Amino acid dipepetide frequency for Mycobacterium virus Nepal

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.317AlaAla: 11.317 ± 1.136
0.871AlaCys: 0.871 ± 0.232
6.558AlaAsp: 6.558 ± 0.564
5.745AlaGlu: 5.745 ± 0.663
2.67AlaPhe: 2.67 ± 0.476
8.009AlaGly: 8.009 ± 0.956
1.509AlaHis: 1.509 ± 0.352
4.179AlaIle: 4.179 ± 0.537
4.295AlaLys: 4.295 ± 0.6
8.879AlaLeu: 8.879 ± 0.912
2.031AlaMet: 2.031 ± 0.403
2.263AlaAsn: 2.263 ± 0.337
5.049AlaPro: 5.049 ± 0.615
2.902AlaGln: 2.902 ± 0.455
6.384AlaArg: 6.384 ± 0.585
4.701AlaSer: 4.701 ± 0.558
5.513AlaThr: 5.513 ± 0.774
7.545AlaVal: 7.545 ± 0.77
1.625AlaTrp: 1.625 ± 0.357
2.728AlaTyr: 2.728 ± 0.401
0.0AlaXaa: 0.0 ± 0.0
Cys
0.812CysAla: 0.812 ± 0.233
0.116CysCys: 0.116 ± 0.088
0.522CysAsp: 0.522 ± 0.151
0.871CysGlu: 0.871 ± 0.241
0.174CysPhe: 0.174 ± 0.098
0.696CysGly: 0.696 ± 0.206
0.29CysHis: 0.29 ± 0.149
0.29CysIle: 0.29 ± 0.132
0.406CysLys: 0.406 ± 0.151
0.58CysLeu: 0.58 ± 0.255
0.174CysMet: 0.174 ± 0.091
0.29CysAsn: 0.29 ± 0.125
0.29CysPro: 0.29 ± 0.152
0.29CysGln: 0.29 ± 0.121
0.754CysArg: 0.754 ± 0.274
0.522CysSer: 0.522 ± 0.16
0.406CysThr: 0.406 ± 0.146
0.464CysVal: 0.464 ± 0.153
0.174CysTrp: 0.174 ± 0.103
0.116CysTyr: 0.116 ± 0.08
0.0CysXaa: 0.0 ± 0.0
Asp
6.21AspAla: 6.21 ± 0.693
0.58AspCys: 0.58 ± 0.185
4.295AspAsp: 4.295 ± 0.484
3.25AspGlu: 3.25 ± 0.485
2.437AspPhe: 2.437 ± 0.316
6.326AspGly: 6.326 ± 0.605
0.929AspHis: 0.929 ± 0.234
2.612AspIle: 2.612 ± 0.418
2.437AspLys: 2.437 ± 0.404
6.268AspLeu: 6.268 ± 0.629
1.393AspMet: 1.393 ± 0.255
1.799AspAsn: 1.799 ± 0.336
5.049AspPro: 5.049 ± 0.484
1.683AspGln: 1.683 ± 0.325
3.946AspArg: 3.946 ± 0.48
3.018AspSer: 3.018 ± 0.452
3.714AspThr: 3.714 ± 0.361
4.527AspVal: 4.527 ± 0.54
1.567AspTrp: 1.567 ± 0.281
2.263AspTyr: 2.263 ± 0.346
0.0AspXaa: 0.0 ± 0.0
Glu
5.397GluAla: 5.397 ± 0.665
0.29GluCys: 0.29 ± 0.127
4.933GluAsp: 4.933 ± 0.538
4.933GluGlu: 4.933 ± 0.596
2.147GluPhe: 2.147 ± 0.332
4.643GluGly: 4.643 ± 0.535
1.451GluHis: 1.451 ± 0.295
3.598GluIle: 3.598 ± 0.427
2.786GluLys: 2.786 ± 0.424
6.268GluLeu: 6.268 ± 0.525
1.741GluMet: 1.741 ± 0.339
1.393GluAsn: 1.393 ± 0.34
2.844GluPro: 2.844 ± 0.41
2.67GluGln: 2.67 ± 0.372
3.888GluArg: 3.888 ± 0.532
3.366GluSer: 3.366 ± 0.382
3.424GluThr: 3.424 ± 0.486
5.165GluVal: 5.165 ± 0.584
1.567GluTrp: 1.567 ± 0.313
2.496GluTyr: 2.496 ± 0.456
0.0GluXaa: 0.0 ± 0.0
Phe
2.379PheAla: 2.379 ± 0.391
0.29PheCys: 0.29 ± 0.143
2.728PheAsp: 2.728 ± 0.269
2.321PheGlu: 2.321 ± 0.329
0.754PhePhe: 0.754 ± 0.23
3.366PheGly: 3.366 ± 0.437
0.696PheHis: 0.696 ± 0.235
1.219PheIle: 1.219 ± 0.241
1.103PheLys: 1.103 ± 0.278
1.973PheLeu: 1.973 ± 0.407
0.58PheMet: 0.58 ± 0.194
1.161PheAsn: 1.161 ± 0.311
1.683PhePro: 1.683 ± 0.33
1.045PheGln: 1.045 ± 0.208
1.857PheArg: 1.857 ± 0.313
1.683PheSer: 1.683 ± 0.27
2.496PheThr: 2.496 ± 0.341
2.031PheVal: 2.031 ± 0.349
0.522PheTrp: 0.522 ± 0.17
0.871PheTyr: 0.871 ± 0.22
0.0PheXaa: 0.0 ± 0.0
Gly
7.951GlyAla: 7.951 ± 1.196
0.871GlyCys: 0.871 ± 0.236
5.745GlyAsp: 5.745 ± 0.601
4.469GlyGlu: 4.469 ± 0.457
2.902GlyPhe: 2.902 ± 0.463
10.388GlyGly: 10.388 ± 2.881
2.089GlyHis: 2.089 ± 0.337
4.469GlyIle: 4.469 ± 0.728
3.656GlyLys: 3.656 ± 0.537
7.835GlyLeu: 7.835 ± 0.667
2.379GlyMet: 2.379 ± 0.365
3.308GlyAsn: 3.308 ± 0.459
3.888GlyPro: 3.888 ± 0.529
2.379GlyGln: 2.379 ± 0.347
5.571GlyArg: 5.571 ± 0.659
6.326GlySer: 6.326 ± 0.789
5.165GlyThr: 5.165 ± 0.593
5.281GlyVal: 5.281 ± 0.557
2.786GlyTrp: 2.786 ± 0.387
2.728GlyTyr: 2.728 ± 0.417
0.0GlyXaa: 0.0 ± 0.0
His
1.451HisAla: 1.451 ± 0.34
0.116HisCys: 0.116 ± 0.112
0.987HisAsp: 0.987 ± 0.203
1.625HisGlu: 1.625 ± 0.311
0.812HisPhe: 0.812 ± 0.212
1.509HisGly: 1.509 ± 0.33
0.638HisHis: 0.638 ± 0.27
0.929HisIle: 0.929 ± 0.211
1.045HisLys: 1.045 ± 0.309
1.625HisLeu: 1.625 ± 0.423
0.058HisMet: 0.058 ± 0.051
0.232HisAsn: 0.232 ± 0.117
1.219HisPro: 1.219 ± 0.208
0.987HisGln: 0.987 ± 0.236
1.799HisArg: 1.799 ± 0.332
0.696HisSer: 0.696 ± 0.185
0.871HisThr: 0.871 ± 0.196
1.567HisVal: 1.567 ± 0.308
0.522HisTrp: 0.522 ± 0.144
0.522HisTyr: 0.522 ± 0.203
0.0HisXaa: 0.0 ± 0.0
Ile
5.745IleAla: 5.745 ± 0.595
0.348IleCys: 0.348 ± 0.123
3.308IleAsp: 3.308 ± 0.4
3.888IleGlu: 3.888 ± 0.449
0.812IlePhe: 0.812 ± 0.257
4.179IleGly: 4.179 ± 0.549
0.812IleHis: 0.812 ± 0.196
1.451IleIle: 1.451 ± 0.3
1.625IleLys: 1.625 ± 0.311
3.192IleLeu: 3.192 ± 0.384
0.812IleMet: 0.812 ± 0.212
1.973IleAsn: 1.973 ± 0.267
2.786IlePro: 2.786 ± 0.336
1.277IleGln: 1.277 ± 0.33
3.482IleArg: 3.482 ± 0.432
3.482IleSer: 3.482 ± 0.422
3.366IleThr: 3.366 ± 0.427
3.076IleVal: 3.076 ± 0.53
0.696IleTrp: 0.696 ± 0.2
1.567IleTyr: 1.567 ± 0.271
0.0IleXaa: 0.0 ± 0.0
Lys
3.946LysAla: 3.946 ± 0.505
0.406LysCys: 0.406 ± 0.154
2.379LysAsp: 2.379 ± 0.422
1.973LysGlu: 1.973 ± 0.339
1.335LysPhe: 1.335 ± 0.273
3.192LysGly: 3.192 ± 0.452
1.161LysHis: 1.161 ± 0.278
2.031LysIle: 2.031 ± 0.406
1.857LysLys: 1.857 ± 0.373
3.482LysLeu: 3.482 ± 0.459
1.103LysMet: 1.103 ± 0.219
1.335LysAsn: 1.335 ± 0.273
2.728LysPro: 2.728 ± 0.489
1.625LysGln: 1.625 ± 0.345
2.554LysArg: 2.554 ± 0.35
2.554LysSer: 2.554 ± 0.47
2.496LysThr: 2.496 ± 0.398
3.308LysVal: 3.308 ± 0.54
0.812LysTrp: 0.812 ± 0.223
1.103LysTyr: 1.103 ± 0.296
0.0LysXaa: 0.0 ± 0.0
Leu
9.228LeuAla: 9.228 ± 0.759
0.29LeuCys: 0.29 ± 0.127
6.094LeuAsp: 6.094 ± 0.554
5.455LeuGlu: 5.455 ± 0.566
2.031LeuPhe: 2.031 ± 0.343
6.906LeuGly: 6.906 ± 0.665
1.335LeuHis: 1.335 ± 0.276
4.295LeuIle: 4.295 ± 0.513
4.062LeuLys: 4.062 ± 0.427
5.862LeuLeu: 5.862 ± 0.574
1.683LeuMet: 1.683 ± 0.282
2.67LeuAsn: 2.67 ± 0.362
5.513LeuPro: 5.513 ± 0.596
2.786LeuGln: 2.786 ± 0.559
6.558LeuArg: 6.558 ± 0.679
5.862LeuSer: 5.862 ± 0.556
5.92LeuThr: 5.92 ± 0.424
4.527LeuVal: 4.527 ± 0.64
0.987LeuTrp: 0.987 ± 0.272
2.205LeuTyr: 2.205 ± 0.34
0.0LeuXaa: 0.0 ± 0.0
Met
2.379MetAla: 2.379 ± 0.4
0.058MetCys: 0.058 ± 0.049
1.045MetAsp: 1.045 ± 0.207
1.393MetGlu: 1.393 ± 0.318
0.58MetPhe: 0.58 ± 0.156
1.451MetGly: 1.451 ± 0.226
0.406MetHis: 0.406 ± 0.267
0.638MetIle: 0.638 ± 0.201
1.335MetLys: 1.335 ± 0.308
1.161MetLeu: 1.161 ± 0.273
0.29MetMet: 0.29 ± 0.132
1.103MetAsn: 1.103 ± 0.249
1.103MetPro: 1.103 ± 0.262
0.638MetGln: 0.638 ± 0.172
1.741MetArg: 1.741 ± 0.33
2.321MetSer: 2.321 ± 0.337
1.857MetThr: 1.857 ± 0.269
1.103MetVal: 1.103 ± 0.286
0.29MetTrp: 0.29 ± 0.11
0.348MetTyr: 0.348 ± 0.164
0.0MetXaa: 0.0 ± 0.0
Asn
3.018AsnAla: 3.018 ± 0.496
0.0AsnCys: 0.0 ± 0.0
1.799AsnAsp: 1.799 ± 0.374
1.973AsnGlu: 1.973 ± 0.357
0.871AsnPhe: 0.871 ± 0.287
3.308AsnGly: 3.308 ± 0.517
0.754AsnHis: 0.754 ± 0.188
1.741AsnIle: 1.741 ± 0.3
0.696AsnLys: 0.696 ± 0.212
2.496AsnLeu: 2.496 ± 0.398
0.522AsnMet: 0.522 ± 0.162
0.812AsnAsn: 0.812 ± 0.183
2.902AsnPro: 2.902 ± 0.357
0.987AsnGln: 0.987 ± 0.243
1.451AsnArg: 1.451 ± 0.363
1.915AsnSer: 1.915 ± 0.429
1.973AsnThr: 1.973 ± 0.307
2.437AsnVal: 2.437 ± 0.37
0.696AsnTrp: 0.696 ± 0.17
1.161AsnTyr: 1.161 ± 0.247
0.0AsnXaa: 0.0 ± 0.0
Pro
4.933ProAla: 4.933 ± 0.631
0.522ProCys: 0.522 ± 0.16
3.946ProAsp: 3.946 ± 0.449
4.004ProGlu: 4.004 ± 0.493
1.973ProPhe: 1.973 ± 0.356
5.455ProGly: 5.455 ± 0.626
0.696ProHis: 0.696 ± 0.2
2.321ProIle: 2.321 ± 0.366
2.437ProLys: 2.437 ± 0.381
4.643ProLeu: 4.643 ± 0.489
1.219ProMet: 1.219 ± 0.249
1.625ProAsn: 1.625 ± 0.294
3.54ProPro: 3.54 ± 0.549
1.393ProGln: 1.393 ± 0.295
3.076ProArg: 3.076 ± 0.511
3.946ProSer: 3.946 ± 0.441
4.12ProThr: 4.12 ± 0.493
3.83ProVal: 3.83 ± 0.512
0.812ProTrp: 0.812 ± 0.268
1.683ProTyr: 1.683 ± 0.345
0.0ProXaa: 0.0 ± 0.0
Gln
2.728GlnAla: 2.728 ± 0.401
0.058GlnCys: 0.058 ± 0.055
1.219GlnAsp: 1.219 ± 0.34
1.973GlnGlu: 1.973 ± 0.318
1.045GlnPhe: 1.045 ± 0.241
2.844GlnGly: 2.844 ± 0.359
0.696GlnHis: 0.696 ± 0.225
2.902GlnIle: 2.902 ± 0.481
1.103GlnLys: 1.103 ± 0.272
3.482GlnLeu: 3.482 ± 0.511
0.812GlnMet: 0.812 ± 0.231
0.464GlnAsn: 0.464 ± 0.143
1.799GlnPro: 1.799 ± 0.337
1.741GlnGln: 1.741 ± 0.324
2.147GlnArg: 2.147 ± 0.426
1.799GlnSer: 1.799 ± 0.305
1.799GlnThr: 1.799 ± 0.295
2.437GlnVal: 2.437 ± 0.34
0.696GlnTrp: 0.696 ± 0.18
0.696GlnTyr: 0.696 ± 0.157
0.0GlnXaa: 0.0 ± 0.0
Arg
5.455ArgAla: 5.455 ± 0.603
1.335ArgCys: 1.335 ± 0.329
3.482ArgAsp: 3.482 ± 0.468
4.933ArgGlu: 4.933 ± 0.638
2.147ArgPhe: 2.147 ± 0.431
5.339ArgGly: 5.339 ± 0.665
0.812ArgHis: 0.812 ± 0.207
3.25ArgIle: 3.25 ± 0.455
3.54ArgLys: 3.54 ± 0.6
6.152ArgLeu: 6.152 ± 0.676
1.915ArgMet: 1.915 ± 0.394
2.67ArgAsn: 2.67 ± 0.43
2.496ArgPro: 2.496 ± 0.41
2.031ArgGln: 2.031 ± 0.274
6.558ArgArg: 6.558 ± 0.891
4.469ArgSer: 4.469 ± 0.652
2.96ArgThr: 2.96 ± 0.498
5.397ArgVal: 5.397 ± 0.595
1.335ArgTrp: 1.335 ± 0.287
1.625ArgTyr: 1.625 ± 0.288
0.0ArgXaa: 0.0 ± 0.0
Ser
5.92SerAla: 5.92 ± 0.646
0.464SerCys: 0.464 ± 0.147
3.308SerAsp: 3.308 ± 0.388
4.004SerGlu: 4.004 ± 0.437
2.205SerPhe: 2.205 ± 0.409
6.442SerGly: 6.442 ± 0.68
1.451SerHis: 1.451 ± 0.272
2.844SerIle: 2.844 ± 0.434
1.973SerLys: 1.973 ± 0.304
4.991SerLeu: 4.991 ± 0.493
1.393SerMet: 1.393 ± 0.25
2.67SerAsn: 2.67 ± 0.444
3.25SerPro: 3.25 ± 0.418
1.973SerGln: 1.973 ± 0.24
3.308SerArg: 3.308 ± 0.399
3.83SerSer: 3.83 ± 0.704
3.366SerThr: 3.366 ± 0.434
4.411SerVal: 4.411 ± 0.536
1.393SerTrp: 1.393 ± 0.262
1.567SerTyr: 1.567 ± 0.315
0.0SerXaa: 0.0 ± 0.0
Thr
5.397ThrAla: 5.397 ± 0.595
0.58ThrCys: 0.58 ± 0.188
4.295ThrAsp: 4.295 ± 0.598
4.062ThrGlu: 4.062 ± 0.541
2.147ThrPhe: 2.147 ± 0.408
6.5ThrGly: 6.5 ± 0.641
0.987ThrHis: 0.987 ± 0.298
2.612ThrIle: 2.612 ± 0.509
2.554ThrLys: 2.554 ± 0.327
5.745ThrLeu: 5.745 ± 0.678
0.929ThrMet: 0.929 ± 0.181
1.799ThrAsn: 1.799 ± 0.313
3.772ThrPro: 3.772 ± 0.443
1.625ThrGln: 1.625 ± 0.293
3.656ThrArg: 3.656 ± 0.525
3.598ThrSer: 3.598 ± 0.564
4.353ThrThr: 4.353 ± 0.561
5.455ThrVal: 5.455 ± 0.724
1.103ThrTrp: 1.103 ± 0.22
1.741ThrTyr: 1.741 ± 0.382
0.0ThrXaa: 0.0 ± 0.0
Val
6.616ValAla: 6.616 ± 0.616
0.58ValCys: 0.58 ± 0.202
5.165ValAsp: 5.165 ± 0.617
4.701ValGlu: 4.701 ± 0.429
2.205ValPhe: 2.205 ± 0.337
5.165ValGly: 5.165 ± 0.625
1.509ValHis: 1.509 ± 0.269
3.83ValIle: 3.83 ± 0.497
2.728ValLys: 2.728 ± 0.401
5.455ValLeu: 5.455 ± 0.584
1.277ValMet: 1.277 ± 0.344
2.321ValAsn: 2.321 ± 0.41
3.946ValPro: 3.946 ± 0.502
2.379ValGln: 2.379 ± 0.433
5.223ValArg: 5.223 ± 0.682
4.12ValSer: 4.12 ± 0.415
5.571ValThr: 5.571 ± 0.641
5.92ValVal: 5.92 ± 0.849
1.393ValTrp: 1.393 ± 0.271
2.379ValTyr: 2.379 ± 0.426
0.0ValXaa: 0.0 ± 0.0
Trp
1.393TrpAla: 1.393 ± 0.316
0.29TrpCys: 0.29 ± 0.123
1.219TrpAsp: 1.219 ± 0.249
1.103TrpGlu: 1.103 ± 0.239
0.929TrpPhe: 0.929 ± 0.222
1.915TrpGly: 1.915 ± 0.361
0.464TrpHis: 0.464 ± 0.158
0.987TrpIle: 0.987 ± 0.22
0.406TrpLys: 0.406 ± 0.172
1.857TrpLeu: 1.857 ± 0.338
0.348TrpMet: 0.348 ± 0.161
0.522TrpAsn: 0.522 ± 0.163
0.987TrpPro: 0.987 ± 0.234
0.987TrpGln: 0.987 ± 0.258
1.161TrpArg: 1.161 ± 0.276
1.045TrpSer: 1.045 ± 0.213
1.567TrpThr: 1.567 ± 0.367
1.915TrpVal: 1.915 ± 0.302
0.58TrpTrp: 0.58 ± 0.196
0.232TrpTyr: 0.232 ± 0.104
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.496TyrAla: 2.496 ± 0.421
0.174TyrCys: 0.174 ± 0.101
1.277TyrAsp: 1.277 ± 0.267
2.321TyrGlu: 2.321 ± 0.327
0.58TyrPhe: 0.58 ± 0.164
2.554TyrGly: 2.554 ± 0.375
0.522TyrHis: 0.522 ± 0.17
1.683TyrIle: 1.683 ± 0.345
1.335TyrLys: 1.335 ± 0.307
2.321TyrLeu: 2.321 ± 0.38
0.522TyrMet: 0.522 ± 0.172
1.103TyrAsn: 1.103 ± 0.292
1.335TyrPro: 1.335 ± 0.305
1.045TyrGln: 1.045 ± 0.263
2.786TyrArg: 2.786 ± 0.442
1.509TyrSer: 1.509 ± 0.322
1.973TyrThr: 1.973 ± 0.384
2.147TyrVal: 2.147 ± 0.335
0.348TyrTrp: 0.348 ± 0.148
0.638TyrTyr: 0.638 ± 0.208
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 100 proteins (17232 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski