Amino acid dipepetide frequency for Aminivibrio pyruvatiphilus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.891AlaAla: 12.891 ± 0.149	1.189AlaCys: 1.189 ± 0.041	4.784AlaAsp: 4.784 ± 0.071	7.15AlaGlu: 7.15 ± 0.095	4.358AlaPhe: 4.358 ± 0.07	10.007AlaGly: 10.007 ± 0.125	1.307AlaHis: 1.307 ± 0.036	4.157AlaIle: 4.157 ± 0.079	3.444AlaLys: 3.444 ± 0.07	11.193AlaLeu: 11.193 ± 0.12	2.774AlaMet: 2.774 ± 0.061	1.878AlaAsn: 1.878 ± 0.044	3.963AlaPro: 3.963 ± 0.078	1.894AlaGln: 1.894 ± 0.054	5.912AlaArg: 5.912 ± 0.093	6.065AlaSer: 6.065 ± 0.079	3.063AlaThr: 3.063 ± 0.063	9.172AlaVal: 9.172 ± 0.118	1.113AlaTrp: 1.113 ± 0.035	2.055AlaTyr: 2.055 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.036	0.162CysCys: 0.162 ± 0.014	0.558CysAsp: 0.558 ± 0.025	0.567CysGlu: 0.567 ± 0.028	0.509CysPhe: 0.509 ± 0.02	1.405CysGly: 1.405 ± 0.05	0.237CysHis: 0.237 ± 0.017	0.633CysIle: 0.633 ± 0.027	0.252CysLys: 0.252 ± 0.017	1.129CysLeu: 1.129 ± 0.035	0.244CysMet: 0.244 ± 0.016	0.247CysAsn: 0.247 ± 0.017	0.777CysPro: 0.777 ± 0.034	0.185CysGln: 0.185 ± 0.014	0.975CysArg: 0.975 ± 0.033	0.856CysSer: 0.856 ± 0.031	0.618CysThr: 0.618 ± 0.029	0.774CysVal: 0.774 ± 0.029	0.129CysTrp: 0.129 ± 0.01	0.252CysTyr: 0.252 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.129AspAla: 4.129 ± 0.072	0.525AspCys: 0.525 ± 0.023	2.346AspAsp: 2.346 ± 0.05	3.443AspGlu: 3.443 ± 0.065	2.388AspPhe: 2.388 ± 0.045	5.066AspGly: 5.066 ± 0.087	0.895AspHis: 0.895 ± 0.032	3.148AspIle: 3.148 ± 0.06	1.443AspLys: 1.443 ± 0.045	5.374AspLeu: 5.374 ± 0.082	1.483AspMet: 1.483 ± 0.039	1.023AspAsn: 1.023 ± 0.032	2.818AspPro: 2.818 ± 0.05	1.004AspGln: 1.004 ± 0.032	3.768AspArg: 3.768 ± 0.071	2.598AspSer: 2.598 ± 0.048	2.091AspThr: 2.091 ± 0.05	3.807AspVal: 3.807 ± 0.067	0.593AspTrp: 0.593 ± 0.024	1.396AspTyr: 1.396 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.716GluAla: 6.716 ± 0.092	0.633GluCys: 0.633 ± 0.023	3.541GluAsp: 3.541 ± 0.066	6.541GluGlu: 6.541 ± 0.1	2.176GluPhe: 2.176 ± 0.05	6.003GluGly: 6.003 ± 0.085	1.091GluHis: 1.091 ± 0.037	4.387GluIle: 4.387 ± 0.072	5.299GluLys: 5.299 ± 0.094	5.796GluLeu: 5.796 ± 0.087	2.217GluMet: 2.217 ± 0.041	2.538GluAsn: 2.538 ± 0.055	2.3GluPro: 2.3 ± 0.056	2.001GluGln: 2.001 ± 0.051	5.064GluArg: 5.064 ± 0.089	3.434GluSer: 3.434 ± 0.064	3.785GluThr: 3.785 ± 0.063	4.245GluVal: 4.245 ± 0.078	0.91GluTrp: 0.91 ± 0.032	1.688GluTyr: 1.688 ± 0.043	0.0GluXaa: 0.0 ± 0.0
Phe	4.067PheAla: 4.067 ± 0.065	0.646PheCys: 0.646 ± 0.025	2.17PheAsp: 2.17 ± 0.048	2.188PheGlu: 2.188 ± 0.05	2.514PhePhe: 2.514 ± 0.051	3.762PheGly: 3.762 ± 0.072	0.752PheHis: 0.752 ± 0.028	2.163PheIle: 2.163 ± 0.061	1.069PheLys: 1.069 ± 0.028	5.529PheLeu: 5.529 ± 0.094	0.924PheMet: 0.924 ± 0.034	1.009PheAsn: 1.009 ± 0.035	2.383PhePro: 2.383 ± 0.056	0.994PheGln: 0.994 ± 0.033	3.132PheArg: 3.132 ± 0.06	3.912PheSer: 3.912 ± 0.068	2.258PheThr: 2.258 ± 0.047	2.858PheVal: 2.858 ± 0.061	0.592PheTrp: 0.592 ± 0.026	1.034PheTyr: 1.034 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.363GlyAla: 8.363 ± 0.113	1.187GlyCys: 1.187 ± 0.042	4.292GlyAsp: 4.292 ± 0.069	6.583GlyGlu: 6.583 ± 0.096	3.793GlyPhe: 3.793 ± 0.072	8.519GlyGly: 8.519 ± 0.151	1.531GlyHis: 1.531 ± 0.04	5.934GlyIle: 5.934 ± 0.1	5.562GlyLys: 5.562 ± 0.089	8.379GlyLeu: 8.379 ± 0.112	3.01GlyMet: 3.01 ± 0.064	2.678GlyAsn: 2.678 ± 0.051	2.955GlyPro: 2.955 ± 0.053	2.028GlyGln: 2.028 ± 0.046	6.096GlyArg: 6.096 ± 0.101	5.35GlySer: 5.35 ± 0.075	5.367GlyThr: 5.367 ± 0.079	6.551GlyVal: 6.551 ± 0.095	1.202GlyTrp: 1.202 ± 0.032	2.638GlyTyr: 2.638 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	1.269HisAla: 1.269 ± 0.035	0.235HisCys: 0.235 ± 0.018	0.805HisAsp: 0.805 ± 0.03	0.914HisGlu: 0.914 ± 0.032	0.852HisPhe: 0.852 ± 0.029	1.495HisGly: 1.495 ± 0.038	0.378HisHis: 0.378 ± 0.022	0.958HisIle: 0.958 ± 0.031	0.472HisLys: 0.472 ± 0.025	1.681HisLeu: 1.681 ± 0.041	0.377HisMet: 0.377 ± 0.021	0.454HisAsn: 0.454 ± 0.02	1.227HisPro: 1.227 ± 0.038	0.338HisGln: 0.338 ± 0.018	1.088HisArg: 1.088 ± 0.035	0.96HisSer: 0.96 ± 0.029	0.762HisThr: 0.762 ± 0.03	1.125HisVal: 1.125 ± 0.035	0.178HisTrp: 0.178 ± 0.013	0.47HisTyr: 0.47 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.379IleAla: 5.379 ± 0.096	0.652IleCys: 0.652 ± 0.026	2.54IleAsp: 2.54 ± 0.054	2.949IleGlu: 2.949 ± 0.056	2.248IlePhe: 2.248 ± 0.053	4.382IleGly: 4.382 ± 0.083	0.922IleHis: 0.922 ± 0.027	2.823IleIle: 2.823 ± 0.074	1.43IleLys: 1.43 ± 0.04	6.674IleLeu: 6.674 ± 0.098	1.193IleMet: 1.193 ± 0.036	1.343IleAsn: 1.343 ± 0.037	3.585IlePro: 3.585 ± 0.066	1.259IleGln: 1.259 ± 0.035	3.947IleArg: 3.947 ± 0.06	3.793IleSer: 3.793 ± 0.067	2.909IleThr: 2.909 ± 0.054	3.856IleVal: 3.856 ± 0.079	0.502IleTrp: 0.502 ± 0.024	1.217IleTyr: 1.217 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.177LysAla: 4.177 ± 0.079	0.398LysCys: 0.398 ± 0.022	2.45LysAsp: 2.45 ± 0.054	3.64LysGlu: 3.64 ± 0.073	1.244LysPhe: 1.244 ± 0.035	4.143LysGly: 4.143 ± 0.061	0.651LysHis: 0.651 ± 0.027	2.833LysIle: 2.833 ± 0.049	3.356LysLys: 3.356 ± 0.067	3.489LysLeu: 3.489 ± 0.066	1.485LysMet: 1.485 ± 0.042	1.802LysAsn: 1.802 ± 0.043	1.684LysPro: 1.684 ± 0.044	0.936LysGln: 0.936 ± 0.033	2.62LysArg: 2.62 ± 0.048	2.25LysSer: 2.25 ± 0.051	2.675LysThr: 2.675 ± 0.058	3.077LysVal: 3.077 ± 0.06	0.483LysTrp: 0.483 ± 0.023	1.186LysTyr: 1.186 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	11.338LeuAla: 11.338 ± 0.13	1.301LeuCys: 1.301 ± 0.038	5.246LeuAsp: 5.246 ± 0.078	7.102LeuGlu: 7.102 ± 0.104	5.202LeuPhe: 5.202 ± 0.082	8.82LeuGly: 8.82 ± 0.109	1.644LeuHis: 1.644 ± 0.039	4.215LeuIle: 4.215 ± 0.09	4.464LeuLys: 4.464 ± 0.08	11.971LeuLeu: 11.971 ± 0.147	2.248LeuMet: 2.248 ± 0.044	2.429LeuAsn: 2.429 ± 0.048	6.071LeuPro: 6.071 ± 0.08	2.43LeuGln: 2.43 ± 0.05	6.976LeuArg: 6.976 ± 0.105	8.45LeuSer: 8.45 ± 0.114	4.569LeuThr: 4.569 ± 0.08	7.277LeuVal: 7.277 ± 0.091	1.276LeuTrp: 1.276 ± 0.038	2.296LeuTyr: 2.296 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.013MetAla: 3.013 ± 0.055	0.197MetCys: 0.197 ± 0.014	1.591MetAsp: 1.591 ± 0.039	2.241MetGlu: 2.241 ± 0.042	0.838MetPhe: 0.838 ± 0.031	2.382MetGly: 2.382 ± 0.058	0.328MetHis: 0.328 ± 0.018	1.532MetIle: 1.532 ± 0.038	1.899MetLys: 1.899 ± 0.044	2.332MetLeu: 2.332 ± 0.06	0.705MetMet: 0.705 ± 0.029	1.085MetAsn: 1.085 ± 0.034	1.177MetPro: 1.177 ± 0.034	0.564MetGln: 0.564 ± 0.026	1.324MetArg: 1.324 ± 0.037	1.484MetSer: 1.484 ± 0.039	1.679MetThr: 1.679 ± 0.041	1.968MetVal: 1.968 ± 0.055	0.185MetTrp: 0.185 ± 0.014	0.55MetTyr: 0.55 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	2.361AsnAla: 2.361 ± 0.048	0.345AsnCys: 0.345 ± 0.022	1.216AsnAsp: 1.216 ± 0.035	1.385AsnGlu: 1.385 ± 0.04	1.075AsnPhe: 1.075 ± 0.036	2.425AsnGly: 2.425 ± 0.047	0.454AsnHis: 0.454 ± 0.021	1.7AsnIle: 1.7 ± 0.042	0.816AsnLys: 0.816 ± 0.029	2.999AsnLeu: 2.999 ± 0.052	0.786AsnMet: 0.786 ± 0.027	0.777AsnAsn: 0.777 ± 0.03	1.966AsnPro: 1.966 ± 0.048	0.598AsnGln: 0.598 ± 0.022	1.95AsnArg: 1.95 ± 0.046	1.587AsnSer: 1.587 ± 0.053	1.336AsnThr: 1.336 ± 0.04	1.998AsnVal: 1.998 ± 0.045	0.36AsnTrp: 0.36 ± 0.021	0.748AsnTyr: 0.748 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	4.814ProAla: 4.814 ± 0.076	0.512ProCys: 0.512 ± 0.023	2.878ProAsp: 2.878 ± 0.054	4.704ProGlu: 4.704 ± 0.081	2.44ProPhe: 2.44 ± 0.048	5.28ProGly: 5.28 ± 0.081	0.726ProHis: 0.726 ± 0.026	1.649ProIle: 1.649 ± 0.045	1.673ProLys: 1.673 ± 0.051	5.239ProLeu: 5.239 ± 0.074	1.041ProMet: 1.041 ± 0.035	0.923ProAsn: 0.923 ± 0.034	2.316ProPro: 2.316 ± 0.057	1.029ProGln: 1.029 ± 0.035	2.489ProArg: 2.489 ± 0.053	3.302ProSer: 3.302 ± 0.065	1.632ProThr: 1.632 ± 0.041	4.669ProVal: 4.669 ± 0.069	0.691ProTrp: 0.691 ± 0.027	1.21ProTyr: 1.21 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	2.402GlnAla: 2.402 ± 0.054	0.219GlnCys: 0.219 ± 0.016	1.043GlnAsp: 1.043 ± 0.031	1.627GlnGlu: 1.627 ± 0.046	0.828GlnPhe: 0.828 ± 0.033	2.046GlnGly: 2.046 ± 0.045	0.354GlnHis: 0.354 ± 0.021	1.341GlnIle: 1.341 ± 0.035	1.33GlnLys: 1.33 ± 0.04	1.786GlnLeu: 1.786 ± 0.04	0.702GlnMet: 0.702 ± 0.027	0.762GlnAsn: 0.762 ± 0.026	0.89GlnPro: 0.89 ± 0.032	0.712GlnGln: 0.712 ± 0.03	1.333GlnArg: 1.333 ± 0.036	1.233GlnSer: 1.233 ± 0.036	1.041GlnThr: 1.041 ± 0.035	1.672GlnVal: 1.672 ± 0.044	0.328GlnTrp: 0.328 ± 0.016	0.694GlnTyr: 0.694 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.193ArgAla: 5.193 ± 0.078	0.699ArgCys: 0.699 ± 0.026	3.415ArgAsp: 3.415 ± 0.063	5.863ArgGlu: 5.863 ± 0.09	2.763ArgPhe: 2.763 ± 0.059	5.297ArgGly: 5.297 ± 0.096	1.121ArgHis: 1.121 ± 0.033	4.211ArgIle: 4.211 ± 0.063	3.962ArgLys: 3.962 ± 0.063	6.34ArgLeu: 6.34 ± 0.099	2.043ArgMet: 2.043 ± 0.049	2.201ArgAsn: 2.201 ± 0.049	2.729ArgPro: 2.729 ± 0.058	1.775ArgGln: 1.775 ± 0.041	4.435ArgArg: 4.435 ± 0.091	3.752ArgSer: 3.752 ± 0.064	3.375ArgThr: 3.375 ± 0.061	4.008ArgVal: 4.008 ± 0.074	0.853ArgTrp: 0.853 ± 0.03	1.654ArgTyr: 1.654 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.155SerAla: 6.155 ± 0.087	0.783SerCys: 0.783 ± 0.028	2.63SerAsp: 2.63 ± 0.051	3.468SerGlu: 3.468 ± 0.067	3.247SerPhe: 3.247 ± 0.065	7.082SerGly: 7.082 ± 0.104	0.978SerHis: 0.978 ± 0.034	3.292SerIle: 3.292 ± 0.067	1.89SerLys: 1.89 ± 0.045	7.705SerLeu: 7.705 ± 0.105	1.862SerMet: 1.862 ± 0.046	1.18SerAsn: 1.18 ± 0.032	3.696SerPro: 3.696 ± 0.067	1.208SerGln: 1.208 ± 0.039	4.289SerArg: 4.289 ± 0.065	4.174SerSer: 4.174 ± 0.083	2.511SerThr: 2.511 ± 0.056	5.401SerVal: 5.401 ± 0.08	0.857SerTrp: 0.857 ± 0.031	1.397SerTyr: 1.397 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.42ThrAla: 5.42 ± 0.077	0.49ThrCys: 0.49 ± 0.024	2.285ThrAsp: 2.285 ± 0.04	2.977ThrGlu: 2.977 ± 0.057	2.084ThrPhe: 2.084 ± 0.045	5.314ThrGly: 5.314 ± 0.087	0.717ThrHis: 0.717 ± 0.023	2.462ThrIle: 2.462 ± 0.049	1.496ThrLys: 1.496 ± 0.042	5.076ThrLeu: 5.076 ± 0.077	1.232ThrMet: 1.232 ± 0.035	1.117ThrAsn: 1.117 ± 0.035	2.84ThrPro: 2.84 ± 0.058	0.785ThrGln: 0.785 ± 0.027	2.441ThrArg: 2.441 ± 0.055	2.625ThrSer: 2.625 ± 0.044	2.058ThrThr: 2.058 ± 0.047	4.787ThrVal: 4.787 ± 0.08	0.592ThrTrp: 0.592 ± 0.027	1.099ThrTyr: 1.099 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	6.619ValAla: 6.619 ± 0.09	0.927ValCys: 0.927 ± 0.035	3.521ValAsp: 3.521 ± 0.064	4.782ValGlu: 4.782 ± 0.073	3.688ValPhe: 3.688 ± 0.074	4.948ValGly: 4.948 ± 0.093	1.321ValHis: 1.321 ± 0.037	4.182ValIle: 4.182 ± 0.077	3.203ValLys: 3.203 ± 0.062	9.026ValLeu: 9.026 ± 0.106	1.824ValMet: 1.824 ± 0.046	2.253ValAsn: 2.253 ± 0.053	4.055ValPro: 4.055 ± 0.069	1.731ValGln: 1.731 ± 0.042	5.189ValArg: 5.189 ± 0.075	5.465ValSer: 5.465 ± 0.083	4.257ValThr: 4.257 ± 0.066	5.799ValVal: 5.799 ± 0.092	0.733ValTrp: 0.733 ± 0.027	1.89ValTyr: 1.89 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.948TrpAla: 0.948 ± 0.029	0.128TrpCys: 0.128 ± 0.011	0.593TrpAsp: 0.593 ± 0.026	0.814TrpGlu: 0.814 ± 0.031	0.497TrpPhe: 0.497 ± 0.021	1.202TrpGly: 1.202 ± 0.041	0.192TrpHis: 0.192 ± 0.014	0.727TrpIle: 0.727 ± 0.027	0.827TrpLys: 0.827 ± 0.029	1.122TrpLeu: 1.122 ± 0.035	0.357TrpMet: 0.357 ± 0.018	0.524TrpAsn: 0.524 ± 0.022	0.438TrpPro: 0.438 ± 0.022	0.345TrpGln: 0.345 ± 0.018	0.76TrpArg: 0.76 ± 0.029	0.774TrpSer: 0.774 ± 0.029	0.684TrpThr: 0.684 ± 0.035	0.684TrpVal: 0.684 ± 0.027	0.153TrpTrp: 0.153 ± 0.013	0.292TrpTyr: 0.292 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.053TyrAla: 2.053 ± 0.049	0.343TyrCys: 0.343 ± 0.018	1.435TyrAsp: 1.435 ± 0.041	1.424TyrGlu: 1.424 ± 0.039	1.21TyrPhe: 1.21 ± 0.038	2.44TyrGly: 2.44 ± 0.054	0.44TyrHis: 0.44 ± 0.019	1.258TyrIle: 1.258 ± 0.032	0.691TyrLys: 0.691 ± 0.034	2.485TyrLeu: 2.485 ± 0.048	0.562TyrMet: 0.562 ± 0.026	0.659TyrAsn: 0.659 ± 0.03	1.35TyrPro: 1.35 ± 0.036	0.53TyrGln: 0.53 ± 0.024	1.901TyrArg: 1.901 ± 0.046	1.741TyrSer: 1.741 ± 0.044	1.228TyrThr: 1.228 ± 0.038	1.681TyrVal: 1.681 ± 0.048	0.334TyrTrp: 0.334 ± 0.019	0.688TyrTyr: 0.688 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2990 proteins (1007143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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