.084
1.683GlnArg: 1.683 ± 0.046
2.151GlnSer: 2.151 ± 0.06
2.273GlnThr: 2.273 ± 0.058
3.024GlnVal: 3.024 ± 0.054
0.437GlnTrp: 0.437 ± 0.025
1.091GlnTyr: 1.091 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
3.078ArgAla: 3.078 ± 0.066
0.242ArgCys: 0.242 ± 0.021
2.363ArgAsp: 2.363 ± 0.052
3.474ArgGlu: 3.474 ± 0.074
2.148ArgPhe: 2.148 ± 0.051
2.508ArgGly: 2.508 ± 0.054
1.013ArgHis: 1.013 ± 0.038
3.298ArgIle: 3.298 ± 0.067
2.902ArgLys: 2.902 ± 0.059
4.632ArgLeu: 4.632 ± 0.078
1.386ArgMet: 1.386 ± 0.044
1.766ArgAsn: 1.766 ± 0.047
1.633ArgPro: 1.633 ± 0.049
1.939ArgGln: 1.939 ± 0.052
2.069ArgArg: 2.069 ± 0.057
2.44ArgSer: 2.44 ± 0.049
2.322ArgThr: 2.322 ± 0.061
3.069ArgVal: 3.069 ± 0.068
0.428ArgTrp: 0.428 ± 0.027
1.664ArgTyr: 1.664 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
4.088SerAla: 4.088 ± 0.072
0.334SerCys: 0.334 ± 0.02
2.785SerAsp: 2.785 ± 0.061
4.048SerGlu: 4.048 ± 0.086
2.98SerPhe: 2.98 ± 0.063
4.527SerGly: 4.527 ± 0.084
1.253SerHis: 1.253 ± 0.04
4.481SerIle: 4.481 ± 0.089
3.288SerLys: 3.288 ± 0.058
5.712SerLeu: 5.712 ± 0.091
1.625SerMet: 1.625 ± 0.043
2.188SerAsn: 2.188 ± 0.057
2.148SerPro: 2.148 ± 0.049
2.131SerGln: 2.131 ± 0.045
2.552SerArg: 2.552 ± 0.052
3.815SerSer: 3.815 ± 0.075
3.457SerThr: 3.457 ± 0.068
4.09SerVal: 4.09 ± 0.079
0.644SerTrp: 0.644 ± 0.026
2.298SerTyr: 2.298 ± 0.042
0.0SerXaa: 0.0 ± 0.0
Thr
4.649ThrAla: 4.649 ± 0.074
0.345ThrCys: 0.345 ± 0.023
3.0ThrAsp: 3.0 ± 0.064
4.266ThrGlu: 4.266 ± 0.075
2.753ThrPhe: 2.753 ± 0.06
4.426ThrGly: 4.426 ± 0.091
1.207ThrHis: 1.207 ± 0.041
4.399ThrIle: 4.399 ± 0.07
3.37ThrLys: 3.37 ± 0.074
5.914ThrLeu: 5.914 ± 0.096
1.38ThrMet: 1.38 ± 0.039
2.195ThrAsn: 2.195 ± 0.053
2.521ThrPro: 2.521 ± 0.06
1.79ThrGln: 1.79 ± 0.048
2.344ThrArg: 2.344 ± 0.053
3.516ThrSer: 3.516 ± 0.073
3.665ThrThr: 3.665 ± 0.086
4.568ThrVal: 4.568 ± 0.076
0.532ThrTrp: 0.532 ± 0.024
2.085ThrTyr: 2.085 ± 0.054
0.0ThrXaa: 0.0 ± 0.0
Val
6.016ValAla: 6.016 ± 0.093
0.472ValCys: 0.472 ± 0.028
4.002ValAsp: 4.002 ± 0.075
5.708ValGlu: 5.708 ± 0.093
3.264ValPhe: 3.264 ± 0.076
4.84ValGly: 4.84 ± 0.074
1.556ValHis: 1.556 ± 0.049
5.38ValIle: 5.38 ± 0.076
4.196ValLys: 4.196 ± 0.08
7.237ValLeu: 7.237 ± 0.097
1.942ValMet: 1.942 ± 0.05
2.674ValAsn: 2.674 ± 0.064
2.907ValPro: 2.907 ± 0.057
2.664ValGln: 2.664 ± 0.056
3.156ValArg: 3.156 ± 0.06
4.586ValSer: 4.586 ± 0.075
4.81ValThr: 4.81 ± 0.088
5.85ValVal: 5.85 ± 0.094
0.649ValTrp: 0.649 ± 0.03
2.363ValTyr: 2.363 ± 0.054
0.0ValXaa: 0.0 ± 0.0
Trp
0.635TrpAla: 0.635 ± 0.027
0.064TrpCys: 0.064 ± 0.009
0.494TrpAsp: 0.494 ± 0.026
0.648TrpGlu: 0.648 ± 0.028
0.484TrpPhe: 0.484 ± 0.026
0.638TrpGly: 0.638 ± 0.03
0.219TrpHis: 0.219 ± 0.018
0.884TrpIle: 0.884 ± 0.039
0.719TrpLys: 0.719 ± 0.029
1.142TrpLeu: 1.142 ± 0.039
0.394TrpMet: 0.394 ± 0.022
0.541TrpAsn: 0.541 ± 0.028
0.264TrpPro: 0.264 ± 0.019
0.394TrpGln: 0.394 ± 0.021
0.451TrpArg: 0.451 ± 0.025
0.626TrpSer: 0.626 ± 0.03
0.589TrpThr: 0.589 ± 0.028
0.663TrpVal: 0.663 ± 0.032
0.135TrpTrp: 0.135 ± 0.013
0.352TrpTyr: 0.352 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.467TyrAla: 2.467 ± 0.057
0.232TyrCys: 0.232 ± 0.02
2.013TyrAsp: 2.013 ± 0.061
2.532TyrGlu: 2.532 ± 0.055
1.8TyrPhe: 1.8 ± 0.052
2.346TyrGly: 2.346 ± 0.065
0.726TyrHis: 0.726 ± 0.03
2.076TyrIle: 2.076 ± 0.045
1.798TyrLys: 1.798 ± 0.05
3.296TyrLeu: 3.296 ± 0.067
0.866TyrMet: 0.866 ± 0.033
1.228TyrAsn: 1.228 ± 0.046
1.374TyrPro: 1.374 ± 0.037
1.491TyrGln: 1.491 ± 0.041
1.642TyrArg: 1.642 ± 0.047
2.104TyrSer: 2.104 ± 0.051
1.965TyrThr: 1.965 ± 0.051
2.288TyrVal: 2.288 ± 0.057
0.402TyrTrp: 0.402 ± 0.021
1.371TyrTyr: 1.371 ± 0.047
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2916 proteins (802905 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski