Amino acid dipepetide frequency for Kitasatospora griseola (Streptomyces griseolosporeus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.111AlaAla: 24.111 ± 0.218	1.05AlaCys: 1.05 ± 0.022	9.037AlaAsp: 9.037 ± 0.076	9.677AlaGlu: 9.677 ± 0.112	3.732AlaPhe: 3.732 ± 0.049	13.656AlaGly: 13.656 ± 0.113	3.013AlaHis: 3.013 ± 0.044	3.566AlaIle: 3.566 ± 0.044	2.885AlaLys: 2.885 ± 0.052	15.726AlaLeu: 15.726 ± 0.143	2.5AlaMet: 2.5 ± 0.037	2.162AlaAsn: 2.162 ± 0.043	7.249AlaPro: 7.249 ± 0.102	3.912AlaGln: 3.912 ± 0.042	10.143AlaArg: 10.143 ± 0.101	5.412AlaSer: 5.412 ± 0.058	7.176AlaThr: 7.176 ± 0.072	13.14AlaVal: 13.14 ± 0.116	1.92AlaTrp: 1.92 ± 0.035	2.578AlaTyr: 2.578 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.063CysAla: 1.063 ± 0.026	0.097CysCys: 0.097 ± 0.008	0.505CysAsp: 0.505 ± 0.019	0.383CysGlu: 0.383 ± 0.015	0.243CysPhe: 0.243 ± 0.011	0.923CysGly: 0.923 ± 0.022	0.226CysHis: 0.226 ± 0.015	0.174CysIle: 0.174 ± 0.009	0.105CysLys: 0.105 ± 0.006	0.787CysLeu: 0.787 ± 0.019	0.12CysMet: 0.12 ± 0.009	0.135CysAsn: 0.135 ± 0.008	0.535CysPro: 0.535 ± 0.02	0.183CysGln: 0.183 ± 0.01	0.617CysArg: 0.617 ± 0.018	0.44CysSer: 0.44 ± 0.017	0.547CysThr: 0.547 ± 0.019	0.57CysVal: 0.57 ± 0.018	0.127CysTrp: 0.127 ± 0.009	0.162CysTyr: 0.162 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.885AspAla: 7.885 ± 0.073	0.458AspCys: 0.458 ± 0.017	3.192AspAsp: 3.192 ± 0.047	3.514AspGlu: 3.514 ± 0.048	1.571AspPhe: 1.571 ± 0.033	6.578AspGly: 6.578 ± 0.072	1.458AspHis: 1.458 ± 0.031	1.542AspIle: 1.542 ± 0.031	1.014AspLys: 1.014 ± 0.028	6.658AspLeu: 6.658 ± 0.065	0.651AspMet: 0.651 ± 0.02	0.929AspAsn: 0.929 ± 0.029	4.747AspPro: 4.747 ± 0.059	1.661AspGln: 1.661 ± 0.032	5.369AspArg: 5.369 ± 0.06	2.381AspSer: 2.381 ± 0.039	3.119AspThr: 3.119 ± 0.044	4.295AspVal: 4.295 ± 0.049	1.057AspTrp: 1.057 ± 0.024	1.1AspTyr: 1.1 ± 0.028	0.0AspXaa: 0.0 ± 0.0
Glu	6.854GluAla: 6.854 ± 0.085	0.351GluCys: 0.351 ± 0.013	2.67GluAsp: 2.67 ± 0.041	3.152GluGlu: 3.152 ± 0.05	1.655GluPhe: 1.655 ± 0.03	3.772GluGly: 3.772 ± 0.053	1.618GluHis: 1.618 ± 0.028	2.144GluIle: 2.144 ± 0.041	1.168GluLys: 1.168 ± 0.031	7.739GluLeu: 7.739 ± 0.087	0.78GluMet: 0.78 ± 0.021	0.985GluAsn: 0.985 ± 0.023	3.261GluPro: 3.261 ± 0.052	2.661GluGln: 2.661 ± 0.043	5.285GluArg: 5.285 ± 0.066	2.374GluSer: 2.374 ± 0.034	2.624GluThr: 2.624 ± 0.041	4.371GluVal: 4.371 ± 0.055	0.738GluTrp: 0.738 ± 0.021	1.074GluTyr: 1.074 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.902PheAla: 3.902 ± 0.052	0.275PheCys: 0.275 ± 0.013	2.065PheAsp: 2.065 ± 0.038	1.435PheGlu: 1.435 ± 0.027	0.824PhePhe: 0.824 ± 0.026	3.113PheGly: 3.113 ± 0.05	0.656PheHis: 0.656 ± 0.022	0.633PheIle: 0.633 ± 0.021	0.476PheLys: 0.476 ± 0.018	2.558PheLeu: 2.558 ± 0.037	0.36PheMet: 0.36 ± 0.016	0.543PheAsn: 0.543 ± 0.019	1.401PhePro: 1.401 ± 0.03	0.723PheGln: 0.723 ± 0.02	1.864PheArg: 1.864 ± 0.032	1.385PheSer: 1.385 ± 0.029	2.0PheThr: 2.0 ± 0.038	2.119PheVal: 2.119 ± 0.037	0.422PheTrp: 0.422 ± 0.014	0.569PheTyr: 0.569 ± 0.02	0.0PheXaa: 0.0 ± 0.0
Gly	11.328GlyAla: 11.328 ± 0.091	0.881GlyCys: 0.881 ± 0.023	4.812GlyAsp: 4.812 ± 0.051	5.038GlyGlu: 5.038 ± 0.055	2.867GlyPhe: 2.867 ± 0.043	8.597GlyGly: 8.597 ± 0.093	2.341GlyHis: 2.341 ± 0.039	3.288GlyIle: 3.288 ± 0.041	2.147GlyLys: 2.147 ± 0.04	9.87GlyLeu: 9.87 ± 0.087	1.906GlyMet: 1.906 ± 0.037	1.78GlyAsn: 1.78 ± 0.042	5.409GlyPro: 5.409 ± 0.058	2.765GlyGln: 2.765 ± 0.049	8.022GlyArg: 8.022 ± 0.084	5.232GlySer: 5.232 ± 0.066	6.01GlyThr: 6.01 ± 0.076	7.308GlyVal: 7.308 ± 0.067	1.827GlyTrp: 1.827 ± 0.035	2.316GlyTyr: 2.316 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	2.781HisAla: 2.781 ± 0.038	0.238HisCys: 0.238 ± 0.013	1.271HisAsp: 1.271 ± 0.025	1.117HisGlu: 1.117 ± 0.03	0.664HisPhe: 0.664 ± 0.019	2.505HisGly: 2.505 ± 0.038	0.717HisHis: 0.717 ± 0.024	0.559HisIle: 0.559 ± 0.019	0.315HisLys: 0.315 ± 0.013	2.774HisLeu: 2.774 ± 0.046	0.273HisMet: 0.273 ± 0.013	0.383HisAsn: 0.383 ± 0.017	2.01HisPro: 2.01 ± 0.032	0.677HisGln: 0.677 ± 0.021	2.406HisArg: 2.406 ± 0.039	1.038HisSer: 1.038 ± 0.026	1.276HisThr: 1.276 ± 0.024	1.6HisVal: 1.6 ± 0.041	0.411HisTrp: 0.411 ± 0.015	0.496HisTyr: 0.496 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	4.702IleAla: 4.702 ± 0.058	0.298IleCys: 0.298 ± 0.013	2.253IleAsp: 2.253 ± 0.04	1.912IleGlu: 1.912 ± 0.034	0.63IlePhe: 0.63 ± 0.02	3.576IleGly: 3.576 ± 0.047	0.581IleHis: 0.581 ± 0.019	0.751IleIle: 0.751 ± 0.022	0.651IleLys: 0.651 ± 0.022	2.186IleLeu: 2.186 ± 0.04	0.38IleMet: 0.38 ± 0.015	0.689IleAsn: 0.689 ± 0.025	1.622IlePro: 1.622 ± 0.031	0.704IleGln: 0.704 ± 0.024	2.214IleArg: 2.214 ± 0.035	1.609IleSer: 1.609 ± 0.032	2.117IleThr: 2.117 ± 0.038	2.439IleVal: 2.439 ± 0.037	0.383IleTrp: 0.383 ± 0.014	0.464IleTyr: 0.464 ± 0.019	0.0IleXaa: 0.0 ± 0.0
Lys	2.698LysAla: 2.698 ± 0.043	0.107LysCys: 0.107 ± 0.007	1.16LysAsp: 1.16 ± 0.033	0.925LysGlu: 0.925 ± 0.028	0.456LysPhe: 0.456 ± 0.015	1.562LysGly: 1.562 ± 0.035	0.443LysHis: 0.443 ± 0.014	0.749LysIle: 0.749 ± 0.024	0.632LysLys: 0.632 ± 0.024	1.949LysLeu: 1.949 ± 0.035	0.368LysMet: 0.368 ± 0.016	0.45LysAsn: 0.45 ± 0.018	1.224LysPro: 1.224 ± 0.032	0.655LysGln: 0.655 ± 0.022	1.283LysArg: 1.283 ± 0.032	1.05LysSer: 1.05 ± 0.028	1.084LysThr: 1.084 ± 0.031	1.793LysVal: 1.793 ± 0.036	0.242LysTrp: 0.242 ± 0.011	0.448LysTyr: 0.448 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	17.526LeuAla: 17.526 ± 0.16	0.832LeuCys: 0.832 ± 0.023	7.222LeuAsp: 7.222 ± 0.075	4.688LeuGlu: 4.688 ± 0.062	2.653LeuPhe: 2.653 ± 0.04	9.815LeuGly: 9.815 ± 0.067	2.586LeuHis: 2.586 ± 0.043	3.249LeuIle: 3.249 ± 0.041	1.82LeuLys: 1.82 ± 0.041	12.412LeuLeu: 12.412 ± 0.132	1.566LeuMet: 1.566 ± 0.029	1.79LeuAsn: 1.79 ± 0.031	7.183LeuPro: 7.183 ± 0.076	2.282LeuGln: 2.282 ± 0.038	8.935LeuArg: 8.935 ± 0.088	5.206LeuSer: 5.206 ± 0.056	7.232LeuThr: 7.232 ± 0.072	9.097LeuVal: 9.097 ± 0.087	1.316LeuTrp: 1.316 ± 0.035	1.754LeuTyr: 1.754 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.222MetAla: 2.222 ± 0.031	0.113MetCys: 0.113 ± 0.007	0.863MetAsp: 0.863 ± 0.019	0.671MetGlu: 0.671 ± 0.019	0.467MetPhe: 0.467 ± 0.019	1.203MetGly: 1.203 ± 0.025	0.321MetHis: 0.321 ± 0.012	0.62MetIle: 0.62 ± 0.018	0.364MetLys: 0.364 ± 0.014	1.696MetLeu: 1.696 ± 0.035	0.283MetMet: 0.283 ± 0.012	0.396MetAsn: 0.396 ± 0.015	1.03MetPro: 1.03 ± 0.022	0.422MetGln: 0.422 ± 0.015	1.285MetArg: 1.285 ± 0.028	1.171MetSer: 1.171 ± 0.022	1.433MetThr: 1.433 ± 0.027	1.261MetVal: 1.261 ± 0.027	0.17MetTrp: 0.17 ± 0.009	0.308MetTyr: 0.308 ± 0.012	0.0MetXaa: 0.0 ± 0.0
Asn	2.273AsnAla: 2.273 ± 0.039	0.176AsnCys: 0.176 ± 0.01	0.955AsnAsp: 0.955 ± 0.025	0.796AsnGlu: 0.796 ± 0.022	0.474AsnPhe: 0.474 ± 0.017	2.012AsnGly: 2.012 ± 0.043	0.404AsnHis: 0.404 ± 0.017	0.554AsnIle: 0.554 ± 0.018	0.357AsnLys: 0.357 ± 0.018	1.819AsnLeu: 1.819 ± 0.034	0.307AsnMet: 0.307 ± 0.013	0.45AsnAsn: 0.45 ± 0.018	1.421AsnPro: 1.421 ± 0.034	0.569AsnGln: 0.569 ± 0.018	1.304AsnArg: 1.304 ± 0.029	0.988AsnSer: 0.988 ± 0.03	1.129AsnThr: 1.129 ± 0.034	1.338AsnVal: 1.338 ± 0.031	0.291AsnTrp: 0.291 ± 0.014	0.417AsnTyr: 0.417 ± 0.017	0.0AsnXaa: 0.0 ± 0.0
Pro	9.606ProAla: 9.606 ± 0.095	0.346ProCys: 0.346 ± 0.013	4.58ProAsp: 4.58 ± 0.058	4.281ProGlu: 4.281 ± 0.053	1.602ProPhe: 1.602 ± 0.037	6.578ProGly: 6.578 ± 0.073	1.32ProHis: 1.32 ± 0.023	1.467ProIle: 1.467 ± 0.032	1.12ProLys: 1.12 ± 0.025	5.52ProLeu: 5.52 ± 0.061	0.979ProMet: 0.979 ± 0.024	1.025ProAsn: 1.025 ± 0.028	3.345ProPro: 3.345 ± 0.069	1.852ProGln: 1.852 ± 0.039	3.578ProArg: 3.578 ± 0.043	3.091ProSer: 3.091 ± 0.052	3.418ProThr: 3.418 ± 0.052	5.651ProVal: 5.651 ± 0.064	0.913ProTrp: 0.913 ± 0.022	1.286ProTyr: 1.286 ± 0.026	0.0ProXaa: 0.0 ± 0.0
Gln	4.028GlnAla: 4.028 ± 0.056	0.206GlnCys: 0.206 ± 0.01	1.429GlnAsp: 1.429 ± 0.027	1.319GlnGlu: 1.319 ± 0.029	0.715GlnPhe: 0.715 ± 0.018	2.277GlnGly: 2.277 ± 0.036	0.754GlnHis: 0.754 ± 0.023	1.054GlnIle: 1.054 ± 0.025	0.538GlnLys: 0.538 ± 0.017	3.626GlnLeu: 3.626 ± 0.046	0.439GlnMet: 0.439 ± 0.02	0.531GlnAsn: 0.531 ± 0.017	1.836GlnPro: 1.836 ± 0.039	1.541GlnGln: 1.541 ± 0.043	2.396GlnArg: 2.396 ± 0.041	1.298GlnSer: 1.298 ± 0.029	1.253GlnThr: 1.253 ± 0.03	2.703GlnVal: 2.703 ± 0.045	0.5GlnTrp: 0.5 ± 0.017	0.63GlnTyr: 0.63 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	10.117ArgAla: 10.117 ± 0.107	0.612ArgCys: 0.612 ± 0.021	3.965ArgAsp: 3.965 ± 0.051	4.62ArgGlu: 4.62 ± 0.061	2.253ArgPhe: 2.253 ± 0.036	5.438ArgGly: 5.438 ± 0.054	2.187ArgHis: 2.187 ± 0.036	3.324ArgIle: 3.324 ± 0.055	1.428ArgLys: 1.428 ± 0.032	9.295ArgLeu: 9.295 ± 0.095	1.649ArgMet: 1.649 ± 0.033	1.334ArgAsn: 1.334 ± 0.031	5.198ArgPro: 5.198 ± 0.071	2.47ArgGln: 2.47 ± 0.039	7.802ArgArg: 7.802 ± 0.095	3.995ArgSer: 3.995 ± 0.046	5.413ArgThr: 5.413 ± 0.054	5.473ArgVal: 5.473 ± 0.057	1.385ArgTrp: 1.385 ± 0.029	1.767ArgTyr: 1.767 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	6.739SerAla: 6.739 ± 0.063	0.445SerCys: 0.445 ± 0.019	2.388SerAsp: 2.388 ± 0.036	2.126SerGlu: 2.126 ± 0.039	1.493SerPhe: 1.493 ± 0.03	5.653SerGly: 5.653 ± 0.07	0.942SerHis: 0.942 ± 0.023	1.409SerIle: 1.409 ± 0.033	0.9SerLys: 0.9 ± 0.026	4.485SerLeu: 4.485 ± 0.055	1.014SerMet: 1.014 ± 0.023	0.914SerAsn: 0.914 ± 0.025	3.069SerPro: 3.069 ± 0.047	1.151SerGln: 1.151 ± 0.029	3.402SerArg: 3.402 ± 0.051	2.641SerSer: 2.641 ± 0.054	3.061SerThr: 3.061 ± 0.054	3.955SerVal: 3.955 ± 0.05	0.934SerTrp: 0.934 ± 0.02	1.148SerTyr: 1.148 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	9.627ThrAla: 9.627 ± 0.097	0.428ThrCys: 0.428 ± 0.02	3.646ThrAsp: 3.646 ± 0.051	3.057ThrGlu: 3.057 ± 0.036	1.474ThrPhe: 1.474 ± 0.03	6.788ThrGly: 6.788 ± 0.08	1.074ThrHis: 1.074 ± 0.025	1.518ThrIle: 1.518 ± 0.036	1.025ThrLys: 1.025 ± 0.023	5.803ThrLeu: 5.803 ± 0.06	0.916ThrMet: 0.916 ± 0.021	1.026ThrAsn: 1.026 ± 0.039	3.922ThrPro: 3.922 ± 0.06	1.167ThrGln: 1.167 ± 0.029	3.655ThrArg: 3.655 ± 0.046	2.753ThrSer: 2.753 ± 0.052	3.701ThrThr: 3.701 ± 0.059	6.552ThrVal: 6.552 ± 0.078	0.827ThrTrp: 0.827 ± 0.022	1.147ThrTyr: 1.147 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.919ValAla: 10.919 ± 0.095	0.687ValCys: 0.687 ± 0.022	5.018ValAsp: 5.018 ± 0.052	4.846ValGlu: 4.846 ± 0.061	2.404ValPhe: 2.404 ± 0.037	6.557ValGly: 6.557 ± 0.073	2.097ValHis: 2.097 ± 0.037	2.616ValIle: 2.616 ± 0.045	1.665ValLys: 1.665 ± 0.037	10.108ValLeu: 10.108 ± 0.093	1.312ValMet: 1.312 ± 0.029	1.707ValAsn: 1.707 ± 0.036	5.183ValPro: 5.183 ± 0.061	2.326ValGln: 2.326 ± 0.04	6.888ValArg: 6.888 ± 0.063	3.934ValSer: 3.934 ± 0.054	5.314ValThr: 5.314 ± 0.092	7.858ValVal: 7.858 ± 0.079	1.05ValTrp: 1.05 ± 0.022	1.467ValTyr: 1.467 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.764TrpAla: 1.764 ± 0.035	0.151TrpCys: 0.151 ± 0.009	0.811TrpAsp: 0.811 ± 0.022	0.722TrpGlu: 0.722 ± 0.022	0.505TrpPhe: 0.505 ± 0.014	1.029TrpGly: 1.029 ± 0.025	0.398TrpHis: 0.398 ± 0.014	0.531TrpIle: 0.531 ± 0.017	0.321TrpLys: 0.321 ± 0.014	1.823TrpLeu: 1.823 ± 0.038	0.274TrpMet: 0.274 ± 0.013	0.397TrpAsn: 0.397 ± 0.017	0.821TrpPro: 0.821 ± 0.023	0.691TrpGln: 0.691 ± 0.02	1.308TrpArg: 1.308 ± 0.026	0.936TrpSer: 0.936 ± 0.02	1.062TrpThr: 1.062 ± 0.024	0.984TrpVal: 0.984 ± 0.022	0.363TrpTrp: 0.363 ± 0.016	0.355TrpTyr: 0.355 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.503TyrAla: 2.503 ± 0.032	0.191TyrCys: 0.191 ± 0.009	1.338TyrAsp: 1.338 ± 0.034	0.995TyrGlu: 0.995 ± 0.028	0.64TyrPhe: 0.64 ± 0.019	2.112TyrGly: 2.112 ± 0.033	0.375TyrHis: 0.375 ± 0.013	0.413TyrIle: 0.413 ± 0.014	0.348TyrLys: 0.348 ± 0.016	2.331TyrLeu: 2.331 ± 0.04	0.221TyrMet: 0.221 ± 0.011	0.407TyrAsn: 0.407 ± 0.018	1.089TyrPro: 1.089 ± 0.024	0.663TyrGln: 0.663 ± 0.022	1.973TyrArg: 1.973 ± 0.036	0.934TyrSer: 0.934 ± 0.026	1.137TyrThr: 1.137 ± 0.035	1.447TyrVal: 1.447 ± 0.03	0.368TyrTrp: 0.368 ± 0.014	0.428TyrTyr: 0.428 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5875 proteins (1865248 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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