Amino acid dipepetide frequency for Legionella massiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.301AlaAla: 7.301 ± 0.107	1.045AlaCys: 1.045 ± 0.027	3.783AlaAsp: 3.783 ± 0.06	5.016AlaGlu: 5.016 ± 0.083	3.316AlaPhe: 3.316 ± 0.058	5.071AlaGly: 5.071 ± 0.098	1.699AlaHis: 1.699 ± 0.036	6.259AlaIle: 6.259 ± 0.084	5.325AlaLys: 5.325 ± 0.078	9.697AlaLeu: 9.697 ± 0.107	2.157AlaMet: 2.157 ± 0.041	3.999AlaAsn: 3.999 ± 0.065	2.76AlaPro: 2.76 ± 0.057	3.624AlaGln: 3.624 ± 0.061	3.462AlaArg: 3.462 ± 0.058	5.168AlaSer: 5.168 ± 0.07	4.166AlaThr: 4.166 ± 0.072	5.024AlaVal: 5.024 ± 0.087	0.848AlaTrp: 0.848 ± 0.026	2.682AlaTyr: 2.682 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.813CysAla: 0.813 ± 0.029	0.177CysCys: 0.177 ± 0.013	0.55CysAsp: 0.55 ± 0.025	0.647CysGlu: 0.647 ± 0.023	0.671CysPhe: 0.671 ± 0.024	0.818CysGly: 0.818 ± 0.028	0.32CysHis: 0.32 ± 0.017	0.762CysIle: 0.762 ± 0.025	0.57CysLys: 0.57 ± 0.024	1.399CysLeu: 1.399 ± 0.033	0.234CysMet: 0.234 ± 0.012	0.437CysAsn: 0.437 ± 0.021	0.495CysPro: 0.495 ± 0.021	0.557CysGln: 0.557 ± 0.022	0.483CysArg: 0.483 ± 0.02	0.852CysSer: 0.852 ± 0.029	0.574CysThr: 0.574 ± 0.026	0.569CysVal: 0.569 ± 0.022	0.153CysTrp: 0.153 ± 0.012	0.454CysTyr: 0.454 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	3.587AspAla: 3.587 ± 0.06	0.626AspCys: 0.626 ± 0.025	2.578AspAsp: 2.578 ± 0.048	3.676AspGlu: 3.676 ± 0.061	2.464AspPhe: 2.464 ± 0.05	2.782AspGly: 2.782 ± 0.055	0.866AspHis: 0.866 ± 0.027	3.36AspIle: 3.36 ± 0.057	3.45AspLys: 3.45 ± 0.062	5.593AspLeu: 5.593 ± 0.074	0.988AspMet: 0.988 ± 0.031	2.437AspAsn: 2.437 ± 0.048	1.957AspPro: 1.957 ± 0.041	1.728AspGln: 1.728 ± 0.038	1.982AspArg: 1.982 ± 0.045	3.473AspSer: 3.473 ± 0.056	2.144AspThr: 2.144 ± 0.045	2.758AspVal: 2.758 ± 0.05	0.707AspTrp: 0.707 ± 0.023	2.197AspTyr: 2.197 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.744GluAla: 4.744 ± 0.077	0.503GluCys: 0.503 ± 0.019	2.566GluAsp: 2.566 ± 0.056	4.259GluGlu: 4.259 ± 0.084	2.311GluPhe: 2.311 ± 0.048	3.151GluGly: 3.151 ± 0.052	1.538GluHis: 1.538 ± 0.036	4.413GluIle: 4.413 ± 0.064	4.296GluLys: 4.296 ± 0.074	7.351GluLeu: 7.351 ± 0.088	1.415GluMet: 1.415 ± 0.033	2.985GluAsn: 2.985 ± 0.051	2.068GluPro: 2.068 ± 0.046	3.894GluGln: 3.894 ± 0.061	3.16GluArg: 3.16 ± 0.061	3.542GluSer: 3.542 ± 0.052	3.117GluThr: 3.117 ± 0.061	3.486GluVal: 3.486 ± 0.061	0.584GluTrp: 0.584 ± 0.024	1.71GluTyr: 1.71 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.813PheAla: 3.813 ± 0.059	0.597PheCys: 0.597 ± 0.026	2.463PheAsp: 2.463 ± 0.046	2.192PheGlu: 2.192 ± 0.043	2.358PhePhe: 2.358 ± 0.054	2.581PheGly: 2.581 ± 0.05	0.962PheHis: 0.962 ± 0.03	3.358PheIle: 3.358 ± 0.061	2.349PheLys: 2.349 ± 0.043	4.573PheLeu: 4.573 ± 0.08	0.89PheMet: 0.89 ± 0.025	2.369PheAsn: 2.369 ± 0.048	1.701PhePro: 1.701 ± 0.04	1.529PheGln: 1.529 ± 0.037	1.626PheArg: 1.626 ± 0.043	3.71PheSer: 3.71 ± 0.061	2.308PheThr: 2.308 ± 0.049	2.478PheVal: 2.478 ± 0.047	0.549PheTrp: 0.549 ± 0.022	1.78PheTyr: 1.78 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.464GlyAla: 4.464 ± 0.084	0.825GlyCys: 0.825 ± 0.024	2.66GlyAsp: 2.66 ± 0.044	3.317GlyGlu: 3.317 ± 0.052	3.18GlyPhe: 3.18 ± 0.056	3.896GlyGly: 3.896 ± 0.086	1.414GlyHis: 1.414 ± 0.038	4.413GlyIle: 4.413 ± 0.064	3.608GlyLys: 3.608 ± 0.065	6.87GlyLeu: 6.87 ± 0.089	1.619GlyMet: 1.619 ± 0.039	2.473GlyAsn: 2.473 ± 0.067	1.616GlyPro: 1.616 ± 0.038	2.712GlyGln: 2.712 ± 0.058	2.549GlyArg: 2.549 ± 0.056	3.869GlySer: 3.869 ± 0.07	2.981GlyThr: 2.981 ± 0.075	3.818GlyVal: 3.818 ± 0.068	0.832GlyTrp: 0.832 ± 0.029	2.48GlyTyr: 2.48 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.593HisAla: 1.593 ± 0.035	0.371HisCys: 0.371 ± 0.019	1.081HisAsp: 1.081 ± 0.031	1.239HisGlu: 1.239 ± 0.033	1.268HisPhe: 1.268 ± 0.034	1.404HisGly: 1.404 ± 0.035	0.698HisHis: 0.698 ± 0.026	1.299HisIle: 1.299 ± 0.034	1.105HisLys: 1.105 ± 0.035	2.63HisLeu: 2.63 ± 0.052	0.447HisMet: 0.447 ± 0.023	0.926HisAsn: 0.926 ± 0.027	1.238HisPro: 1.238 ± 0.035	1.149HisGln: 1.149 ± 0.033	1.198HisArg: 1.198 ± 0.031	1.625HisSer: 1.625 ± 0.04	0.926HisThr: 0.926 ± 0.027	1.12HisVal: 1.12 ± 0.031	0.374HisTrp: 0.374 ± 0.018	1.062HisTyr: 1.062 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.504IleAla: 6.504 ± 0.085	0.784IleCys: 0.784 ± 0.027	4.22IleAsp: 4.22 ± 0.058	4.499IleGlu: 4.499 ± 0.065	2.653IlePhe: 2.653 ± 0.051	4.127IleGly: 4.127 ± 0.068	1.585IleHis: 1.585 ± 0.036	4.651IleIle: 4.651 ± 0.079	4.355IleLys: 4.355 ± 0.068	6.469IleLeu: 6.469 ± 0.073	1.251IleMet: 1.251 ± 0.035	4.042IleAsn: 4.042 ± 0.054	3.194IlePro: 3.194 ± 0.055	2.733IleGln: 2.733 ± 0.05	2.978IleArg: 2.978 ± 0.053	5.118IleSer: 5.118 ± 0.069	3.616IleThr: 3.616 ± 0.06	3.866IleVal: 3.866 ± 0.057	0.598IleTrp: 0.598 ± 0.022	2.152IleTyr: 2.152 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.957LysAla: 4.957 ± 0.072	0.362LysCys: 0.362 ± 0.019	3.082LysAsp: 3.082 ± 0.063	4.303LysGlu: 4.303 ± 0.07	1.751LysPhe: 1.751 ± 0.041	3.167LysGly: 3.167 ± 0.059	1.291LysHis: 1.291 ± 0.035	4.28LysIle: 4.28 ± 0.062	4.011LysLys: 4.011 ± 0.065	5.947LysLeu: 5.947 ± 0.086	1.301LysMet: 1.301 ± 0.04	3.253LysAsn: 3.253 ± 0.061	2.749LysPro: 2.749 ± 0.051	3.274LysGln: 3.274 ± 0.055	2.94LysArg: 2.94 ± 0.05	3.645LysSer: 3.645 ± 0.057	3.651LysThr: 3.651 ± 0.055	3.282LysVal: 3.282 ± 0.061	0.504LysTrp: 0.504 ± 0.023	1.619LysTyr: 1.619 ± 0.039	0.0LysXaa: 0.0 ± 0.0
Leu	10.571LeuAla: 10.571 ± 0.1	1.411LeuCys: 1.411 ± 0.037	5.431LeuAsp: 5.431 ± 0.072	6.093LeuGlu: 6.093 ± 0.09	4.924LeuPhe: 4.924 ± 0.077	6.725LeuGly: 6.725 ± 0.088	2.369LeuHis: 2.369 ± 0.048	7.936LeuIle: 7.936 ± 0.087	6.456LeuLys: 6.456 ± 0.078	12.055LeuLeu: 12.055 ± 0.139	2.503LeuMet: 2.503 ± 0.049	5.312LeuAsn: 5.312 ± 0.066	4.98LeuPro: 4.98 ± 0.072	4.82LeuGln: 4.82 ± 0.079	4.864LeuArg: 4.864 ± 0.072	8.659LeuSer: 8.659 ± 0.089	5.949LeuThr: 5.949 ± 0.073	6.553LeuVal: 6.553 ± 0.077	1.094LeuTrp: 1.094 ± 0.037	3.209LeuTyr: 3.209 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	1.909MetAla: 1.909 ± 0.042	0.156MetCys: 0.156 ± 0.012	1.087MetAsp: 1.087 ± 0.033	1.069MetGlu: 1.069 ± 0.03	0.744MetPhe: 0.744 ± 0.027	1.357MetGly: 1.357 ± 0.036	0.544MetHis: 0.544 ± 0.023	1.419MetIle: 1.419 ± 0.038	1.474MetLys: 1.474 ± 0.036	2.473MetLeu: 2.473 ± 0.045	0.613MetMet: 0.613 ± 0.023	1.088MetAsn: 1.088 ± 0.032	1.069MetPro: 1.069 ± 0.029	1.271MetGln: 1.271 ± 0.031	1.135MetArg: 1.135 ± 0.03	1.566MetSer: 1.566 ± 0.035	1.346MetThr: 1.346 ± 0.034	1.317MetVal: 1.317 ± 0.036	0.158MetTrp: 0.158 ± 0.012	0.492MetTyr: 0.492 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.447AsnAla: 3.447 ± 0.056	0.599AsnCys: 0.599 ± 0.025	2.263AsnAsp: 2.263 ± 0.049	2.982AsnGlu: 2.982 ± 0.055	2.059AsnPhe: 2.059 ± 0.039	2.628AsnGly: 2.628 ± 0.06	1.236AsnHis: 1.236 ± 0.037	3.036AsnIle: 3.036 ± 0.056	3.023AsnLys: 3.023 ± 0.066	5.203AsnLeu: 5.203 ± 0.07	0.891AsnMet: 0.891 ± 0.027	2.556AsnAsn: 2.556 ± 0.057	2.767AsnPro: 2.767 ± 0.048	2.609AsnGln: 2.609 ± 0.049	2.18AsnArg: 2.18 ± 0.042	3.461AsnSer: 3.461 ± 0.057	2.454AsnThr: 2.454 ± 0.049	2.252AsnVal: 2.252 ± 0.054	0.608AsnTrp: 0.608 ± 0.024	1.94AsnTyr: 1.94 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	3.258ProAla: 3.258 ± 0.057	0.389ProCys: 0.389 ± 0.018	2.128ProAsp: 2.128 ± 0.043	3.214ProGlu: 3.214 ± 0.06	1.847ProPhe: 1.847 ± 0.04	2.626ProGly: 2.626 ± 0.05	0.906ProHis: 0.906 ± 0.03	2.781ProIle: 2.781 ± 0.051	2.287ProLys: 2.287 ± 0.048	4.634ProLeu: 4.634 ± 0.069	0.868ProMet: 0.868 ± 0.025	1.913ProAsn: 1.913 ± 0.04	1.553ProPro: 1.553 ± 0.04	1.977ProGln: 1.977 ± 0.047	1.52ProArg: 1.52 ± 0.036	2.845ProSer: 2.845 ± 0.055	2.134ProThr: 2.134 ± 0.042	2.875ProVal: 2.875 ± 0.057	0.477ProTrp: 0.477 ± 0.021	1.419ProTyr: 1.419 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.427GlnAla: 4.427 ± 0.063	0.409GlnCys: 0.409 ± 0.019	2.09GlnAsp: 2.09 ± 0.04	2.983GlnGlu: 2.983 ± 0.056	2.059GlnPhe: 2.059 ± 0.039	2.798GlnGly: 2.798 ± 0.048	1.105GlnHis: 1.105 ± 0.032	3.15GlnIle: 3.15 ± 0.055	2.513GlnLys: 2.513 ± 0.047	5.539GlnLeu: 5.539 ± 0.082	1.009GlnMet: 1.009 ± 0.028	2.073GlnAsn: 2.073 ± 0.047	1.875GlnPro: 1.875 ± 0.042	3.11GlnGln: 3.11 ± 0.08	2.274GlnArg: 2.274 ± 0.046	2.918GlnSer: 2.918 ± 0.056	2.444GlnThr: 2.444 ± 0.049	2.81GlnVal: 2.81 ± 0.053	0.578GlnTrp: 0.578 ± 0.02	1.41GlnTyr: 1.41 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.385ArgAla: 3.385 ± 0.057	0.499ArgCys: 0.499 ± 0.019	2.28ArgAsp: 2.28 ± 0.044	2.959ArgGlu: 2.959 ± 0.056	2.169ArgPhe: 2.169 ± 0.047	2.397ArgGly: 2.397 ± 0.048	1.175ArgHis: 1.175 ± 0.032	3.022ArgIle: 3.022 ± 0.05	2.452ArgLys: 2.452 ± 0.05	5.233ArgLeu: 5.233 ± 0.078	1.057ArgMet: 1.057 ± 0.028	1.904ArgAsn: 1.904 ± 0.036	1.563ArgPro: 1.563 ± 0.035	2.207ArgGln: 2.207 ± 0.04	2.086ArgArg: 2.086 ± 0.044	2.533ArgSer: 2.533 ± 0.052	2.059ArgThr: 2.059 ± 0.04	2.767ArgVal: 2.767 ± 0.05	0.548ArgTrp: 0.548 ± 0.024	1.819ArgTyr: 1.819 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.07SerAla: 5.07 ± 0.083	0.94SerCys: 0.94 ± 0.03	3.249SerAsp: 3.249 ± 0.051	3.907SerGlu: 3.907 ± 0.071	3.346SerPhe: 3.346 ± 0.056	4.342SerGly: 4.342 ± 0.077	1.581SerHis: 1.581 ± 0.038	4.417SerIle: 4.417 ± 0.065	3.815SerLys: 3.815 ± 0.06	8.297SerLeu: 8.297 ± 0.089	1.695SerMet: 1.695 ± 0.039	3.172SerAsn: 3.172 ± 0.062	3.134SerPro: 3.134 ± 0.057	3.173SerGln: 3.173 ± 0.056	2.746SerArg: 2.746 ± 0.045	5.402SerSer: 5.402 ± 0.107	3.597SerThr: 3.597 ± 0.065	3.692SerVal: 3.692 ± 0.059	0.871SerTrp: 0.871 ± 0.028	2.626SerTyr: 2.626 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	4.409ThrAla: 4.409 ± 0.09	0.513ThrCys: 0.513 ± 0.022	2.384ThrAsp: 2.384 ± 0.061	2.881ThrGlu: 2.881 ± 0.053	1.906ThrPhe: 1.906 ± 0.044	3.572ThrGly: 3.572 ± 0.07	1.135ThrHis: 1.135 ± 0.03	3.837ThrIle: 3.837 ± 0.062	2.697ThrLys: 2.697 ± 0.049	6.0ThrLeu: 6.0 ± 0.069	1.091ThrMet: 1.091 ± 0.03	2.378ThrAsn: 2.378 ± 0.05	2.667ThrPro: 2.667 ± 0.068	2.234ThrGln: 2.234 ± 0.048	2.148ThrArg: 2.148 ± 0.045	3.307ThrSer: 3.307 ± 0.066	3.069ThrThr: 3.069 ± 0.092	3.433ThrVal: 3.433 ± 0.076	0.518ThrTrp: 0.518 ± 0.019	1.563ThrTyr: 1.563 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	4.991ValAla: 4.991 ± 0.075	0.665ValCys: 0.665 ± 0.025	3.295ValAsp: 3.295 ± 0.052	3.525ValGlu: 3.525 ± 0.058	2.773ValPhe: 2.773 ± 0.05	3.391ValGly: 3.391 ± 0.066	1.16ValHis: 1.16 ± 0.032	4.371ValIle: 4.371 ± 0.07	3.309ValLys: 3.309 ± 0.059	6.259ValLeu: 6.259 ± 0.074	1.353ValMet: 1.353 ± 0.032	2.944ValAsn: 2.944 ± 0.05	2.23ValPro: 2.23 ± 0.048	2.09ValGln: 2.09 ± 0.039	2.408ValArg: 2.408 ± 0.046	4.237ValSer: 4.237 ± 0.067	3.054ValThr: 3.054 ± 0.078	3.928ValVal: 3.928 ± 0.066	0.582ValTrp: 0.582 ± 0.022	1.817ValTyr: 1.817 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.731TrpAla: 0.731 ± 0.026	0.14TrpCys: 0.14 ± 0.011	0.499TrpAsp: 0.499 ± 0.019	0.527TrpGlu: 0.527 ± 0.019	0.567TrpPhe: 0.567 ± 0.022	0.702TrpGly: 0.702 ± 0.026	0.344TrpHis: 0.344 ± 0.018	0.674TrpIle: 0.674 ± 0.025	0.517TrpLys: 0.517 ± 0.022	1.54TrpLeu: 1.54 ± 0.04	0.276TrpMet: 0.276 ± 0.015	0.455TrpAsn: 0.455 ± 0.02	0.458TrpPro: 0.458 ± 0.018	0.816TrpGln: 0.816 ± 0.028	0.59TrpArg: 0.59 ± 0.025	0.698TrpSer: 0.698 ± 0.025	0.481TrpThr: 0.481 ± 0.02	0.674TrpVal: 0.674 ± 0.027	0.159TrpTrp: 0.159 ± 0.012	0.382TrpTyr: 0.382 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.426TyrAla: 2.426 ± 0.046	0.524TyrCys: 0.524 ± 0.02	1.661TyrAsp: 1.661 ± 0.072	1.805TyrGlu: 1.805 ± 0.041	1.821TyrPhe: 1.821 ± 0.042	2.061TyrGly: 2.061 ± 0.043	0.826TyrHis: 0.826 ± 0.026	1.956TyrIle: 1.956 ± 0.049	1.757TyrLys: 1.757 ± 0.044	4.151TyrLeu: 4.151 ± 0.062	0.626TyrMet: 0.626 ± 0.022	1.479TyrAsn: 1.479 ± 0.039	1.578TyrPro: 1.578 ± 0.039	2.065TyrGln: 2.065 ± 0.044	1.783TyrArg: 1.783 ± 0.04	2.445TyrSer: 2.445 ± 0.051	1.672TyrThr: 1.672 ± 0.042	1.684TyrVal: 1.684 ± 0.035	0.492TyrTrp: 0.492 ± 0.021	1.347TyrTyr: 1.347 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3750 proteins (1263423 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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