Amino acid dipepetide frequency for Psychromonas sp. B3M02

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.097AlaAla: 7.097 ± 0.124	0.987AlaCys: 0.987 ± 0.031	4.494AlaAsp: 4.494 ± 0.059	5.399AlaGlu: 5.399 ± 0.074	3.487AlaPhe: 3.487 ± 0.068	5.536AlaGly: 5.536 ± 0.089	1.543AlaHis: 1.543 ± 0.043	6.447AlaIle: 6.447 ± 0.086	4.998AlaLys: 4.998 ± 0.076	9.718AlaLeu: 9.718 ± 0.117	2.421AlaMet: 2.421 ± 0.048	3.614AlaAsn: 3.614 ± 0.06	2.554AlaPro: 2.554 ± 0.054	3.684AlaGln: 3.684 ± 0.063	2.973AlaArg: 2.973 ± 0.055	5.196AlaSer: 5.196 ± 0.071	4.547AlaThr: 4.547 ± 0.066	5.569AlaVal: 5.569 ± 0.08	0.863AlaTrp: 0.863 ± 0.032	2.468AlaTyr: 2.468 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.763CysAla: 0.763 ± 0.022	0.172CysCys: 0.172 ± 0.014	0.594CysAsp: 0.594 ± 0.025	0.631CysGlu: 0.631 ± 0.024	0.495CysPhe: 0.495 ± 0.023	0.83CysGly: 0.83 ± 0.029	0.315CysHis: 0.315 ± 0.021	0.724CysIle: 0.724 ± 0.026	0.508CysLys: 0.508 ± 0.022	1.087CysLeu: 1.087 ± 0.036	0.235CysMet: 0.235 ± 0.017	0.38CysAsn: 0.38 ± 0.019	0.457CysPro: 0.457 ± 0.018	0.436CysGln: 0.436 ± 0.021	0.388CysArg: 0.388 ± 0.019	0.744CysSer: 0.744 ± 0.029	0.499CysThr: 0.499 ± 0.021	0.647CysVal: 0.647 ± 0.026	0.122CysTrp: 0.122 ± 0.011	0.378CysTyr: 0.378 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.261AspAla: 4.261 ± 0.063	0.564AspCys: 0.564 ± 0.022	3.179AspAsp: 3.179 ± 0.079	3.356AspGlu: 3.356 ± 0.069	2.604AspPhe: 2.604 ± 0.048	3.48AspGly: 3.48 ± 0.086	1.121AspHis: 1.121 ± 0.037	4.327AspIle: 4.327 ± 0.064	3.661AspLys: 3.661 ± 0.069	5.682AspLeu: 5.682 ± 0.08	1.265AspMet: 1.265 ± 0.035	2.867AspAsn: 2.867 ± 0.057	2.112AspPro: 2.112 ± 0.049	2.494AspGln: 2.494 ± 0.054	1.865AspArg: 1.865 ± 0.043	3.399AspSer: 3.399 ± 0.067	2.932AspThr: 2.932 ± 0.061	3.482AspVal: 3.482 ± 0.06	0.768AspTrp: 0.768 ± 0.028	2.116AspTyr: 2.116 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	4.966GluAla: 4.966 ± 0.078	0.474GluCys: 0.474 ± 0.023	2.965GluAsp: 2.965 ± 0.053	3.645GluGlu: 3.645 ± 0.076	2.421GluPhe: 2.421 ± 0.052	3.516GluGly: 3.516 ± 0.063	1.467GluHis: 1.467 ± 0.039	4.094GluIle: 4.094 ± 0.064	4.005GluLys: 4.005 ± 0.071	6.596GluLeu: 6.596 ± 0.089	1.718GluMet: 1.718 ± 0.038	2.96GluAsn: 2.96 ± 0.062	1.644GluPro: 1.644 ± 0.045	4.204GluGln: 4.204 ± 0.072	2.583GluArg: 2.583 ± 0.055	3.796GluSer: 3.796 ± 0.058	3.281GluThr: 3.281 ± 0.06	4.379GluVal: 4.379 ± 0.065	0.664GluTrp: 0.664 ± 0.027	1.741GluTyr: 1.741 ± 0.037	0.0GluXaa: 0.0 ± 0.0
Phe	3.65PheAla: 3.65 ± 0.066	0.542PheCys: 0.542 ± 0.023	2.774PheAsp: 2.774 ± 0.062	2.529PheGlu: 2.529 ± 0.054	1.829PhePhe: 1.829 ± 0.048	2.826PheGly: 2.826 ± 0.06	0.794PheHis: 0.794 ± 0.03	3.47PheIle: 3.47 ± 0.068	2.41PheLys: 2.41 ± 0.041	3.684PheLeu: 3.684 ± 0.068	1.028PheMet: 1.028 ± 0.033	2.312PheAsn: 2.312 ± 0.049	1.478PhePro: 1.478 ± 0.036	1.255PheGln: 1.255 ± 0.034	1.231PheArg: 1.231 ± 0.033	3.638PheSer: 3.638 ± 0.068	2.662PheThr: 2.662 ± 0.051	2.858PheVal: 2.858 ± 0.055	0.464PheTrp: 0.464 ± 0.023	1.493PheTyr: 1.493 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.831GlyAla: 4.831 ± 0.087	0.852GlyCys: 0.852 ± 0.029	3.586GlyAsp: 3.586 ± 0.066	4.237GlyGlu: 4.237 ± 0.066	3.227GlyPhe: 3.227 ± 0.063	4.366GlyGly: 4.366 ± 0.082	1.429GlyHis: 1.429 ± 0.039	4.771GlyIle: 4.771 ± 0.072	3.922GlyLys: 3.922 ± 0.064	6.897GlyLeu: 6.897 ± 0.101	1.713GlyMet: 1.713 ± 0.043	2.405GlyAsn: 2.405 ± 0.054	1.506GlyPro: 1.506 ± 0.043	2.645GlyGln: 2.645 ± 0.052	2.494GlyArg: 2.494 ± 0.054	3.821GlySer: 3.821 ± 0.067	3.258GlyThr: 3.258 ± 0.06	4.854GlyVal: 4.854 ± 0.075	0.808GlyTrp: 0.808 ± 0.026	2.557GlyTyr: 2.557 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	1.526HisAla: 1.526 ± 0.048	0.351HisCys: 0.351 ± 0.018	1.043HisAsp: 1.043 ± 0.036	1.015HisGlu: 1.015 ± 0.035	1.233HisPhe: 1.233 ± 0.036	1.34HisGly: 1.34 ± 0.036	0.681HisHis: 0.681 ± 0.031	1.495HisIle: 1.495 ± 0.031	1.136HisLys: 1.136 ± 0.037	2.269HisLeu: 2.269 ± 0.054	0.487HisMet: 0.487 ± 0.023	0.954HisAsn: 0.954 ± 0.031	1.038HisPro: 1.038 ± 0.036	1.261HisGln: 1.261 ± 0.045	0.864HisArg: 0.864 ± 0.027	1.42HisSer: 1.42 ± 0.036	0.995HisThr: 0.995 ± 0.03	1.096HisVal: 1.096 ± 0.033	0.315HisTrp: 0.315 ± 0.016	0.844HisTyr: 0.844 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.837IleAla: 6.837 ± 0.092	0.78IleCys: 0.78 ± 0.028	4.707IleAsp: 4.707 ± 0.067	5.018IleGlu: 5.018 ± 0.066	2.681IlePhe: 2.681 ± 0.063	4.819IleGly: 4.819 ± 0.076	1.309IleHis: 1.309 ± 0.034	4.689IleIle: 4.689 ± 0.084	4.317IleLys: 4.317 ± 0.072	6.112IleLeu: 6.112 ± 0.081	1.434IleMet: 1.434 ± 0.04	3.988IleAsn: 3.988 ± 0.06	2.729IlePro: 2.729 ± 0.048	2.544IleGln: 2.544 ± 0.053	2.382IleArg: 2.382 ± 0.047	5.281IleSer: 5.281 ± 0.069	4.297IleThr: 4.297 ± 0.066	4.399IleVal: 4.399 ± 0.076	0.662IleTrp: 0.662 ± 0.029	2.03IleTyr: 2.03 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	5.108LysAla: 5.108 ± 0.082	0.348LysCys: 0.348 ± 0.02	2.812LysAsp: 2.812 ± 0.051	3.666LysGlu: 3.666 ± 0.064	1.72LysPhe: 1.72 ± 0.044	3.388LysGly: 3.388 ± 0.059	1.338LysHis: 1.338 ± 0.031	3.718LysIle: 3.718 ± 0.059	3.708LysLys: 3.708 ± 0.073	5.757LysLeu: 5.757 ± 0.079	1.607LysMet: 1.607 ± 0.041	2.595LysAsn: 2.595 ± 0.058	2.28LysPro: 2.28 ± 0.051	3.72LysGln: 3.72 ± 0.061	2.652LysArg: 2.652 ± 0.051	3.678LysSer: 3.678 ± 0.065	3.124LysThr: 3.124 ± 0.063	4.263LysVal: 4.263 ± 0.065	0.565LysTrp: 0.565 ± 0.021	1.462LysTyr: 1.462 ± 0.043	0.0LysXaa: 0.0 ± 0.0
Leu	9.592LeuAla: 9.592 ± 0.098	1.09LeuCys: 1.09 ± 0.033	5.73LeuAsp: 5.73 ± 0.08	5.337LeuGlu: 5.337 ± 0.081	4.739LeuPhe: 4.739 ± 0.086	6.565LeuGly: 6.565 ± 0.093	2.017LeuHis: 2.017 ± 0.046	7.484LeuIle: 7.484 ± 0.102	5.956LeuLys: 5.956 ± 0.082	11.611LeuLeu: 11.611 ± 0.147	2.63LeuMet: 2.63 ± 0.055	5.067LeuAsn: 5.067 ± 0.073	4.623LeuPro: 4.623 ± 0.068	4.413LeuGln: 4.413 ± 0.083	3.75LeuArg: 3.75 ± 0.071	8.565LeuSer: 8.565 ± 0.107	6.662LeuThr: 6.662 ± 0.083	6.771LeuVal: 6.771 ± 0.097	0.987LeuTrp: 0.987 ± 0.035	2.795LeuTyr: 2.795 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.196MetAla: 2.196 ± 0.045	0.194MetCys: 0.194 ± 0.014	1.23MetAsp: 1.23 ± 0.031	1.193MetGlu: 1.193 ± 0.034	0.914MetPhe: 0.914 ± 0.029	1.648MetGly: 1.648 ± 0.041	0.459MetHis: 0.459 ± 0.02	1.622MetIle: 1.622 ± 0.039	1.462MetLys: 1.462 ± 0.036	2.696MetLeu: 2.696 ± 0.052	0.692MetMet: 0.692 ± 0.027	1.089MetAsn: 1.089 ± 0.035	1.116MetPro: 1.116 ± 0.037	1.246MetGln: 1.246 ± 0.03	1.019MetArg: 1.019 ± 0.029	1.872MetSer: 1.872 ± 0.043	1.47MetThr: 1.47 ± 0.043	1.669MetVal: 1.669 ± 0.044	0.179MetTrp: 0.179 ± 0.013	0.49MetTyr: 0.49 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.542AsnAla: 3.542 ± 0.058	0.416AsnCys: 0.416 ± 0.018	2.599AsnAsp: 2.599 ± 0.068	2.763AsnGlu: 2.763 ± 0.059	1.717AsnPhe: 1.717 ± 0.04	2.9AsnGly: 2.9 ± 0.061	0.933AsnHis: 0.933 ± 0.03	3.56AsnIle: 3.56 ± 0.067	3.059AsnLys: 3.059 ± 0.056	4.366AsnLeu: 4.366 ± 0.066	1.08AsnMet: 1.08 ± 0.035	2.528AsnAsn: 2.528 ± 0.06	1.975AsnPro: 1.975 ± 0.045	2.3AsnGln: 2.3 ± 0.052	1.769AsnArg: 1.769 ± 0.043	3.04AsnSer: 3.04 ± 0.059	2.632AsnThr: 2.632 ± 0.054	2.68AsnVal: 2.68 ± 0.054	0.566AsnTrp: 0.566 ± 0.023	1.499AsnTyr: 1.499 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.93ProAla: 2.93 ± 0.059	0.325ProCys: 0.325 ± 0.02	2.127ProAsp: 2.127 ± 0.042	3.086ProGlu: 3.086 ± 0.058	1.724ProPhe: 1.724 ± 0.04	2.017ProGly: 2.017 ± 0.046	0.761ProHis: 0.761 ± 0.032	2.63ProIle: 2.63 ± 0.05	1.944ProLys: 1.944 ± 0.048	3.888ProLeu: 3.888 ± 0.066	0.861ProMet: 0.861 ± 0.027	1.703ProAsn: 1.703 ± 0.043	0.992ProPro: 0.992 ± 0.036	1.375ProGln: 1.375 ± 0.039	1.121ProArg: 1.121 ± 0.028	2.399ProSer: 2.399 ± 0.05	2.161ProThr: 2.161 ± 0.045	2.843ProVal: 2.843 ± 0.054	0.408ProTrp: 0.408 ± 0.02	1.169ProTyr: 1.169 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.551GlnAla: 4.551 ± 0.075	0.45GlnCys: 0.45 ± 0.023	2.229GlnAsp: 2.229 ± 0.049	2.444GlnGlu: 2.444 ± 0.044	1.875GlnPhe: 1.875 ± 0.049	3.051GlnGly: 3.051 ± 0.052	1.328GlnHis: 1.328 ± 0.038	2.716GlnIle: 2.716 ± 0.047	2.426GlnLys: 2.426 ± 0.056	5.601GlnLeu: 5.601 ± 0.091	0.966GlnMet: 0.966 ± 0.031	1.611GlnAsn: 1.611 ± 0.035	1.568GlnPro: 1.568 ± 0.039	3.942GlnGln: 3.942 ± 0.106	2.097GlnArg: 2.097 ± 0.047	2.93GlnSer: 2.93 ± 0.061	2.413GlnThr: 2.413 ± 0.054	3.398GlnVal: 3.398 ± 0.06	0.653GlnTrp: 0.653 ± 0.028	1.478GlnTyr: 1.478 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	2.637ArgAla: 2.637 ± 0.057	0.416ArgCys: 0.416 ± 0.019	2.035ArgAsp: 2.035 ± 0.043	2.312ArgGlu: 2.312 ± 0.049	1.957ArgPhe: 1.957 ± 0.04	2.121ArgGly: 2.121 ± 0.049	0.945ArgHis: 0.945 ± 0.03	2.702ArgIle: 2.702 ± 0.056	2.037ArgLys: 2.037 ± 0.047	4.467ArgLeu: 4.467 ± 0.075	0.871ArgMet: 0.871 ± 0.03	1.6ArgAsn: 1.6 ± 0.036	1.334ArgPro: 1.334 ± 0.037	1.638ArgGln: 1.638 ± 0.04	1.629ArgArg: 1.629 ± 0.05	2.298ArgSer: 2.298 ± 0.04	1.809ArgThr: 1.809 ± 0.041	2.59ArgVal: 2.59 ± 0.054	0.506ArgTrp: 0.506 ± 0.022	1.569ArgTyr: 1.569 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	5.452SerAla: 5.452 ± 0.084	0.658SerCys: 0.658 ± 0.024	3.903SerAsp: 3.903 ± 0.072	4.372SerGlu: 4.372 ± 0.068	3.095SerPhe: 3.095 ± 0.059	4.694SerGly: 4.694 ± 0.074	1.479SerHis: 1.479 ± 0.045	4.886SerIle: 4.886 ± 0.078	3.415SerLys: 3.415 ± 0.056	7.588SerLeu: 7.588 ± 0.091	1.669SerMet: 1.669 ± 0.043	2.948SerAsn: 2.948 ± 0.057	2.374SerPro: 2.374 ± 0.051	2.898SerGln: 2.898 ± 0.05	2.524SerArg: 2.524 ± 0.046	4.642SerSer: 4.642 ± 0.087	3.867SerThr: 3.867 ± 0.068	4.713SerVal: 4.713 ± 0.084	0.782SerTrp: 0.782 ± 0.032	2.169SerTyr: 2.169 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.539ThrAla: 4.539 ± 0.072	0.494ThrCys: 0.494 ± 0.021	3.185ThrAsp: 3.185 ± 0.06	3.63ThrGlu: 3.63 ± 0.069	2.293ThrPhe: 2.293 ± 0.043	3.986ThrGly: 3.986 ± 0.064	1.216ThrHis: 1.216 ± 0.03	3.821ThrIle: 3.821 ± 0.055	2.715ThrLys: 2.715 ± 0.048	6.689ThrLeu: 6.689 ± 0.08	1.12ThrMet: 1.12 ± 0.035	2.318ThrAsn: 2.318 ± 0.053	2.615ThrPro: 2.615 ± 0.056	2.483ThrGln: 2.483 ± 0.047	1.985ThrArg: 1.985 ± 0.047	3.672ThrSer: 3.672 ± 0.076	3.229ThrThr: 3.229 ± 0.069	3.789ThrVal: 3.789 ± 0.094	0.627ThrTrp: 0.627 ± 0.026	1.567ThrTyr: 1.567 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.978ValAla: 5.978 ± 0.087	0.724ValCys: 0.724 ± 0.027	4.118ValAsp: 4.118 ± 0.069	4.399ValGlu: 4.399 ± 0.071	2.794ValPhe: 2.794 ± 0.058	4.393ValGly: 4.393 ± 0.073	1.165ValHis: 1.165 ± 0.032	5.156ValIle: 5.156 ± 0.073	3.686ValLys: 3.686 ± 0.06	6.592ValLeu: 6.592 ± 0.088	1.721ValMet: 1.721 ± 0.043	3.339ValAsn: 3.339 ± 0.069	2.271ValPro: 2.271 ± 0.05	2.252ValGln: 2.252 ± 0.047	2.276ValArg: 2.276 ± 0.052	4.863ValSer: 4.863 ± 0.082	4.168ValThr: 4.168 ± 0.075	4.975ValVal: 4.975 ± 0.081	0.644ValTrp: 0.644 ± 0.022	1.923ValTyr: 1.923 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.797TrpAla: 0.797 ± 0.027	0.14TrpCys: 0.14 ± 0.013	0.555TrpAsp: 0.555 ± 0.025	0.516TrpGlu: 0.516 ± 0.021	0.545TrpPhe: 0.545 ± 0.027	0.729TrpGly: 0.729 ± 0.03	0.288TrpHis: 0.288 ± 0.017	0.683TrpIle: 0.683 ± 0.027	0.533TrpLys: 0.533 ± 0.022	1.525TrpLeu: 1.525 ± 0.041	0.305TrpMet: 0.305 ± 0.016	0.401TrpAsn: 0.401 ± 0.02	0.433TrpPro: 0.433 ± 0.023	0.776TrpGln: 0.776 ± 0.031	0.464TrpArg: 0.464 ± 0.021	0.719TrpSer: 0.719 ± 0.028	0.493TrpThr: 0.493 ± 0.023	0.772TrpVal: 0.772 ± 0.029	0.141TrpTrp: 0.141 ± 0.012	0.349TrpTyr: 0.349 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.346TyrAla: 2.346 ± 0.049	0.429TyrCys: 0.429 ± 0.021	1.672TyrAsp: 1.672 ± 0.042	1.569TyrGlu: 1.569 ± 0.044	1.577TyrPhe: 1.577 ± 0.04	1.975TyrGly: 1.975 ± 0.052	0.774TyrHis: 0.774 ± 0.029	2.02TyrIle: 2.02 ± 0.044	1.612TyrLys: 1.612 ± 0.042	3.557TyrLeu: 3.557 ± 0.061	0.631TyrMet: 0.631 ± 0.027	1.244TyrAsn: 1.244 ± 0.039	1.364TyrPro: 1.364 ± 0.034	2.163TyrGln: 2.163 ± 0.047	1.404TyrArg: 1.404 ± 0.034	2.155TyrSer: 2.155 ± 0.051	1.475TyrThr: 1.475 ± 0.039	1.689TyrVal: 1.689 ± 0.032	0.443TyrTrp: 0.443 ± 0.022	1.117TyrTyr: 1.117 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3376 proteins (1096779 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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