Amino acid dipepetide frequency for Arthrobacter phage Judy

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
18.492AlaAla: 18.492 ± 1.652
0.932AlaCys: 0.932 ± 0.256
7.311AlaAsp: 7.311 ± 0.842
6.451AlaGlu: 6.451 ± 0.796
3.01AlaPhe: 3.01 ± 0.397
12.758AlaGly: 12.758 ± 1.449
2.15AlaHis: 2.15 ± 0.473
4.444AlaIle: 4.444 ± 0.596
5.447AlaLys: 5.447 ± 0.645
9.963AlaLeu: 9.963 ± 0.992
2.437AlaMet: 2.437 ± 0.548
4.085AlaAsn: 4.085 ± 0.681
6.236AlaPro: 6.236 ± 1.088
4.659AlaGln: 4.659 ± 0.712
6.952AlaArg: 6.952 ± 0.733
6.021AlaSer: 6.021 ± 0.7
7.526AlaThr: 7.526 ± 0.773
6.451AlaVal: 6.451 ± 0.861
1.935AlaTrp: 1.935 ± 0.376
1.864AlaTyr: 1.864 ± 0.401
0.0AlaXaa: 0.0 ± 0.0
Cys
0.788CysAla: 0.788 ± 0.238
0.215CysCys: 0.215 ± 0.123
0.502CysAsp: 0.502 ± 0.179
0.573CysGlu: 0.573 ± 0.242
0.072CysPhe: 0.072 ± 0.069
1.147CysGly: 1.147 ± 0.34
0.43CysHis: 0.43 ± 0.19
0.43CysIle: 0.43 ± 0.21
0.502CysLys: 0.502 ± 0.203
0.287CysLeu: 0.287 ± 0.137
0.0CysMet: 0.0 ± 0.0
0.287CysAsn: 0.287 ± 0.162
1.433CysPro: 1.433 ± 0.401
0.43CysGln: 0.43 ± 0.178
0.645CysArg: 0.645 ± 0.248
0.717CysSer: 0.717 ± 0.244
0.573CysThr: 0.573 ± 0.224
0.215CysVal: 0.215 ± 0.115
0.072CysTrp: 0.072 ± 0.084
0.215CysTyr: 0.215 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
7.167AspAla: 7.167 ± 0.717
0.788AspCys: 0.788 ± 0.29
3.799AspAsp: 3.799 ± 0.555
3.799AspGlu: 3.799 ± 0.555
2.365AspPhe: 2.365 ± 0.37
6.021AspGly: 6.021 ± 0.77
1.147AspHis: 1.147 ± 0.368
2.58AspIle: 2.58 ± 0.392
2.652AspLys: 2.652 ± 0.436
4.372AspLeu: 4.372 ± 0.439
1.505AspMet: 1.505 ± 0.255
1.72AspAsn: 1.72 ± 0.382
4.085AspPro: 4.085 ± 0.733
2.437AspGln: 2.437 ± 0.405
4.085AspArg: 4.085 ± 0.55
3.082AspSer: 3.082 ± 0.683
2.509AspThr: 2.509 ± 0.419
3.44AspVal: 3.44 ± 0.629
1.147AspTrp: 1.147 ± 0.252
1.433AspTyr: 1.433 ± 0.279
0.0AspXaa: 0.0 ± 0.0
Glu
6.594GluAla: 6.594 ± 0.809
0.645GluCys: 0.645 ± 0.217
3.225GluAsp: 3.225 ± 0.438
3.799GluGlu: 3.799 ± 0.558
1.433GluPhe: 1.433 ± 0.284
4.157GluGly: 4.157 ± 0.611
1.003GluHis: 1.003 ± 0.245
2.652GluIle: 2.652 ± 0.372
1.864GluLys: 1.864 ± 0.394
5.447GluLeu: 5.447 ± 0.603
1.72GluMet: 1.72 ± 0.321
1.577GluAsn: 1.577 ± 0.374
2.867GluPro: 2.867 ± 0.516
3.225GluGln: 3.225 ± 0.378
4.085GluArg: 4.085 ± 0.471
3.154GluSer: 3.154 ± 0.519
3.44GluThr: 3.44 ± 0.419
3.799GluVal: 3.799 ± 0.469
1.72GluTrp: 1.72 ± 0.398
1.433GluTyr: 1.433 ± 0.375
0.0GluXaa: 0.0 ± 0.0
Phe
2.867PheAla: 2.867 ± 0.444
0.573PheCys: 0.573 ± 0.239
2.58PheAsp: 2.58 ± 0.384
1.075PheGlu: 1.075 ± 0.268
0.573PhePhe: 0.573 ± 0.219
2.15PheGly: 2.15 ± 0.343
0.86PheHis: 0.86 ± 0.278
1.147PheIle: 1.147 ± 0.253
1.505PheLys: 1.505 ± 0.319
1.792PheLeu: 1.792 ± 0.411
0.645PheMet: 0.645 ± 0.233
0.645PheAsn: 0.645 ± 0.178
1.29PhePro: 1.29 ± 0.34
1.003PheGln: 1.003 ± 0.23
1.362PheArg: 1.362 ± 0.304
1.003PheSer: 1.003 ± 0.227
1.935PheThr: 1.935 ± 0.367
1.505PheVal: 1.505 ± 0.29
0.358PheTrp: 0.358 ± 0.18
0.717PheTyr: 0.717 ± 0.186
0.0PheXaa: 0.0 ± 0.0
Gly
8.673GlyAla: 8.673 ± 0.969
0.788GlyCys: 0.788 ± 0.266
5.376GlyAsp: 5.376 ± 0.505
4.014GlyGlu: 4.014 ± 0.442
2.652GlyPhe: 2.652 ± 0.419
7.741GlyGly: 7.741 ± 1.026
1.792GlyHis: 1.792 ± 0.289
4.014GlyIle: 4.014 ± 0.619
4.014GlyLys: 4.014 ± 0.51
7.096GlyLeu: 7.096 ± 0.931
2.222GlyMet: 2.222 ± 0.347
3.082GlyAsn: 3.082 ± 0.59
3.512GlyPro: 3.512 ± 0.604
3.44GlyGln: 3.44 ± 0.397
5.806GlyArg: 5.806 ± 0.702
5.089GlySer: 5.089 ± 0.652
6.737GlyThr: 6.737 ± 0.757
6.021GlyVal: 6.021 ± 0.677
2.365GlyTrp: 2.365 ± 0.5
2.15GlyTyr: 2.15 ± 0.388
0.0GlyXaa: 0.0 ± 0.0
His
2.222HisAla: 2.222 ± 0.484
0.215HisCys: 0.215 ± 0.128
1.362HisAsp: 1.362 ± 0.291
1.505HisGlu: 1.505 ± 0.267
0.43HisPhe: 0.43 ± 0.162
1.577HisGly: 1.577 ± 0.413
0.645HisHis: 0.645 ± 0.246
0.287HisIle: 0.287 ± 0.181
0.788HisLys: 0.788 ± 0.213
1.72HisLeu: 1.72 ± 0.399
0.287HisMet: 0.287 ± 0.158
0.43HisAsn: 0.43 ± 0.194
1.505HisPro: 1.505 ± 0.384
0.86HisGln: 0.86 ± 0.25
1.29HisArg: 1.29 ± 0.425
1.075HisSer: 1.075 ± 0.356
1.362HisThr: 1.362 ± 0.334
1.147HisVal: 1.147 ± 0.242
0.358HisTrp: 0.358 ± 0.17
0.502HisTyr: 0.502 ± 0.18
0.0HisXaa: 0.0 ± 0.0
Ile
5.447IleAla: 5.447 ± 0.601
0.43IleCys: 0.43 ± 0.169
3.297IleAsp: 3.297 ± 0.467
3.154IleGlu: 3.154 ± 0.428
0.788IlePhe: 0.788 ± 0.237
2.652IleGly: 2.652 ± 0.444
0.932IleHis: 0.932 ± 0.271
1.864IleIle: 1.864 ± 0.375
1.649IleLys: 1.649 ± 0.317
2.007IleLeu: 2.007 ± 0.333
1.003IleMet: 1.003 ± 0.233
1.147IleAsn: 1.147 ± 0.308
3.44IlePro: 3.44 ± 0.508
1.218IleGln: 1.218 ± 0.248
3.01IleArg: 3.01 ± 0.472
2.939IleSer: 2.939 ± 0.486
3.942IleThr: 3.942 ± 0.519
2.58IleVal: 2.58 ± 0.47
0.287IleTrp: 0.287 ± 0.153
1.29IleTyr: 1.29 ± 0.244
0.0IleXaa: 0.0 ± 0.0
Lys
6.164LysAla: 6.164 ± 0.951
0.215LysCys: 0.215 ± 0.123
2.58LysAsp: 2.58 ± 0.426
2.365LysGlu: 2.365 ± 0.383
0.932LysPhe: 0.932 ± 0.303
3.01LysGly: 3.01 ± 0.537
1.003LysHis: 1.003 ± 0.279
1.362LysIle: 1.362 ± 0.286
2.509LysLys: 2.509 ± 0.37
3.87LysLeu: 3.87 ± 0.47
1.075LysMet: 1.075 ± 0.279
2.007LysAsn: 2.007 ± 0.366
2.939LysPro: 2.939 ± 0.436
1.864LysGln: 1.864 ± 0.44
2.15LysArg: 2.15 ± 0.402
2.079LysSer: 2.079 ± 0.483
2.939LysThr: 2.939 ± 0.405
3.225LysVal: 3.225 ± 0.506
0.43LysTrp: 0.43 ± 0.159
1.362LysTyr: 1.362 ± 0.368
0.0LysXaa: 0.0 ± 0.0
Leu
8.816LeuAla: 8.816 ± 0.804
0.788LeuCys: 0.788 ± 0.274
5.877LeuAsp: 5.877 ± 0.652
4.587LeuGlu: 4.587 ± 0.536
1.792LeuPhe: 1.792 ± 0.361
6.236LeuGly: 6.236 ± 0.715
1.362LeuHis: 1.362 ± 0.418
3.727LeuIle: 3.727 ± 0.499
4.229LeuLys: 4.229 ± 0.668
5.089LeuLeu: 5.089 ± 0.63
1.72LeuMet: 1.72 ± 0.271
2.007LeuAsn: 2.007 ± 0.325
4.515LeuPro: 4.515 ± 0.647
3.512LeuGln: 3.512 ± 0.594
5.662LeuArg: 5.662 ± 0.704
4.731LeuSer: 4.731 ± 0.669
5.734LeuThr: 5.734 ± 0.669
4.587LeuVal: 4.587 ± 0.709
0.788LeuTrp: 0.788 ± 0.27
1.649LeuTyr: 1.649 ± 0.298
0.0LeuXaa: 0.0 ± 0.0
Met
2.58MetAla: 2.58 ± 0.398
0.072MetCys: 0.072 ± 0.084
1.433MetAsp: 1.433 ± 0.285
0.86MetGlu: 0.86 ± 0.283
0.358MetPhe: 0.358 ± 0.152
1.649MetGly: 1.649 ± 0.323
0.072MetHis: 0.072 ± 0.073
0.717MetIle: 0.717 ± 0.221
0.502MetLys: 0.502 ± 0.182
1.72MetLeu: 1.72 ± 0.346
0.143MetMet: 0.143 ± 0.082
0.645MetAsn: 0.645 ± 0.228
1.433MetPro: 1.433 ± 0.374
1.147MetGln: 1.147 ± 0.26
1.362MetArg: 1.362 ± 0.274
2.007MetSer: 2.007 ± 0.324
2.724MetThr: 2.724 ± 0.418
0.932MetVal: 0.932 ± 0.202
0.215MetTrp: 0.215 ± 0.114
0.573MetTyr: 0.573 ± 0.171
0.0MetXaa: 0.0 ± 0.0
Asn
3.584AsnAla: 3.584 ± 0.495
0.143AsnCys: 0.143 ± 0.093
1.218AsnAsp: 1.218 ± 0.276
1.003AsnGlu: 1.003 ± 0.326
0.502AsnPhe: 0.502 ± 0.169
3.799AsnGly: 3.799 ± 0.573
0.788AsnHis: 0.788 ± 0.27
1.72AsnIle: 1.72 ± 0.309
0.932AsnLys: 0.932 ± 0.284
2.079AsnLeu: 2.079 ± 0.379
0.573AsnMet: 0.573 ± 0.218
0.717AsnAsn: 0.717 ± 0.248
2.58AsnPro: 2.58 ± 0.631
1.864AsnGln: 1.864 ± 0.383
1.147AsnArg: 1.147 ± 0.247
1.864AsnSer: 1.864 ± 0.403
1.935AsnThr: 1.935 ± 0.358
2.437AsnVal: 2.437 ± 0.41
0.43AsnTrp: 0.43 ± 0.211
0.86AsnTyr: 0.86 ± 0.209
0.0AsnXaa: 0.0 ± 0.0
Pro
7.167ProAla: 7.167 ± 1.01
0.573ProCys: 0.573 ± 0.201
3.225ProAsp: 3.225 ± 0.688
4.731ProGlu: 4.731 ± 0.716
1.792ProPhe: 1.792 ± 0.367
4.731ProGly: 4.731 ± 0.596
0.86ProHis: 0.86 ± 0.278
1.935ProIle: 1.935 ± 0.393
2.079ProLys: 2.079 ± 0.383
3.942ProLeu: 3.942 ± 0.483
1.147ProMet: 1.147 ± 0.281
1.864ProAsn: 1.864 ± 0.473
3.44ProPro: 3.44 ± 0.839
2.294ProGln: 2.294 ± 0.77
3.44ProArg: 3.44 ± 0.558
3.655ProSer: 3.655 ± 0.52
3.87ProThr: 3.87 ± 0.594
5.304ProVal: 5.304 ± 0.809
1.075ProTrp: 1.075 ± 0.306
1.577ProTyr: 1.577 ± 0.317
0.0ProXaa: 0.0 ± 0.0
Gln
5.017GlnAla: 5.017 ± 0.796
0.143GlnCys: 0.143 ± 0.083
2.437GlnAsp: 2.437 ± 0.403
2.079GlnGlu: 2.079 ± 0.3
1.218GlnPhe: 1.218 ± 0.268
2.939GlnGly: 2.939 ± 0.398
0.788GlnHis: 0.788 ± 0.254
1.72GlnIle: 1.72 ± 0.315
1.505GlnLys: 1.505 ± 0.325
3.297GlnLeu: 3.297 ± 0.491
1.362GlnMet: 1.362 ± 0.247
0.932GlnAsn: 0.932 ± 0.228
2.365GlnPro: 2.365 ± 0.612
3.512GlnGln: 3.512 ± 1.343
3.082GlnArg: 3.082 ± 0.503
2.724GlnSer: 2.724 ± 0.483
2.795GlnThr: 2.795 ± 0.48
3.082GlnVal: 3.082 ± 0.529
0.43GlnTrp: 0.43 ± 0.211
1.433GlnTyr: 1.433 ± 0.403
0.0GlnXaa: 0.0 ± 0.0
Arg
7.024ArgAla: 7.024 ± 0.59
0.932ArgCys: 0.932 ± 0.332
2.939ArgAsp: 2.939 ± 0.344
3.799ArgGlu: 3.799 ± 0.553
0.932ArgPhe: 0.932 ± 0.298
5.304ArgGly: 5.304 ± 0.733
1.29ArgHis: 1.29 ± 0.386
3.01ArgIle: 3.01 ± 0.379
3.297ArgLys: 3.297 ± 0.631
5.877ArgLeu: 5.877 ± 0.768
1.72ArgMet: 1.72 ± 0.305
2.007ArgAsn: 2.007 ± 0.382
3.369ArgPro: 3.369 ± 0.546
1.577ArgGln: 1.577 ± 0.322
4.802ArgArg: 4.802 ± 0.546
3.512ArgSer: 3.512 ± 0.447
4.659ArgThr: 4.659 ± 0.554
5.304ArgVal: 5.304 ± 0.701
2.365ArgTrp: 2.365 ± 0.481
1.362ArgTyr: 1.362 ± 0.314
0.0ArgXaa: 0.0 ± 0.0
Ser
5.591SerAla: 5.591 ± 0.729
0.573SerCys: 0.573 ± 0.182
3.512SerAsp: 3.512 ± 0.438
3.584SerGlu: 3.584 ± 0.584
1.792SerPhe: 1.792 ± 0.381
5.232SerGly: 5.232 ± 0.644
1.003SerHis: 1.003 ± 0.3
3.154SerIle: 3.154 ± 0.613
2.939SerLys: 2.939 ± 0.445
3.87SerLeu: 3.87 ± 0.653
1.003SerMet: 1.003 ± 0.287
1.003SerAsn: 1.003 ± 0.289
2.724SerPro: 2.724 ± 0.493
2.437SerGln: 2.437 ± 0.447
3.942SerArg: 3.942 ± 0.643
1.935SerSer: 1.935 ± 0.474
4.014SerThr: 4.014 ± 0.425
4.444SerVal: 4.444 ± 0.693
1.218SerTrp: 1.218 ± 0.29
1.72SerTyr: 1.72 ± 0.254
0.0SerXaa: 0.0 ± 0.0
Thr
8.028ThrAla: 8.028 ± 0.737
0.215ThrCys: 0.215 ± 0.113
3.87ThrAsp: 3.87 ± 0.446
3.082ThrGlu: 3.082 ± 0.565
2.365ThrPhe: 2.365 ± 0.433
6.952ThrGly: 6.952 ± 0.724
1.577ThrHis: 1.577 ± 0.307
3.297ThrIle: 3.297 ± 0.556
2.294ThrLys: 2.294 ± 0.509
6.307ThrLeu: 6.307 ± 0.732
0.717ThrMet: 0.717 ± 0.198
1.935ThrAsn: 1.935 ± 0.419
4.802ThrPro: 4.802 ± 0.631
2.079ThrGln: 2.079 ± 0.4
4.229ThrArg: 4.229 ± 0.667
4.157ThrSer: 4.157 ± 0.617
5.519ThrThr: 5.519 ± 0.708
6.092ThrVal: 6.092 ± 0.813
1.075ThrTrp: 1.075 ± 0.261
2.724ThrTyr: 2.724 ± 0.439
0.0ThrXaa: 0.0 ± 0.0
Val
7.597ValAla: 7.597 ± 0.862
0.573ValCys: 0.573 ± 0.203
3.225ValAsp: 3.225 ± 0.466
4.587ValGlu: 4.587 ± 0.548
1.362ValPhe: 1.362 ± 0.246
5.447ValGly: 5.447 ± 0.63
1.362ValHis: 1.362 ± 0.332
3.225ValIle: 3.225 ± 0.502
3.44ValLys: 3.44 ± 0.467
4.802ValLeu: 4.802 ± 0.694
0.932ValMet: 0.932 ± 0.219
2.365ValAsn: 2.365 ± 0.406
4.229ValPro: 4.229 ± 0.507
2.652ValGln: 2.652 ± 0.623
4.946ValArg: 4.946 ± 0.669
4.157ValSer: 4.157 ± 0.602
5.877ValThr: 5.877 ± 0.746
4.802ValVal: 4.802 ± 0.64
1.075ValTrp: 1.075 ± 0.27
1.864ValTyr: 1.864 ± 0.39
0.0ValXaa: 0.0 ± 0.0
Trp
2.365TrpAla: 2.365 ± 0.468
0.358TrpCys: 0.358 ± 0.148
1.075TrpAsp: 1.075 ± 0.274
0.932TrpGlu: 0.932 ± 0.272
0.645TrpPhe: 0.645 ± 0.204
1.433TrpGly: 1.433 ± 0.372
0.358TrpHis: 0.358 ± 0.186
0.645TrpIle: 0.645 ± 0.203
0.717TrpLys: 0.717 ± 0.267
1.792TrpLeu: 1.792 ± 0.416
0.43TrpMet: 0.43 ± 0.148
0.573TrpAsn: 0.573 ± 0.214
0.645TrpPro: 0.645 ± 0.224
0.86TrpGln: 0.86 ± 0.257
1.075TrpArg: 1.075 ± 0.277
0.788TrpSer: 0.788 ± 0.228
1.075TrpThr: 1.075 ± 0.232
1.72TrpVal: 1.72 ± 0.388
0.502TrpTrp: 0.502 ± 0.231
0.215TrpTyr: 0.215 ± 0.116
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.939TyrAla: 2.939 ± 0.437
0.358TyrCys: 0.358 ± 0.147
1.29TyrAsp: 1.29 ± 0.284
1.864TyrGlu: 1.864 ± 0.322
0.573TyrPhe: 0.573 ± 0.203
1.649TyrGly: 1.649 ± 0.263
0.143TyrHis: 0.143 ± 0.091
1.147TyrIle: 1.147 ± 0.274
1.218TyrLys: 1.218 ± 0.285
2.079TyrLeu: 2.079 ± 0.495
0.43TyrMet: 0.43 ± 0.138
1.147TyrAsn: 1.147 ± 0.331
1.29TyrPro: 1.29 ± 0.317
1.792TyrGln: 1.792 ± 0.415
2.079TyrArg: 2.079 ± 0.35
1.003TyrSer: 1.003 ± 0.216
2.15TyrThr: 2.15 ± 0.38
1.433TyrVal: 1.433 ± 0.341
0.358TyrTrp: 0.358 ± 0.164
0.43TyrTyr: 0.43 ± 0.166
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 72 proteins (13953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski