Amino acid dipepetide frequency for Romboutsia lituseburensis DSM 797

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.111AlaAla: 3.111 ± 0.08	0.753AlaCys: 0.753 ± 0.028	2.324AlaAsp: 2.324 ± 0.047	2.539AlaGlu: 2.539 ± 0.058	2.291AlaPhe: 2.291 ± 0.049	3.568AlaGly: 3.568 ± 0.078	0.784AlaHis: 0.784 ± 0.03	5.902AlaIle: 5.902 ± 0.078	4.83AlaLys: 4.83 ± 0.075	5.445AlaLeu: 5.445 ± 0.081	1.741AlaMet: 1.741 ± 0.048	2.913AlaAsn: 2.913 ± 0.05	1.365AlaPro: 1.365 ± 0.037	1.581AlaGln: 1.581 ± 0.04	1.664AlaArg: 1.664 ± 0.044	3.338AlaSer: 3.338 ± 0.063	3.022AlaThr: 3.022 ± 0.067	3.618AlaVal: 3.618 ± 0.073	0.339AlaTrp: 0.339 ± 0.017	2.038AlaTyr: 2.038 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.662CysAla: 0.662 ± 0.026	0.188CysCys: 0.188 ± 0.018	0.739CysAsp: 0.739 ± 0.03	0.878CysGlu: 0.878 ± 0.029	0.433CysPhe: 0.433 ± 0.022	1.027CysGly: 1.027 ± 0.034	0.182CysHis: 0.182 ± 0.013	1.315CysIle: 1.315 ± 0.036	1.011CysLys: 1.011 ± 0.033	0.9CysLeu: 0.9 ± 0.03	0.319CysMet: 0.319 ± 0.018	0.778CysAsn: 0.778 ± 0.032	0.471CysPro: 0.471 ± 0.025	0.247CysGln: 0.247 ± 0.016	0.341CysArg: 0.341 ± 0.016	0.824CysSer: 0.824 ± 0.032	0.6CysThr: 0.6 ± 0.025	0.691CysVal: 0.691 ± 0.028	0.051CysTrp: 0.051 ± 0.007	0.425CysTyr: 0.425 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	2.742AspAla: 2.742 ± 0.063	0.656AspCys: 0.656 ± 0.026	2.904AspAsp: 2.904 ± 0.063	4.927AspGlu: 4.927 ± 0.076	2.597AspPhe: 2.597 ± 0.051	3.192AspGly: 3.192 ± 0.063	0.608AspHis: 0.608 ± 0.022	6.852AspIle: 6.852 ± 0.098	5.888AspLys: 5.888 ± 0.07	5.318AspLeu: 5.318 ± 0.076	1.614AspMet: 1.614 ± 0.041	3.593AspAsn: 3.593 ± 0.055	1.312AspPro: 1.312 ± 0.036	0.984AspGln: 0.984 ± 0.034	1.743AspArg: 1.743 ± 0.039	3.197AspSer: 3.197 ± 0.066	2.555AspThr: 2.555 ± 0.051	3.66AspVal: 3.66 ± 0.061	0.336AspTrp: 0.336 ± 0.019	2.701AspTyr: 2.701 ± 0.057	0.0AspXaa: 0.0 ± 0.0
Glu	3.601GluAla: 3.601 ± 0.067	0.781GluCys: 0.781 ± 0.029	4.365GluAsp: 4.365 ± 0.066	6.242GluGlu: 6.242 ± 0.102	2.994GluPhe: 2.994 ± 0.058	3.756GluGly: 3.756 ± 0.063	0.889GluHis: 0.889 ± 0.028	7.182GluIle: 7.182 ± 0.093	7.065GluLys: 7.065 ± 0.094	6.582GluLeu: 6.582 ± 0.093	1.79GluMet: 1.79 ± 0.037	5.813GluAsn: 5.813 ± 0.09	1.193GluPro: 1.193 ± 0.035	1.763GluGln: 1.763 ± 0.044	2.104GluArg: 2.104 ± 0.05	3.862GluSer: 3.862 ± 0.064	2.903GluThr: 2.903 ± 0.048	4.789GluVal: 4.789 ± 0.062	0.383GluTrp: 0.383 ± 0.023	3.25GluTyr: 3.25 ± 0.063	0.0GluXaa: 0.0 ± 0.0
Phe	2.257PheAla: 2.257 ± 0.047	0.461PheCys: 0.461 ± 0.018	2.534PheAsp: 2.534 ± 0.051	2.811PheGlu: 2.811 ± 0.064	1.831PhePhe: 1.831 ± 0.045	2.777PheGly: 2.777 ± 0.056	0.427PheHis: 0.427 ± 0.022	4.85PheIle: 4.85 ± 0.084	3.962PheLys: 3.962 ± 0.068	3.741PheLeu: 3.741 ± 0.072	1.28PheMet: 1.28 ± 0.033	2.907PheAsn: 2.907 ± 0.051	0.968PhePro: 0.968 ± 0.03	0.664PheGln: 0.664 ± 0.025	1.134PheArg: 1.134 ± 0.034	2.855PheSer: 2.855 ± 0.055	2.191PheThr: 2.191 ± 0.046	2.721PheVal: 2.721 ± 0.051	0.257PheTrp: 0.257 ± 0.016	1.677PheTyr: 1.677 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	3.922GlyAla: 3.922 ± 0.075	1.026GlyCys: 1.026 ± 0.035	3.043GlyAsp: 3.043 ± 0.056	3.745GlyGlu: 3.745 ± 0.066	3.012GlyPhe: 3.012 ± 0.059	4.05GlyGly: 4.05 ± 0.081	0.991GlyHis: 0.991 ± 0.033	6.723GlyIle: 6.723 ± 0.092	5.032GlyLys: 5.032 ± 0.08	5.497GlyLeu: 5.497 ± 0.086	1.804GlyMet: 1.804 ± 0.048	3.3GlyAsn: 3.3 ± 0.069	1.248GlyPro: 1.248 ± 0.046	1.52GlyGln: 1.52 ± 0.042	1.821GlyArg: 1.821 ± 0.045	3.809GlySer: 3.809 ± 0.07	3.269GlyThr: 3.269 ± 0.064	4.625GlyVal: 4.625 ± 0.071	0.556GlyTrp: 0.556 ± 0.037	3.075GlyTyr: 3.075 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.663HisAla: 0.663 ± 0.024	0.173HisCys: 0.173 ± 0.014	0.772HisAsp: 0.772 ± 0.032	0.961HisGlu: 0.961 ± 0.03	0.543HisPhe: 0.543 ± 0.022	0.879HisGly: 0.879 ± 0.027	0.267HisHis: 0.267 ± 0.018	1.336HisIle: 1.336 ± 0.037	1.134HisLys: 1.134 ± 0.033	1.157HisLeu: 1.157 ± 0.028	0.382HisMet: 0.382 ± 0.018	0.842HisAsn: 0.842 ± 0.028	0.557HisPro: 0.557 ± 0.023	0.343HisGln: 0.343 ± 0.015	0.462HisArg: 0.462 ± 0.022	0.832HisSer: 0.832 ± 0.031	0.746HisThr: 0.746 ± 0.024	0.782HisVal: 0.782 ± 0.027	0.092HisTrp: 0.092 ± 0.008	0.549HisTyr: 0.549 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.711IleAla: 5.711 ± 0.089	1.377IleCys: 1.377 ± 0.038	6.739IleAsp: 6.739 ± 0.093	7.296IleGlu: 7.296 ± 0.108	4.24IlePhe: 4.24 ± 0.075	6.58IleGly: 6.58 ± 0.096	1.232IleHis: 1.232 ± 0.038	9.674IleIle: 9.674 ± 0.122	9.51IleLys: 9.51 ± 0.108	9.32IleLeu: 9.32 ± 0.117	2.379IleMet: 2.379 ± 0.049	7.224IleAsn: 7.224 ± 0.103	3.252IlePro: 3.252 ± 0.057	2.342IleGln: 2.342 ± 0.05	2.652IleArg: 2.652 ± 0.05	7.43IleSer: 7.43 ± 0.097	4.808IleThr: 4.808 ± 0.071	6.753IleVal: 6.753 ± 0.085	0.548IleTrp: 0.548 ± 0.026	3.957IleTyr: 3.957 ± 0.085	0.0IleXaa: 0.0 ± 0.0
Lys	4.224LysAla: 4.224 ± 0.065	0.868LysCys: 0.868 ± 0.037	6.23LysAsp: 6.23 ± 0.094	8.722LysGlu: 8.722 ± 0.106	3.548LysPhe: 3.548 ± 0.062	4.722LysGly: 4.722 ± 0.07	1.303LysHis: 1.303 ± 0.037	8.555LysIle: 8.555 ± 0.101	8.367LysLys: 8.367 ± 0.111	7.758LysLeu: 7.758 ± 0.094	2.575LysMet: 2.575 ± 0.045	7.281LysAsn: 7.281 ± 0.095	2.056LysPro: 2.056 ± 0.04	2.551LysGln: 2.551 ± 0.054	2.621LysArg: 2.621 ± 0.055	5.868LysSer: 5.868 ± 0.086	4.153LysThr: 4.153 ± 0.067	5.914LysVal: 5.914 ± 0.072	0.586LysTrp: 0.586 ± 0.026	4.446LysTyr: 4.446 ± 0.071	0.0LysXaa: 0.0 ± 0.0
Leu	5.194LeuAla: 5.194 ± 0.081	1.04LeuCys: 1.04 ± 0.028	5.705LeuAsp: 5.705 ± 0.079	6.397LeuGlu: 6.397 ± 0.092	3.661LeuPhe: 3.661 ± 0.064	6.22LeuGly: 6.22 ± 0.098	1.005LeuHis: 1.005 ± 0.03	8.512LeuIle: 8.512 ± 0.125	8.318LeuLys: 8.318 ± 0.1	7.693LeuLeu: 7.693 ± 0.107	2.185LeuMet: 2.185 ± 0.05	6.372LeuAsn: 6.372 ± 0.081	2.579LeuPro: 2.579 ± 0.056	2.045LeuGln: 2.045 ± 0.039	2.686LeuArg: 2.686 ± 0.047	6.671LeuSer: 6.671 ± 0.084	4.379LeuThr: 4.379 ± 0.065	5.892LeuVal: 5.892 ± 0.079	0.472LeuTrp: 0.472 ± 0.023	3.277LeuTyr: 3.277 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.759MetAla: 1.759 ± 0.048	0.285MetCys: 0.285 ± 0.017	1.521MetAsp: 1.521 ± 0.038	1.655MetGlu: 1.655 ± 0.039	1.036MetPhe: 1.036 ± 0.032	1.797MetGly: 1.797 ± 0.05	0.332MetHis: 0.332 ± 0.018	2.535MetIle: 2.535 ± 0.045	2.555MetLys: 2.555 ± 0.047	2.358MetLeu: 2.358 ± 0.049	0.807MetMet: 0.807 ± 0.036	1.815MetAsn: 1.815 ± 0.039	0.914MetPro: 0.914 ± 0.03	0.749MetGln: 0.749 ± 0.027	0.818MetArg: 0.818 ± 0.029	1.82MetSer: 1.82 ± 0.045	1.282MetThr: 1.282 ± 0.038	1.533MetVal: 1.533 ± 0.041	0.153MetTrp: 0.153 ± 0.013	1.003MetTyr: 1.003 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.929AsnAla: 2.929 ± 0.064	0.741AsnCys: 0.741 ± 0.028	3.441AsnAsp: 3.441 ± 0.067	4.76AsnGlu: 4.76 ± 0.071	2.567AsnPhe: 2.567 ± 0.052	3.619AsnGly: 3.619 ± 0.066	0.926AsnHis: 0.926 ± 0.03	8.142AsnIle: 8.142 ± 0.111	7.227AsnLys: 7.227 ± 0.1	6.375AsnLeu: 6.375 ± 0.083	1.809AsnMet: 1.809 ± 0.044	4.971AsnAsn: 4.971 ± 0.092	2.171AsnPro: 2.171 ± 0.045	1.846AsnGln: 1.846 ± 0.043	1.781AsnArg: 1.781 ± 0.038	4.009AsnSer: 4.009 ± 0.062	3.311AsnThr: 3.311 ± 0.065	3.907AsnVal: 3.907 ± 0.06	0.438AsnTrp: 0.438 ± 0.026	2.827AsnTyr: 2.827 ± 0.056	0.0AsnXaa: 0.0 ± 0.0
Pro	1.326ProAla: 1.326 ± 0.041	0.327ProCys: 0.327 ± 0.019	1.334ProAsp: 1.334 ± 0.037	1.789ProGlu: 1.789 ± 0.049	1.302ProPhe: 1.302 ± 0.031	1.659ProGly: 1.659 ± 0.046	0.473ProHis: 0.473 ± 0.022	2.807ProIle: 2.807 ± 0.053	2.262ProLys: 2.262 ± 0.046	2.213ProLeu: 2.213 ± 0.051	0.722ProMet: 0.722 ± 0.029	1.65ProAsn: 1.65 ± 0.045	0.567ProPro: 0.567 ± 0.025	0.851ProGln: 0.851 ± 0.031	0.732ProArg: 0.732 ± 0.025	1.712ProSer: 1.712 ± 0.041	1.541ProThr: 1.541 ± 0.04	1.889ProVal: 1.889 ± 0.041	0.216ProTrp: 0.216 ± 0.014	1.19ProTyr: 1.19 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	1.419GlnAla: 1.419 ± 0.044	0.263GlnCys: 0.263 ± 0.015	1.386GlnAsp: 1.386 ± 0.033	1.839GlnGlu: 1.839 ± 0.048	0.9GlnPhe: 0.9 ± 0.032	1.598GlnGly: 1.598 ± 0.04	0.34GlnHis: 0.34 ± 0.016	2.453GlnIle: 2.453 ± 0.05	2.218GlnLys: 2.218 ± 0.048	2.088GlnLeu: 2.088 ± 0.047	0.768GlnMet: 0.768 ± 0.031	1.716GlnAsn: 1.716 ± 0.039	0.652GlnPro: 0.652 ± 0.022	0.734GlnGln: 0.734 ± 0.028	0.892GlnArg: 0.892 ± 0.029	1.5GlnSer: 1.5 ± 0.033	1.201GlnThr: 1.201 ± 0.034	1.622GlnVal: 1.622 ± 0.039	0.166GlnTrp: 0.166 ± 0.013	1.034GlnTyr: 1.034 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	1.549ArgAla: 1.549 ± 0.04	0.397ArgCys: 0.397 ± 0.02	1.717ArgAsp: 1.717 ± 0.045	2.398ArgGlu: 2.398 ± 0.048	1.208ArgPhe: 1.208 ± 0.039	1.734ArgGly: 1.734 ± 0.045	0.456ArgHis: 0.456 ± 0.021	2.555ArgIle: 2.555 ± 0.049	2.59ArgLys: 2.59 ± 0.046	2.588ArgLeu: 2.588 ± 0.048	0.842ArgMet: 0.842 ± 0.025	1.781ArgAsn: 1.781 ± 0.04	0.814ArgPro: 0.814 ± 0.029	0.826ArgGln: 0.826 ± 0.028	1.111ArgArg: 1.111 ± 0.03	1.474ArgSer: 1.474 ± 0.041	1.356ArgThr: 1.356 ± 0.038	2.032ArgVal: 2.032 ± 0.045	0.188ArgTrp: 0.188 ± 0.013	1.36ArgTyr: 1.36 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	3.223SerAla: 3.223 ± 0.054	0.709SerCys: 0.709 ± 0.027	3.243SerAsp: 3.243 ± 0.055	3.795SerGlu: 3.795 ± 0.065	2.898SerPhe: 2.898 ± 0.056	4.006SerGly: 4.006 ± 0.069	0.972SerHis: 0.972 ± 0.033	7.222SerIle: 7.222 ± 0.092	6.289SerLys: 6.289 ± 0.089	6.078SerLeu: 6.078 ± 0.091	1.722SerMet: 1.722 ± 0.039	4.333SerAsn: 4.333 ± 0.069	1.588SerPro: 1.588 ± 0.035	1.901SerGln: 1.901 ± 0.044	1.867SerArg: 1.867 ± 0.042	4.443SerSer: 4.443 ± 0.078	3.292SerThr: 3.292 ± 0.061	3.905SerVal: 3.905 ± 0.06	0.426SerTrp: 0.426 ± 0.024	2.723SerTyr: 2.723 ± 0.058	0.0SerXaa: 0.0 ± 0.0
Thr	2.577ThrAla: 2.577 ± 0.051	0.553ThrCys: 0.553 ± 0.021	2.378ThrAsp: 2.378 ± 0.048	2.59ThrGlu: 2.59 ± 0.059	2.113ThrPhe: 2.113 ± 0.041	3.425ThrGly: 3.425 ± 0.064	0.79ThrHis: 0.79 ± 0.025	5.199ThrIle: 5.199 ± 0.084	4.157ThrLys: 4.157 ± 0.067	4.746ThrLeu: 4.746 ± 0.076	1.171ThrMet: 1.171 ± 0.027	3.082ThrAsn: 3.082 ± 0.063	1.716ThrPro: 1.716 ± 0.044	1.326ThrGln: 1.326 ± 0.033	1.349ThrArg: 1.349 ± 0.04	3.303ThrSer: 3.303 ± 0.058	2.798ThrThr: 2.798 ± 0.063	3.325ThrVal: 3.325 ± 0.08	0.361ThrTrp: 0.361 ± 0.02	2.033ThrTyr: 2.033 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	3.99ValAla: 3.99 ± 0.084	0.918ValCys: 0.918 ± 0.032	4.126ValAsp: 4.126 ± 0.069	4.482ValGlu: 4.482 ± 0.07	2.931ValPhe: 2.931 ± 0.054	4.56ValGly: 4.56 ± 0.077	0.837ValHis: 0.837 ± 0.026	6.025ValIle: 6.025 ± 0.075	5.316ValLys: 5.316 ± 0.077	6.141ValLeu: 6.141 ± 0.079	1.598ValMet: 1.598 ± 0.038	3.95ValAsn: 3.95 ± 0.059	1.813ValPro: 1.813 ± 0.048	1.372ValGln: 1.372 ± 0.034	1.808ValArg: 1.808 ± 0.042	4.529ValSer: 4.529 ± 0.073	3.125ValThr: 3.125 ± 0.073	4.985ValVal: 4.985 ± 0.092	0.396ValTrp: 0.396 ± 0.023	2.489ValTyr: 2.489 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.35TrpAla: 0.35 ± 0.019	0.084TrpCys: 0.084 ± 0.008	0.382TrpAsp: 0.382 ± 0.021	0.401TrpGlu: 0.401 ± 0.021	0.29TrpPhe: 0.29 ± 0.017	0.438TrpGly: 0.438 ± 0.019	0.104TrpHis: 0.104 ± 0.01	0.671TrpIle: 0.671 ± 0.03	0.455TrpLys: 0.455 ± 0.023	0.505TrpLeu: 0.505 ± 0.025	0.173TrpMet: 0.173 ± 0.015	0.408TrpAsn: 0.408 ± 0.02	0.136TrpPro: 0.136 ± 0.011	0.201TrpGln: 0.201 ± 0.016	0.169TrpArg: 0.169 ± 0.011	0.375TrpSer: 0.375 ± 0.019	0.285TrpThr: 0.285 ± 0.014	0.418TrpVal: 0.418 ± 0.023	0.096TrpTrp: 0.096 ± 0.01	0.397TrpTyr: 0.397 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.956TyrAla: 1.956 ± 0.045	0.482TyrCys: 0.482 ± 0.02	2.497TyrAsp: 2.497 ± 0.06	3.082TyrGlu: 3.082 ± 0.06	1.907TyrPhe: 1.907 ± 0.053	2.463TyrGly: 2.463 ± 0.048	0.557TyrHis: 0.557 ± 0.023	4.513TyrIle: 4.513 ± 0.081	4.163TyrLys: 4.163 ± 0.072	3.803TyrLeu: 3.803 ± 0.063	1.046TyrMet: 1.046 ± 0.031	3.066TyrAsn: 3.066 ± 0.057	1.19TyrPro: 1.19 ± 0.036	0.944TyrGln: 0.944 ± 0.033	1.221TyrArg: 1.221 ± 0.039	2.782TyrSer: 2.782 ± 0.056	2.176TyrThr: 2.176 ± 0.049	2.327TyrVal: 2.327 ± 0.045	0.277TyrTrp: 0.277 ± 0.02	1.886TyrTyr: 1.886 ± 0.053	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3588 proteins (1087853 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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