Amino acid dipepetide frequency for Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.983AlaAla: 10.983 ± 0.132
1.169AlaCys: 1.169 ± 0.022
3.573AlaAsp: 3.573 ± 0.026
4.409AlaGlu: 4.409 ± 0.037
2.173AlaPhe: 2.173 ± 0.019
4.758AlaGly: 4.758 ± 0.038
1.801AlaHis: 1.801 ± 0.02
3.569AlaIle: 3.569 ± 0.025
4.016AlaLys: 4.016 ± 0.031
6.528AlaLeu: 6.528 ± 0.043
1.797AlaMet: 1.797 ± 0.016
3.535AlaAsn: 3.535 ± 0.024
4.008AlaPro: 4.008 ± 0.047
3.593AlaGln: 3.593 ± 0.031
3.295AlaArg: 3.295 ± 0.024
6.148AlaSer: 6.148 ± 0.044
5.849AlaThr: 5.849 ± 0.052
4.592AlaVal: 4.592 ± 0.03
0.591AlaTrp: 0.591 ± 0.011
1.84AlaTyr: 1.84 ± 0.016
0.0AlaXaa: 0.0 ± 0.0
Cys
1.305CysAla: 1.305 ± 0.021
0.547CysCys: 0.547 ± 0.009
1.103CysAsp: 1.103 ± 0.018
1.123CysGlu: 1.123 ± 0.019
0.722CysPhe: 0.722 ± 0.011
1.345CysGly: 1.345 ± 0.022
0.502CysHis: 0.502 ± 0.009
1.016CysIle: 1.016 ± 0.016
0.966CysLys: 0.966 ± 0.012
1.812CysLeu: 1.812 ± 0.022
0.442CysMet: 0.442 ± 0.009
0.99CysAsn: 0.99 ± 0.015
0.96CysPro: 0.96 ± 0.022
0.836CysGln: 0.836 ± 0.017
1.093CysArg: 1.093 ± 0.022
1.607CysSer: 1.607 ± 0.024
1.013CysThr: 1.013 ± 0.017
1.208CysVal: 1.208 ± 0.02
0.206CysTrp: 0.206 ± 0.006
0.598CysTyr: 0.598 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.0AspAla: 4.0 ± 0.025
1.034AspCys: 1.034 ± 0.019
4.205AspAsp: 4.205 ± 0.054
4.361AspGlu: 4.361 ± 0.035
2.074AspPhe: 2.074 ± 0.021
3.047AspGly: 3.047 ± 0.028
1.034AspHis: 1.034 ± 0.014
2.871AspIle: 2.871 ± 0.025
2.68AspLys: 2.68 ± 0.025
4.494AspLeu: 4.494 ± 0.035
1.327AspMet: 1.327 ± 0.013
2.524AspAsn: 2.524 ± 0.025
2.066AspPro: 2.066 ± 0.023
1.809AspGln: 1.809 ± 0.019
2.267AspArg: 2.267 ± 0.024
3.689AspSer: 3.689 ± 0.029
2.423AspThr: 2.423 ± 0.018
3.39AspVal: 3.39 ± 0.026
0.604AspTrp: 0.604 ± 0.008
1.885AspTyr: 1.885 ± 0.017
0.0AspXaa: 0.0 ± 0.0
Glu
4.258GluAla: 4.258 ± 0.035
1.132GluCys: 1.132 ± 0.023
3.5GluAsp: 3.5 ± 0.03
5.136GluGlu: 5.136 ± 0.055
2.039GluPhe: 2.039 ± 0.021
2.397GluGly: 2.397 ± 0.027
1.733GluHis: 1.733 ± 0.017
3.071GluIle: 3.071 ± 0.028
3.611GluLys: 3.611 ± 0.035
6.538GluLeu: 6.538 ± 0.053
1.572GluMet: 1.572 ± 0.018
2.689GluAsn: 2.689 ± 0.025
2.713GluPro: 2.713 ± 0.027
4.052GluGln: 4.052 ± 0.033
3.945GluArg: 3.945 ± 0.031
4.073GluSer: 4.073 ± 0.056
3.286GluThr: 3.286 ± 0.028
3.116GluVal: 3.116 ± 0.025
0.554GluTrp: 0.554 ± 0.009
1.732GluTyr: 1.732 ± 0.016
0.0GluXaa: 0.0 ± 0.0
Phe
2.342PheAla: 2.342 ± 0.02
0.732PheCys: 0.732 ± 0.013
2.046PheAsp: 2.046 ± 0.021
2.116PheGlu: 2.116 ± 0.02
1.376PhePhe: 1.376 ± 0.018
2.361PheGly: 2.361 ± 0.025
0.865PheHis: 0.865 ± 0.011
1.836PheIle: 1.836 ± 0.02
1.852PheLys: 1.852 ± 0.019
3.13PheLeu: 3.13 ± 0.033
0.916PheMet: 0.916 ± 0.013
1.769PheAsn: 1.769 ± 0.019
1.349PhePro: 1.349 ± 0.014
1.4PheGln: 1.4 ± 0.015
1.778PheArg: 1.778 ± 0.018
2.417PheSer: 2.417 ± 0.022
1.759PheThr: 1.759 ± 0.021
2.369PheVal: 2.369 ± 0.023
0.419PheTrp: 0.419 ± 0.009
1.296PheTyr: 1.296 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
4.406GlyAla: 4.406 ± 0.039
1.053GlyCys: 1.053 ± 0.016
2.871GlyAsp: 2.871 ± 0.021
2.861GlyGlu: 2.861 ± 0.03
2.044GlyPhe: 2.044 ± 0.021
6.073GlyGly: 6.073 ± 0.095
1.581GlyHis: 1.581 ± 0.023
2.971GlyIle: 2.971 ± 0.029
2.887GlyLys: 2.887 ± 0.025
4.459GlyLeu: 4.459 ± 0.033
1.272GlyMet: 1.272 ± 0.017
3.056GlyAsn: 3.056 ± 0.027
2.098GlyPro: 2.098 ± 0.033
2.332GlyGln: 2.332 ± 0.024
2.814GlyArg: 2.814 ± 0.026
5.16GlySer: 5.16 ± 0.043
3.016GlyThr: 3.016 ± 0.024
3.424GlyVal: 3.424 ± 0.026
0.597GlyTrp: 0.597 ± 0.01
2.051GlyTyr: 2.051 ± 0.024
0.0GlyXaa: 0.0 ± 0.0
His
1.709HisAla: 1.709 ± 0.02
0.613HisCys: 0.613 ± 0.012
1.14HisAsp: 1.14 ± 0.015
1.423HisGlu: 1.423 ± 0.017
1.054HisPhe: 1.054 ± 0.012
1.509HisGly: 1.509 ± 0.019
1.53HisHis: 1.53 ± 0.034
1.44HisIle: 1.44 ± 0.015
1.42HisLys: 1.42 ± 0.016
2.609HisLeu: 2.609 ± 0.019
0.755HisMet: 0.755 ± 0.011
1.389HisAsn: 1.389 ± 0.017
1.373HisPro: 1.373 ± 0.018
1.813HisGln: 1.813 ± 0.024
1.442HisArg: 1.442 ± 0.016
2.196HisSer: 2.196 ± 0.018
1.406HisThr: 1.406 ± 0.015
1.485HisVal: 1.485 ± 0.016
0.314HisTrp: 0.314 ± 0.007
0.927HisTyr: 0.927 ± 0.012
0.0HisXaa: 0.0 ± 0.0
Ile
3.636IleAla: 3.636 ± 0.032
1.26IleCys: 1.26 ± 0.021
2.824IleAsp: 2.824 ± 0.025
3.198IleGlu: 3.198 ± 0.029
2.119IlePhe: 2.119 ± 0.021
2.767IleGly: 2.767 ± 0.026
1.074IleHis: 1.074 ± 0.013
2.823IleIle: 2.823 ± 0.025
2.864IleLys: 2.864 ± 0.022
4.152IleLeu: 4.152 ± 0.034
1.189IleMet: 1.189 ± 0.014
2.556IleAsn: 2.556 ± 0.023
2.116IlePro: 2.116 ± 0.017
1.875IleGln: 1.875 ± 0.017
2.383IleArg: 2.383 ± 0.02
4.095IleSer: 4.095 ± 0.028
2.803IleThr: 2.803 ± 0.023
3.313IleVal: 3.313 ± 0.024
0.566IleTrp: 0.566 ± 0.01
1.808IleTyr: 1.808 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
3.346LysAla: 3.346 ± 0.027
1.128LysCys: 1.128 ± 0.019
2.712LysAsp: 2.712 ± 0.034
3.486LysGlu: 3.486 ± 0.033
1.835LysPhe: 1.835 ± 0.019
2.097LysGly: 2.097 ± 0.022
1.454LysHis: 1.454 ± 0.016
2.677LysIle: 2.677 ± 0.024
3.707LysLys: 3.707 ± 0.046
5.443LysLeu: 5.443 ± 0.039
1.424LysMet: 1.424 ± 0.016
2.268LysAsn: 2.268 ± 0.02
2.913LysPro: 2.913 ± 0.041
3.071LysGln: 3.071 ± 0.031
3.654LysArg: 3.654 ± 0.029
4.142LysSer: 4.142 ± 0.036
2.983LysThr: 2.983 ± 0.026
2.802LysVal: 2.802 ± 0.026
0.589LysTrp: 0.589 ± 0.01
1.797LysTyr: 1.797 ± 0.018
0.0LysXaa: 0.0 ± 0.0
Leu
6.795LeuAla: 6.795 ± 0.038
1.803LeuCys: 1.803 ± 0.02
4.858LeuAsp: 4.858 ± 0.031
5.866LeuGlu: 5.866 ± 0.043
2.967LeuPhe: 2.967 ± 0.026
4.751LeuGly: 4.751 ± 0.03
2.698LeuHis: 2.698 ± 0.024
4.442LeuIle: 4.442 ± 0.035
5.265LeuLys: 5.265 ± 0.034
9.839LeuLeu: 9.839 ± 0.071
2.222LeuMet: 2.222 ± 0.02
4.453LeuAsn: 4.453 ± 0.033
5.277LeuPro: 5.277 ± 0.031
5.69LeuGln: 5.69 ± 0.046
5.58LeuArg: 5.58 ± 0.041
6.941LeuSer: 6.941 ± 0.034
4.879LeuThr: 4.879 ± 0.031
4.939LeuVal: 4.939 ± 0.034
0.869LeuTrp: 0.869 ± 0.013
2.577LeuTyr: 2.577 ± 0.027
0.0LeuXaa: 0.0 ± 0.0
Met
1.838MetAla: 1.838 ± 0.018
0.456MetCys: 0.456 ± 0.008
1.398MetAsp: 1.398 ± 0.014
1.575MetGlu: 1.575 ± 0.016
0.793MetPhe: 0.793 ± 0.012
1.348MetGly: 1.348 ± 0.017
0.684MetHis: 0.684 ± 0.011
0.977MetIle: 0.977 ± 0.012
1.197MetLys: 1.197 ± 0.014
2.436MetLeu: 2.436 ± 0.022
0.636MetMet: 0.636 ± 0.009
1.009MetAsn: 1.009 ± 0.014
1.5MetPro: 1.5 ± 0.017
1.411MetGln: 1.411 ± 0.016
1.565MetArg: 1.565 ± 0.017
1.888MetSer: 1.888 ± 0.017
1.181MetThr: 1.181 ± 0.015
1.215MetVal: 1.215 ± 0.015
0.238MetTrp: 0.238 ± 0.005
0.647MetTyr: 0.647 ± 0.01
0.0MetXaa: 0.0 ± 0.0
Asn
3.72AsnAla: 3.72 ± 0.025
1.085AsnCys: 1.085 ± 0.017
2.49AsnAsp: 2.49 ± 0.024
2.923AsnGlu: 2.923 ± 0.022
1.783AsnPhe: 1.783 ± 0.017
3.422AsnGly: 3.422 ± 0.033
1.123AsnHis: 1.123 ± 0.015
2.638AsnIle: 2.638 ± 0.024
2.448AsnLys: 2.448 ± 0.021
4.081AsnLeu: 4.081 ± 0.03
1.265AsnMet: 1.265 ± 0.014
4.479AsnAsn: 4.479 ± 0.067
2.138AsnPro: 2.138 ± 0.02
1.874AsnGln: 1.874 ± 0.018
2.272AsnArg: 2.272 ± 0.02
4.617AsnSer: 4.617 ± 0.04
2.601AsnThr: 2.601 ± 0.022
3.038AsnVal: 3.038 ± 0.023
0.549AsnTrp: 0.549 ± 0.01
1.698AsnTyr: 1.698 ± 0.019
0.0AsnXaa: 0.0 ± 0.0
Pro
4.314ProAla: 4.314 ± 0.046
0.715ProCys: 0.715 ± 0.021
2.318ProAsp: 2.318 ± 0.02
3.084ProGlu: 3.084 ± 0.037
1.549ProPhe: 1.549 ± 0.018
2.657ProGly: 2.657 ± 0.041
1.492ProHis: 1.492 ± 0.02
2.433ProIle: 2.433 ± 0.022
2.762ProLys: 2.762 ± 0.028
4.44ProLeu: 4.44 ± 0.027
1.155ProMet: 1.155 ± 0.016
2.434ProAsn: 2.434 ± 0.023
4.512ProPro: 4.512 ± 0.066
2.807ProGln: 2.807 ± 0.034
2.345ProArg: 2.345 ± 0.021
4.022ProSer: 4.022 ± 0.037
3.611ProThr: 3.611 ± 0.034
3.045ProVal: 3.045 ± 0.041
0.439ProTrp: 0.439 ± 0.009
1.384ProTyr: 1.384 ± 0.018
0.0ProXaa: 0.0 ± 0.0
Gln
3.3GlnAla: 3.3 ± 0.028
0.88GlnCys: 0.88 ± 0.018
1.798GlnAsp: 1.798 ± 0.017
2.773GlnGlu: 2.773 ± 0.026
1.587GlnPhe: 1.587 ± 0.018
1.762GlnGly: 1.762 ± 0.019
2.301GlnHis: 2.301 ± 0.028
2.206GlnIle: 2.206 ± 0.018
2.505GlnLys: 2.505 ± 0.024
6.575GlnLeu: 6.575 ± 0.058
1.347GlnMet: 1.347 ± 0.016
1.995GlnAsn: 1.995 ± 0.016
3.075GlnPro: 3.075 ± 0.039
11.731GlnGln: 11.731 ± 0.259
3.601GlnArg: 3.601 ± 0.028
3.547GlnSer: 3.547 ± 0.028
2.626GlnThr: 2.626 ± 0.019
2.403GlnVal: 2.403 ± 0.022
0.437GlnTrp: 0.437 ± 0.008
1.301GlnTyr: 1.301 ± 0.015
0.001GlnXaa: 0.001 ± 0.0
Arg
3.29ArgAla: 3.29 ± 0.023
1.14ArgCys: 1.14 ± 0.02
2.719ArgAsp: 2.719 ± 0.023
3.336ArgGlu: 3.336 ± 0.032
1.946ArgPhe: 1.946 ± 0.02
2.649ArgGly: 2.649 ± 0.026
1.653ArgHis: 1.653 ± 0.016
2.858ArgIle: 2.858 ± 0.024
3.359ArgLys: 3.359 ± 0.028
5.159ArgLeu: 5.159 ± 0.032
1.252ArgMet: 1.252 ± 0.013
2.814ArgAsn: 2.814 ± 0.022
2.557ArgPro: 2.557 ± 0.033
3.028ArgGln: 3.028 ± 0.028
4.392ArgArg: 4.392 ± 0.036
4.244ArgSer: 4.244 ± 0.037
2.734ArgThr: 2.734 ± 0.021
2.752ArgVal: 2.752 ± 0.02
0.563ArgTrp: 0.563 ± 0.01
1.715ArgTyr: 1.715 ± 0.016
0.001ArgXaa: 0.001 ± 0.0
Ser
6.08SerAla: 6.08 ± 0.045
1.545SerCys: 1.545 ± 0.022
4.012SerAsp: 4.012 ± 0.028
4.162SerGlu: 4.162 ± 0.032
2.572SerPhe: 2.572 ± 0.022
5.137SerGly: 5.137 ± 0.038
1.923SerHis: 1.923 ± 0.018
3.804SerIle: 3.804 ± 0.027
4.027SerLys: 4.027 ± 0.034
6.609SerLeu: 6.609 ± 0.04
1.814SerMet: 1.814 ± 0.02
4.851SerAsn: 4.851 ± 0.041
4.135SerPro: 4.135 ± 0.036
3.262SerGln: 3.262 ± 0.027
3.697SerArg: 3.697 ± 0.037
10.481SerSer: 10.481 ± 0.121
5.329SerThr: 5.329 ± 0.047
4.45SerVal: 4.45 ± 0.047
0.739SerTrp: 0.739 ± 0.01
2.326SerTyr: 2.326 ± 0.026
0.001SerXaa: 0.001 ± 0.0
Thr
5.287ThrAla: 5.287 ± 0.046
0.996ThrCys: 0.996 ± 0.015
2.741ThrAsp: 2.741 ± 0.03
3.228ThrGlu: 3.228 ± 0.029
1.82ThrPhe: 1.82 ± 0.017
3.235ThrGly: 3.235 ± 0.026
1.456ThrHis: 1.456 ± 0.015
2.917ThrIle: 2.917 ± 0.022
2.788ThrLys: 2.788 ± 0.023
5.191ThrLeu: 5.191 ± 0.034
1.251ThrMet: 1.251 ± 0.013
2.701ThrAsn: 2.701 ± 0.021
3.906ThrPro: 3.906 ± 0.037
2.55ThrGln: 2.55 ± 0.021
2.593ThrArg: 2.593 ± 0.017
4.768ThrSer: 4.768 ± 0.038
5.943ThrThr: 5.943 ± 0.089
3.396ThrVal: 3.396 ± 0.029
0.494ThrTrp: 0.494 ± 0.008
1.503ThrTyr: 1.503 ± 0.016
0.001ThrXaa: 0.001 ± 0.0
Val
4.941ValAla: 4.941 ± 0.038
1.206ValCys: 1.206 ± 0.017
3.216ValAsp: 3.216 ± 0.025
3.706ValGlu: 3.706 ± 0.034
1.997ValPhe: 1.997 ± 0.021
3.324ValGly: 3.324 ± 0.026
1.515ValHis: 1.515 ± 0.017
2.847ValIle: 2.847 ± 0.025
3.021ValLys: 3.021 ± 0.029
5.339ValLeu: 5.339 ± 0.033
1.264ValMet: 1.264 ± 0.014
2.643ValAsn: 2.643 ± 0.019
3.085ValPro: 3.085 ± 0.025
2.676ValGln: 2.676 ± 0.021
3.052ValArg: 3.052 ± 0.026
4.016ValSer: 4.016 ± 0.032
3.157ValThr: 3.157 ± 0.028
3.82ValVal: 3.82 ± 0.032
0.583ValTrp: 0.583 ± 0.01
1.698ValTyr: 1.698 ± 0.018
0.0ValXaa: 0.0 ± 0.0
Trp
0.526TrpAla: 0.526 ± 0.009
0.206TrpCys: 0.206 ± 0.005
0.488TrpAsp: 0.488 ± 0.009
0.506TrpGlu: 0.506 ± 0.008
0.381TrpPhe: 0.381 ± 0.008
0.5TrpGly: 0.5 ± 0.009
0.312TrpHis: 0.312 ± 0.007
0.529TrpIle: 0.529 ± 0.01
0.541TrpLys: 0.541 ± 0.01
1.132TrpLeu: 1.132 ± 0.016
0.273TrpMet: 0.273 ± 0.007
0.484TrpAsn: 0.484 ± 0.01
0.422TrpPro: 0.422 ± 0.008
0.587TrpGln: 0.587 ± 0.01
0.698TrpArg: 0.698 ± 0.011
0.774TrpSer: 0.774 ± 0.012
0.561TrpThr: 0.561 ± 0.009
0.483TrpVal: 0.483 ± 0.009
0.161TrpTrp: 0.161 ± 0.005
0.316TrpTyr: 0.316 ± 0.008
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.151TyrAla: 2.151 ± 0.019
0.695TyrCys: 0.695 ± 0.012
1.771TyrAsp: 1.771 ± 0.016
1.878TyrGlu: 1.878 ± 0.015
1.296TyrPhe: 1.296 ± 0.015
1.885TyrGly: 1.885 ± 0.022
0.815TyrHis: 0.815 ± 0.012
1.496TyrIle: 1.496 ± 0.017
1.614TyrLys: 1.614 ± 0.015
2.743TyrLeu: 2.743 ± 0.026
0.819TyrMet: 0.819 ± 0.012
1.603TyrAsn: 1.603 ± 0.018
1.315TyrPro: 1.315 ± 0.019
1.357TyrGln: 1.357 ± 0.016
1.699TyrArg: 1.699 ± 0.017
2.127TyrSer: 2.127 ± 0.023
1.603TyrThr: 1.603 ± 0.019
1.864TyrVal: 1.864 ± 0.018
0.368TyrTrp: 0.368 ± 0.009
1.23TyrTyr: 1.23 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.001XaaSer: 0.001 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.373XaaXaa: 0.373 ± 0.112
Statistics based on 14754 proteins (7386485 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski