Amino acid dipepetide frequency for Corynebacterium sp. 366

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.611AlaAla: 14.611 ± 0.263	0.941AlaCys: 0.941 ± 0.044	6.798AlaAsp: 6.798 ± 0.118	7.913AlaGlu: 7.913 ± 0.137	3.365AlaPhe: 3.365 ± 0.076	9.931AlaGly: 9.931 ± 0.147	2.646AlaHis: 2.646 ± 0.062	5.091AlaIle: 5.091 ± 0.09	3.542AlaLys: 3.542 ± 0.089	11.345AlaLeu: 11.345 ± 0.141	2.709AlaMet: 2.709 ± 0.066	2.607AlaAsn: 2.607 ± 0.069	4.941AlaPro: 4.941 ± 0.178	4.955AlaGln: 4.955 ± 0.1	7.011AlaArg: 7.011 ± 0.133	6.322AlaSer: 6.322 ± 0.117	6.574AlaThr: 6.574 ± 0.109	9.166AlaVal: 9.166 ± 0.147	1.516AlaTrp: 1.516 ± 0.053	2.216AlaTyr: 2.216 ± 0.063	0.0AlaXaa: 0.0 ± 0.0
Cys	0.902CysAla: 0.902 ± 0.037	0.083CysCys: 0.083 ± 0.013	0.454CysAsp: 0.454 ± 0.029	0.407CysGlu: 0.407 ± 0.025	0.23CysPhe: 0.23 ± 0.019	0.853CysGly: 0.853 ± 0.038	0.163CysHis: 0.163 ± 0.016	0.332CysIle: 0.332 ± 0.025	0.116CysLys: 0.116 ± 0.013	0.617CysLeu: 0.617 ± 0.035	0.124CysMet: 0.124 ± 0.012	0.171CysAsn: 0.171 ± 0.016	0.424CysPro: 0.424 ± 0.027	0.199CysGln: 0.199 ± 0.018	0.421CysArg: 0.421 ± 0.027	0.532CysSer: 0.532 ± 0.028	0.457CysThr: 0.457 ± 0.027	0.692CysVal: 0.692 ± 0.034	0.089CysTrp: 0.089 ± 0.012	0.128CysTyr: 0.128 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	7.064AspAla: 7.064 ± 0.134	0.382AspCys: 0.382 ± 0.024	3.332AspAsp: 3.332 ± 0.083	4.336AspGlu: 4.336 ± 0.088	2.0AspPhe: 2.0 ± 0.06	4.963AspGly: 4.963 ± 0.092	1.438AspHis: 1.438 ± 0.05	3.215AspIle: 3.215 ± 0.074	2.136AspLys: 2.136 ± 0.075	5.506AspLeu: 5.506 ± 0.103	1.281AspMet: 1.281 ± 0.047	1.925AspAsn: 1.925 ± 0.066	3.578AspPro: 3.578 ± 0.08	2.039AspGln: 2.039 ± 0.053	3.517AspArg: 3.517 ± 0.08	3.592AspSer: 3.592 ± 0.075	3.229AspThr: 3.229 ± 0.079	5.039AspVal: 5.039 ± 0.093	0.664AspTrp: 0.664 ± 0.035	1.481AspTyr: 1.481 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	6.989GluAla: 6.989 ± 0.129	0.402GluCys: 0.402 ± 0.026	4.061GluAsp: 4.061 ± 0.093	4.742GluGlu: 4.742 ± 0.117	2.23GluPhe: 2.23 ± 0.066	4.541GluGly: 4.541 ± 0.092	1.787GluHis: 1.787 ± 0.055	3.071GluIle: 3.071 ± 0.078	2.432GluLys: 2.432 ± 0.061	6.496GluLeu: 6.496 ± 0.106	1.292GluMet: 1.292 ± 0.041	1.74GluAsn: 1.74 ± 0.062	2.766GluPro: 2.766 ± 0.075	3.032GluGln: 3.032 ± 0.076	4.317GluArg: 4.317 ± 0.09	3.414GluSer: 3.414 ± 0.073	3.005GluThr: 3.005 ± 0.072	4.627GluVal: 4.627 ± 0.097	0.827GluTrp: 0.827 ± 0.033	1.422GluTyr: 1.422 ± 0.051	0.0GluXaa: 0.0 ± 0.0
Phe	3.497PheAla: 3.497 ± 0.071	0.282PheCys: 0.282 ± 0.023	2.102PheAsp: 2.102 ± 0.063	1.743PheGlu: 1.743 ± 0.063	1.21PhePhe: 1.21 ± 0.055	3.212PheGly: 3.212 ± 0.071	0.764PheHis: 0.764 ± 0.034	1.6PheIle: 1.6 ± 0.059	0.866PheLys: 0.866 ± 0.043	2.933PheLeu: 2.933 ± 0.076	0.706PheMet: 0.706 ± 0.036	1.048PheAsn: 1.048 ± 0.045	1.427PhePro: 1.427 ± 0.054	0.936PheGln: 0.936 ± 0.042	1.71PheArg: 1.71 ± 0.05	2.202PheSer: 2.202 ± 0.062	2.1PheThr: 2.1 ± 0.059	2.481PheVal: 2.481 ± 0.059	0.412PheTrp: 0.412 ± 0.026	0.741PheTyr: 0.741 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.824GlyAla: 8.824 ± 0.162	0.626GlyCys: 0.626 ± 0.033	4.59GlyAsp: 4.59 ± 0.089	5.017GlyGlu: 5.017 ± 0.089	3.016GlyPhe: 3.016 ± 0.076	6.918GlyGly: 6.918 ± 0.132	2.075GlyHis: 2.075 ± 0.057	4.364GlyIle: 4.364 ± 0.095	3.138GlyLys: 3.138 ± 0.09	7.883GlyLeu: 7.883 ± 0.099	2.195GlyMet: 2.195 ± 0.058	2.275GlyAsn: 2.275 ± 0.057	3.334GlyPro: 3.334 ± 0.076	3.025GlyGln: 3.025 ± 0.069	4.995GlyArg: 4.995 ± 0.102	5.274GlySer: 5.274 ± 0.095	5.348GlyThr: 5.348 ± 0.096	7.236GlyVal: 7.236 ± 0.127	1.3GlyTrp: 1.3 ± 0.047	2.105GlyTyr: 2.105 ± 0.06	0.0GlyXaa: 0.0 ± 0.0
His	2.573HisAla: 2.573 ± 0.067	0.23HisCys: 0.23 ± 0.019	1.325HisAsp: 1.325 ± 0.052	1.247HisGlu: 1.247 ± 0.045	0.755HisPhe: 0.755 ± 0.041	2.177HisGly: 2.177 ± 0.065	0.64HisHis: 0.64 ± 0.041	1.14HisIle: 1.14 ± 0.038	0.634HisLys: 0.634 ± 0.033	1.972HisLeu: 1.972 ± 0.056	0.512HisMet: 0.512 ± 0.027	0.7HisAsn: 0.7 ± 0.034	1.456HisPro: 1.456 ± 0.047	0.822HisGln: 0.822 ± 0.038	1.546HisArg: 1.546 ± 0.058	1.53HisSer: 1.53 ± 0.049	1.513HisThr: 1.513 ± 0.06	1.892HisVal: 1.892 ± 0.051	0.279HisTrp: 0.279 ± 0.02	0.595HisTyr: 0.595 ± 0.034	0.0HisXaa: 0.0 ± 0.0
Ile	6.269IleAla: 6.269 ± 0.096	0.357IleCys: 0.357 ± 0.024	3.284IleAsp: 3.284 ± 0.075	2.823IleGlu: 2.823 ± 0.075	1.519IlePhe: 1.519 ± 0.055	4.139IleGly: 4.139 ± 0.096	1.095IleHis: 1.095 ± 0.04	2.553IleIle: 2.553 ± 0.065	1.461IleLys: 1.461 ± 0.047	4.255IleLeu: 4.255 ± 0.083	1.032IleMet: 1.032 ± 0.041	1.663IleAsn: 1.663 ± 0.052	2.728IlePro: 2.728 ± 0.072	1.372IleGln: 1.372 ± 0.045	2.65IleArg: 2.65 ± 0.069	2.932IleSer: 2.932 ± 0.064	3.343IleThr: 3.343 ± 0.074	4.493IleVal: 4.493 ± 0.085	0.448IleTrp: 0.448 ± 0.027	0.891IleTyr: 0.891 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.625LysAla: 3.625 ± 0.094	0.133LysCys: 0.133 ± 0.014	2.39LysAsp: 2.39 ± 0.069	2.127LysGlu: 2.127 ± 0.061	0.825LysPhe: 0.825 ± 0.036	2.412LysGly: 2.412 ± 0.066	0.731LysHis: 0.731 ± 0.029	1.708LysIle: 1.708 ± 0.049	2.045LysLys: 2.045 ± 0.085	2.891LysLeu: 2.891 ± 0.07	0.755LysMet: 0.755 ± 0.038	1.34LysAsn: 1.34 ± 0.048	1.81LysPro: 1.81 ± 0.065	1.165LysGln: 1.165 ± 0.041	2.02LysArg: 2.02 ± 0.056	1.837LysSer: 1.837 ± 0.06	1.97LysThr: 1.97 ± 0.068	2.557LysVal: 2.557 ± 0.071	0.357LysTrp: 0.357 ± 0.022	0.728LysTyr: 0.728 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	11.071LeuAla: 11.071 ± 0.155	0.822LeuCys: 0.822 ± 0.04	5.86LeuAsp: 5.86 ± 0.104	5.342LeuGlu: 5.342 ± 0.089	2.693LeuPhe: 2.693 ± 0.074	8.062LeuGly: 8.062 ± 0.117	1.964LeuHis: 1.964 ± 0.05	4.604LeuIle: 4.604 ± 0.095	3.099LeuLys: 3.099 ± 0.072	8.719LeuLeu: 8.719 ± 0.154	2.1LeuMet: 2.1 ± 0.062	2.816LeuAsn: 2.816 ± 0.065	4.966LeuPro: 4.966 ± 0.092	2.845LeuGln: 2.845 ± 0.062	5.808LeuArg: 5.808 ± 0.104	6.245LeuSer: 6.245 ± 0.096	5.625LeuThr: 5.625 ± 0.098	7.691LeuVal: 7.691 ± 0.123	1.231LeuTrp: 1.231 ± 0.052	1.738LeuTyr: 1.738 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.651MetAla: 2.651 ± 0.064	0.163MetCys: 0.163 ± 0.016	1.309MetAsp: 1.309 ± 0.042	1.159MetGlu: 1.159 ± 0.053	0.789MetPhe: 0.789 ± 0.036	1.851MetGly: 1.851 ± 0.053	0.498MetHis: 0.498 ± 0.025	1.153MetIle: 1.153 ± 0.044	0.83MetLys: 0.83 ± 0.038	2.211MetLeu: 2.211 ± 0.056	0.619MetMet: 0.619 ± 0.034	0.77MetAsn: 0.77 ± 0.032	1.137MetPro: 1.137 ± 0.041	0.672MetGln: 0.672 ± 0.031	1.387MetArg: 1.387 ± 0.054	1.76MetSer: 1.76 ± 0.056	1.776MetThr: 1.776 ± 0.049	1.708MetVal: 1.708 ± 0.061	0.257MetTrp: 0.257 ± 0.021	0.385MetTyr: 0.385 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.213AsnAla: 3.213 ± 0.076	0.21AsnCys: 0.21 ± 0.018	1.582AsnAsp: 1.582 ± 0.052	1.503AsnGlu: 1.503 ± 0.054	0.874AsnPhe: 0.874 ± 0.036	2.449AsnGly: 2.449 ± 0.066	0.633AsnHis: 0.633 ± 0.032	1.536AsnIle: 1.536 ± 0.052	1.027AsnLys: 1.027 ± 0.035	2.571AsnLeu: 2.571 ± 0.069	0.611AsnMet: 0.611 ± 0.032	1.196AsnAsn: 1.196 ± 0.048	2.174AsnPro: 2.174 ± 0.06	1.032AsnGln: 1.032 ± 0.039	1.58AsnArg: 1.58 ± 0.059	1.817AsnSer: 1.817 ± 0.057	1.857AsnThr: 1.857 ± 0.055	2.094AsnVal: 2.094 ± 0.063	0.374AsnTrp: 0.374 ± 0.025	0.719AsnTyr: 0.719 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.456ProAla: 5.456 ± 0.139	0.26ProCys: 0.26 ± 0.024	3.202ProAsp: 3.202 ± 0.069	4.306ProGlu: 4.306 ± 0.104	1.555ProPhe: 1.555 ± 0.049	4.465ProGly: 4.465 ± 0.085	1.402ProHis: 1.402 ± 0.054	2.172ProIle: 2.172 ± 0.06	1.625ProLys: 1.625 ± 0.056	4.291ProLeu: 4.291 ± 0.086	1.037ProMet: 1.037 ± 0.035	1.375ProAsn: 1.375 ± 0.044	1.651ProPro: 1.651 ± 0.06	2.192ProGln: 2.192 ± 0.064	2.849ProArg: 2.849 ± 0.074	3.04ProSer: 3.04 ± 0.071	3.168ProThr: 3.168 ± 0.068	4.192ProVal: 4.192 ± 0.079	0.756ProTrp: 0.756 ± 0.04	1.046ProTyr: 1.046 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.242GlnAla: 4.242 ± 0.1	0.254GlnCys: 0.254 ± 0.017	2.106GlnAsp: 2.106 ± 0.057	2.253GlnGlu: 2.253 ± 0.062	1.029GlnPhe: 1.029 ± 0.042	2.764GlnGly: 2.764 ± 0.072	1.016GlnHis: 1.016 ± 0.037	1.724GlnIle: 1.724 ± 0.051	1.165GlnLys: 1.165 ± 0.05	3.622GlnLeu: 3.622 ± 0.088	0.816GlnMet: 0.816 ± 0.036	0.91GlnAsn: 0.91 ± 0.039	1.965GlnPro: 1.965 ± 0.058	1.801GlnGln: 1.801 ± 0.069	2.819GlnArg: 2.819 ± 0.074	1.832GlnSer: 1.832 ± 0.05	1.564GlnThr: 1.564 ± 0.048	2.758GlnVal: 2.758 ± 0.073	0.783GlnTrp: 0.783 ± 0.032	0.681GlnTyr: 0.681 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	6.477ArgAla: 6.477 ± 0.122	0.395ArgCys: 0.395 ± 0.025	3.456ArgAsp: 3.456 ± 0.089	4.206ArgGlu: 4.206 ± 0.083	2.02ArgPhe: 2.02 ± 0.057	4.469ArgGly: 4.469 ± 0.092	1.387ArgHis: 1.387 ± 0.045	3.173ArgIle: 3.173 ± 0.062	2.031ArgLys: 2.031 ± 0.065	5.241ArgLeu: 5.241 ± 0.085	1.74ArgMet: 1.74 ± 0.044	1.774ArgAsn: 1.774 ± 0.053	2.947ArgPro: 2.947 ± 0.074	2.321ArgGln: 2.321 ± 0.068	4.958ArgArg: 4.958 ± 0.112	3.736ArgSer: 3.736 ± 0.073	3.824ArgThr: 3.824 ± 0.081	4.782ArgVal: 4.782 ± 0.093	1.046ArgTrp: 1.046 ± 0.037	1.542ArgTyr: 1.542 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.914SerAla: 6.914 ± 0.119	0.388SerCys: 0.388 ± 0.027	3.439SerAsp: 3.439 ± 0.085	3.455SerGlu: 3.455 ± 0.079	1.993SerPhe: 1.993 ± 0.063	5.517SerGly: 5.517 ± 0.098	1.378SerHis: 1.378 ± 0.045	2.872SerIle: 2.872 ± 0.07	1.885SerLys: 1.885 ± 0.069	5.678SerLeu: 5.678 ± 0.098	1.522SerMet: 1.522 ± 0.049	1.715SerAsn: 1.715 ± 0.051	3.118SerPro: 3.118 ± 0.069	2.131SerGln: 2.131 ± 0.057	3.556SerArg: 3.556 ± 0.065	4.285SerSer: 4.285 ± 0.109	4.416SerThr: 4.416 ± 0.09	4.848SerVal: 4.848 ± 0.082	0.803SerTrp: 0.803 ± 0.036	1.283SerTyr: 1.283 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	6.61ThrAla: 6.61 ± 0.112	0.462ThrCys: 0.462 ± 0.024	3.597ThrAsp: 3.597 ± 0.088	3.17ThrGlu: 3.17 ± 0.079	1.951ThrPhe: 1.951 ± 0.054	5.429ThrGly: 5.429 ± 0.091	1.513ThrHis: 1.513 ± 0.052	3.085ThrIle: 3.085 ± 0.071	1.868ThrLys: 1.868 ± 0.05	5.75ThrLeu: 5.75 ± 0.095	1.361ThrMet: 1.361 ± 0.048	1.658ThrAsn: 1.658 ± 0.051	3.791ThrPro: 3.791 ± 0.084	1.954ThrGln: 1.954 ± 0.059	3.331ThrArg: 3.331 ± 0.074	3.791ThrSer: 3.791 ± 0.091	4.045ThrThr: 4.045 ± 0.108	5.605ThrVal: 5.605 ± 0.099	0.877ThrTrp: 0.877 ± 0.039	1.384ThrTyr: 1.384 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	9.513ValAla: 9.513 ± 0.144	0.677ValCys: 0.677 ± 0.033	5.716ValAsp: 5.716 ± 0.105	5.481ValGlu: 5.481 ± 0.104	2.587ValPhe: 2.587 ± 0.068	6.449ValGly: 6.449 ± 0.128	1.738ValHis: 1.738 ± 0.053	4.123ValIle: 4.123 ± 0.1	2.451ValLys: 2.451 ± 0.065	7.822ValLeu: 7.822 ± 0.128	1.871ValMet: 1.871 ± 0.051	2.3ValAsn: 2.3 ± 0.061	4.026ValPro: 4.026 ± 0.084	2.371ValGln: 2.371 ± 0.062	4.699ValArg: 4.699 ± 0.088	4.836ValSer: 4.836 ± 0.092	5.282ValThr: 5.282 ± 0.107	7.568ValVal: 7.568 ± 0.136	1.048ValTrp: 1.048 ± 0.04	1.528ValTyr: 1.528 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.461TrpAla: 1.461 ± 0.052	0.136TrpCys: 0.136 ± 0.015	0.821TrpAsp: 0.821 ± 0.037	0.727TrpGlu: 0.727 ± 0.038	0.554TrpPhe: 0.554 ± 0.03	0.99TrpGly: 0.99 ± 0.044	0.293TrpHis: 0.293 ± 0.023	0.775TrpIle: 0.775 ± 0.033	0.435TrpLys: 0.435 ± 0.026	1.42TrpLeu: 1.42 ± 0.049	0.396TrpMet: 0.396 ± 0.027	0.443TrpAsn: 0.443 ± 0.03	0.584TrpPro: 0.584 ± 0.032	0.495TrpGln: 0.495 ± 0.027	0.935TrpArg: 0.935 ± 0.042	0.805TrpSer: 0.805 ± 0.038	0.866TrpThr: 0.866 ± 0.038	1.008TrpVal: 1.008 ± 0.042	0.323TrpTrp: 0.323 ± 0.023	0.244TrpTyr: 0.244 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.238TyrAla: 2.238 ± 0.062	0.193TyrCys: 0.193 ± 0.018	1.295TyrAsp: 1.295 ± 0.048	1.236TyrGlu: 1.236 ± 0.045	0.774TyrPhe: 0.774 ± 0.036	1.951TyrGly: 1.951 ± 0.051	0.376TyrHis: 0.376 ± 0.024	1.013TyrIle: 1.013 ± 0.039	0.64TyrLys: 0.64 ± 0.038	2.076TyrLeu: 2.076 ± 0.061	0.406TyrMet: 0.406 ± 0.026	0.625TyrAsn: 0.625 ± 0.035	1.217TyrPro: 1.217 ± 0.041	0.745TyrGln: 0.745 ± 0.033	1.417TyrArg: 1.417 ± 0.052	1.416TyrSer: 1.416 ± 0.05	1.27TyrThr: 1.27 ± 0.045	1.649TyrVal: 1.649 ± 0.045	0.323TyrTrp: 0.323 ± 0.022	0.517TyrTyr: 0.517 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1880 proteins (638581 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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