Amino acid dipepetide frequency for Roseivivax pacificus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.617AlaAla: 16.617 ± 0.156	1.105AlaCys: 1.105 ± 0.028	6.605AlaAsp: 6.605 ± 0.074	9.011AlaGlu: 9.011 ± 0.11	4.251AlaPhe: 4.251 ± 0.058	10.928AlaGly: 10.928 ± 0.105	2.314AlaHis: 2.314 ± 0.046	5.445AlaIle: 5.445 ± 0.071	3.064AlaLys: 3.064 ± 0.051	14.165AlaLeu: 14.165 ± 0.15	3.865AlaMet: 3.865 ± 0.054	2.319AlaAsn: 2.319 ± 0.046	6.281AlaPro: 6.281 ± 0.08	4.335AlaGln: 4.335 ± 0.066	9.506AlaArg: 9.506 ± 0.11	5.645AlaSer: 5.645 ± 0.07	6.087AlaThr: 6.087 ± 0.065	8.497AlaVal: 8.497 ± 0.083	1.587AlaTrp: 1.587 ± 0.035	2.497AlaTyr: 2.497 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	1.058CysAla: 1.058 ± 0.027	0.117CysCys: 0.117 ± 0.011	0.61CysAsp: 0.61 ± 0.021	0.484CysGlu: 0.484 ± 0.021	0.316CysPhe: 0.316 ± 0.015	0.923CysGly: 0.923 ± 0.031	0.272CysHis: 0.272 ± 0.015	0.378CysIle: 0.378 ± 0.016	0.168CysLys: 0.168 ± 0.01	0.845CysLeu: 0.845 ± 0.022	0.163CysMet: 0.163 ± 0.012	0.203CysAsn: 0.203 ± 0.011	0.478CysPro: 0.478 ± 0.021	0.209CysGln: 0.209 ± 0.014	0.617CysArg: 0.617 ± 0.023	0.421CysSer: 0.421 ± 0.017	0.435CysThr: 0.435 ± 0.019	0.606CysVal: 0.606 ± 0.02	0.115CysTrp: 0.115 ± 0.01	0.201CysTyr: 0.201 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.144AspAla: 7.144 ± 0.079	0.524AspCys: 0.524 ± 0.022	3.365AspAsp: 3.365 ± 0.055	3.808AspGlu: 3.808 ± 0.051	2.313AspPhe: 2.313 ± 0.041	5.449AspGly: 5.449 ± 0.076	1.373AspHis: 1.373 ± 0.029	2.781AspIle: 2.781 ± 0.043	1.453AspLys: 1.453 ± 0.038	6.436AspLeu: 6.436 ± 0.071	1.754AspMet: 1.754 ± 0.036	1.205AspAsn: 1.205 ± 0.032	4.029AspPro: 4.029 ± 0.051	1.734AspGln: 1.734 ± 0.036	4.712AspArg: 4.712 ± 0.067	2.26AspSer: 2.26 ± 0.044	2.935AspThr: 2.935 ± 0.047	4.1AspVal: 4.1 ± 0.054	1.242AspTrp: 1.242 ± 0.026	1.52AspTyr: 1.52 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	9.177GluAla: 9.177 ± 0.114	0.355GluCys: 0.355 ± 0.015	3.962GluAsp: 3.962 ± 0.056	4.289GluGlu: 4.289 ± 0.069	1.722GluPhe: 1.722 ± 0.04	5.847GluGly: 5.847 ± 0.076	1.179GluHis: 1.179 ± 0.028	3.716GluIle: 3.716 ± 0.057	2.009GluLys: 2.009 ± 0.047	5.51GluLeu: 5.51 ± 0.07	1.943GluMet: 1.943 ± 0.036	1.677GluAsn: 1.677 ± 0.037	2.855GluPro: 2.855 ± 0.055	2.039GluGln: 2.039 ± 0.036	4.803GluArg: 4.803 ± 0.075	2.636GluSer: 2.636 ± 0.043	4.22GluThr: 4.22 ± 0.055	4.807GluVal: 4.807 ± 0.06	0.707GluTrp: 0.707 ± 0.024	1.019GluTyr: 1.019 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	4.328PheAla: 4.328 ± 0.052	0.405PheCys: 0.405 ± 0.017	2.781PheAsp: 2.781 ± 0.05	2.368PheGlu: 2.368 ± 0.047	1.438PhePhe: 1.438 ± 0.034	3.686PheGly: 3.686 ± 0.054	0.76PheHis: 0.76 ± 0.02	1.507PheIle: 1.507 ± 0.04	0.718PheLys: 0.718 ± 0.024	3.397PheLeu: 3.397 ± 0.06	0.8PheMet: 0.8 ± 0.025	0.933PheAsn: 0.933 ± 0.028	1.58PhePro: 1.58 ± 0.034	0.923PheGln: 0.923 ± 0.027	2.258PheArg: 2.258 ± 0.042	2.07PheSer: 2.07 ± 0.039	1.997PheThr: 1.997 ± 0.038	2.703PheVal: 2.703 ± 0.044	0.573PheTrp: 0.573 ± 0.023	0.848PheTyr: 0.848 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	10.382GlyAla: 10.382 ± 0.096	0.861GlyCys: 0.861 ± 0.027	4.841GlyAsp: 4.841 ± 0.063	5.358GlyGlu: 5.358 ± 0.065	3.603GlyPhe: 3.603 ± 0.05	7.806GlyGly: 7.806 ± 0.101	2.012GlyHis: 2.012 ± 0.04	4.504GlyIle: 4.504 ± 0.06	2.667GlyLys: 2.667 ± 0.049	9.489GlyLeu: 9.489 ± 0.092	2.706GlyMet: 2.706 ± 0.044	1.971GlyAsn: 1.971 ± 0.039	4.003GlyPro: 4.003 ± 0.06	3.01GlyGln: 3.01 ± 0.05	6.415GlyArg: 6.415 ± 0.081	4.467GlySer: 4.467 ± 0.062	4.975GlyThr: 4.975 ± 0.067	6.448GlyVal: 6.448 ± 0.073	1.542GlyTrp: 1.542 ± 0.031	2.314GlyTyr: 2.314 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.387HisAla: 2.387 ± 0.043	0.23HisCys: 0.23 ± 0.013	1.348HisAsp: 1.348 ± 0.033	1.23HisGlu: 1.23 ± 0.033	0.816HisPhe: 0.816 ± 0.023	1.947HisGly: 1.947 ± 0.039	0.574HisHis: 0.574 ± 0.025	0.836HisIle: 0.836 ± 0.024	0.43HisLys: 0.43 ± 0.018	2.101HisLeu: 2.101 ± 0.046	0.549HisMet: 0.549 ± 0.02	0.41HisAsn: 0.41 ± 0.016	1.309HisPro: 1.309 ± 0.032	0.534HisGln: 0.534 ± 0.017	1.443HisArg: 1.443 ± 0.034	0.875HisSer: 0.875 ± 0.025	0.779HisThr: 0.779 ± 0.023	1.621HisVal: 1.621 ± 0.037	0.392HisTrp: 0.392 ± 0.016	0.517HisTyr: 0.517 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.649IleAla: 6.649 ± 0.075	0.56IleCys: 0.56 ± 0.017	3.21IleAsp: 3.21 ± 0.051	3.412IleGlu: 3.412 ± 0.056	1.727IlePhe: 1.727 ± 0.042	4.526IleGly: 4.526 ± 0.058	0.823IleHis: 0.823 ± 0.026	1.861IleIle: 1.861 ± 0.046	1.017IleLys: 1.017 ± 0.031	4.629IleLeu: 4.629 ± 0.074	0.996IleMet: 0.996 ± 0.026	1.076IleAsn: 1.076 ± 0.032	2.347IlePro: 2.347 ± 0.042	1.03IleGln: 1.03 ± 0.031	3.15IleArg: 3.15 ± 0.048	2.807IleSer: 2.807 ± 0.044	2.665IleThr: 2.665 ± 0.044	3.675IleVal: 3.675 ± 0.059	0.676IleTrp: 0.676 ± 0.022	1.079IleTyr: 1.079 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.35LysAla: 3.35 ± 0.051	0.147LysCys: 0.147 ± 0.01	1.451LysAsp: 1.451 ± 0.035	1.382LysGlu: 1.382 ± 0.041	0.696LysPhe: 0.696 ± 0.021	2.288LysGly: 2.288 ± 0.042	0.496LysHis: 0.496 ± 0.02	1.306LysIle: 1.306 ± 0.033	0.894LysLys: 0.894 ± 0.035	2.64LysLeu: 2.64 ± 0.049	0.687LysMet: 0.687 ± 0.023	0.575LysAsn: 0.575 ± 0.02	1.53LysPro: 1.53 ± 0.037	0.734LysGln: 0.734 ± 0.023	2.006LysArg: 2.006 ± 0.042	1.435LysSer: 1.435 ± 0.038	1.637LysThr: 1.637 ± 0.039	2.036LysVal: 2.036 ± 0.045	0.335LysTrp: 0.335 ± 0.015	0.499LysTyr: 0.499 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.175LeuAla: 13.175 ± 0.138	0.969LeuCys: 0.969 ± 0.027	6.261LeuAsp: 6.261 ± 0.072	5.773LeuGlu: 5.773 ± 0.075	3.549LeuPhe: 3.549 ± 0.058	8.821LeuGly: 8.821 ± 0.095	1.961LeuHis: 1.961 ± 0.044	4.781LeuIle: 4.781 ± 0.069	2.703LeuLys: 2.703 ± 0.045	9.338LeuLeu: 9.338 ± 0.126	2.667LeuMet: 2.667 ± 0.047	2.356LeuAsn: 2.356 ± 0.038	5.872LeuPro: 5.872 ± 0.077	2.726LeuGln: 2.726 ± 0.045	7.634LeuArg: 7.634 ± 0.082	6.817LeuSer: 6.817 ± 0.081	5.921LeuThr: 5.921 ± 0.064	7.198LeuVal: 7.198 ± 0.079	1.436LeuTrp: 1.436 ± 0.038	1.999LeuTyr: 1.999 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.463MetAla: 3.463 ± 0.044	0.169MetCys: 0.169 ± 0.01	1.361MetAsp: 1.361 ± 0.033	1.403MetGlu: 1.403 ± 0.03	0.759MetPhe: 0.759 ± 0.023	2.236MetGly: 2.236 ± 0.04	0.458MetHis: 0.458 ± 0.018	1.494MetIle: 1.494 ± 0.033	0.948MetLys: 0.948 ± 0.026	2.641MetLeu: 2.641 ± 0.049	0.78MetMet: 0.78 ± 0.026	0.755MetAsn: 0.755 ± 0.022	1.635MetPro: 1.635 ± 0.035	0.941MetGln: 0.941 ± 0.024	1.972MetArg: 1.972 ± 0.035	1.812MetSer: 1.812 ± 0.032	2.178MetThr: 2.178 ± 0.037	1.925MetVal: 1.925 ± 0.037	0.247MetTrp: 0.247 ± 0.013	0.316MetTyr: 0.316 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.826AsnAla: 2.826 ± 0.051	0.229AsnCys: 0.229 ± 0.014	1.294AsnAsp: 1.294 ± 0.03	1.118AsnGlu: 1.118 ± 0.031	0.816AsnPhe: 0.816 ± 0.024	2.119AsnGly: 2.119 ± 0.039	0.442AsnHis: 0.442 ± 0.018	1.156AsnIle: 1.156 ± 0.033	0.494AsnLys: 0.494 ± 0.023	2.384AsnLeu: 2.384 ± 0.044	0.604AsnMet: 0.604 ± 0.021	0.557AsnAsn: 0.557 ± 0.02	1.689AsnPro: 1.689 ± 0.041	0.606AsnGln: 0.606 ± 0.021	1.634AsnArg: 1.634 ± 0.033	1.023AsnSer: 1.023 ± 0.029	1.2AsnThr: 1.2 ± 0.032	1.659AsnVal: 1.659 ± 0.034	0.379AsnTrp: 0.379 ± 0.017	0.585AsnTyr: 0.585 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	6.087ProAla: 6.087 ± 0.07	0.371ProCys: 0.371 ± 0.016	4.017ProAsp: 4.017 ± 0.054	4.978ProGlu: 4.978 ± 0.071	1.978ProPhe: 1.978 ± 0.037	5.044ProGly: 5.044 ± 0.067	1.072ProHis: 1.072 ± 0.03	2.055ProIle: 2.055 ± 0.038	1.401ProLys: 1.401 ± 0.033	4.875ProLeu: 4.875 ± 0.063	1.259ProMet: 1.259 ± 0.032	1.147ProAsn: 1.147 ± 0.025	2.462ProPro: 2.462 ± 0.046	1.725ProGln: 1.725 ± 0.036	3.255ProArg: 3.255 ± 0.048	2.616ProSer: 2.616 ± 0.038	2.403ProThr: 2.403 ± 0.036	4.459ProVal: 4.459 ± 0.06	0.732ProTrp: 0.732 ± 0.022	1.188ProTyr: 1.188 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	3.935GlnAla: 3.935 ± 0.054	0.165GlnCys: 0.165 ± 0.01	1.672GlnAsp: 1.672 ± 0.034	1.702GlnGlu: 1.702 ± 0.039	0.946GlnPhe: 0.946 ± 0.025	2.657GlnGly: 2.657 ± 0.047	0.558GlnHis: 0.558 ± 0.022	1.792GlnIle: 1.792 ± 0.038	0.904GlnLys: 0.904 ± 0.028	2.814GlnLeu: 2.814 ± 0.048	1.003GlnMet: 1.003 ± 0.027	0.777GlnAsn: 0.777 ± 0.023	1.596GlnPro: 1.596 ± 0.036	1.071GlnGln: 1.071 ± 0.033	2.2GlnArg: 2.2 ± 0.035	1.669GlnSer: 1.669 ± 0.032	1.687GlnThr: 1.687 ± 0.041	2.43GlnVal: 2.43 ± 0.042	0.363GlnTrp: 0.363 ± 0.017	0.532GlnTyr: 0.532 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	8.662ArgAla: 8.662 ± 0.093	0.507ArgCys: 0.507 ± 0.021	4.579ArgAsp: 4.579 ± 0.066	4.556ArgGlu: 4.556 ± 0.069	2.736ArgPhe: 2.736 ± 0.043	5.182ArgGly: 5.182 ± 0.063	1.7ArgHis: 1.7 ± 0.038	3.901ArgIle: 3.901 ± 0.057	2.082ArgLys: 2.082 ± 0.042	7.899ArgLeu: 7.899 ± 0.097	2.076ArgMet: 2.076 ± 0.039	1.781ArgAsn: 1.781 ± 0.039	3.756ArgPro: 3.756 ± 0.05	2.418ArgGln: 2.418 ± 0.046	5.714ArgArg: 5.714 ± 0.076	3.474ArgSer: 3.474 ± 0.047	3.283ArgThr: 3.283 ± 0.047	4.935ArgVal: 4.935 ± 0.07	0.992ArgTrp: 0.992 ± 0.029	1.636ArgTyr: 1.636 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	5.916SerAla: 5.916 ± 0.068	0.454SerCys: 0.454 ± 0.019	3.296SerAsp: 3.296 ± 0.052	3.347SerGlu: 3.347 ± 0.052	2.183SerPhe: 2.183 ± 0.045	5.532SerGly: 5.532 ± 0.069	1.076SerHis: 1.076 ± 0.027	2.34SerIle: 2.34 ± 0.045	1.233SerLys: 1.233 ± 0.032	5.059SerLeu: 5.059 ± 0.062	1.341SerMet: 1.341 ± 0.031	1.153SerAsn: 1.153 ± 0.031	2.541SerPro: 2.541 ± 0.043	1.542SerGln: 1.542 ± 0.034	3.488SerArg: 3.488 ± 0.057	2.67SerSer: 2.67 ± 0.05	2.528SerThr: 2.528 ± 0.044	3.869SerVal: 3.869 ± 0.056	0.728SerTrp: 0.728 ± 0.027	1.281SerTyr: 1.281 ± 0.03	0.0SerXaa: 0.0 ± 0.0
Thr	6.153ThrAla: 6.153 ± 0.065	0.496ThrCys: 0.496 ± 0.019	3.14ThrAsp: 3.14 ± 0.046	3.395ThrGlu: 3.395 ± 0.051	1.982ThrPhe: 1.982 ± 0.044	5.671ThrGly: 5.671 ± 0.064	1.074ThrHis: 1.074 ± 0.029	2.479ThrIle: 2.479 ± 0.044	1.167ThrLys: 1.167 ± 0.034	6.203ThrLeu: 6.203 ± 0.076	1.247ThrMet: 1.247 ± 0.03	1.185ThrAsn: 1.185 ± 0.029	3.479ThrPro: 3.479 ± 0.056	1.536ThrGln: 1.536 ± 0.035	3.86ThrArg: 3.86 ± 0.055	2.685ThrSer: 2.685 ± 0.046	2.791ThrThr: 2.791 ± 0.056	4.143ThrVal: 4.143 ± 0.057	0.696ThrTrp: 0.696 ± 0.024	1.199ThrTyr: 1.199 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	8.947ValAla: 8.947 ± 0.077	0.595ValCys: 0.595 ± 0.021	4.023ValAsp: 4.023 ± 0.058	4.755ValGlu: 4.755 ± 0.062	2.841ValPhe: 2.841 ± 0.049	5.546ValGly: 5.546 ± 0.073	1.293ValHis: 1.293 ± 0.027	4.036ValIle: 4.036 ± 0.065	1.872ValLys: 1.872 ± 0.042	7.659ValLeu: 7.659 ± 0.095	2.141ValMet: 2.141 ± 0.038	1.789ValAsn: 1.789 ± 0.039	3.835ValPro: 3.835 ± 0.058	2.082ValGln: 2.082 ± 0.03	4.463ValArg: 4.463 ± 0.054	4.302ValSer: 4.302 ± 0.054	4.951ValThr: 4.951 ± 0.063	5.649ValVal: 5.649 ± 0.072	0.944ValTrp: 0.944 ± 0.032	1.453ValTyr: 1.453 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.375TrpAla: 1.375 ± 0.033	0.129TrpCys: 0.129 ± 0.009	0.764TrpAsp: 0.764 ± 0.026	0.729TrpGlu: 0.729 ± 0.023	0.557TrpPhe: 0.557 ± 0.021	1.062TrpGly: 1.062 ± 0.027	0.375TrpHis: 0.375 ± 0.017	0.71TrpIle: 0.71 ± 0.023	0.443TrpLys: 0.443 ± 0.018	1.73TrpLeu: 1.73 ± 0.041	0.419TrpMet: 0.419 ± 0.017	0.425TrpAsn: 0.425 ± 0.016	0.756TrpPro: 0.756 ± 0.024	0.658TrpGln: 0.658 ± 0.024	1.14TrpArg: 1.14 ± 0.031	0.817TrpSer: 0.817 ± 0.026	0.816TrpThr: 0.816 ± 0.028	0.873TrpVal: 0.873 ± 0.024	0.223TrpTrp: 0.223 ± 0.013	0.266TrpTyr: 0.266 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.491TyrAla: 2.491 ± 0.038	0.226TyrCys: 0.226 ± 0.012	1.559TyrAsp: 1.559 ± 0.037	1.373TyrGlu: 1.373 ± 0.034	0.843TyrPhe: 0.843 ± 0.024	2.103TyrGly: 2.103 ± 0.035	0.517TyrHis: 0.517 ± 0.019	0.836TyrIle: 0.836 ± 0.026	0.458TyrLys: 0.458 ± 0.017	2.144TyrLeu: 2.144 ± 0.034	0.492TyrMet: 0.492 ± 0.02	0.521TyrAsn: 0.521 ± 0.019	1.088TyrPro: 1.088 ± 0.027	0.619TyrGln: 0.619 ± 0.021	1.6TyrArg: 1.6 ± 0.031	1.08TyrSer: 1.08 ± 0.027	1.094TyrThr: 1.094 ± 0.031	1.544TyrVal: 1.544 ± 0.034	0.358TyrTrp: 0.358 ± 0.014	0.558TyrTyr: 0.558 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4615 proteins (1438208 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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