Amino acid dipepetide frequency for Rhizobium sp. Root1212

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.959AlaAla: 15.959 ± 0.178	0.994AlaCys: 0.994 ± 0.026	6.822AlaAsp: 6.822 ± 0.064	7.511AlaGlu: 7.511 ± 0.086	4.61AlaPhe: 4.61 ± 0.058	10.379AlaGly: 10.379 ± 0.083	2.042AlaHis: 2.042 ± 0.043	6.86AlaIle: 6.86 ± 0.075	4.411AlaLys: 4.411 ± 0.059	12.517AlaLeu: 12.517 ± 0.126	3.504AlaMet: 3.504 ± 0.053	3.074AlaAsn: 3.074 ± 0.045	4.613AlaPro: 4.613 ± 0.059	3.387AlaGln: 3.387 ± 0.06	7.604AlaArg: 7.604 ± 0.078	6.435AlaSer: 6.435 ± 0.072	5.929AlaThr: 5.929 ± 0.076	8.567AlaVal: 8.567 ± 0.081	1.291AlaTrp: 1.291 ± 0.032	2.617AlaTyr: 2.617 ± 0.046	0.001AlaXaa: 0.001 ± 0.001
Cys	0.819CysAla: 0.819 ± 0.022	0.098CysCys: 0.098 ± 0.008	0.495CysAsp: 0.495 ± 0.019	0.432CysGlu: 0.432 ± 0.016	0.342CysPhe: 0.342 ± 0.016	0.899CysGly: 0.899 ± 0.027	0.23CysHis: 0.23 ± 0.014	0.414CysIle: 0.414 ± 0.019	0.196CysLys: 0.196 ± 0.011	0.822CysLeu: 0.822 ± 0.022	0.147CysMet: 0.147 ± 0.01	0.174CysAsn: 0.174 ± 0.01	0.374CysPro: 0.374 ± 0.017	0.206CysGln: 0.206 ± 0.01	0.579CysArg: 0.579 ± 0.018	0.452CysSer: 0.452 ± 0.018	0.392CysThr: 0.392 ± 0.018	0.569CysVal: 0.569 ± 0.02	0.114CysTrp: 0.114 ± 0.009	0.209CysTyr: 0.209 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	6.596AspAla: 6.596 ± 0.071	0.485AspCys: 0.485 ± 0.018	3.327AspAsp: 3.327 ± 0.054	3.505AspGlu: 3.505 ± 0.057	2.499AspPhe: 2.499 ± 0.046	5.25AspGly: 5.25 ± 0.068	1.247AspHis: 1.247 ± 0.03	3.759AspIle: 3.759 ± 0.055	2.004AspLys: 2.004 ± 0.041	5.7AspLeu: 5.7 ± 0.057	1.46AspMet: 1.46 ± 0.03	1.516AspAsn: 1.516 ± 0.034	3.164AspPro: 3.164 ± 0.048	1.683AspGln: 1.683 ± 0.046	4.119AspArg: 4.119 ± 0.052	2.118AspSer: 2.118 ± 0.044	2.843AspThr: 2.843 ± 0.064	4.235AspVal: 4.235 ± 0.062	0.934AspTrp: 0.934 ± 0.027	1.57AspTyr: 1.57 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	7.439GluAla: 7.439 ± 0.081	0.34GluCys: 0.34 ± 0.015	2.967GluAsp: 2.967 ± 0.044	3.538GluGlu: 3.538 ± 0.053	1.802GluPhe: 1.802 ± 0.033	4.365GluGly: 4.365 ± 0.049	1.131GluHis: 1.131 ± 0.031	3.847GluIle: 3.847 ± 0.049	2.95GluLys: 2.95 ± 0.043	5.198GluLeu: 5.198 ± 0.069	1.642GluMet: 1.642 ± 0.032	2.063GluAsn: 2.063 ± 0.037	2.6GluPro: 2.6 ± 0.044	2.071GluGln: 2.071 ± 0.046	4.647GluArg: 4.647 ± 0.072	2.403GluSer: 2.403 ± 0.044	3.922GluThr: 3.922 ± 0.058	3.551GluVal: 3.551 ± 0.049	0.669GluTrp: 0.669 ± 0.02	1.025GluTyr: 1.025 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.604PheAla: 4.604 ± 0.061	0.415PheCys: 0.415 ± 0.017	2.836PheAsp: 2.836 ± 0.042	2.273PheGlu: 2.273 ± 0.036	1.613PhePhe: 1.613 ± 0.042	3.673PheGly: 3.673 ± 0.054	0.797PheHis: 0.797 ± 0.024	1.977PheIle: 1.977 ± 0.035	1.226PheLys: 1.226 ± 0.033	3.699PheLeu: 3.699 ± 0.063	0.858PheMet: 0.858 ± 0.022	1.196PheAsn: 1.196 ± 0.029	1.635PhePro: 1.635 ± 0.035	1.127PheGln: 1.127 ± 0.029	2.301PheArg: 2.301 ± 0.043	2.69PheSer: 2.69 ± 0.041	2.078PheThr: 2.078 ± 0.04	2.906PheVal: 2.906 ± 0.044	0.561PheTrp: 0.561 ± 0.022	0.966PheTyr: 0.966 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	8.368GlyAla: 8.368 ± 0.075	0.806GlyCys: 0.806 ± 0.025	4.443GlyAsp: 4.443 ± 0.064	4.922GlyGlu: 4.922 ± 0.054	3.749GlyPhe: 3.749 ± 0.055	7.153GlyGly: 7.153 ± 0.097	1.814GlyHis: 1.814 ± 0.036	5.11GlyIle: 5.11 ± 0.059	3.902GlyLys: 3.902 ± 0.056	8.783GlyLeu: 8.783 ± 0.089	2.339GlyMet: 2.339 ± 0.046	2.674GlyAsn: 2.674 ± 0.067	3.074GlyPro: 3.074 ± 0.046	2.638GlyGln: 2.638 ± 0.043	5.56GlyArg: 5.56 ± 0.064	4.756GlySer: 4.756 ± 0.051	4.656GlyThr: 4.656 ± 0.057	5.819GlyVal: 5.819 ± 0.055	1.289GlyTrp: 1.289 ± 0.035	2.445GlyTyr: 2.445 ± 0.041	0.001GlyXaa: 0.001 ± 0.001
His	2.192HisAla: 2.192 ± 0.04	0.223HisCys: 0.223 ± 0.013	1.274HisAsp: 1.274 ± 0.031	1.053HisGlu: 1.053 ± 0.028	0.904HisPhe: 0.904 ± 0.026	1.854HisGly: 1.854 ± 0.036	0.559HisHis: 0.559 ± 0.023	1.049HisIle: 1.049 ± 0.026	0.524HisLys: 0.524 ± 0.02	1.975HisLeu: 1.975 ± 0.044	0.559HisMet: 0.559 ± 0.018	0.459HisAsn: 0.459 ± 0.019	1.255HisPro: 1.255 ± 0.033	0.585HisGln: 0.585 ± 0.02	1.266HisArg: 1.266 ± 0.031	0.97HisSer: 0.97 ± 0.027	0.81HisThr: 0.81 ± 0.024	1.445HisVal: 1.445 ± 0.033	0.266HisTrp: 0.266 ± 0.014	0.542HisTyr: 0.542 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.789IleAla: 7.789 ± 0.08	0.57IleCys: 0.57 ± 0.017	4.056IleAsp: 4.056 ± 0.053	3.768IleGlu: 3.768 ± 0.053	2.025IlePhe: 2.025 ± 0.038	5.468IleGly: 5.468 ± 0.07	0.986IleHis: 0.986 ± 0.025	2.684IleIle: 2.684 ± 0.042	1.633IleLys: 1.633 ± 0.036	4.915IleLeu: 4.915 ± 0.064	1.095IleMet: 1.095 ± 0.024	1.641IleAsn: 1.641 ± 0.032	2.396IlePro: 2.396 ± 0.039	1.228IleGln: 1.228 ± 0.031	3.521IleArg: 3.521 ± 0.051	3.406IleSer: 3.406 ± 0.053	2.932IleThr: 2.932 ± 0.051	4.748IleVal: 4.748 ± 0.064	0.617IleTrp: 0.617 ± 0.024	1.289IleTyr: 1.289 ± 0.033	0.001IleXaa: 0.001 ± 0.001
Lys	4.953LysAla: 4.953 ± 0.062	0.169LysCys: 0.169 ± 0.011	2.074LysAsp: 2.074 ± 0.046	1.869LysGlu: 1.869 ± 0.038	1.009LysPhe: 1.009 ± 0.026	3.081LysGly: 3.081 ± 0.044	0.665LysHis: 0.665 ± 0.022	2.146LysIle: 2.146 ± 0.037	1.602LysLys: 1.602 ± 0.045	3.706LysLeu: 3.706 ± 0.055	0.954LysMet: 0.954 ± 0.027	1.106LysAsn: 1.106 ± 0.027	2.428LysPro: 2.428 ± 0.045	1.151LysGln: 1.151 ± 0.031	2.53LysArg: 2.53 ± 0.047	2.251LysSer: 2.251 ± 0.037	2.493LysThr: 2.493 ± 0.041	2.69LysVal: 2.69 ± 0.043	0.389LysTrp: 0.389 ± 0.016	0.671LysTyr: 0.671 ± 0.024	0.001LysXaa: 0.001 ± 0.001
Leu	12.501LeuAla: 12.501 ± 0.12	0.811LeuCys: 0.811 ± 0.023	5.913LeuAsp: 5.913 ± 0.066	5.316LeuGlu: 5.316 ± 0.066	3.784LeuPhe: 3.784 ± 0.065	7.883LeuGly: 7.883 ± 0.083	1.809LeuHis: 1.809 ± 0.035	5.217LeuIle: 5.217 ± 0.072	4.355LeuLys: 4.355 ± 0.062	9.243LeuLeu: 9.243 ± 0.092	2.42LeuMet: 2.42 ± 0.04	2.722LeuAsn: 2.722 ± 0.042	5.192LeuPro: 5.192 ± 0.062	2.85LeuGln: 2.85 ± 0.044	5.983LeuArg: 5.983 ± 0.065	7.376LeuSer: 7.376 ± 0.085	5.568LeuThr: 5.568 ± 0.069	7.34LeuVal: 7.34 ± 0.074	1.058LeuTrp: 1.058 ± 0.029	2.169LeuTyr: 2.169 ± 0.042	0.001LeuXaa: 0.001 ± 0.001
Met	3.15MetAla: 3.15 ± 0.048	0.136MetCys: 0.136 ± 0.009	1.207MetAsp: 1.207 ± 0.028	1.344MetGlu: 1.344 ± 0.031	0.699MetPhe: 0.699 ± 0.022	1.75MetGly: 1.75 ± 0.032	0.426MetHis: 0.426 ± 0.017	1.506MetIle: 1.506 ± 0.033	1.176MetLys: 1.176 ± 0.028	2.605MetLeu: 2.605 ± 0.048	0.755MetMet: 0.755 ± 0.027	0.834MetAsn: 0.834 ± 0.025	1.506MetPro: 1.506 ± 0.034	0.834MetGln: 0.834 ± 0.023	1.824MetArg: 1.824 ± 0.031	1.741MetSer: 1.741 ± 0.033	1.94MetThr: 1.94 ± 0.038	1.798MetVal: 1.798 ± 0.037	0.191MetTrp: 0.191 ± 0.011	0.311MetTyr: 0.311 ± 0.014	0.001MetXaa: 0.001 ± 0.001
Asn	3.38AsnAla: 3.38 ± 0.053	0.234AsnCys: 0.234 ± 0.012	1.741AsnAsp: 1.741 ± 0.045	1.351AsnGlu: 1.351 ± 0.033	1.13AsnPhe: 1.13 ± 0.029	2.794AsnGly: 2.794 ± 0.05	0.586AsnHis: 0.586 ± 0.02	1.615AsnIle: 1.615 ± 0.031	0.815AsnLys: 0.815 ± 0.026	2.756AsnLeu: 2.756 ± 0.048	0.657AsnMet: 0.657 ± 0.022	0.797AsnAsn: 0.797 ± 0.027	1.887AsnPro: 1.887 ± 0.036	0.809AsnGln: 0.809 ± 0.024	1.987AsnArg: 1.987 ± 0.034	1.419AsnSer: 1.419 ± 0.033	1.451AsnThr: 1.451 ± 0.032	1.993AsnVal: 1.993 ± 0.035	0.468AsnTrp: 0.468 ± 0.02	0.725AsnTyr: 0.725 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	5.737ProAla: 5.737 ± 0.068	0.253ProCys: 0.253 ± 0.013	3.324ProAsp: 3.324 ± 0.049	3.616ProGlu: 3.616 ± 0.058	2.024ProPhe: 2.024 ± 0.034	3.953ProGly: 3.953 ± 0.053	1.02ProHis: 1.02 ± 0.027	2.253ProIle: 2.253 ± 0.043	1.849ProLys: 1.849 ± 0.038	4.521ProLeu: 4.521 ± 0.067	1.133ProMet: 1.133 ± 0.026	1.301ProAsn: 1.301 ± 0.031	2.059ProPro: 2.059 ± 0.038	1.682ProGln: 1.682 ± 0.035	2.42ProArg: 2.42 ± 0.042	2.657ProSer: 2.657 ± 0.041	2.215ProThr: 2.215 ± 0.042	4.231ProVal: 4.231 ± 0.063	0.59ProTrp: 0.59 ± 0.021	1.198ProTyr: 1.198 ± 0.033	0.001ProXaa: 0.001 ± 0.001
Gln	3.822GlnAla: 3.822 ± 0.059	0.169GlnCys: 0.169 ± 0.011	1.4GlnAsp: 1.4 ± 0.033	1.531GlnGlu: 1.531 ± 0.033	1.045GlnPhe: 1.045 ± 0.028	2.185GlnGly: 2.185 ± 0.035	0.581GlnHis: 0.581 ± 0.022	1.839GlnIle: 1.839 ± 0.065	1.256GlnLys: 1.256 ± 0.024	2.823GlnLeu: 2.823 ± 0.05	0.916GlnMet: 0.916 ± 0.023	0.885GlnAsn: 0.885 ± 0.023	1.664GlnPro: 1.664 ± 0.037	1.256GlnGln: 1.256 ± 0.038	2.141GlnArg: 2.141 ± 0.042	1.859GlnSer: 1.859 ± 0.035	1.745GlnThr: 1.745 ± 0.034	2.09GlnVal: 2.09 ± 0.055	0.386GlnTrp: 0.386 ± 0.016	0.616GlnTyr: 0.616 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	6.762ArgAla: 6.762 ± 0.073	0.456ArgCys: 0.456 ± 0.016	3.757ArgAsp: 3.757 ± 0.055	3.871ArgGlu: 3.871 ± 0.058	2.904ArgPhe: 2.904 ± 0.052	4.382ArgGly: 4.382 ± 0.061	1.592ArgHis: 1.592 ± 0.036	3.948ArgIle: 3.948 ± 0.053	2.629ArgLys: 2.629 ± 0.046	7.097ArgLeu: 7.097 ± 0.083	1.896ArgMet: 1.896 ± 0.035	2.023ArgAsn: 2.023 ± 0.035	3.064ArgPro: 3.064 ± 0.051	2.484ArgGln: 2.484 ± 0.042	5.094ArgArg: 5.094 ± 0.063	3.62ArgSer: 3.62 ± 0.05	3.201ArgThr: 3.201 ± 0.05	4.164ArgVal: 4.164 ± 0.057	0.83ArgTrp: 0.83 ± 0.026	1.716ArgTyr: 1.716 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.443SerAla: 6.443 ± 0.079	0.403SerCys: 0.403 ± 0.015	3.271SerAsp: 3.271 ± 0.047	3.125SerGlu: 3.125 ± 0.043	2.574SerPhe: 2.574 ± 0.045	5.814SerGly: 5.814 ± 0.071	1.161SerHis: 1.161 ± 0.03	3.182SerIle: 3.182 ± 0.052	1.825SerLys: 1.825 ± 0.036	5.891SerLeu: 5.891 ± 0.058	1.417SerMet: 1.417 ± 0.033	1.516SerAsn: 1.516 ± 0.037	2.759SerPro: 2.759 ± 0.038	1.669SerGln: 1.669 ± 0.038	3.667SerArg: 3.667 ± 0.056	3.244SerSer: 3.244 ± 0.064	2.963SerThr: 2.963 ± 0.065	4.206SerVal: 4.206 ± 0.054	0.758SerTrp: 0.758 ± 0.021	1.453SerTyr: 1.453 ± 0.033	0.001SerXaa: 0.001 ± 0.001
Thr	6.332ThrAla: 6.332 ± 0.078	0.422ThrCys: 0.422 ± 0.017	2.972ThrAsp: 2.972 ± 0.049	2.79ThrGlu: 2.79 ± 0.043	2.151ThrPhe: 2.151 ± 0.037	5.209ThrGly: 5.209 ± 0.063	0.992ThrHis: 0.992 ± 0.025	3.346ThrIle: 3.346 ± 0.054	1.712ThrLys: 1.712 ± 0.032	5.945ThrLeu: 5.945 ± 0.079	1.268ThrMet: 1.268 ± 0.031	1.408ThrAsn: 1.408 ± 0.037	3.077ThrPro: 3.077 ± 0.045	1.41ThrGln: 1.41 ± 0.041	3.035ThrArg: 3.035 ± 0.048	2.978ThrSer: 2.978 ± 0.049	3.015ThrThr: 3.015 ± 0.068	4.601ThrVal: 4.601 ± 0.059	0.59ThrTrp: 0.59 ± 0.024	1.329ThrTyr: 1.329 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	8.645ValAla: 8.645 ± 0.087	0.617ValCys: 0.617 ± 0.022	4.051ValAsp: 4.051 ± 0.057	4.487ValGlu: 4.487 ± 0.056	3.021ValPhe: 3.021 ± 0.044	5.213ValGly: 5.213 ± 0.062	1.349ValHis: 1.349 ± 0.029	4.336ValIle: 4.336 ± 0.048	2.638ValLys: 2.638 ± 0.052	7.385ValLeu: 7.385 ± 0.076	1.855ValMet: 1.855 ± 0.035	2.061ValAsn: 2.061 ± 0.037	3.493ValPro: 3.493 ± 0.053	1.878ValGln: 1.878 ± 0.033	4.501ValArg: 4.501 ± 0.057	4.875ValSer: 4.875 ± 0.051	4.565ValThr: 4.565 ± 0.059	5.855ValVal: 5.855 ± 0.062	0.813ValTrp: 0.813 ± 0.026	1.59ValTyr: 1.59 ± 0.037	0.0ValXaa: 0.0 ± 0.0
Trp	1.141TrpAla: 1.141 ± 0.029	0.121TrpCys: 0.121 ± 0.008	0.574TrpAsp: 0.574 ± 0.023	0.552TrpGlu: 0.552 ± 0.021	0.526TrpPhe: 0.526 ± 0.02	0.797TrpGly: 0.797 ± 0.025	0.302TrpHis: 0.302 ± 0.014	0.614TrpIle: 0.614 ± 0.021	0.526TrpLys: 0.526 ± 0.021	1.571TrpLeu: 1.571 ± 0.034	0.347TrpMet: 0.347 ± 0.015	0.472TrpAsn: 0.472 ± 0.016	0.645TrpPro: 0.645 ± 0.023	0.515TrpGln: 0.515 ± 0.019	0.956TrpArg: 0.956 ± 0.027	0.777TrpSer: 0.777 ± 0.026	0.711TrpThr: 0.711 ± 0.026	0.75TrpVal: 0.75 ± 0.022	0.214TrpTrp: 0.214 ± 0.011	0.285TrpTyr: 0.285 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.494TyrAla: 2.494 ± 0.043	0.24TyrCys: 0.24 ± 0.012	1.509TyrAsp: 1.509 ± 0.03	1.313TyrGlu: 1.313 ± 0.029	1.021TyrPhe: 1.021 ± 0.025	2.198TyrGly: 2.198 ± 0.038	0.475TyrHis: 0.475 ± 0.019	1.065TyrIle: 1.065 ± 0.028	0.707TyrLys: 0.707 ± 0.023	2.359TyrLeu: 2.359 ± 0.043	0.511TyrMet: 0.511 ± 0.02	0.672TyrAsn: 0.672 ± 0.023	1.152TyrPro: 1.152 ± 0.026	0.743TyrGln: 0.743 ± 0.027	1.755TyrArg: 1.755 ± 0.038	1.318TyrSer: 1.318 ± 0.028	1.154TyrThr: 1.154 ± 0.028	1.672TyrVal: 1.672 ± 0.033	0.366TyrTrp: 0.366 ± 0.015	0.664TyrTyr: 0.664 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4824 proteins (1524751 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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