Amino acid dipepetide frequency for Candidatus Mycoplasma girerdii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.921AlaAla: 2.921 ± 0.169
0.619AlaCys: 0.619 ± 0.059
2.475AlaAsp: 2.475 ± 0.117
2.48AlaGlu: 2.48 ± 0.149
3.765AlaPhe: 3.765 ± 0.258
2.795AlaGly: 2.795 ± 0.152
0.86AlaHis: 0.86 ± 0.063
5.921AlaIle: 5.921 ± 0.217
5.459AlaLys: 5.459 ± 0.169
4.982AlaLeu: 4.982 ± 0.159
1.238AlaMet: 1.238 ± 0.089
4.652AlaAsn: 4.652 ± 0.171
1.222AlaPro: 1.222 ± 0.077
1.384AlaGln: 1.384 ± 0.079
1.851AlaArg: 1.851 ± 0.114
3.125AlaSer: 3.125 ± 0.131
3.094AlaThr: 3.094 ± 0.131
2.842AlaVal: 2.842 ± 0.123
0.43AlaTrp: 0.43 ± 0.056
2.224AlaTyr: 2.224 ± 0.118
0.0AlaXaa: 0.0 ± 0.0
Cys
0.687CysAla: 0.687 ± 0.061
0.199CysCys: 0.199 ± 0.032
0.614CysAsp: 0.614 ± 0.057
0.661CysGlu: 0.661 ± 0.058
0.692CysPhe: 0.692 ± 0.058
1.012CysGly: 1.012 ± 0.085
0.304CysHis: 0.304 ± 0.04
1.033CysIle: 1.033 ± 0.073
0.745CysLys: 0.745 ± 0.072
1.185CysLeu: 1.185 ± 0.095
0.194CysMet: 0.194 ± 0.033
0.645CysAsn: 0.645 ± 0.057
0.404CysPro: 0.404 ± 0.056
0.435CysGln: 0.435 ± 0.053
0.241CysArg: 0.241 ± 0.036
1.432CysSer: 1.432 ± 0.149
0.65CysThr: 0.65 ± 0.074
0.676CysVal: 0.676 ± 0.058
0.1CysTrp: 0.1 ± 0.025
0.482CysTyr: 0.482 ± 0.048
0.0CysXaa: 0.0 ± 0.0
Asp
2.848AspAla: 2.848 ± 0.132
0.718AspCys: 0.718 ± 0.079
2.543AspAsp: 2.543 ± 0.14
3.823AspGlu: 3.823 ± 0.174
2.633AspPhe: 2.633 ± 0.14
2.501AspGly: 2.501 ± 0.121
1.065AspHis: 1.065 ± 0.077
4.657AspIle: 4.657 ± 0.17
4.248AspLys: 4.248 ± 0.172
5.349AspLeu: 5.349 ± 0.192
0.755AspMet: 0.755 ± 0.064
3.482AspAsn: 3.482 ± 0.156
1.773AspPro: 1.773 ± 0.103
2.218AspGln: 2.218 ± 0.113
1.405AspArg: 1.405 ± 0.078
2.758AspSer: 2.758 ± 0.14
2.376AspThr: 2.376 ± 0.11
3.278AspVal: 3.278 ± 0.126
0.661AspTrp: 0.661 ± 0.071
2.459AspTyr: 2.459 ± 0.116
0.0AspXaa: 0.0 ± 0.0
Glu
3.015GluAla: 3.015 ± 0.171
0.629GluCys: 0.629 ± 0.059
2.155GluAsp: 2.155 ± 0.118
2.952GluGlu: 2.952 ± 0.155
2.449GluPhe: 2.449 ± 0.111
1.919GluGly: 1.919 ± 0.106
1.217GluHis: 1.217 ± 0.09
6.073GluIle: 6.073 ± 0.211
5.103GluLys: 5.103 ± 0.166
5.716GluLeu: 5.716 ± 0.186
1.133GluMet: 1.133 ± 0.084
4.127GluAsn: 4.127 ± 0.157
1.253GluPro: 1.253 ± 0.079
2.391GluGln: 2.391 ± 0.112
1.704GluArg: 1.704 ± 0.108
2.391GluSer: 2.391 ± 0.119
2.669GluThr: 2.669 ± 0.114
3.157GluVal: 3.157 ± 0.125
0.477GluTrp: 0.477 ± 0.053
2.407GluTyr: 2.407 ± 0.13
0.0GluXaa: 0.0 ± 0.0
Phe
3.089PheAla: 3.089 ± 0.169
0.535PheCys: 0.535 ± 0.056
3.55PheAsp: 3.55 ± 0.128
2.134PheGlu: 2.134 ± 0.104
2.286PhePhe: 2.286 ± 0.13
2.837PheGly: 2.837 ± 0.139
0.933PheHis: 0.933 ± 0.067
4.898PheIle: 4.898 ± 0.206
4.321PheLys: 4.321 ± 0.155
4.027PheLeu: 4.027 ± 0.211
0.965PheMet: 0.965 ± 0.07
4.956PheAsn: 4.956 ± 0.2
1.054PhePro: 1.054 ± 0.077
1.201PheGln: 1.201 ± 0.088
1.18PheArg: 1.18 ± 0.093
3.639PheSer: 3.639 ± 0.166
2.685PheThr: 2.685 ± 0.113
2.842PheVal: 2.842 ± 0.146
0.54PheTrp: 0.54 ± 0.057
2.077PheTyr: 2.077 ± 0.114
0.0PheXaa: 0.0 ± 0.0
Gly
3.105GlyAla: 3.105 ± 0.134
0.965GlyCys: 0.965 ± 0.09
2.334GlyAsp: 2.334 ± 0.131
2.192GlyGlu: 2.192 ± 0.111
2.811GlyPhe: 2.811 ± 0.13
3.099GlyGly: 3.099 ± 0.162
0.912GlyHis: 0.912 ± 0.07
5.559GlyIle: 5.559 ± 0.193
4.405GlyLys: 4.405 ± 0.164
5.04GlyLeu: 5.04 ± 0.176
1.044GlyMet: 1.044 ± 0.073
3.01GlyAsn: 3.01 ± 0.146
1.054GlyPro: 1.054 ± 0.069
1.615GlyGln: 1.615 ± 0.086
1.568GlyArg: 1.568 ± 0.107
3.388GlySer: 3.388 ± 0.155
2.669GlyThr: 2.669 ± 0.14
3.655GlyVal: 3.655 ± 0.149
0.519GlyTrp: 0.519 ± 0.059
2.349GlyTyr: 2.349 ± 0.124
0.0GlyXaa: 0.0 ± 0.0
His
0.829HisAla: 0.829 ± 0.07
0.21HisCys: 0.21 ± 0.03
0.944HisAsp: 0.944 ± 0.072
1.175HisGlu: 1.175 ± 0.072
0.891HisPhe: 0.891 ± 0.075
1.159HisGly: 1.159 ± 0.085
0.488HisHis: 0.488 ± 0.047
1.673HisIle: 1.673 ± 0.085
1.568HisLys: 1.568 ± 0.101
1.94HisLeu: 1.94 ± 0.114
0.304HisMet: 0.304 ± 0.045
1.484HisAsn: 1.484 ± 0.1
0.687HisPro: 0.687 ± 0.068
0.776HisGln: 0.776 ± 0.065
0.64HisArg: 0.64 ± 0.055
1.138HisSer: 1.138 ± 0.076
0.991HisThr: 0.991 ± 0.071
1.091HisVal: 1.091 ± 0.076
0.225HisTrp: 0.225 ± 0.038
0.844HisTyr: 0.844 ± 0.063
0.0HisXaa: 0.0 ± 0.0
Ile
5.643IleAla: 5.643 ± 0.172
1.264IleCys: 1.264 ± 0.095
6.157IleAsp: 6.157 ± 0.195
5.27IleGlu: 5.27 ± 0.186
4.253IlePhe: 4.253 ± 0.182
5.978IleGly: 5.978 ± 0.272
1.757IleHis: 1.757 ± 0.102
8.936IleIle: 8.936 ± 0.268
9.487IleLys: 9.487 ± 0.269
7.027IleLeu: 7.027 ± 0.207
1.715IleMet: 1.715 ± 0.099
10.121IleAsn: 10.121 ± 0.332
3.771IlePro: 3.771 ± 0.235
2.643IleGln: 2.643 ± 0.109
2.842IleArg: 2.842 ± 0.132
6.587IleSer: 6.587 ± 0.186
5.559IleThr: 5.559 ± 0.188
5.58IleVal: 5.58 ± 0.178
0.64IleTrp: 0.64 ± 0.063
4.18IleTyr: 4.18 ± 0.161
0.0IleXaa: 0.0 ± 0.0
Lys
4.877LysAla: 4.877 ± 0.202
0.802LysCys: 0.802 ± 0.077
4.657LysAsp: 4.657 ± 0.16
5.947LysGlu: 5.947 ± 0.22
3.729LysPhe: 3.729 ± 0.176
3.388LysGly: 3.388 ± 0.137
1.956LysHis: 1.956 ± 0.099
8.92LysIle: 8.92 ± 0.241
9.529LysLys: 9.529 ± 0.279
8.6LysLeu: 8.6 ± 0.207
2.454LysMet: 2.454 ± 0.123
7.971LysAsn: 7.971 ± 0.247
2.323LysPro: 2.323 ± 0.124
3.986LysGln: 3.986 ± 0.168
3.021LysArg: 3.021 ± 0.142
4.699LysSer: 4.699 ± 0.153
5.894LysThr: 5.894 ± 0.2
4.835LysVal: 4.835 ± 0.171
0.834LysTrp: 0.834 ± 0.066
3.907LysTyr: 3.907 ± 0.139
0.0LysXaa: 0.0 ± 0.0
Leu
5.176LeuAla: 5.176 ± 0.154
0.902LeuCys: 0.902 ± 0.063
4.573LeuAsp: 4.573 ± 0.167
3.771LeuGlu: 3.771 ± 0.172
4.337LeuPhe: 4.337 ± 0.171
4.557LeuGly: 4.557 ± 0.176
1.505LeuHis: 1.505 ± 0.084
10.153LeuIle: 10.153 ± 0.31
9.445LeuLys: 9.445 ± 0.262
7.51LeuLeu: 7.51 ± 0.212
2.113LeuMet: 2.113 ± 0.121
7.572LeuAsn: 7.572 ± 0.223
3.188LeuPro: 3.188 ± 0.116
2.098LeuGln: 2.098 ± 0.094
2.538LeuArg: 2.538 ± 0.118
6.199LeuSer: 6.199 ± 0.208
7.038LeuThr: 7.038 ± 0.288
5.449LeuVal: 5.449 ± 0.187
0.797LeuTrp: 0.797 ± 0.067
3.042LeuTyr: 3.042 ± 0.132
0.0LeuXaa: 0.0 ± 0.0
Met
1.327MetAla: 1.327 ± 0.093
0.288MetCys: 0.288 ± 0.037
0.907MetAsp: 0.907 ± 0.069
0.944MetGlu: 0.944 ± 0.063
1.086MetPhe: 1.086 ± 0.083
0.912MetGly: 0.912 ± 0.071
0.414MetHis: 0.414 ± 0.042
1.909MetIle: 1.909 ± 0.118
2.14MetLys: 2.14 ± 0.106
1.636MetLeu: 1.636 ± 0.096
0.482MetMet: 0.482 ± 0.048
1.589MetAsn: 1.589 ± 0.086
0.577MetPro: 0.577 ± 0.053
0.792MetGln: 0.792 ± 0.076
0.687MetArg: 0.687 ± 0.069
1.405MetSer: 1.405 ± 0.101
0.954MetThr: 0.954 ± 0.079
0.996MetVal: 0.996 ± 0.069
0.184MetTrp: 0.184 ± 0.03
0.718MetTyr: 0.718 ± 0.06
0.0MetXaa: 0.0 ± 0.0
Asn
4.106AsnAla: 4.106 ± 0.155
1.033AsnCys: 1.033 ± 0.073
4.374AsnAsp: 4.374 ± 0.184
5.894AsnGlu: 5.894 ± 0.225
3.907AsnPhe: 3.907 ± 0.156
3.676AsnGly: 3.676 ± 0.154
1.746AsnHis: 1.746 ± 0.096
7.101AsnIle: 7.101 ± 0.252
8.543AsnLys: 8.543 ± 0.225
7.106AsnLeu: 7.106 ± 0.248
1.211AsnMet: 1.211 ± 0.079
6.996AsnAsn: 6.996 ± 0.261
2.591AsnPro: 2.591 ± 0.104
3.372AsnGln: 3.372 ± 0.171
2.444AsnArg: 2.444 ± 0.127
4.804AsnSer: 4.804 ± 0.192
3.739AsnThr: 3.739 ± 0.153
4.405AsnVal: 4.405 ± 0.16
1.07AsnTrp: 1.07 ± 0.098
3.535AsnTyr: 3.535 ± 0.157
0.0AsnXaa: 0.0 ± 0.0
Pro
1.306ProAla: 1.306 ± 0.085
0.325ProCys: 0.325 ± 0.043
1.369ProAsp: 1.369 ± 0.083
1.563ProGlu: 1.563 ± 0.097
1.306ProPhe: 1.306 ± 0.091
1.516ProGly: 1.516 ± 0.107
0.603ProHis: 0.603 ± 0.058
2.952ProIle: 2.952 ± 0.138
2.208ProLys: 2.208 ± 0.118
2.737ProLeu: 2.737 ± 0.123
0.477ProMet: 0.477 ± 0.054
2.412ProAsn: 2.412 ± 0.114
0.54ProPro: 0.54 ± 0.054
0.718ProGln: 0.718 ± 0.062
0.692ProArg: 0.692 ± 0.074
2.528ProSer: 2.528 ± 0.149
2.003ProThr: 2.003 ± 0.103
1.668ProVal: 1.668 ± 0.104
0.336ProTrp: 0.336 ± 0.04
1.332ProTyr: 1.332 ± 0.085
0.0ProXaa: 0.0 ± 0.0
Gln
1.72GlnAla: 1.72 ± 0.097
0.325GlnCys: 0.325 ± 0.04
1.201GlnAsp: 1.201 ± 0.079
1.353GlnGlu: 1.353 ± 0.087
1.846GlnPhe: 1.846 ± 0.1
1.243GlnGly: 1.243 ± 0.09
0.645GlnHis: 0.645 ± 0.066
3.692GlnIle: 3.692 ± 0.134
2.842GlnLys: 2.842 ± 0.119
3.991GlnLeu: 3.991 ± 0.154
0.776GlnMet: 0.776 ± 0.071
2.36GlnAsn: 2.36 ± 0.112
0.923GlnPro: 0.923 ± 0.06
1.222GlnGln: 1.222 ± 0.086
1.091GlnArg: 1.091 ± 0.095
1.599GlnSer: 1.599 ± 0.093
1.993GlnThr: 1.993 ± 0.101
1.72GlnVal: 1.72 ± 0.091
0.451GlnTrp: 0.451 ± 0.053
2.04GlnTyr: 2.04 ± 0.101
0.0GlnXaa: 0.0 ± 0.0
Arg
1.411ArgAla: 1.411 ± 0.086
0.414ArgCys: 0.414 ± 0.047
1.647ArgAsp: 1.647 ± 0.087
1.615ArgGlu: 1.615 ± 0.105
1.479ArgPhe: 1.479 ± 0.091
1.447ArgGly: 1.447 ± 0.118
0.514ArgHis: 0.514 ± 0.056
2.947ArgIle: 2.947 ± 0.124
2.879ArgLys: 2.879 ± 0.123
2.648ArgLeu: 2.648 ± 0.135
0.76ArgMet: 0.76 ± 0.068
2.271ArgAsn: 2.271 ± 0.123
0.729ArgPro: 0.729 ± 0.061
0.996ArgGln: 0.996 ± 0.063
1.012ArgArg: 1.012 ± 0.087
1.814ArgSer: 1.814 ± 0.107
1.437ArgThr: 1.437 ± 0.085
1.731ArgVal: 1.731 ± 0.099
0.315ArgTrp: 0.315 ± 0.045
1.468ArgTyr: 1.468 ± 0.093
0.0ArgXaa: 0.0 ± 0.0
Ser
3.22SerAla: 3.22 ± 0.132
0.823SerCys: 0.823 ± 0.073
2.869SerAsp: 2.869 ± 0.139
3.209SerGlu: 3.209 ± 0.138
3.209SerPhe: 3.209 ± 0.161
3.765SerGly: 3.765 ± 0.139
1.049SerHis: 1.049 ± 0.071
6.948SerIle: 6.948 ± 0.348
5.401SerLys: 5.401 ± 0.16
7.158SerLeu: 7.158 ± 0.215
1.196SerMet: 1.196 ± 0.077
4.568SerAsn: 4.568 ± 0.199
1.426SerPro: 1.426 ± 0.083
2.187SerGln: 2.187 ± 0.11
1.814SerArg: 1.814 ± 0.106
5.291SerSer: 5.291 ± 0.234
3.057SerThr: 3.057 ± 0.152
4.19SerVal: 4.19 ± 0.215
0.676SerTrp: 0.676 ± 0.054
2.921SerTyr: 2.921 ± 0.124
0.0SerXaa: 0.0 ± 0.0
Thr
2.654ThrAla: 2.654 ± 0.117
0.561ThrCys: 0.561 ± 0.057
2.863ThrAsp: 2.863 ± 0.128
2.271ThrGlu: 2.271 ± 0.118
3.089ThrPhe: 3.089 ± 0.151
3.293ThrGly: 3.293 ± 0.155
1.096ThrHis: 1.096 ± 0.076
5.679ThrIle: 5.679 ± 0.188
5.019ThrLys: 5.019 ± 0.161
4.447ThrLeu: 4.447 ± 0.171
0.834ThrMet: 0.834 ± 0.071
5.013ThrAsn: 5.013 ± 0.183
1.982ThrPro: 1.982 ± 0.113
1.39ThrGln: 1.39 ± 0.092
1.584ThrArg: 1.584 ± 0.103
5.276ThrSer: 5.276 ± 0.406
3.361ThrThr: 3.361 ± 0.155
3.052ThrVal: 3.052 ± 0.129
0.503ThrTrp: 0.503 ± 0.06
2.381ThrTyr: 2.381 ± 0.111
0.0ThrXaa: 0.0 ± 0.0
Val
3.477ValAla: 3.477 ± 0.168
0.933ValCys: 0.933 ± 0.075
3.461ValAsp: 3.461 ± 0.146
2.816ValGlu: 2.816 ± 0.127
2.905ValPhe: 2.905 ± 0.153
3.314ValGly: 3.314 ± 0.132
0.939ValHis: 0.939 ± 0.07
5.653ValIle: 5.653 ± 0.182
4.793ValLys: 4.793 ± 0.183
5.197ValLeu: 5.197 ± 0.18
1.133ValMet: 1.133 ± 0.088
4.898ValAsn: 4.898 ± 0.197
1.694ValPro: 1.694 ± 0.096
1.363ValGln: 1.363 ± 0.086
1.463ValArg: 1.463 ± 0.085
3.55ValSer: 3.55 ± 0.161
3.618ValThr: 3.618 ± 0.241
3.723ValVal: 3.723 ± 0.156
0.535ValTrp: 0.535 ± 0.055
2.397ValTyr: 2.397 ± 0.109
0.0ValXaa: 0.0 ± 0.0
Trp
0.43TrpAla: 0.43 ± 0.045
0.21TrpCys: 0.21 ± 0.036
0.54TrpAsp: 0.54 ± 0.061
0.32TrpGlu: 0.32 ± 0.038
0.682TrpPhe: 0.682 ± 0.066
0.472TrpGly: 0.472 ± 0.051
0.157TrpHis: 0.157 ± 0.03
1.269TrpIle: 1.269 ± 0.087
0.645TrpLys: 0.645 ± 0.066
0.939TrpLeu: 0.939 ± 0.082
0.341TrpMet: 0.341 ± 0.045
0.813TrpAsn: 0.813 ± 0.071
0.262TrpPro: 0.262 ± 0.041
0.246TrpGln: 0.246 ± 0.042
0.22TrpArg: 0.22 ± 0.033
0.718TrpSer: 0.718 ± 0.077
0.566TrpThr: 0.566 ± 0.052
0.577TrpVal: 0.577 ± 0.055
0.136TrpTrp: 0.136 ± 0.026
0.393TrpTyr: 0.393 ± 0.052
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.507TyrAla: 2.507 ± 0.12
0.635TyrCys: 0.635 ± 0.061
2.318TyrAsp: 2.318 ± 0.12
2.549TyrGlu: 2.549 ± 0.105
2.397TyrPhe: 2.397 ± 0.118
2.407TyrGly: 2.407 ± 0.12
0.897TyrHis: 0.897 ± 0.063
3.435TyrIle: 3.435 ± 0.144
3.55TyrLys: 3.55 ± 0.137
4.725TyrLeu: 4.725 ± 0.186
0.818TyrMet: 0.818 ± 0.069
2.711TyrAsn: 2.711 ± 0.149
1.138TyrPro: 1.138 ± 0.079
1.998TyrGln: 1.998 ± 0.105
1.537TyrArg: 1.537 ± 0.085
2.638TyrSer: 2.638 ± 0.13
1.993TyrThr: 1.993 ± 0.104
2.397TyrVal: 2.397 ± 0.133
0.509TyrTrp: 0.509 ± 0.049
1.94TyrTyr: 1.94 ± 0.092
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 572 proteins (190691 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski