Amino acid dipepetide frequency for Paraphaeosphaeria sporulosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.618AlaAla: 9.618 ± 0.058	1.231AlaCys: 1.231 ± 0.016	4.332AlaAsp: 4.332 ± 0.031	5.125AlaGlu: 5.125 ± 0.037	3.345AlaPhe: 3.345 ± 0.028	6.134AlaGly: 6.134 ± 0.042	2.055AlaHis: 2.055 ± 0.021	4.332AlaIle: 4.332 ± 0.032	4.294AlaLys: 4.294 ± 0.032	8.11AlaLeu: 8.11 ± 0.041	2.018AlaMet: 2.018 ± 0.018	3.139AlaAsn: 3.139 ± 0.022	5.47AlaPro: 5.47 ± 0.045	3.673AlaGln: 3.673 ± 0.033	5.277AlaArg: 5.277 ± 0.033	7.499AlaSer: 7.499 ± 0.046	5.613AlaThr: 5.613 ± 0.035	5.538AlaVal: 5.538 ± 0.035	1.316AlaTrp: 1.316 ± 0.016	2.392AlaTyr: 2.392 ± 0.02	0.0AlaXaa: 0.0 ± 0.0
Cys	1.119CysAla: 1.119 ± 0.014	0.301CysCys: 0.301 ± 0.009	0.671CysAsp: 0.671 ± 0.01	0.612CysGlu: 0.612 ± 0.01	0.565CysPhe: 0.565 ± 0.01	1.041CysGly: 1.041 ± 0.016	0.335CysHis: 0.335 ± 0.007	0.748CysIle: 0.748 ± 0.012	0.546CysLys: 0.546 ± 0.011	1.232CysLeu: 1.232 ± 0.017	0.312CysMet: 0.312 ± 0.007	0.476CysAsn: 0.476 ± 0.01	0.703CysPro: 0.703 ± 0.012	0.433CysGln: 0.433 ± 0.009	0.812CysArg: 0.812 ± 0.012	0.977CysSer: 0.977 ± 0.015	0.804CysThr: 0.804 ± 0.014	0.864CysVal: 0.864 ± 0.012	0.223CysTrp: 0.223 ± 0.006	0.387CysTyr: 0.387 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	5.101AspAla: 5.101 ± 0.032	0.617AspCys: 0.617 ± 0.009	3.985AspAsp: 3.985 ± 0.032	4.265AspGlu: 4.265 ± 0.033	2.188AspPhe: 2.188 ± 0.018	3.986AspGly: 3.986 ± 0.025	1.201AspHis: 1.201 ± 0.014	2.866AspIle: 2.866 ± 0.02	2.381AspLys: 2.381 ± 0.021	4.712AspLeu: 4.712 ± 0.025	1.249AspMet: 1.249 ± 0.016	1.774AspAsn: 1.774 ± 0.019	3.256AspPro: 3.256 ± 0.025	1.735AspGln: 1.735 ± 0.016	2.934AspArg: 2.934 ± 0.029	3.788AspSer: 3.788 ± 0.028	2.975AspThr: 2.975 ± 0.018	3.777AspVal: 3.777 ± 0.023	0.952AspTrp: 0.952 ± 0.012	1.568AspTyr: 1.568 ± 0.015	0.0AspXaa: 0.0 ± 0.0
Glu	5.379GluAla: 5.379 ± 0.037	0.65GluCys: 0.65 ± 0.01	4.047GluAsp: 4.047 ± 0.03	5.223GluGlu: 5.223 ± 0.045	1.839GluPhe: 1.839 ± 0.018	3.918GluGly: 3.918 ± 0.028	1.476GluHis: 1.476 ± 0.016	2.788GluIle: 2.788 ± 0.021	3.671GluLys: 3.671 ± 0.033	5.009GluLeu: 5.009 ± 0.031	1.395GluMet: 1.395 ± 0.015	2.09GluAsn: 2.09 ± 0.02	2.725GluPro: 2.725 ± 0.031	2.506GluGln: 2.506 ± 0.024	3.959GluArg: 3.959 ± 0.035	3.79GluSer: 3.79 ± 0.028	3.25GluThr: 3.25 ± 0.025	3.57GluVal: 3.57 ± 0.028	0.913GluTrp: 0.913 ± 0.012	1.639GluTyr: 1.639 ± 0.015	0.0GluXaa: 0.0 ± 0.0
Phe	3.344PheAla: 3.344 ± 0.024	0.569PheCys: 0.569 ± 0.01	2.258PheAsp: 2.258 ± 0.02	2.16PheGlu: 2.16 ± 0.019	1.638PhePhe: 1.638 ± 0.02	2.933PheGly: 2.933 ± 0.029	0.899PheHis: 0.899 ± 0.012	1.732PheIle: 1.732 ± 0.021	1.558PheLys: 1.558 ± 0.017	3.425PheLeu: 3.425 ± 0.027	0.754PheMet: 0.754 ± 0.011	1.44PheAsn: 1.44 ± 0.015	1.967PhePro: 1.967 ± 0.021	1.352PheGln: 1.352 ± 0.016	1.967PheArg: 1.967 ± 0.02	2.941PheSer: 2.941 ± 0.023	2.225PheThr: 2.225 ± 0.022	2.478PheVal: 2.478 ± 0.022	0.714PheTrp: 0.714 ± 0.011	1.104PheTyr: 1.104 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.823GlyAla: 5.823 ± 0.04	0.976GlyCys: 0.976 ± 0.014	3.593GlyAsp: 3.593 ± 0.026	3.697GlyGlu: 3.697 ± 0.024	2.857GlyPhe: 2.857 ± 0.026	5.975GlyGly: 5.975 ± 0.063	1.7GlyHis: 1.7 ± 0.018	3.538GlyIle: 3.538 ± 0.028	3.587GlyLys: 3.587 ± 0.029	6.031GlyLeu: 6.031 ± 0.039	1.686GlyMet: 1.686 ± 0.02	2.536GlyAsn: 2.536 ± 0.024	3.324GlyPro: 3.324 ± 0.028	2.472GlyGln: 2.472 ± 0.023	4.206GlyArg: 4.206 ± 0.031	5.592GlySer: 5.592 ± 0.035	4.171GlyThr: 4.171 ± 0.029	4.512GlyVal: 4.512 ± 0.029	1.307GlyTrp: 1.307 ± 0.017	2.18GlyTyr: 2.18 ± 0.022	0.0GlyXaa: 0.0 ± 0.0
His	2.12HisAla: 2.12 ± 0.018	0.391HisCys: 0.391 ± 0.009	1.361HisAsp: 1.361 ± 0.018	1.364HisGlu: 1.364 ± 0.017	0.954HisPhe: 0.954 ± 0.012	1.74HisGly: 1.74 ± 0.019	0.858HisHis: 0.858 ± 0.015	1.235HisIle: 1.235 ± 0.014	0.972HisLys: 0.972 ± 0.014	2.227HisLeu: 2.227 ± 0.023	0.516HisMet: 0.516 ± 0.009	0.859HisAsn: 0.859 ± 0.013	1.697HisPro: 1.697 ± 0.016	0.963HisGln: 0.963 ± 0.014	1.567HisArg: 1.567 ± 0.016	1.857HisSer: 1.857 ± 0.021	1.409HisThr: 1.409 ± 0.015	1.558HisVal: 1.558 ± 0.015	0.371HisTrp: 0.371 ± 0.008	0.709HisTyr: 0.709 ± 0.01	0.0HisXaa: 0.0 ± 0.0
Ile	4.423IleAla: 4.423 ± 0.026	0.737IleCys: 0.737 ± 0.011	2.773IleAsp: 2.773 ± 0.024	2.757IleGlu: 2.757 ± 0.022	1.936IlePhe: 1.936 ± 0.023	3.225IleGly: 3.225 ± 0.029	1.166IleHis: 1.166 ± 0.013	2.359IleIle: 2.359 ± 0.025	2.11IleLys: 2.11 ± 0.019	4.277IleLeu: 4.277 ± 0.035	0.991IleMet: 0.991 ± 0.013	1.731IleAsn: 1.731 ± 0.014	2.974IlePro: 2.974 ± 0.024	1.787IleGln: 1.787 ± 0.017	2.653IleArg: 2.653 ± 0.019	3.601IleSer: 3.601 ± 0.025	2.887IleThr: 2.887 ± 0.024	3.225IleVal: 3.225 ± 0.032	0.746IleTrp: 0.746 ± 0.011	1.39IleTyr: 1.39 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	4.377LysAla: 4.377 ± 0.033	0.523LysCys: 0.523 ± 0.011	2.865LysAsp: 2.865 ± 0.023	3.452LysGlu: 3.452 ± 0.03	1.447LysPhe: 1.447 ± 0.017	3.172LysGly: 3.172 ± 0.026	1.21LysHis: 1.21 ± 0.017	2.233LysIle: 2.233 ± 0.021	3.484LysLys: 3.484 ± 0.047	4.027LysLeu: 4.027 ± 0.028	1.024LysMet: 1.024 ± 0.012	1.803LysAsn: 1.803 ± 0.018	2.72LysPro: 2.72 ± 0.024	1.879LysGln: 1.879 ± 0.018	3.445LysArg: 3.445 ± 0.03	3.328LysSer: 3.328 ± 0.026	2.886LysThr: 2.886 ± 0.023	2.834LysVal: 2.834 ± 0.023	0.716LysTrp: 0.716 ± 0.01	1.402LysTyr: 1.402 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	7.991LeuAla: 7.991 ± 0.041	1.247LeuCys: 1.247 ± 0.014	4.901LeuAsp: 4.901 ± 0.026	5.234LeuGlu: 5.234 ± 0.032	3.295LeuPhe: 3.295 ± 0.028	5.933LeuGly: 5.933 ± 0.039	2.319LeuHis: 2.319 ± 0.021	3.778LeuIle: 3.778 ± 0.027	4.134LeuLys: 4.134 ± 0.026	8.092LeuLeu: 8.092 ± 0.055	1.71LeuMet: 1.71 ± 0.019	3.103LeuAsn: 3.103 ± 0.023	5.611LeuPro: 5.611 ± 0.039	3.727LeuGln: 3.727 ± 0.026	5.626LeuArg: 5.626 ± 0.038	7.047LeuSer: 7.047 ± 0.039	4.759LeuThr: 4.759 ± 0.031	5.363LeuVal: 5.363 ± 0.035	1.226LeuTrp: 1.226 ± 0.014	2.377LeuTyr: 2.377 ± 0.022	0.0LeuXaa: 0.0 ± 0.0
Met	2.179MetAla: 2.179 ± 0.018	0.276MetCys: 0.276 ± 0.007	1.21MetAsp: 1.21 ± 0.016	1.197MetGlu: 1.197 ± 0.018	0.788MetPhe: 0.788 ± 0.01	1.465MetGly: 1.465 ± 0.016	0.576MetHis: 0.576 ± 0.009	0.949MetIle: 0.949 ± 0.013	1.007MetLys: 1.007 ± 0.012	1.892MetLeu: 1.892 ± 0.019	0.553MetMet: 0.553 ± 0.009	0.795MetAsn: 0.795 ± 0.012	1.316MetPro: 1.316 ± 0.017	0.872MetGln: 0.872 ± 0.011	1.33MetArg: 1.33 ± 0.014	1.85MetSer: 1.85 ± 0.019	1.218MetThr: 1.218 ± 0.013	1.298MetVal: 1.298 ± 0.013	0.302MetTrp: 0.302 ± 0.007	0.589MetTyr: 0.589 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	3.383AsnAla: 3.383 ± 0.024	0.455AsnCys: 0.455 ± 0.008	1.939AsnAsp: 1.939 ± 0.021	1.944AsnGlu: 1.944 ± 0.021	1.394AsnPhe: 1.394 ± 0.016	3.037AsnGly: 3.037 ± 0.029	0.829AsnHis: 0.829 ± 0.01	2.005AsnIle: 2.005 ± 0.018	1.573AsnLys: 1.573 ± 0.017	3.087AsnLeu: 3.087 ± 0.027	0.827AsnMet: 0.827 ± 0.013	1.423AsnAsn: 1.423 ± 0.019	2.328AsnPro: 2.328 ± 0.021	1.242AsnGln: 1.242 ± 0.016	1.848AsnArg: 1.848 ± 0.017	2.581AsnSer: 2.581 ± 0.025	2.233AsnThr: 2.233 ± 0.019	2.422AsnVal: 2.422 ± 0.019	0.597AsnTrp: 0.597 ± 0.012	1.083AsnTyr: 1.083 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.625ProAla: 5.625 ± 0.045	0.584ProCys: 0.584 ± 0.011	3.039ProAsp: 3.039 ± 0.025	3.643ProGlu: 3.643 ± 0.031	2.071ProPhe: 2.071 ± 0.016	3.916ProGly: 3.916 ± 0.03	1.455ProHis: 1.455 ± 0.017	2.541ProIle: 2.541 ± 0.021	2.792ProLys: 2.792 ± 0.021	4.8ProLeu: 4.8 ± 0.029	1.112ProMet: 1.112 ± 0.014	2.237ProAsn: 2.237 ± 0.019	5.186ProPro: 5.186 ± 0.063	2.542ProGln: 2.542 ± 0.024	3.515ProArg: 3.515 ± 0.029	5.945ProSer: 5.945 ± 0.043	4.2ProThr: 4.2 ± 0.035	3.497ProVal: 3.497 ± 0.023	0.798ProTrp: 0.798 ± 0.01	1.581ProTyr: 1.581 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.478GlnAla: 3.478 ± 0.027	0.481GlnCys: 0.481 ± 0.009	2.028GlnAsp: 2.028 ± 0.018	2.283GlnGlu: 2.283 ± 0.023	1.284GlnPhe: 1.284 ± 0.014	2.407GlnGly: 2.407 ± 0.021	1.141GlnHis: 1.141 ± 0.015	1.825GlnIle: 1.825 ± 0.018	1.96GlnLys: 1.96 ± 0.019	3.396GlnLeu: 3.396 ± 0.024	0.868GlnMet: 0.868 ± 0.014	1.532GlnAsn: 1.532 ± 0.017	2.493GlnPro: 2.493 ± 0.028	2.295GlnGln: 2.295 ± 0.041	2.664GlnArg: 2.664 ± 0.023	2.948GlnSer: 2.948 ± 0.023	2.305GlnThr: 2.305 ± 0.018	2.095GlnVal: 2.095 ± 0.018	0.615GlnTrp: 0.615 ± 0.011	1.197GlnTyr: 1.197 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	5.001ArgAla: 5.001 ± 0.034	0.812ArgCys: 0.812 ± 0.013	3.254ArgAsp: 3.254 ± 0.028	3.715ArgGlu: 3.715 ± 0.033	2.155ArgPhe: 2.155 ± 0.02	3.826ArgGly: 3.826 ± 0.032	1.568ArgHis: 1.568 ± 0.016	2.871ArgIle: 2.871 ± 0.023	3.524ArgLys: 3.524 ± 0.027	5.289ArgLeu: 5.289 ± 0.032	1.369ArgMet: 1.369 ± 0.013	2.247ArgAsn: 2.247 ± 0.022	3.569ArgPro: 3.569 ± 0.026	2.499ArgGln: 2.499 ± 0.021	5.095ArgArg: 5.095 ± 0.042	4.74ArgSer: 4.74 ± 0.034	3.513ArgThr: 3.513 ± 0.025	3.361ArgVal: 3.361 ± 0.024	1.023ArgTrp: 1.023 ± 0.014	1.667ArgTyr: 1.667 ± 0.016	0.0ArgXaa: 0.0 ± 0.0
Ser	6.893SerAla: 6.893 ± 0.038	0.937SerCys: 0.937 ± 0.014	3.979SerAsp: 3.979 ± 0.026	3.859SerGlu: 3.859 ± 0.03	2.998SerPhe: 2.998 ± 0.022	5.437SerGly: 5.437 ± 0.038	1.927SerHis: 1.927 ± 0.019	3.847SerIle: 3.847 ± 0.029	3.605SerLys: 3.605 ± 0.031	6.838SerLeu: 6.838 ± 0.041	1.714SerMet: 1.714 ± 0.018	2.891SerAsn: 2.891 ± 0.023	5.363SerPro: 5.363 ± 0.044	2.987SerGln: 2.987 ± 0.024	4.793SerArg: 4.793 ± 0.036	8.032SerSer: 8.032 ± 0.067	5.572SerThr: 5.572 ± 0.035	4.561SerVal: 4.561 ± 0.026	1.166SerTrp: 1.166 ± 0.013	2.085SerTyr: 2.085 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	5.524ThrAla: 5.524 ± 0.034	0.843ThrCys: 0.843 ± 0.012	2.788ThrAsp: 2.788 ± 0.025	2.947ThrGlu: 2.947 ± 0.023	2.409ThrPhe: 2.409 ± 0.021	4.16ThrGly: 4.16 ± 0.029	1.393ThrHis: 1.393 ± 0.014	3.092ThrIle: 3.092 ± 0.026	2.674ThrLys: 2.674 ± 0.022	5.433ThrLeu: 5.433 ± 0.032	1.206ThrMet: 1.206 ± 0.017	2.15ThrAsn: 2.15 ± 0.019	4.489ThrPro: 4.489 ± 0.034	2.161ThrGln: 2.161 ± 0.02	3.237ThrArg: 3.237 ± 0.026	5.349ThrSer: 5.349 ± 0.036	4.233ThrThr: 4.233 ± 0.032	3.785ThrVal: 3.785 ± 0.027	0.954ThrTrp: 0.954 ± 0.012	1.713ThrTyr: 1.713 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.55ValAla: 5.55 ± 0.033	0.859ValCys: 0.859 ± 0.012	3.676ValAsp: 3.676 ± 0.025	3.904ValGlu: 3.904 ± 0.03	2.477ValPhe: 2.477 ± 0.024	4.26ValGly: 4.26 ± 0.031	1.475ValHis: 1.475 ± 0.015	2.795ValIle: 2.795 ± 0.023	2.915ValLys: 2.915 ± 0.026	5.594ValLeu: 5.594 ± 0.037	1.305ValMet: 1.305 ± 0.014	2.182ValAsn: 2.182 ± 0.016	3.684ValPro: 3.684 ± 0.031	2.472ValGln: 2.472 ± 0.02	3.531ValArg: 3.531 ± 0.024	4.491ValSer: 4.491 ± 0.027	3.514ValThr: 3.514 ± 0.029	4.385ValVal: 4.385 ± 0.032	0.96ValTrp: 0.96 ± 0.013	1.787ValTyr: 1.787 ± 0.019	0.0ValXaa: 0.0 ± 0.0
Trp	1.231TrpAla: 1.231 ± 0.015	0.233TrpCys: 0.233 ± 0.006	0.934TrpAsp: 0.934 ± 0.014	0.879TrpGlu: 0.879 ± 0.013	0.585TrpPhe: 0.585 ± 0.011	1.033TrpGly: 1.033 ± 0.015	0.391TrpHis: 0.391 ± 0.007	0.811TrpIle: 0.811 ± 0.013	0.868TrpLys: 0.868 ± 0.011	1.412TrpLeu: 1.412 ± 0.018	0.399TrpMet: 0.399 ± 0.008	0.676TrpAsn: 0.676 ± 0.012	0.673TrpPro: 0.673 ± 0.012	0.599TrpGln: 0.599 ± 0.009	1.039TrpArg: 1.039 ± 0.014	1.132TrpSer: 1.132 ± 0.014	1.012TrpThr: 1.012 ± 0.014	0.973TrpVal: 0.973 ± 0.013	0.3TrpTrp: 0.3 ± 0.007	0.494TrpTyr: 0.494 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.355TyrAla: 2.355 ± 0.02	0.44TyrCys: 0.44 ± 0.008	1.674TyrAsp: 1.674 ± 0.016	1.579TyrGlu: 1.579 ± 0.016	1.233TyrPhe: 1.233 ± 0.015	2.165TyrGly: 2.165 ± 0.021	0.757TyrHis: 0.757 ± 0.012	1.402TyrIle: 1.402 ± 0.016	1.174TyrLys: 1.174 ± 0.014	2.591TyrLeu: 2.591 ± 0.022	0.651TyrMet: 0.651 ± 0.011	1.144TyrAsn: 1.144 ± 0.014	1.531TyrPro: 1.531 ± 0.018	1.102TyrGln: 1.102 ± 0.015	1.597TyrArg: 1.597 ± 0.016	1.994TyrSer: 1.994 ± 0.017	1.762TyrThr: 1.762 ± 0.017	1.718TyrVal: 1.718 ± 0.018	0.475TyrTrp: 0.475 ± 0.01	0.966TyrTyr: 0.966 ± 0.014	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 14732 proteins (6378640 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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