Amino acid dipepetide frequency for Gryllotalpicola protaetiae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.18AlaAla: 22.18 ± 0.245	0.662AlaCys: 0.662 ± 0.027	8.128AlaAsp: 8.128 ± 0.116	7.952AlaGlu: 7.952 ± 0.112	4.05AlaPhe: 4.05 ± 0.056	12.673AlaGly: 12.673 ± 0.111	2.687AlaHis: 2.687 ± 0.048	5.993AlaIle: 5.993 ± 0.079	3.026AlaLys: 3.026 ± 0.065	14.523AlaLeu: 14.523 ± 0.162	2.543AlaMet: 2.543 ± 0.044	2.568AlaAsn: 2.568 ± 0.055	6.566AlaPro: 6.566 ± 0.089	4.381AlaGln: 4.381 ± 0.074	9.466AlaArg: 9.466 ± 0.126	8.177AlaSer: 8.177 ± 0.084	7.396AlaThr: 7.396 ± 0.101	11.844AlaVal: 11.844 ± 0.123	2.021AlaTrp: 2.021 ± 0.05	2.47AlaTyr: 2.47 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.649CysAla: 0.649 ± 0.025	0.056CysCys: 0.056 ± 0.008	0.283CysAsp: 0.283 ± 0.017	0.232CysGlu: 0.232 ± 0.015	0.167CysPhe: 0.167 ± 0.012	0.544CysGly: 0.544 ± 0.023	0.103CysHis: 0.103 ± 0.01	0.186CysIle: 0.186 ± 0.014	0.061CysLys: 0.061 ± 0.007	0.441CysLeu: 0.441 ± 0.019	0.071CysMet: 0.071 ± 0.008	0.089CysAsn: 0.089 ± 0.009	0.279CysPro: 0.279 ± 0.018	0.123CysGln: 0.123 ± 0.011	0.3CysArg: 0.3 ± 0.019	0.359CysSer: 0.359 ± 0.02	0.318CysThr: 0.318 ± 0.018	0.4CysVal: 0.4 ± 0.018	0.084CysTrp: 0.084 ± 0.008	0.095CysTyr: 0.095 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	8.919AspAla: 8.919 ± 0.107	0.235AspCys: 0.235 ± 0.015	3.706AspAsp: 3.706 ± 0.079	4.347AspGlu: 4.347 ± 0.077	1.917AspPhe: 1.917 ± 0.037	5.777AspGly: 5.777 ± 0.096	1.198AspHis: 1.198 ± 0.038	2.096AspIle: 2.096 ± 0.046	1.047AspLys: 1.047 ± 0.034	5.432AspLeu: 5.432 ± 0.071	0.613AspMet: 0.613 ± 0.027	0.976AspAsn: 0.976 ± 0.032	3.787AspPro: 3.787 ± 0.07	1.62AspGln: 1.62 ± 0.038	4.03AspArg: 4.03 ± 0.071	2.836AspSer: 2.836 ± 0.166	2.67AspThr: 2.67 ± 0.057	4.958AspVal: 4.958 ± 0.076	0.992AspTrp: 0.992 ± 0.031	1.387AspTyr: 1.387 ± 0.035	0.0AspXaa: 0.0 ± 0.0
Glu	6.749GluAla: 6.749 ± 0.089	0.199GluCys: 0.199 ± 0.014	2.206GluAsp: 2.206 ± 0.05	2.357GluGlu: 2.357 ± 0.053	1.829GluPhe: 1.829 ± 0.04	3.473GluGly: 3.473 ± 0.061	1.404GluHis: 1.404 ± 0.038	2.398GluIle: 2.398 ± 0.047	1.452GluLys: 1.452 ± 0.041	7.707GluLeu: 7.707 ± 0.105	0.762GluMet: 0.762 ± 0.025	1.186GluAsn: 1.186 ± 0.03	2.81GluPro: 2.81 ± 0.058	2.189GluGln: 2.189 ± 0.041	4.908GluArg: 4.908 ± 0.072	2.858GluSer: 2.858 ± 0.056	2.943GluThr: 2.943 ± 0.051	4.358GluVal: 4.358 ± 0.072	0.883GluTrp: 0.883 ± 0.028	1.135GluTyr: 1.135 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.612PheAla: 4.612 ± 0.068	0.199PheCys: 0.199 ± 0.014	2.434PheAsp: 2.434 ± 0.052	1.91PheGlu: 1.91 ± 0.043	1.12PhePhe: 1.12 ± 0.038	3.58PheGly: 3.58 ± 0.061	0.62PheHis: 0.62 ± 0.028	1.246PheIle: 1.246 ± 0.038	0.557PheLys: 0.557 ± 0.023	2.837PheLeu: 2.837 ± 0.056	0.409PheMet: 0.409 ± 0.02	0.74PheAsn: 0.74 ± 0.034	1.455PhePro: 1.455 ± 0.035	0.873PheGln: 0.873 ± 0.031	1.831PheArg: 1.831 ± 0.039	1.718PheSer: 1.718 ± 0.039	2.189PheThr: 2.189 ± 0.046	2.827PheVal: 2.827 ± 0.056	0.527PheTrp: 0.527 ± 0.021	0.714PheTyr: 0.714 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	11.372GlyAla: 11.372 ± 0.137	0.57GlyCys: 0.57 ± 0.024	4.844GlyAsp: 4.844 ± 0.076	4.744GlyGlu: 4.744 ± 0.069	3.575GlyPhe: 3.575 ± 0.06	7.862GlyGly: 7.862 ± 0.102	1.951GlyHis: 1.951 ± 0.037	4.552GlyIle: 4.552 ± 0.071	2.377GlyLys: 2.377 ± 0.05	9.147GlyLeu: 9.147 ± 0.094	1.635GlyMet: 1.635 ± 0.041	1.833GlyAsn: 1.833 ± 0.05	3.802GlyPro: 3.802 ± 0.065	2.617GlyGln: 2.617 ± 0.056	6.392GlyArg: 6.392 ± 0.081	5.459GlySer: 5.459 ± 0.08	5.479GlyThr: 5.479 ± 0.094	7.948GlyVal: 7.948 ± 0.095	1.711GlyTrp: 1.711 ± 0.046	2.305GlyTyr: 2.305 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.494HisAla: 2.494 ± 0.048	0.108HisCys: 0.108 ± 0.011	1.308HisAsp: 1.308 ± 0.033	1.211HisGlu: 1.211 ± 0.032	0.6HisPhe: 0.6 ± 0.025	2.072HisGly: 2.072 ± 0.044	0.552HisHis: 0.552 ± 0.029	0.725HisIle: 0.725 ± 0.023	0.324HisLys: 0.324 ± 0.018	2.049HisLeu: 2.049 ± 0.047	0.274HisMet: 0.274 ± 0.016	0.385HisAsn: 0.385 ± 0.017	1.576HisPro: 1.576 ± 0.039	0.566HisGln: 0.566 ± 0.02	1.474HisArg: 1.474 ± 0.034	1.095HisSer: 1.095 ± 0.029	1.077HisThr: 1.077 ± 0.032	1.686HisVal: 1.686 ± 0.041	0.339HisTrp: 0.339 ± 0.018	0.472HisTyr: 0.472 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	7.174IleAla: 7.174 ± 0.092	0.235IleCys: 0.235 ± 0.016	3.213IleAsp: 3.213 ± 0.054	2.801IleGlu: 2.801 ± 0.062	1.151IlePhe: 1.151 ± 0.035	4.801IleGly: 4.801 ± 0.076	0.677IleHis: 0.677 ± 0.023	1.761IleIle: 1.761 ± 0.051	0.833IleLys: 0.833 ± 0.03	3.172IleLeu: 3.172 ± 0.048	0.598IleMet: 0.598 ± 0.024	0.882IleAsn: 0.882 ± 0.029	2.259IlePro: 2.259 ± 0.044	1.016IleGln: 1.016 ± 0.038	2.555IleArg: 2.555 ± 0.054	2.419IleSer: 2.419 ± 0.049	2.946IleThr: 2.946 ± 0.057	4.552IleVal: 4.552 ± 0.077	0.546IleTrp: 0.546 ± 0.023	0.79IleTyr: 0.79 ± 0.027	0.0IleXaa: 0.0 ± 0.0
Lys	2.806LysAla: 2.806 ± 0.056	0.078LysCys: 0.078 ± 0.008	1.168LysAsp: 1.168 ± 0.041	0.866LysGlu: 0.866 ± 0.032	0.547LysPhe: 0.547 ± 0.024	1.618LysGly: 1.618 ± 0.042	0.482LysHis: 0.482 ± 0.022	1.0LysIle: 1.0 ± 0.033	0.834LysLys: 0.834 ± 0.032	2.343LysLeu: 2.343 ± 0.051	0.359LysMet: 0.359 ± 0.017	0.61LysAsn: 0.61 ± 0.026	1.431LysPro: 1.431 ± 0.044	0.831LysGln: 0.831 ± 0.028	1.562LysArg: 1.562 ± 0.04	1.313LysSer: 1.313 ± 0.039	1.479LysThr: 1.479 ± 0.041	1.797LysVal: 1.797 ± 0.046	0.313LysTrp: 0.313 ± 0.017	0.475LysTyr: 0.475 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	15.541LeuAla: 15.541 ± 0.16	0.478LeuCys: 0.478 ± 0.024	6.416LeuAsp: 6.416 ± 0.088	5.24LeuGlu: 5.24 ± 0.081	2.934LeuPhe: 2.934 ± 0.064	9.475LeuGly: 9.475 ± 0.105	1.937LeuHis: 1.937 ± 0.043	4.81LeuIle: 4.81 ± 0.087	2.061LeuLys: 2.061 ± 0.049	9.96LeuLeu: 9.96 ± 0.123	1.514LeuMet: 1.514 ± 0.041	2.024LeuAsn: 2.024 ± 0.042	5.62LeuPro: 5.62 ± 0.104	2.565LeuGln: 2.565 ± 0.051	7.211LeuArg: 7.211 ± 0.091	5.766LeuSer: 5.766 ± 0.073	6.494LeuThr: 6.494 ± 0.087	9.112LeuVal: 9.112 ± 0.118	1.395LeuTrp: 1.395 ± 0.036	1.744LeuTyr: 1.744 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	1.923MetAla: 1.923 ± 0.046	0.079MetCys: 0.079 ± 0.008	0.637MetAsp: 0.637 ± 0.022	0.487MetGlu: 0.487 ± 0.02	0.506MetPhe: 0.506 ± 0.024	1.16MetGly: 1.16 ± 0.034	0.316MetHis: 0.316 ± 0.016	0.732MetIle: 0.732 ± 0.029	0.384MetLys: 0.384 ± 0.019	1.686MetLeu: 1.686 ± 0.04	0.251MetMet: 0.251 ± 0.017	0.434MetAsn: 0.434 ± 0.019	1.129MetPro: 1.129 ± 0.034	0.474MetGln: 0.474 ± 0.021	1.17MetArg: 1.17 ± 0.028	1.365MetSer: 1.365 ± 0.036	1.522MetThr: 1.522 ± 0.039	1.181MetVal: 1.181 ± 0.036	0.186MetTrp: 0.186 ± 0.013	0.249MetTyr: 0.249 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.653AsnAla: 2.653 ± 0.046	0.107AsnCys: 0.107 ± 0.009	1.156AsnAsp: 1.156 ± 0.037	0.96AsnGlu: 0.96 ± 0.031	0.686AsnPhe: 0.686 ± 0.027	2.11AsnGly: 2.11 ± 0.06	0.402AsnHis: 0.402 ± 0.019	0.849AsnIle: 0.849 ± 0.03	0.41AsnLys: 0.41 ± 0.022	1.963AsnLeu: 1.963 ± 0.049	0.309AsnMet: 0.309 ± 0.017	0.537AsnAsn: 0.537 ± 0.024	1.679AsnPro: 1.679 ± 0.038	0.621AsnGln: 0.621 ± 0.026	1.356AsnArg: 1.356 ± 0.042	1.169AsnSer: 1.169 ± 0.036	1.29AsnThr: 1.29 ± 0.04	1.825AsnVal: 1.825 ± 0.041	0.362AsnTrp: 0.362 ± 0.017	0.491AsnTyr: 0.491 ± 0.023	0.0AsnXaa: 0.0 ± 0.0
Pro	7.242ProAla: 7.242 ± 0.084	0.194ProCys: 0.194 ± 0.012	3.585ProAsp: 3.585 ± 0.079	3.646ProGlu: 3.646 ± 0.065	1.703ProPhe: 1.703 ± 0.035	5.052ProGly: 5.052 ± 0.075	1.063ProHis: 1.063 ± 0.035	2.2ProIle: 2.2 ± 0.041	1.201ProLys: 1.201 ± 0.033	5.032ProLeu: 5.032 ± 0.073	0.777ProMet: 0.777 ± 0.025	1.184ProAsn: 1.184 ± 0.029	2.209ProPro: 2.209 ± 0.056	1.666ProGln: 1.666 ± 0.042	3.337ProArg: 3.337 ± 0.055	3.243ProSer: 3.243 ± 0.064	3.28ProThr: 3.28 ± 0.074	4.913ProVal: 4.913 ± 0.071	0.907ProTrp: 0.907 ± 0.029	1.128ProTyr: 1.128 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.062GlnAla: 4.062 ± 0.07	0.119GlnCys: 0.119 ± 0.009	1.135GlnAsp: 1.135 ± 0.033	1.128GlnGlu: 1.128 ± 0.037	0.983GlnPhe: 0.983 ± 0.027	2.145GlnGly: 2.145 ± 0.046	0.68GlnHis: 0.68 ± 0.024	1.422GlnIle: 1.422 ± 0.037	0.754GlnLys: 0.754 ± 0.029	3.866GlnLeu: 3.866 ± 0.053	0.447GlnMet: 0.447 ± 0.022	0.756GlnAsn: 0.756 ± 0.031	1.719GlnPro: 1.719 ± 0.049	1.423GlnGln: 1.423 ± 0.046	2.305GlnArg: 2.305 ± 0.056	1.675GlnSer: 1.675 ± 0.045	1.808GlnThr: 1.808 ± 0.048	2.368GlnVal: 2.368 ± 0.055	0.456GlnTrp: 0.456 ± 0.019	0.696GlnTyr: 0.696 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.885ArgAla: 8.885 ± 0.11	0.294ArgCys: 0.294 ± 0.019	3.776ArgAsp: 3.776 ± 0.064	4.187ArgGlu: 4.187 ± 0.073	2.412ArgPhe: 2.412 ± 0.052	5.403ArgGly: 5.403 ± 0.087	1.651ArgHis: 1.651 ± 0.042	3.282ArgIle: 3.282 ± 0.05	1.396ArgLys: 1.396 ± 0.036	7.544ArgLeu: 7.544 ± 0.09	1.519ArgMet: 1.519 ± 0.041	1.402ArgAsn: 1.402 ± 0.035	3.599ArgPro: 3.599 ± 0.064	2.124ArgGln: 2.124 ± 0.045	6.324ArgArg: 6.324 ± 0.114	3.902ArgSer: 3.902 ± 0.06	3.805ArgThr: 3.805 ± 0.066	5.85ArgVal: 5.85 ± 0.08	1.126ArgTrp: 1.126 ± 0.03	1.552ArgTyr: 1.552 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	7.681SerAla: 7.681 ± 0.09	0.289SerCys: 0.289 ± 0.021	3.371SerAsp: 3.371 ± 0.077	2.601SerGlu: 2.601 ± 0.053	1.989SerPhe: 1.989 ± 0.044	6.109SerGly: 6.109 ± 0.096	1.06SerHis: 1.06 ± 0.034	2.614SerIle: 2.614 ± 0.052	1.229SerLys: 1.229 ± 0.037	5.466SerLeu: 5.466 ± 0.136	1.039SerMet: 1.039 ± 0.035	1.255SerAsn: 1.255 ± 0.036	3.187SerPro: 3.187 ± 0.062	1.567SerGln: 1.567 ± 0.046	3.622SerArg: 3.622 ± 0.062	3.661SerSer: 3.661 ± 0.074	3.516SerThr: 3.516 ± 0.066	4.953SerVal: 4.953 ± 0.08	0.979SerTrp: 0.979 ± 0.033	1.361SerTyr: 1.361 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	8.086ThrAla: 8.086 ± 0.11	0.253ThrCys: 0.253 ± 0.018	3.608ThrAsp: 3.608 ± 0.063	2.795ThrGlu: 2.795 ± 0.052	1.84ThrPhe: 1.84 ± 0.044	5.953ThrGly: 5.953 ± 0.089	1.189ThrHis: 1.189 ± 0.035	2.78ThrIle: 2.78 ± 0.062	1.339ThrLys: 1.339 ± 0.042	5.733ThrLeu: 5.733 ± 0.082	0.918ThrMet: 0.918 ± 0.03	1.242ThrAsn: 1.242 ± 0.043	3.923ThrPro: 3.923 ± 0.066	1.711ThrGln: 1.711 ± 0.049	3.717ThrArg: 3.717 ± 0.057	3.371ThrSer: 3.371 ± 0.065	3.813ThrThr: 3.813 ± 0.076	5.787ThrVal: 5.787 ± 0.086	0.861ThrTrp: 0.861 ± 0.027	1.111ThrTyr: 1.111 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	11.869ValAla: 11.869 ± 0.13	0.463ValCys: 0.463 ± 0.021	5.472ValAsp: 5.472 ± 0.11	4.612ValGlu: 4.612 ± 0.066	3.01ValPhe: 3.01 ± 0.054	7.189ValGly: 7.189 ± 0.094	1.713ValHis: 1.713 ± 0.036	4.462ValIle: 4.462 ± 0.071	1.852ValLys: 1.852 ± 0.043	9.237ValLeu: 9.237 ± 0.107	1.347ValMet: 1.347 ± 0.031	1.903ValAsn: 1.903 ± 0.039	4.724ValPro: 4.724 ± 0.065	2.23ValGln: 2.23 ± 0.045	5.562ValArg: 5.562 ± 0.078	4.962ValSer: 4.962 ± 0.066	5.986ValThr: 5.986 ± 0.085	8.608ValVal: 8.608 ± 0.107	1.154ValTrp: 1.154 ± 0.038	1.568ValTyr: 1.568 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.818TrpAla: 1.818 ± 0.043	0.102TrpCys: 0.102 ± 0.009	0.737TrpAsp: 0.737 ± 0.024	0.566TrpGlu: 0.566 ± 0.024	0.642TrpPhe: 0.642 ± 0.028	1.218TrpGly: 1.218 ± 0.034	0.372TrpHis: 0.372 ± 0.019	0.651TrpIle: 0.651 ± 0.027	0.363TrpLys: 0.363 ± 0.021	1.889TrpLeu: 1.889 ± 0.047	0.265TrpMet: 0.265 ± 0.014	0.446TrpAsn: 0.446 ± 0.021	0.767TrpPro: 0.767 ± 0.028	0.678TrpGln: 0.678 ± 0.024	1.27TrpArg: 1.27 ± 0.039	1.0TrpSer: 1.0 ± 0.031	0.819TrpThr: 0.819 ± 0.028	1.308TrpVal: 1.308 ± 0.033	0.355TrpTrp: 0.355 ± 0.018	0.31TrpTyr: 0.31 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.59TyrAla: 2.59 ± 0.049	0.12TyrCys: 0.12 ± 0.01	1.363TyrAsp: 1.363 ± 0.047	1.164TyrGlu: 1.164 ± 0.032	0.736TyrPhe: 0.736 ± 0.027	1.961TyrGly: 1.961 ± 0.042	0.331TyrHis: 0.331 ± 0.016	0.621TyrIle: 0.621 ± 0.024	0.41TyrLys: 0.41 ± 0.021	2.266TyrLeu: 2.266 ± 0.045	0.222TyrMet: 0.222 ± 0.014	0.486TyrAsn: 0.486 ± 0.022	1.042TyrPro: 1.042 ± 0.033	0.671TyrGln: 0.671 ± 0.027	1.643TyrArg: 1.643 ± 0.036	1.2TyrSer: 1.2 ± 0.036	1.204TyrThr: 1.204 ± 0.04	1.647TyrVal: 1.647 ± 0.036	0.378TyrTrp: 0.378 ± 0.019	0.481TyrTyr: 0.481 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3481 proteins (1118351 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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