Amino acid dipepetide frequency for Enterococcus durans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.007AlaAla: 5.007 ± 0.098	0.482AlaCys: 0.482 ± 0.023	3.603AlaAsp: 3.603 ± 0.135	4.628AlaGlu: 4.628 ± 0.084	3.139AlaPhe: 3.139 ± 0.068	4.635AlaGly: 4.635 ± 0.092	1.194AlaHis: 1.194 ± 0.036	5.885AlaIle: 5.885 ± 0.087	4.99AlaLys: 4.99 ± 0.085	6.628AlaLeu: 6.628 ± 0.091	1.898AlaMet: 1.898 ± 0.05	2.925AlaAsn: 2.925 ± 0.054	2.018AlaPro: 2.018 ± 0.054	2.712AlaGln: 2.712 ± 0.069	2.37AlaArg: 2.37 ± 0.052	3.978AlaSer: 3.978 ± 0.084	4.133AlaThr: 4.133 ± 0.077	4.806AlaVal: 4.806 ± 0.091	0.558AlaTrp: 0.558 ± 0.028	2.471AlaTyr: 2.471 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.35CysAla: 0.35 ± 0.021	0.091CysCys: 0.091 ± 0.01	0.286CysAsp: 0.286 ± 0.018	0.327CysGlu: 0.327 ± 0.021	0.36CysPhe: 0.36 ± 0.021	0.614CysGly: 0.614 ± 0.032	0.175CysHis: 0.175 ± 0.016	0.408CysIle: 0.408 ± 0.022	0.259CysLys: 0.259 ± 0.02	0.684CysLeu: 0.684 ± 0.028	0.151CysMet: 0.151 ± 0.014	0.211CysAsn: 0.211 ± 0.015	0.246CysPro: 0.246 ± 0.018	0.262CysGln: 0.262 ± 0.018	0.23CysArg: 0.23 ± 0.016	0.431CysSer: 0.431 ± 0.026	0.334CysThr: 0.334 ± 0.021	0.389CysVal: 0.389 ± 0.023	0.061CysTrp: 0.061 ± 0.008	0.255CysTyr: 0.255 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.313AspAla: 3.313 ± 0.125	0.306AspCys: 0.306 ± 0.019	2.449AspAsp: 2.449 ± 0.059	4.163AspGlu: 4.163 ± 0.069	2.703AspPhe: 2.703 ± 0.056	3.317AspGly: 3.317 ± 0.081	1.173AspHis: 1.173 ± 0.037	3.748AspIle: 3.748 ± 0.074	3.285AspLys: 3.285 ± 0.067	5.188AspLeu: 5.188 ± 0.073	1.231AspMet: 1.231 ± 0.039	2.026AspAsn: 2.026 ± 0.062	2.121AspPro: 2.121 ± 0.054	2.49AspGln: 2.49 ± 0.062	2.105AspArg: 2.105 ± 0.048	2.9AspSer: 2.9 ± 0.07	2.888AspThr: 2.888 ± 0.056	3.335AspVal: 3.335 ± 0.074	0.613AspTrp: 0.613 ± 0.026	2.458AspTyr: 2.458 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	5.097GluAla: 5.097 ± 0.102	0.366GluCys: 0.366 ± 0.023	3.483GluAsp: 3.483 ± 0.071	6.885GluGlu: 6.885 ± 0.107	2.624GluPhe: 2.624 ± 0.06	3.763GluGly: 3.763 ± 0.079	1.231GluHis: 1.231 ± 0.05	5.658GluIle: 5.658 ± 0.1	7.354GluLys: 7.354 ± 0.102	7.306GluLeu: 7.306 ± 0.101	2.245GluMet: 2.245 ± 0.051	4.165GluAsn: 4.165 ± 0.063	1.931GluPro: 1.931 ± 0.072	3.575GluGln: 3.575 ± 0.079	3.112GluArg: 3.112 ± 0.073	3.442GluSer: 3.442 ± 0.077	4.294GluThr: 4.294 ± 0.075	4.76GluVal: 4.76 ± 0.083	0.728GluTrp: 0.728 ± 0.032	2.293GluTyr: 2.293 ± 0.06	0.0GluXaa: 0.0 ± 0.0
Phe	3.005PheAla: 3.005 ± 0.065	0.324PheCys: 0.324 ± 0.02	2.791PheAsp: 2.791 ± 0.064	2.848PheGlu: 2.848 ± 0.062	2.64PhePhe: 2.64 ± 0.081	3.114PheGly: 3.114 ± 0.068	0.893PheHis: 0.893 ± 0.033	3.598PheIle: 3.598 ± 0.083	2.52PheLys: 2.52 ± 0.054	4.875PheLeu: 4.875 ± 0.101	1.111PheMet: 1.111 ± 0.041	1.874PheAsn: 1.874 ± 0.047	1.582PhePro: 1.582 ± 0.041	1.689PheGln: 1.689 ± 0.05	1.541PheArg: 1.541 ± 0.045	3.602PheSer: 3.602 ± 0.069	2.67PheThr: 2.67 ± 0.056	3.067PheVal: 3.067 ± 0.061	0.485PheTrp: 0.485 ± 0.025	1.995PheTyr: 1.995 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	4.204GlyAla: 4.204 ± 0.075	0.433GlyCys: 0.433 ± 0.025	2.872GlyAsp: 2.872 ± 0.067	4.02GlyGlu: 4.02 ± 0.077	3.122GlyPhe: 3.122 ± 0.06	4.181GlyGly: 4.181 ± 0.089	1.173GlyHis: 1.173 ± 0.046	5.735GlyIle: 5.735 ± 0.099	4.946GlyLys: 4.946 ± 0.078	6.244GlyLeu: 6.244 ± 0.097	1.934GlyMet: 1.934 ± 0.056	2.84GlyAsn: 2.84 ± 0.07	1.372GlyPro: 1.372 ± 0.04	2.29GlyGln: 2.29 ± 0.051	2.403GlyArg: 2.403 ± 0.058	3.752GlySer: 3.752 ± 0.077	4.15GlyThr: 4.15 ± 0.067	4.547GlyVal: 4.547 ± 0.081	0.684GlyTrp: 0.684 ± 0.031	2.688GlyTyr: 2.688 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.13HisAla: 1.13 ± 0.038	0.182HisCys: 0.182 ± 0.015	0.92HisAsp: 0.92 ± 0.038	1.269HisGlu: 1.269 ± 0.048	1.056HisPhe: 1.056 ± 0.037	1.215HisGly: 1.215 ± 0.039	0.557HisHis: 0.557 ± 0.026	1.165HisIle: 1.165 ± 0.044	0.911HisLys: 0.911 ± 0.036	2.044HisLeu: 2.044 ± 0.055	0.376HisMet: 0.376 ± 0.023	0.636HisAsn: 0.636 ± 0.028	0.984HisPro: 0.984 ± 0.035	0.988HisGln: 0.988 ± 0.036	0.778HisArg: 0.778 ± 0.031	1.146HisSer: 1.146 ± 0.039	1.043HisThr: 1.043 ± 0.037	1.168HisVal: 1.168 ± 0.033	0.187HisTrp: 0.187 ± 0.016	0.936HisTyr: 0.936 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	5.742IleAla: 5.742 ± 0.08	0.644IleCys: 0.644 ± 0.029	4.646IleAsp: 4.646 ± 0.074	5.487IleGlu: 5.487 ± 0.08	3.468IlePhe: 3.468 ± 0.078	5.4IleGly: 5.4 ± 0.072	1.529IleHis: 1.529 ± 0.046	5.609IleIle: 5.609 ± 0.087	4.79IleLys: 4.79 ± 0.085	7.312IleLeu: 7.312 ± 0.108	1.74IleMet: 1.74 ± 0.043	3.412IleAsn: 3.412 ± 0.069	3.159IlePro: 3.159 ± 0.06	3.133IleGln: 3.133 ± 0.057	3.025IleArg: 3.025 ± 0.057	5.053IleSer: 5.053 ± 0.074	4.377IleThr: 4.377 ± 0.075	5.339IleVal: 5.339 ± 0.086	0.642IleTrp: 0.642 ± 0.03	2.815IleTyr: 2.815 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.618LysAla: 4.618 ± 0.081	0.23LysCys: 0.23 ± 0.017	3.818LysAsp: 3.818 ± 0.069	7.563LysGlu: 7.563 ± 0.095	2.059LysPhe: 2.059 ± 0.049	3.99LysGly: 3.99 ± 0.076	1.153LysHis: 1.153 ± 0.036	5.607LysIle: 5.607 ± 0.094	7.402LysLys: 7.402 ± 0.109	5.618LysLeu: 5.618 ± 0.08	2.312LysMet: 2.312 ± 0.051	4.361LysAsn: 4.361 ± 0.083	1.923LysPro: 1.923 ± 0.049	3.438LysGln: 3.438 ± 0.072	3.285LysArg: 3.285 ± 0.068	3.434LysSer: 3.434 ± 0.063	4.038LysThr: 4.038 ± 0.078	4.515LysVal: 4.515 ± 0.083	0.684LysTrp: 0.684 ± 0.025	2.386LysTyr: 2.386 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	7.822LeuAla: 7.822 ± 0.118	0.62LeuCys: 0.62 ± 0.03	5.167LeuAsp: 5.167 ± 0.073	6.458LeuGlu: 6.458 ± 0.106	5.149LeuPhe: 5.149 ± 0.104	6.301LeuGly: 6.301 ± 0.094	1.637LeuHis: 1.637 ± 0.046	7.294LeuIle: 7.294 ± 0.117	6.681LeuLys: 6.681 ± 0.102	10.616LeuLeu: 10.616 ± 0.135	2.455LeuMet: 2.455 ± 0.066	4.622LeuAsn: 4.622 ± 0.072	4.142LeuPro: 4.142 ± 0.07	3.437LeuGln: 3.437 ± 0.063	3.451LeuArg: 3.451 ± 0.062	7.001LeuSer: 7.001 ± 0.089	6.28LeuThr: 6.28 ± 0.091	6.474LeuVal: 6.474 ± 0.103	0.758LeuTrp: 0.758 ± 0.03	3.083LeuTyr: 3.083 ± 0.066	0.0LeuXaa: 0.0 ± 0.0
Met	1.863MetAla: 1.863 ± 0.044	0.138MetCys: 0.138 ± 0.013	1.505MetAsp: 1.505 ± 0.05	1.724MetGlu: 1.724 ± 0.043	0.903MetPhe: 0.903 ± 0.036	1.62MetGly: 1.62 ± 0.046	0.368MetHis: 0.368 ± 0.019	2.404MetIle: 2.404 ± 0.062	2.245MetLys: 2.245 ± 0.047	2.241MetLeu: 2.241 ± 0.048	0.814MetMet: 0.814 ± 0.029	1.568MetAsn: 1.568 ± 0.05	0.895MetPro: 0.895 ± 0.029	0.872MetGln: 0.872 ± 0.034	0.982MetArg: 0.982 ± 0.035	1.518MetSer: 1.518 ± 0.04	1.751MetThr: 1.751 ± 0.046	1.717MetVal: 1.717 ± 0.048	0.181MetTrp: 0.181 ± 0.015	0.755MetTyr: 0.755 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.674AsnAla: 2.674 ± 0.057	0.304AsnCys: 0.304 ± 0.02	2.471AsnAsp: 2.471 ± 0.055	3.646AsnGlu: 3.646 ± 0.068	1.872AsnPhe: 1.872 ± 0.048	3.421AsnGly: 3.421 ± 0.072	1.172AsnHis: 1.172 ± 0.037	3.3AsnIle: 3.3 ± 0.061	3.161AsnLys: 3.161 ± 0.064	4.188AsnLeu: 4.188 ± 0.07	1.079AsnMet: 1.079 ± 0.035	2.14AsnAsn: 2.14 ± 0.063	1.85AsnPro: 1.85 ± 0.046	2.691AsnGln: 2.691 ± 0.067	2.022AsnArg: 2.022 ± 0.05	2.475AsnSer: 2.475 ± 0.057	2.334AsnThr: 2.334 ± 0.061	2.91AsnVal: 2.91 ± 0.058	0.528AsnTrp: 0.528 ± 0.031	2.12AsnTyr: 2.12 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.178ProAla: 2.178 ± 0.06	0.14ProCys: 0.14 ± 0.013	1.991ProAsp: 1.991 ± 0.049	3.076ProGlu: 3.076 ± 0.066	1.806ProPhe: 1.806 ± 0.044	1.857ProGly: 1.857 ± 0.051	0.595ProHis: 0.595 ± 0.029	2.702ProIle: 2.702 ± 0.058	2.398ProLys: 2.398 ± 0.051	3.37ProLeu: 3.37 ± 0.067	0.82ProMet: 0.82 ± 0.033	1.608ProAsn: 1.608 ± 0.046	0.668ProPro: 0.668 ± 0.033	1.355ProGln: 1.355 ± 0.043	1.015ProArg: 1.015 ± 0.037	2.08ProSer: 2.08 ± 0.051	2.252ProThr: 2.252 ± 0.062	2.622ProVal: 2.622 ± 0.057	0.29ProTrp: 0.29 ± 0.019	1.413ProTyr: 1.413 ± 0.045	0.0ProXaa: 0.0 ± 0.0
Gln	3.29GlnAla: 3.29 ± 0.071	0.156GlnCys: 0.156 ± 0.016	1.639GlnAsp: 1.639 ± 0.042	3.431GlnGlu: 3.431 ± 0.08	1.7GlnPhe: 1.7 ± 0.045	2.218GlnGly: 2.218 ± 0.053	0.778GlnHis: 0.778 ± 0.027	2.97GlnIle: 2.97 ± 0.062	3.498GlnLys: 3.498 ± 0.071	4.95GlnLeu: 4.95 ± 0.098	1.15GlnMet: 1.15 ± 0.031	1.819GlnAsn: 1.819 ± 0.047	1.386GlnPro: 1.386 ± 0.045	2.331GlnGln: 2.331 ± 0.069	1.844GlnArg: 1.844 ± 0.053	2.202GlnSer: 2.202 ± 0.056	2.786GlnThr: 2.786 ± 0.064	2.689GlnVal: 2.689 ± 0.064	0.433GlnTrp: 0.433 ± 0.024	1.373GlnTyr: 1.373 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	2.115ArgAla: 2.115 ± 0.052	0.237ArgCys: 0.237 ± 0.019	1.684ArgAsp: 1.684 ± 0.042	2.906ArgGlu: 2.906 ± 0.068	2.021ArgPhe: 2.021 ± 0.051	2.096ArgGly: 2.096 ± 0.052	0.71ArgHis: 0.71 ± 0.027	2.974ArgIle: 2.974 ± 0.059	3.293ArgLys: 3.293 ± 0.071	4.097ArgLeu: 4.097 ± 0.07	1.126ArgMet: 1.126 ± 0.04	1.885ArgAsn: 1.885 ± 0.048	1.318ArgPro: 1.318 ± 0.047	1.788ArgGln: 1.788 ± 0.047	1.785ArgArg: 1.785 ± 0.047	2.236ArgSer: 2.236 ± 0.056	2.12ArgThr: 2.12 ± 0.052	2.393ArgVal: 2.393 ± 0.056	0.377ArgTrp: 0.377 ± 0.022	1.69ArgTyr: 1.69 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	3.821SerAla: 3.821 ± 0.072	0.338SerCys: 0.338 ± 0.019	3.063SerAsp: 3.063 ± 0.068	4.166SerGlu: 4.166 ± 0.075	3.271SerPhe: 3.271 ± 0.07	4.368SerGly: 4.368 ± 0.074	1.086SerHis: 1.086 ± 0.034	4.706SerIle: 4.706 ± 0.08	3.918SerLys: 3.918 ± 0.076	6.231SerLeu: 6.231 ± 0.09	1.547SerMet: 1.547 ± 0.044	2.57SerAsn: 2.57 ± 0.057	1.851SerPro: 1.851 ± 0.048	2.321SerGln: 2.321 ± 0.051	2.195SerArg: 2.195 ± 0.057	3.86SerSer: 3.86 ± 0.098	3.507SerThr: 3.507 ± 0.081	4.03SerVal: 4.03 ± 0.078	0.63SerTrp: 0.63 ± 0.029	2.494SerTyr: 2.494 ± 0.048	0.0SerXaa: 0.0 ± 0.0
Thr	4.107ThrAla: 4.107 ± 0.072	0.309ThrCys: 0.309 ± 0.017	3.21ThrAsp: 3.21 ± 0.057	3.969ThrGlu: 3.969 ± 0.079	2.778ThrPhe: 2.778 ± 0.057	4.042ThrGly: 4.042 ± 0.078	1.134ThrHis: 1.134 ± 0.038	5.286ThrIle: 5.286 ± 0.087	4.04ThrLys: 4.04 ± 0.073	5.661ThrLeu: 5.661 ± 0.087	1.411ThrMet: 1.411 ± 0.046	2.804ThrAsn: 2.804 ± 0.064	2.524ThrPro: 2.524 ± 0.065	2.069ThrGln: 2.069 ± 0.051	1.966ThrArg: 1.966 ± 0.048	3.538ThrSer: 3.538 ± 0.07	3.856ThrThr: 3.856 ± 0.095	4.332ThrVal: 4.332 ± 0.077	0.51ThrTrp: 0.51 ± 0.025	2.274ThrTyr: 2.274 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	4.981ValAla: 4.981 ± 0.087	0.447ValCys: 0.447 ± 0.022	3.669ValAsp: 3.669 ± 0.088	4.583ValGlu: 4.583 ± 0.091	2.98ValPhe: 2.98 ± 0.066	4.36ValGly: 4.36 ± 0.087	1.074ValHis: 1.074 ± 0.032	5.347ValIle: 5.347 ± 0.067	4.286ValLys: 4.286 ± 0.074	6.69ValLeu: 6.69 ± 0.098	1.651ValMet: 1.651 ± 0.046	2.871ValAsn: 2.871 ± 0.054	2.511ValPro: 2.511 ± 0.057	2.297ValGln: 2.297 ± 0.057	2.451ValArg: 2.451 ± 0.056	4.408ValSer: 4.408 ± 0.063	4.423ValThr: 4.423 ± 0.085	4.844ValVal: 4.844 ± 0.091	0.545ValTrp: 0.545 ± 0.026	2.306ValTyr: 2.306 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.495TrpAla: 0.495 ± 0.022	0.076TrpCys: 0.076 ± 0.01	0.442TrpAsp: 0.442 ± 0.019	0.614TrpGlu: 0.614 ± 0.025	0.48TrpPhe: 0.48 ± 0.027	0.635TrpGly: 0.635 ± 0.028	0.214TrpHis: 0.214 ± 0.015	0.697TrpIle: 0.697 ± 0.027	0.584TrpLys: 0.584 ± 0.028	1.18TrpLeu: 1.18 ± 0.039	0.242TrpMet: 0.242 ± 0.017	0.525TrpAsn: 0.525 ± 0.027	0.213TrpPro: 0.213 ± 0.015	0.559TrpGln: 0.559 ± 0.027	0.399TrpArg: 0.399 ± 0.019	0.581TrpSer: 0.581 ± 0.031	0.52TrpThr: 0.52 ± 0.023	0.527TrpVal: 0.527 ± 0.023	0.13TrpTrp: 0.13 ± 0.014	0.354TrpTyr: 0.354 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.247TyrAla: 2.247 ± 0.053	0.3TyrCys: 0.3 ± 0.021	2.103TyrAsp: 2.103 ± 0.051	2.548TyrGlu: 2.548 ± 0.062	2.091TyrPhe: 2.091 ± 0.054	2.448TyrGly: 2.448 ± 0.054	0.845TyrHis: 0.845 ± 0.035	2.229TyrIle: 2.229 ± 0.055	1.872TyrLys: 1.872 ± 0.05	4.323TyrLeu: 4.323 ± 0.078	0.77TyrMet: 0.77 ± 0.032	1.498TyrAsn: 1.498 ± 0.048	1.541TyrPro: 1.541 ± 0.046	2.344TyrGln: 2.344 ± 0.056	1.892TyrArg: 1.892 ± 0.052	2.337TyrSer: 2.337 ± 0.057	2.065TyrThr: 2.065 ± 0.052	2.265TyrVal: 2.265 ± 0.052	0.441TyrTrp: 0.441 ± 0.02	1.684TyrTyr: 1.684 ± 0.046	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3031 proteins (869336 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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