Amino acid dipepetide frequency for Vibrio rumoiensis 1S-45

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.018AlaAla: 7.018 ± 0.102
0.952AlaCys: 0.952 ± 0.033
4.305AlaAsp: 4.305 ± 0.071
4.968AlaGlu: 4.968 ± 0.077
3.439AlaPhe: 3.439 ± 0.064
5.738AlaGly: 5.738 ± 0.099
1.563AlaHis: 1.563 ± 0.041
6.073AlaIle: 6.073 ± 0.086
5.032AlaLys: 5.032 ± 0.081
9.382AlaLeu: 9.382 ± 0.105
2.56AlaMet: 2.56 ± 0.055
3.48AlaAsn: 3.48 ± 0.071
2.7AlaPro: 2.7 ± 0.065
3.893AlaGln: 3.893 ± 0.062
3.215AlaArg: 3.215 ± 0.063
5.164AlaSer: 5.164 ± 0.084
4.318AlaThr: 4.318 ± 0.076
5.535AlaVal: 5.535 ± 0.087
0.969AlaTrp: 0.969 ± 0.037
2.27AlaTyr: 2.27 ± 0.053
0.0AlaXaa: 0.0 ± 0.0
Cys
0.771CysAla: 0.771 ± 0.029
0.163CysCys: 0.163 ± 0.013
0.635CysAsp: 0.635 ± 0.025
0.607CysGlu: 0.607 ± 0.029
0.495CysPhe: 0.495 ± 0.025
0.944CysGly: 0.944 ± 0.035
0.366CysHis: 0.366 ± 0.023
0.655CysIle: 0.655 ± 0.025
0.436CysLys: 0.436 ± 0.022
0.967CysLeu: 0.967 ± 0.033
0.254CysMet: 0.254 ± 0.017
0.35CysAsn: 0.35 ± 0.018
0.437CysPro: 0.437 ± 0.023
0.551CysGln: 0.551 ± 0.025
0.451CysArg: 0.451 ± 0.021
0.723CysSer: 0.723 ± 0.027
0.523CysThr: 0.523 ± 0.024
0.695CysVal: 0.695 ± 0.026
0.123CysTrp: 0.123 ± 0.011
0.341CysTyr: 0.341 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.288AspAla: 4.288 ± 0.075
0.566AspCys: 0.566 ± 0.022
3.25AspAsp: 3.25 ± 0.078
3.656AspGlu: 3.656 ± 0.073
2.486AspPhe: 2.486 ± 0.051
3.735AspGly: 3.735 ± 0.107
1.224AspHis: 1.224 ± 0.034
4.13AspIle: 4.13 ± 0.057
3.354AspLys: 3.354 ± 0.061
5.368AspLeu: 5.368 ± 0.076
1.554AspMet: 1.554 ± 0.04
2.604AspAsn: 2.604 ± 0.058
2.156AspPro: 2.156 ± 0.051
2.188AspGln: 2.188 ± 0.05
2.24AspArg: 2.24 ± 0.06
3.447AspSer: 3.447 ± 0.072
2.789AspThr: 2.789 ± 0.066
3.973AspVal: 3.973 ± 0.077
0.872AspTrp: 0.872 ± 0.031
2.032AspTyr: 2.032 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
4.933GluAla: 4.933 ± 0.069
0.565GluCys: 0.565 ± 0.028
2.795GluAsp: 2.795 ± 0.07
3.514GluGlu: 3.514 ± 0.083
2.497GluPhe: 2.497 ± 0.047
3.476GluGly: 3.476 ± 0.067
1.644GluHis: 1.644 ± 0.043
3.733GluIle: 3.733 ± 0.068
3.94GluLys: 3.94 ± 0.073
6.59GluLeu: 6.59 ± 0.096
1.715GluMet: 1.715 ± 0.047
2.554GluAsn: 2.554 ± 0.047
1.975GluPro: 1.975 ± 0.045
3.722GluGln: 3.722 ± 0.068
3.011GluArg: 3.011 ± 0.065
3.638GluSer: 3.638 ± 0.062
3.034GluThr: 3.034 ± 0.059
4.176GluVal: 4.176 ± 0.07
0.793GluTrp: 0.793 ± 0.027
1.762GluTyr: 1.762 ± 0.045
0.0GluXaa: 0.0 ± 0.0
Phe
3.438PheAla: 3.438 ± 0.071
0.532PheCys: 0.532 ± 0.025
2.866PheAsp: 2.866 ± 0.061
2.5PheGlu: 2.5 ± 0.051
1.841PhePhe: 1.841 ± 0.054
3.257PheGly: 3.257 ± 0.075
0.895PheHis: 0.895 ± 0.033
3.184PheIle: 3.184 ± 0.058
1.993PheLys: 1.993 ± 0.047
3.541PheLeu: 3.541 ± 0.072
1.106PheMet: 1.106 ± 0.032
2.105PheAsn: 2.105 ± 0.049
1.482PhePro: 1.482 ± 0.04
1.408PheGln: 1.408 ± 0.037
1.406PheArg: 1.406 ± 0.039
3.354PheSer: 3.354 ± 0.067
2.513PheThr: 2.513 ± 0.05
2.805PheVal: 2.805 ± 0.059
0.512PheTrp: 0.512 ± 0.028
1.331PheTyr: 1.331 ± 0.039
0.0PheXaa: 0.0 ± 0.0
Gly
5.092GlyAla: 5.092 ± 0.092
0.956GlyCys: 0.956 ± 0.029
3.665GlyAsp: 3.665 ± 0.075
4.104GlyGlu: 4.104 ± 0.064
3.268GlyPhe: 3.268 ± 0.056
4.788GlyGly: 4.788 ± 0.095
1.563GlyHis: 1.563 ± 0.043
5.065GlyIle: 5.065 ± 0.078
4.15GlyLys: 4.15 ± 0.07
7.067GlyLeu: 7.067 ± 0.107
2.102GlyMet: 2.102 ± 0.05
2.558GlyAsn: 2.558 ± 0.057
1.645GlyPro: 1.645 ± 0.04
2.919GlyGln: 2.919 ± 0.063
2.92GlyArg: 2.92 ± 0.059
4.185GlySer: 4.185 ± 0.084
3.384GlyThr: 3.384 ± 0.068
5.209GlyVal: 5.209 ± 0.087
0.974GlyTrp: 0.974 ± 0.033
2.622GlyTyr: 2.622 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
1.624HisAla: 1.624 ± 0.04
0.324HisCys: 0.324 ± 0.019
1.184HisAsp: 1.184 ± 0.04
1.116HisGlu: 1.116 ± 0.036
1.216HisPhe: 1.216 ± 0.04
1.494HisGly: 1.494 ± 0.042
0.732HisHis: 0.732 ± 0.031
1.561HisIle: 1.561 ± 0.043
1.085HisLys: 1.085 ± 0.031
2.418HisLeu: 2.418 ± 0.056
0.514HisMet: 0.514 ± 0.023
0.968HisAsn: 0.968 ± 0.031
1.214HisPro: 1.214 ± 0.033
1.37HisGln: 1.37 ± 0.041
1.004HisArg: 1.004 ± 0.03
1.507HisSer: 1.507 ± 0.039
1.154HisThr: 1.154 ± 0.035
1.292HisVal: 1.292 ± 0.038
0.41HisTrp: 0.41 ± 0.02
0.9HisTyr: 0.9 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.423IleAla: 6.423 ± 0.08
0.716IleCys: 0.716 ± 0.027
4.431IleAsp: 4.431 ± 0.081
4.907IleGlu: 4.907 ± 0.078
2.464IlePhe: 2.464 ± 0.054
5.025IleGly: 5.025 ± 0.09
1.394IleHis: 1.394 ± 0.042
4.217IleIle: 4.217 ± 0.078
3.577IleLys: 3.577 ± 0.061
5.641IleLeu: 5.641 ± 0.079
1.538IleMet: 1.538 ± 0.043
3.048IleAsn: 3.048 ± 0.065
2.885IlePro: 2.885 ± 0.056
2.642IleGln: 2.642 ± 0.05
2.815IleArg: 2.815 ± 0.051
4.724IleSer: 4.724 ± 0.081
4.075IleThr: 4.075 ± 0.081
4.333IleVal: 4.333 ± 0.072
0.733IleTrp: 0.733 ± 0.027
1.78IleTyr: 1.78 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
5.016LysAla: 5.016 ± 0.082
0.314LysCys: 0.314 ± 0.018
2.993LysAsp: 2.993 ± 0.054
3.394LysGlu: 3.394 ± 0.064
1.617LysPhe: 1.617 ± 0.04
3.591LysGly: 3.591 ± 0.066
1.373LysHis: 1.373 ± 0.039
3.299LysIle: 3.299 ± 0.054
3.241LysLys: 3.241 ± 0.074
5.291LysLeu: 5.291 ± 0.078
1.652LysMet: 1.652 ± 0.042
2.425LysAsn: 2.425 ± 0.056
2.526LysPro: 2.526 ± 0.056
3.289LysGln: 3.289 ± 0.074
2.606LysArg: 2.606 ± 0.056
3.24LysSer: 3.24 ± 0.059
3.106LysThr: 3.106 ± 0.056
4.083LysVal: 4.083 ± 0.063
0.623LysTrp: 0.623 ± 0.029
1.486LysTyr: 1.486 ± 0.04
0.0LysXaa: 0.0 ± 0.0
Leu
9.089LeuAla: 9.089 ± 0.105
1.118LeuCys: 1.118 ± 0.031
5.777LeuAsp: 5.777 ± 0.083
5.965LeuGlu: 5.965 ± 0.092
4.193LeuPhe: 4.193 ± 0.074
6.936LeuGly: 6.936 ± 0.093
2.184LeuHis: 2.184 ± 0.046
6.563LeuIle: 6.563 ± 0.091
5.504LeuLys: 5.504 ± 0.081
10.165LeuLeu: 10.165 ± 0.135
2.85LeuMet: 2.85 ± 0.054
4.82LeuAsn: 4.82 ± 0.077
4.839LeuPro: 4.839 ± 0.069
3.803LeuGln: 3.803 ± 0.073
4.05LeuArg: 4.05 ± 0.082
7.847LeuSer: 7.847 ± 0.11
6.066LeuThr: 6.066 ± 0.081
6.843LeuVal: 6.843 ± 0.085
1.099LeuTrp: 1.099 ± 0.037
2.574LeuTyr: 2.574 ± 0.059
0.0LeuXaa: 0.0 ± 0.0
Met
2.602MetAla: 2.602 ± 0.05
0.228MetCys: 0.228 ± 0.016
1.372MetAsp: 1.372 ± 0.041
1.324MetGlu: 1.324 ± 0.037
1.012MetPhe: 1.012 ± 0.034
1.828MetGly: 1.828 ± 0.042
0.52MetHis: 0.52 ± 0.023
1.677MetIle: 1.677 ± 0.041
1.729MetLys: 1.729 ± 0.042
2.78MetLeu: 2.78 ± 0.052
0.859MetMet: 0.859 ± 0.034
1.216MetAsn: 1.216 ± 0.031
1.343MetPro: 1.343 ± 0.032
1.143MetGln: 1.143 ± 0.034
1.079MetArg: 1.079 ± 0.033
2.049MetSer: 2.049 ± 0.037
1.662MetThr: 1.662 ± 0.04
2.057MetVal: 2.057 ± 0.052
0.25MetTrp: 0.25 ± 0.014
0.58MetTyr: 0.58 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.368AsnAla: 3.368 ± 0.063
0.402AsnCys: 0.402 ± 0.017
2.508AsnAsp: 2.508 ± 0.058
2.428AsnGlu: 2.428 ± 0.049
1.652AsnPhe: 1.652 ± 0.046
3.064AsnGly: 3.064 ± 0.067
1.042AsnHis: 1.042 ± 0.032
3.077AsnIle: 3.077 ± 0.062
2.475AsnLys: 2.475 ± 0.049
4.031AsnLeu: 4.031 ± 0.074
1.061AsnMet: 1.061 ± 0.029
2.049AsnAsn: 2.049 ± 0.049
2.189AsnPro: 2.189 ± 0.044
2.321AsnGln: 2.321 ± 0.054
1.896AsnArg: 1.896 ± 0.044
2.541AsnSer: 2.541 ± 0.052
2.41AsnThr: 2.41 ± 0.056
2.86AsnVal: 2.86 ± 0.054
0.606AsnTrp: 0.606 ± 0.028
1.352AsnTyr: 1.352 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
2.891ProAla: 2.891 ± 0.053
0.348ProCys: 0.348 ± 0.02
2.301ProAsp: 2.301 ± 0.051
3.173ProGlu: 3.173 ± 0.061
1.795ProPhe: 1.795 ± 0.041
2.115ProGly: 2.115 ± 0.046
0.871ProHis: 0.871 ± 0.03
2.785ProIle: 2.785 ± 0.055
2.24ProLys: 2.24 ± 0.046
4.023ProLeu: 4.023 ± 0.065
1.139ProMet: 1.139 ± 0.03
1.892ProAsn: 1.892 ± 0.043
1.185ProPro: 1.185 ± 0.04
1.73ProGln: 1.73 ± 0.044
1.285ProArg: 1.285 ± 0.04
2.721ProSer: 2.721 ± 0.056
2.378ProThr: 2.378 ± 0.052
2.916ProVal: 2.916 ± 0.056
0.549ProTrp: 0.549 ± 0.025
1.312ProTyr: 1.312 ± 0.039
0.0ProXaa: 0.0 ± 0.0
Gln
4.477GlnAla: 4.477 ± 0.088
0.478GlnCys: 0.478 ± 0.024
2.438GlnAsp: 2.438 ± 0.051
2.464GlnGlu: 2.464 ± 0.053
1.841GlnPhe: 1.841 ± 0.043
3.067GlnGly: 3.067 ± 0.055
1.273GlnHis: 1.273 ± 0.039
2.606GlnIle: 2.606 ± 0.063
2.454GlnLys: 2.454 ± 0.051
5.188GlnLeu: 5.188 ± 0.074
1.167GlnMet: 1.167 ± 0.037
1.72GlnAsn: 1.72 ± 0.043
1.815GlnPro: 1.815 ± 0.047
3.152GlnGln: 3.152 ± 0.075
2.167GlnArg: 2.167 ± 0.05
3.047GlnSer: 3.047 ± 0.057
2.433GlnThr: 2.433 ± 0.057
3.342GlnVal: 3.342 ± 0.066
0.718GlnTrp: 0.718 ± 0.022
1.535GlnTyr: 1.535 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.945ArgAla: 2.945 ± 0.059
0.421ArgCys: 0.421 ± 0.021
2.237ArgAsp: 2.237 ± 0.047
2.569ArgGlu: 2.569 ± 0.057
2.061ArgPhe: 2.061 ± 0.051
2.459ArgGly: 2.459 ± 0.053
1.074ArgHis: 1.074 ± 0.033
2.956ArgIle: 2.956 ± 0.061
2.248ArgLys: 2.248 ± 0.05
4.554ArgLeu: 4.554 ± 0.074
1.161ArgMet: 1.161 ± 0.036
1.787ArgAsn: 1.787 ± 0.045
1.485ArgPro: 1.485 ± 0.043
2.086ArgGln: 2.086 ± 0.055
2.08ArgArg: 2.08 ± 0.056
2.492ArgSer: 2.492 ± 0.058
2.095ArgThr: 2.095 ± 0.04
2.823ArgVal: 2.823 ± 0.058
0.572ArgTrp: 0.572 ± 0.025
1.63ArgTyr: 1.63 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
5.147SerAla: 5.147 ± 0.082
0.566SerCys: 0.566 ± 0.025
3.899SerAsp: 3.899 ± 0.077
3.836SerGlu: 3.836 ± 0.074
2.94SerPhe: 2.94 ± 0.058
4.93SerGly: 4.93 ± 0.068
1.64SerHis: 1.64 ± 0.045
4.608SerIle: 4.608 ± 0.074
3.384SerLys: 3.384 ± 0.062
6.919SerLeu: 6.919 ± 0.094
1.836SerMet: 1.836 ± 0.04
2.855SerAsn: 2.855 ± 0.056
2.521SerPro: 2.521 ± 0.045
3.122SerGln: 3.122 ± 0.059
2.652SerArg: 2.652 ± 0.051
4.542SerSer: 4.542 ± 0.079
3.548SerThr: 3.548 ± 0.066
4.582SerVal: 4.582 ± 0.075
0.842SerTrp: 0.842 ± 0.027
1.987SerTyr: 1.987 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
4.346ThrAla: 4.346 ± 0.077
0.51ThrCys: 0.51 ± 0.023
2.934ThrAsp: 2.934 ± 0.075
3.113ThrGlu: 3.113 ± 0.055
2.283ThrPhe: 2.283 ± 0.052
4.116ThrGly: 4.116 ± 0.07
1.296ThrHis: 1.296 ± 0.036
3.715ThrIle: 3.715 ± 0.081
2.502ThrLys: 2.502 ± 0.057
6.448ThrLeu: 6.448 ± 0.084
1.221ThrMet: 1.221 ± 0.036
2.177ThrAsn: 2.177 ± 0.055
2.699ThrPro: 2.699 ± 0.05
2.622ThrGln: 2.622 ± 0.054
2.034ThrArg: 2.034 ± 0.045
3.526ThrSer: 3.526 ± 0.059
3.042ThrThr: 3.042 ± 0.071
3.808ThrVal: 3.808 ± 0.09
0.671ThrTrp: 0.671 ± 0.029
1.495ThrTyr: 1.495 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
5.966ValAla: 5.966 ± 0.097
0.756ValCys: 0.756 ± 0.029
4.083ValAsp: 4.083 ± 0.077
4.476ValGlu: 4.476 ± 0.081
2.868ValPhe: 2.868 ± 0.062
4.818ValGly: 4.818 ± 0.086
1.25ValHis: 1.25 ± 0.038
4.991ValIle: 4.991 ± 0.089
3.779ValLys: 3.779 ± 0.062
6.762ValLeu: 6.762 ± 0.095
2.037ValMet: 2.037 ± 0.05
3.037ValAsn: 3.037 ± 0.06
2.654ValPro: 2.654 ± 0.049
2.336ValGln: 2.336 ± 0.049
2.713ValArg: 2.713 ± 0.058
4.895ValSer: 4.895 ± 0.076
3.941ValThr: 3.941 ± 0.071
5.219ValVal: 5.219 ± 0.093
0.779ValTrp: 0.779 ± 0.03
1.938ValTyr: 1.938 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.868TrpAla: 0.868 ± 0.028
0.162TrpCys: 0.162 ± 0.013
0.569TrpAsp: 0.569 ± 0.023
0.538TrpGlu: 0.538 ± 0.022
0.645TrpPhe: 0.645 ± 0.028
0.78TrpGly: 0.78 ± 0.033
0.344TrpHis: 0.344 ± 0.019
0.787TrpIle: 0.787 ± 0.029
0.663TrpLys: 0.663 ± 0.027
1.756TrpLeu: 1.756 ± 0.048
0.359TrpMet: 0.359 ± 0.017
0.536TrpAsn: 0.536 ± 0.026
0.495TrpPro: 0.495 ± 0.024
0.979TrpGln: 0.979 ± 0.037
0.581TrpArg: 0.581 ± 0.025
0.719TrpSer: 0.719 ± 0.026
0.533TrpThr: 0.533 ± 0.025
0.888TrpVal: 0.888 ± 0.032
0.215TrpTrp: 0.215 ± 0.016
0.379TrpTyr: 0.379 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.273TyrAla: 2.273 ± 0.047
0.41TyrCys: 0.41 ± 0.018
1.671TyrAsp: 1.671 ± 0.043
1.416TyrGlu: 1.416 ± 0.042
1.457TyrPhe: 1.457 ± 0.04
2.073TyrGly: 2.073 ± 0.05
0.838TyrHis: 0.838 ± 0.031
1.688TyrIle: 1.688 ± 0.04
1.379TyrLys: 1.379 ± 0.037
3.392TyrLeu: 3.392 ± 0.066
0.623TyrMet: 0.623 ± 0.026
1.15TyrAsn: 1.15 ± 0.039
1.403TyrPro: 1.403 ± 0.039
2.106TyrGln: 2.106 ± 0.054
1.528TyrArg: 1.528 ± 0.039
1.996TyrSer: 1.996 ± 0.053
1.557TyrThr: 1.557 ± 0.045
1.861TyrVal: 1.861 ± 0.052
0.484TyrTrp: 0.484 ± 0.022
1.013TyrTyr: 1.013 ± 0.037
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2981 proteins (974289 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski