Amino acid dipepetide frequency for Acidianus filamentous virus 7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.377AlaCys: 0.377 ± 0.245
2.541AlaAsp: 2.541 ± 0.44
2.636AlaGlu: 2.636 ± 0.543
2.071AlaPhe: 2.071 ± 0.558
3.294AlaGly: 3.294 ± 0.628
0.753AlaHis: 0.753 ± 0.247
5.177AlaIle: 5.177 ± 0.652
4.706AlaLys: 4.706 ± 0.681
5.553AlaLeu: 5.553 ± 0.69
1.412AlaMet: 1.412 ± 0.514
2.541AlaAsn: 2.541 ± 0.527
1.506AlaPro: 1.506 ± 0.291
1.6AlaGln: 1.6 ± 0.381
2.353AlaArg: 2.353 ± 0.484
3.953AlaSer: 3.953 ± 0.672
4.047AlaThr: 4.047 ± 0.729
3.389AlaVal: 3.389 ± 0.558
0.565AlaTrp: 0.565 ± 0.182
3.106AlaTyr: 3.106 ± 0.564
0.0AlaXaa: 0.0 ± 0.0
Cys
0.471CysAla: 0.471 ± 0.252
0.188CysCys: 0.188 ± 0.177
0.377CysAsp: 0.377 ± 0.224
0.659CysGlu: 0.659 ± 0.301
0.565CysPhe: 0.565 ± 0.247
0.753CysGly: 0.753 ± 0.297
0.188CysHis: 0.188 ± 0.142
0.753CysIle: 0.753 ± 0.332
0.471CysLys: 0.471 ± 0.221
0.847CysLeu: 0.847 ± 0.262
0.188CysMet: 0.188 ± 0.114
0.847CysAsn: 0.847 ± 0.278
0.471CysPro: 0.471 ± 0.228
0.282CysGln: 0.282 ± 0.19
0.471CysArg: 0.471 ± 0.188
1.13CysSer: 1.13 ± 0.291
0.282CysThr: 0.282 ± 0.18
1.412CysVal: 1.412 ± 0.359
0.094CysTrp: 0.094 ± 0.084
0.753CysTyr: 0.753 ± 0.249
0.0CysXaa: 0.0 ± 0.0
Asp
2.165AspAla: 2.165 ± 0.529
0.377AspCys: 0.377 ± 0.236
3.483AspAsp: 3.483 ± 0.632
4.612AspGlu: 4.612 ± 0.601
1.883AspPhe: 1.883 ± 0.398
2.636AspGly: 2.636 ± 0.436
0.847AspHis: 0.847 ± 0.25
4.518AspIle: 4.518 ± 0.651
2.918AspLys: 2.918 ± 0.625
3.859AspLeu: 3.859 ± 0.558
0.941AspMet: 0.941 ± 0.267
1.788AspAsn: 1.788 ± 0.464
2.071AspPro: 2.071 ± 0.379
0.659AspGln: 0.659 ± 0.266
1.318AspArg: 1.318 ± 0.354
1.412AspSer: 1.412 ± 0.338
1.6AspThr: 1.6 ± 0.414
5.365AspVal: 5.365 ± 0.816
0.377AspTrp: 0.377 ± 0.173
3.483AspTyr: 3.483 ± 0.559
0.0AspXaa: 0.0 ± 0.0
Glu
2.918GluAla: 2.918 ± 0.529
0.941GluCys: 0.941 ± 0.326
2.918GluAsp: 2.918 ± 0.541
6.777GluGlu: 6.777 ± 1.268
3.2GluPhe: 3.2 ± 0.517
3.859GluGly: 3.859 ± 0.64
0.659GluHis: 0.659 ± 0.304
8.471GluIle: 8.471 ± 1.17
8.283GluLys: 8.283 ± 1.17
7.248GluLeu: 7.248 ± 0.912
1.883GluMet: 1.883 ± 0.473
3.953GluAsn: 3.953 ± 0.586
1.035GluPro: 1.035 ± 0.275
1.412GluGln: 1.412 ± 0.372
1.977GluArg: 1.977 ± 0.393
2.636GluSer: 2.636 ± 0.459
2.73GluThr: 2.73 ± 0.51
4.236GluVal: 4.236 ± 0.604
0.753GluTrp: 0.753 ± 0.232
3.483GluTyr: 3.483 ± 0.57
0.0GluXaa: 0.0 ± 0.0
Phe
2.353PheAla: 2.353 ± 0.56
0.377PheCys: 0.377 ± 0.187
2.541PheAsp: 2.541 ± 0.465
3.294PheGlu: 3.294 ± 0.562
2.541PhePhe: 2.541 ± 0.559
1.694PheGly: 1.694 ± 0.485
1.318PheHis: 1.318 ± 0.327
2.73PheIle: 2.73 ± 0.478
2.165PheLys: 2.165 ± 0.467
4.612PheLeu: 4.612 ± 0.597
1.224PheMet: 1.224 ± 0.326
2.541PheAsn: 2.541 ± 0.361
1.13PhePro: 1.13 ± 0.322
2.259PheGln: 2.259 ± 0.396
0.659PheArg: 0.659 ± 0.261
3.765PheSer: 3.765 ± 0.664
2.636PheThr: 2.636 ± 0.457
4.142PheVal: 4.142 ± 0.63
0.471PheTrp: 0.471 ± 0.256
2.071PheTyr: 2.071 ± 0.382
0.094PheXaa: 0.094 ± 0.096
Gly
3.483GlyAla: 3.483 ± 0.61
1.13GlyCys: 1.13 ± 0.31
2.636GlyAsp: 2.636 ± 0.535
4.047GlyGlu: 4.047 ± 0.621
2.259GlyPhe: 2.259 ± 0.413
2.259GlyGly: 2.259 ± 0.635
0.565GlyHis: 0.565 ± 0.213
5.648GlyIle: 5.648 ± 0.738
6.306GlyLys: 6.306 ± 0.771
4.612GlyLeu: 4.612 ± 0.594
0.847GlyMet: 0.847 ± 0.285
3.294GlyAsn: 3.294 ± 0.697
0.188GlyPro: 0.188 ± 0.117
2.353GlyGln: 2.353 ± 0.504
2.636GlyArg: 2.636 ± 0.528
2.73GlySer: 2.73 ± 0.56
2.636GlyThr: 2.636 ± 0.441
3.953GlyVal: 3.953 ± 0.649
0.471GlyTrp: 0.471 ± 0.242
2.447GlyTyr: 2.447 ± 0.509
0.0GlyXaa: 0.0 ± 0.0
His
0.941HisAla: 0.941 ± 0.295
0.282HisCys: 0.282 ± 0.169
1.13HisAsp: 1.13 ± 0.315
1.035HisGlu: 1.035 ± 0.291
0.565HisPhe: 0.565 ± 0.245
0.753HisGly: 0.753 ± 0.301
0.377HisHis: 0.377 ± 0.206
0.659HisIle: 0.659 ± 0.268
0.471HisLys: 0.471 ± 0.199
1.224HisLeu: 1.224 ± 0.347
0.188HisMet: 0.188 ± 0.154
0.659HisAsn: 0.659 ± 0.3
0.565HisPro: 0.565 ± 0.237
0.377HisGln: 0.377 ± 0.206
0.282HisArg: 0.282 ± 0.161
0.659HisSer: 0.659 ± 0.228
0.659HisThr: 0.659 ± 0.208
1.506HisVal: 1.506 ± 0.404
0.094HisTrp: 0.094 ± 0.087
1.412HisTyr: 1.412 ± 0.348
0.0HisXaa: 0.0 ± 0.0
Ile
6.683IleAla: 6.683 ± 0.916
0.753IleCys: 0.753 ± 0.255
4.424IleAsp: 4.424 ± 0.682
5.459IleGlu: 5.459 ± 0.773
3.765IlePhe: 3.765 ± 0.488
4.989IleGly: 4.989 ± 0.714
1.318IleHis: 1.318 ± 0.39
7.812IleIle: 7.812 ± 1.341
5.459IleLys: 5.459 ± 0.946
6.777IleLeu: 6.777 ± 0.894
1.694IleMet: 1.694 ± 0.363
4.33IleAsn: 4.33 ± 0.904
4.33IlePro: 4.33 ± 0.589
2.541IleGln: 2.541 ± 0.501
3.577IleArg: 3.577 ± 0.574
5.742IleSer: 5.742 ± 0.709
5.271IleThr: 5.271 ± 0.681
7.154IleVal: 7.154 ± 0.659
1.035IleTrp: 1.035 ± 0.338
3.765IleTyr: 3.765 ± 0.539
0.0IleXaa: 0.0 ± 0.0
Lys
3.106LysAla: 3.106 ± 0.717
0.565LysCys: 0.565 ± 0.224
2.447LysAsp: 2.447 ± 0.486
7.154LysGlu: 7.154 ± 1.014
2.73LysPhe: 2.73 ± 0.552
3.577LysGly: 3.577 ± 0.482
0.282LysHis: 0.282 ± 0.164
8.754LysIle: 8.754 ± 1.152
8.471LysLys: 8.471 ± 1.199
8.283LysLeu: 8.283 ± 1.095
2.353LysMet: 2.353 ± 0.475
3.2LysAsn: 3.2 ± 0.742
2.259LysPro: 2.259 ± 0.419
1.883LysGln: 1.883 ± 0.41
3.483LysArg: 3.483 ± 0.663
3.577LysSer: 3.577 ± 0.609
4.424LysThr: 4.424 ± 0.554
5.177LysVal: 5.177 ± 0.809
0.471LysTrp: 0.471 ± 0.205
3.859LysTyr: 3.859 ± 0.608
0.0LysXaa: 0.0 ± 0.0
Leu
4.989LeuAla: 4.989 ± 0.792
2.071LeuCys: 2.071 ± 0.515
3.671LeuAsp: 3.671 ± 0.63
6.683LeuGlu: 6.683 ± 0.776
4.236LeuPhe: 4.236 ± 0.524
3.577LeuGly: 3.577 ± 0.608
1.6LeuHis: 1.6 ± 0.403
5.648LeuIle: 5.648 ± 0.882
7.154LeuLys: 7.154 ± 1.089
9.13LeuLeu: 9.13 ± 1.104
1.6LeuMet: 1.6 ± 0.438
3.2LeuAsn: 3.2 ± 0.455
4.518LeuPro: 4.518 ± 0.72
4.33LeuGln: 4.33 ± 0.592
4.236LeuArg: 4.236 ± 0.704
7.059LeuSer: 7.059 ± 0.65
5.365LeuThr: 5.365 ± 0.697
8.189LeuVal: 8.189 ± 0.83
0.847LeuTrp: 0.847 ± 0.255
4.8LeuTyr: 4.8 ± 0.637
0.0LeuXaa: 0.0 ± 0.0
Met
1.6MetAla: 1.6 ± 0.409
0.282MetCys: 0.282 ± 0.158
0.471MetAsp: 0.471 ± 0.2
1.318MetGlu: 1.318 ± 0.386
0.753MetPhe: 0.753 ± 0.255
1.13MetGly: 1.13 ± 0.344
0.094MetHis: 0.094 ± 0.094
1.506MetIle: 1.506 ± 0.392
1.883MetLys: 1.883 ± 0.326
2.071MetLeu: 2.071 ± 0.36
0.565MetMet: 0.565 ± 0.207
0.659MetAsn: 0.659 ± 0.224
0.753MetPro: 0.753 ± 0.331
1.13MetGln: 1.13 ± 0.266
1.788MetArg: 1.788 ± 0.413
1.977MetSer: 1.977 ± 0.405
1.224MetThr: 1.224 ± 0.361
1.6MetVal: 1.6 ± 0.419
0.565MetTrp: 0.565 ± 0.219
0.753MetTyr: 0.753 ± 0.319
0.0MetXaa: 0.0 ± 0.0
Asn
3.2AsnAla: 3.2 ± 0.45
0.565AsnCys: 0.565 ± 0.28
2.447AsnAsp: 2.447 ± 0.516
3.106AsnGlu: 3.106 ± 0.501
2.918AsnPhe: 2.918 ± 0.572
3.389AsnGly: 3.389 ± 0.508
0.941AsnHis: 0.941 ± 0.288
3.294AsnIle: 3.294 ± 0.458
3.483AsnLys: 3.483 ± 0.595
3.953AsnLeu: 3.953 ± 0.595
1.412AsnMet: 1.412 ± 0.364
3.2AsnAsn: 3.2 ± 0.551
1.694AsnPro: 1.694 ± 0.388
1.506AsnGln: 1.506 ± 0.393
0.847AsnArg: 0.847 ± 0.33
3.953AsnSer: 3.953 ± 0.769
2.447AsnThr: 2.447 ± 0.437
5.177AsnVal: 5.177 ± 0.866
0.753AsnTrp: 0.753 ± 0.195
2.918AsnTyr: 2.918 ± 0.576
0.0AsnXaa: 0.0 ± 0.0
Pro
2.165ProAla: 2.165 ± 0.429
0.377ProCys: 0.377 ± 0.186
1.694ProAsp: 1.694 ± 0.359
2.353ProGlu: 2.353 ± 0.419
2.071ProPhe: 2.071 ± 0.383
1.6ProGly: 1.6 ± 0.395
0.847ProHis: 0.847 ± 0.398
3.671ProIle: 3.671 ± 0.594
1.788ProLys: 1.788 ± 0.464
2.918ProLeu: 2.918 ± 0.421
0.565ProMet: 0.565 ± 0.216
1.883ProAsn: 1.883 ± 0.435
3.106ProPro: 3.106 ± 0.554
1.6ProGln: 1.6 ± 0.394
1.506ProArg: 1.506 ± 0.465
4.047ProSer: 4.047 ± 0.696
2.918ProThr: 2.918 ± 0.513
2.73ProVal: 2.73 ± 0.507
0.094ProTrp: 0.094 ± 0.087
1.788ProTyr: 1.788 ± 0.38
0.0ProXaa: 0.0 ± 0.0
Gln
1.412GlnAla: 1.412 ± 0.351
0.377GlnCys: 0.377 ± 0.219
0.847GlnAsp: 0.847 ± 0.247
2.447GlnGlu: 2.447 ± 0.51
1.883GlnPhe: 1.883 ± 0.426
2.636GlnGly: 2.636 ± 0.451
0.0GlnHis: 0.0 ± 0.0
3.294GlnIle: 3.294 ± 0.505
2.165GlnLys: 2.165 ± 0.415
3.577GlnLeu: 3.577 ± 0.639
1.035GlnMet: 1.035 ± 0.3
1.412GlnAsn: 1.412 ± 0.383
0.753GlnPro: 0.753 ± 0.255
1.6GlnGln: 1.6 ± 0.437
0.941GlnArg: 0.941 ± 0.348
1.412GlnSer: 1.412 ± 0.422
2.353GlnThr: 2.353 ± 0.499
2.824GlnVal: 2.824 ± 0.666
0.377GlnTrp: 0.377 ± 0.178
1.788GlnTyr: 1.788 ± 0.398
0.0GlnXaa: 0.0 ± 0.0
Arg
1.6ArgAla: 1.6 ± 0.505
0.094ArgCys: 0.094 ± 0.096
2.165ArgAsp: 2.165 ± 0.551
3.389ArgGlu: 3.389 ± 0.571
1.412ArgPhe: 1.412 ± 0.332
2.447ArgGly: 2.447 ± 0.439
0.659ArgHis: 0.659 ± 0.259
4.142ArgIle: 4.142 ± 0.835
4.236ArgLys: 4.236 ± 0.671
3.953ArgLeu: 3.953 ± 0.617
1.13ArgMet: 1.13 ± 0.328
1.224ArgAsn: 1.224 ± 0.316
0.941ArgPro: 0.941 ± 0.295
1.13ArgGln: 1.13 ± 0.31
1.883ArgArg: 1.883 ± 0.456
1.6ArgSer: 1.6 ± 0.393
1.224ArgThr: 1.224 ± 0.3
2.071ArgVal: 2.071 ± 0.362
0.282ArgTrp: 0.282 ± 0.202
2.636ArgTyr: 2.636 ± 0.482
0.0ArgXaa: 0.0 ± 0.0
Ser
3.2SerAla: 3.2 ± 0.601
0.282SerCys: 0.282 ± 0.195
2.259SerAsp: 2.259 ± 0.45
3.2SerGlu: 3.2 ± 0.545
4.236SerPhe: 4.236 ± 0.645
4.706SerGly: 4.706 ± 0.858
0.941SerHis: 0.941 ± 0.351
3.953SerIle: 3.953 ± 0.711
3.012SerLys: 3.012 ± 0.418
7.624SerLeu: 7.624 ± 0.859
1.318SerMet: 1.318 ± 0.304
3.859SerAsn: 3.859 ± 0.654
3.294SerPro: 3.294 ± 0.648
2.636SerGln: 2.636 ± 0.485
2.447SerArg: 2.447 ± 0.531
5.93SerSer: 5.93 ± 1.197
3.765SerThr: 3.765 ± 0.648
4.518SerVal: 4.518 ± 0.796
0.377SerTrp: 0.377 ± 0.173
3.012SerTyr: 3.012 ± 0.554
0.0SerXaa: 0.0 ± 0.0
Thr
3.012ThrAla: 3.012 ± 0.663
0.377ThrCys: 0.377 ± 0.192
2.165ThrAsp: 2.165 ± 0.561
2.447ThrGlu: 2.447 ± 0.49
2.541ThrPhe: 2.541 ± 0.51
3.671ThrGly: 3.671 ± 0.633
0.565ThrHis: 0.565 ± 0.223
4.047ThrIle: 4.047 ± 0.61
3.859ThrLys: 3.859 ± 0.541
5.271ThrLeu: 5.271 ± 0.632
1.035ThrMet: 1.035 ± 0.315
3.389ThrAsn: 3.389 ± 0.51
4.424ThrPro: 4.424 ± 0.72
1.412ThrGln: 1.412 ± 0.473
2.259ThrArg: 2.259 ± 0.443
4.047ThrSer: 4.047 ± 0.668
5.553ThrThr: 5.553 ± 1.109
4.518ThrVal: 4.518 ± 0.775
0.565ThrTrp: 0.565 ± 0.207
3.953ThrTyr: 3.953 ± 0.595
0.0ThrXaa: 0.0 ± 0.0
Val
5.271ValAla: 5.271 ± 0.686
0.659ValCys: 0.659 ± 0.244
4.236ValAsp: 4.236 ± 0.733
4.989ValGlu: 4.989 ± 0.745
2.918ValPhe: 2.918 ± 0.545
4.236ValGly: 4.236 ± 0.682
0.847ValHis: 0.847 ± 0.299
6.965ValIle: 6.965 ± 0.889
5.742ValLys: 5.742 ± 0.73
6.306ValLeu: 6.306 ± 0.746
1.035ValMet: 1.035 ± 0.301
5.742ValAsn: 5.742 ± 0.781
3.953ValPro: 3.953 ± 0.426
2.541ValGln: 2.541 ± 0.479
3.294ValArg: 3.294 ± 0.564
4.612ValSer: 4.612 ± 0.734
6.306ValThr: 6.306 ± 1.006
6.965ValVal: 6.965 ± 0.948
0.282ValTrp: 0.282 ± 0.158
4.424ValTyr: 4.424 ± 0.629
0.0ValXaa: 0.0 ± 0.0
Trp
0.282TrpAla: 0.282 ± 0.141
0.377TrpCys: 0.377 ± 0.166
0.753TrpAsp: 0.753 ± 0.211
0.753TrpGlu: 0.753 ± 0.245
0.188TrpPhe: 0.188 ± 0.114
0.094TrpGly: 0.094 ± 0.087
0.188TrpHis: 0.188 ± 0.119
1.224TrpIle: 1.224 ± 0.35
0.565TrpLys: 0.565 ± 0.226
0.847TrpLeu: 0.847 ± 0.259
0.094TrpMet: 0.094 ± 0.092
0.471TrpAsn: 0.471 ± 0.184
0.0TrpPro: 0.0 ± 0.0
0.377TrpGln: 0.377 ± 0.168
0.282TrpArg: 0.282 ± 0.154
0.847TrpSer: 0.847 ± 0.287
0.847TrpThr: 0.847 ± 0.221
0.282TrpVal: 0.282 ± 0.158
0.282TrpTrp: 0.282 ± 0.189
0.565TrpTyr: 0.565 ± 0.191
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.73TyrAla: 2.73 ± 0.505
0.753TyrCys: 0.753 ± 0.283
3.012TyrAsp: 3.012 ± 0.461
3.012TyrGlu: 3.012 ± 0.586
1.883TyrPhe: 1.883 ± 0.423
3.2TyrGly: 3.2 ± 0.633
0.847TyrHis: 0.847 ± 0.299
4.612TyrIle: 4.612 ± 0.642
2.918TyrLys: 2.918 ± 0.49
4.236TyrLeu: 4.236 ± 0.58
1.506TyrMet: 1.506 ± 0.365
3.012TyrAsn: 3.012 ± 0.593
2.824TyrPro: 2.824 ± 0.593
1.506TyrGln: 1.506 ± 0.379
1.977TyrArg: 1.977 ± 0.37
3.483TyrSer: 3.483 ± 0.62
2.824TyrThr: 2.824 ± 0.449
6.118TyrVal: 6.118 ± 0.703
0.565TyrTrp: 0.565 ± 0.2
2.918TyrTyr: 2.918 ± 0.667
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.094XaaAsp: 0.094 ± 0.096
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (10625 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski