Amino acid dipepetide frequency for Melampsora larici-populina (strain 98AG31 / pathotype 3-4-7) (Poplar leaf rust fungus)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.077AlaAla: 5.077 ± 0.045	0.981AlaCys: 0.981 ± 0.014	3.065AlaAsp: 3.065 ± 0.025	3.705AlaGlu: 3.705 ± 0.026	2.428AlaPhe: 2.428 ± 0.023	3.793AlaGly: 3.793 ± 0.037	1.669AlaHis: 1.669 ± 0.017	3.695AlaIle: 3.695 ± 0.027	3.788AlaLys: 3.788 ± 0.031	6.079AlaLeu: 6.079 ± 0.037	1.493AlaMet: 1.493 ± 0.016	2.774AlaAsn: 2.774 ± 0.023	3.588AlaPro: 3.588 ± 0.037	2.882AlaGln: 2.882 ± 0.027	3.659AlaArg: 3.659 ± 0.028	6.114AlaSer: 6.114 ± 0.038	4.104AlaThr: 4.104 ± 0.028	3.459AlaVal: 3.459 ± 0.028	0.806AlaTrp: 0.806 ± 0.013	1.728AlaTyr: 1.728 ± 0.017	0.0AlaXaa: 0.0 ± 0.0
Cys	0.809CysAla: 0.809 ± 0.012	0.292CysCys: 0.292 ± 0.007	0.773CysAsp: 0.773 ± 0.011	0.735CysGlu: 0.735 ± 0.011	0.636CysPhe: 0.636 ± 0.012	0.934CysGly: 0.934 ± 0.015	0.444CysHis: 0.444 ± 0.008	0.705CysIle: 0.705 ± 0.011	0.782CysLys: 0.782 ± 0.014	1.423CysLeu: 1.423 ± 0.018	0.282CysMet: 0.282 ± 0.007	0.575CysAsn: 0.575 ± 0.011	0.824CysPro: 0.824 ± 0.014	0.641CysGln: 0.641 ± 0.012	0.773CysArg: 0.773 ± 0.011	1.204CysSer: 1.204 ± 0.016	0.815CysThr: 0.815 ± 0.013	0.736CysVal: 0.736 ± 0.011	0.195CysTrp: 0.195 ± 0.005	0.417CysTyr: 0.417 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.143AspAla: 3.143 ± 0.022	0.77AspCys: 0.77 ± 0.011	3.902AspAsp: 3.902 ± 0.034	4.45AspGlu: 4.45 ± 0.038	2.087AspPhe: 2.087 ± 0.02	3.269AspGly: 3.269 ± 0.024	1.754AspHis: 1.754 ± 0.018	2.755AspIle: 2.755 ± 0.023	2.44AspLys: 2.44 ± 0.021	5.666AspLeu: 5.666 ± 0.034	1.054AspMet: 1.054 ± 0.012	1.946AspAsn: 1.946 ± 0.017	3.461AspPro: 3.461 ± 0.029	2.891AspGln: 2.891 ± 0.023	2.696AspArg: 2.696 ± 0.024	4.664AspSer: 4.664 ± 0.03	2.749AspThr: 2.749 ± 0.023	3.006AspVal: 3.006 ± 0.023	0.858AspTrp: 0.858 ± 0.013	1.476AspTyr: 1.476 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	4.347GluAla: 4.347 ± 0.029	0.718GluCys: 0.718 ± 0.012	4.215GluAsp: 4.215 ± 0.032	5.773GluGlu: 5.773 ± 0.053	2.075GluPhe: 2.075 ± 0.021	3.196GluGly: 3.196 ± 0.028	1.398GluHis: 1.398 ± 0.015	3.628GluIle: 3.628 ± 0.032	3.679GluLys: 3.679 ± 0.03	5.447GluLeu: 5.447 ± 0.04	1.425GluMet: 1.425 ± 0.016	2.598GluAsn: 2.598 ± 0.024	2.642GluPro: 2.642 ± 0.025	2.11GluGln: 2.11 ± 0.024	3.235GluArg: 3.235 ± 0.03	4.891GluSer: 4.891 ± 0.03	3.291GluThr: 3.291 ± 0.023	3.629GluVal: 3.629 ± 0.03	0.813GluTrp: 0.813 ± 0.013	1.437GluTyr: 1.437 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	2.19PheAla: 2.19 ± 0.022	0.63PheCys: 0.63 ± 0.012	2.263PheAsp: 2.263 ± 0.021	2.323PheGlu: 2.323 ± 0.022	1.511PhePhe: 1.511 ± 0.018	2.531PheGly: 2.531 ± 0.025	1.066PheHis: 1.066 ± 0.013	2.037PheIle: 2.037 ± 0.021	2.189PheLys: 2.189 ± 0.02	3.44PheLeu: 3.44 ± 0.026	0.785PheMet: 0.785 ± 0.012	1.868PheAsn: 1.868 ± 0.019	1.911PhePro: 1.911 ± 0.016	1.659PheGln: 1.659 ± 0.017	1.736PheArg: 1.736 ± 0.017	3.107PheSer: 3.107 ± 0.024	2.081PheThr: 2.081 ± 0.019	2.083PheVal: 2.083 ± 0.023	0.531PheTrp: 0.531 ± 0.009	1.002PheTyr: 1.002 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	3.384GlyAla: 3.384 ± 0.036	0.86GlyCys: 0.86 ± 0.013	2.74GlyAsp: 2.74 ± 0.027	2.839GlyGlu: 2.839 ± 0.024	2.53GlyPhe: 2.53 ± 0.023	4.415GlyGly: 4.415 ± 0.056	1.477GlyHis: 1.477 ± 0.015	3.308GlyIle: 3.308 ± 0.022	3.443GlyLys: 3.443 ± 0.027	5.472GlyLeu: 5.472 ± 0.034	1.298GlyMet: 1.298 ± 0.016	2.549GlyAsn: 2.549 ± 0.024	2.861GlyPro: 2.861 ± 0.026	2.288GlyGln: 2.288 ± 0.023	3.139GlyArg: 3.139 ± 0.025	5.348GlySer: 5.348 ± 0.033	3.331GlyThr: 3.331 ± 0.025	3.291GlyVal: 3.291 ± 0.026	0.873GlyTrp: 0.873 ± 0.013	1.677GlyTyr: 1.677 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.537HisAla: 1.537 ± 0.016	0.423HisCys: 0.423 ± 0.009	1.375HisAsp: 1.375 ± 0.017	1.447HisGlu: 1.447 ± 0.016	1.074HisPhe: 1.074 ± 0.014	1.456HisGly: 1.456 ± 0.015	1.462HisHis: 1.462 ± 0.025	1.387HisIle: 1.387 ± 0.016	1.212HisLys: 1.212 ± 0.016	2.926HisLeu: 2.926 ± 0.024	0.502HisMet: 0.502 ± 0.011	1.111HisAsn: 1.111 ± 0.016	2.013HisPro: 2.013 ± 0.022	1.82HisGln: 1.82 ± 0.02	1.591HisArg: 1.591 ± 0.016	2.612HisSer: 2.612 ± 0.026	1.513HisThr: 1.513 ± 0.017	1.348HisVal: 1.348 ± 0.014	0.394HisTrp: 0.394 ± 0.008	0.753HisTyr: 0.753 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.332IleAla: 3.332 ± 0.023	0.897IleCys: 0.897 ± 0.016	3.385IleAsp: 3.385 ± 0.027	3.648IleGlu: 3.648 ± 0.03	2.118IlePhe: 2.118 ± 0.023	3.299IleGly: 3.299 ± 0.027	1.605IleHis: 1.605 ± 0.018	2.983IleIle: 2.983 ± 0.027	3.483IleLys: 3.483 ± 0.026	5.015IleLeu: 5.015 ± 0.032	1.067IleMet: 1.067 ± 0.014	2.691IleAsn: 2.691 ± 0.024	3.546IlePro: 3.546 ± 0.024	2.536IleGln: 2.536 ± 0.023	2.876IleArg: 2.876 ± 0.022	5.077IleSer: 5.077 ± 0.035	3.213IleThr: 3.213 ± 0.026	2.891IleVal: 2.891 ± 0.024	0.73IleTrp: 0.73 ± 0.012	1.43IleTyr: 1.43 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	4.232LysAla: 4.232 ± 0.036	0.71LysCys: 0.71 ± 0.013	3.137LysAsp: 3.137 ± 0.024	3.744LysGlu: 3.744 ± 0.032	1.873LysPhe: 1.873 ± 0.017	3.092LysGly: 3.092 ± 0.025	1.41LysHis: 1.41 ± 0.017	3.128LysIle: 3.128 ± 0.024	4.608LysLys: 4.608 ± 0.041	5.251LysLeu: 5.251 ± 0.03	1.274LysMet: 1.274 ± 0.017	2.531LysAsn: 2.531 ± 0.025	3.408LysPro: 3.408 ± 0.023	2.16LysGln: 2.16 ± 0.02	3.705LysArg: 3.705 ± 0.027	5.299LysSer: 5.299 ± 0.033	3.621LysThr: 3.621 ± 0.029	3.315LysVal: 3.315 ± 0.028	0.684LysTrp: 0.684 ± 0.012	1.412LysTyr: 1.412 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	6.385LeuAla: 6.385 ± 0.038	1.281LeuCys: 1.281 ± 0.015	5.4LeuAsp: 5.4 ± 0.031	5.763LeuGlu: 5.763 ± 0.039	3.216LeuPhe: 3.216 ± 0.023	5.156LeuGly: 5.156 ± 0.03	2.344LeuHis: 2.344 ± 0.021	5.332LeuIle: 5.332 ± 0.033	5.689LeuLys: 5.689 ± 0.035	7.98LeuLeu: 7.98 ± 0.051	1.988LeuMet: 1.988 ± 0.02	4.56LeuAsn: 4.56 ± 0.03	5.809LeuPro: 5.809 ± 0.036	3.869LeuGln: 3.869 ± 0.026	4.959LeuArg: 4.959 ± 0.034	8.412LeuSer: 8.412 ± 0.038	5.479LeuThr: 5.479 ± 0.031	4.993LeuVal: 4.993 ± 0.035	1.082LeuTrp: 1.082 ± 0.014	2.227LeuTyr: 2.227 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	1.569MetAla: 1.569 ± 0.015	0.281MetCys: 0.281 ± 0.007	1.187MetAsp: 1.187 ± 0.013	1.178MetGlu: 1.178 ± 0.013	0.683MetPhe: 0.683 ± 0.011	1.174MetGly: 1.174 ± 0.015	0.407MetHis: 0.407 ± 0.008	1.413MetIle: 1.413 ± 0.016	1.407MetLys: 1.407 ± 0.015	1.687MetLeu: 1.687 ± 0.016	0.642MetMet: 0.642 ± 0.01	1.174MetAsn: 1.174 ± 0.014	1.088MetPro: 1.088 ± 0.014	0.68MetGln: 0.68 ± 0.012	1.063MetArg: 1.063 ± 0.012	2.034MetSer: 2.034 ± 0.016	1.358MetThr: 1.358 ± 0.016	1.202MetVal: 1.202 ± 0.016	0.244MetTrp: 0.244 ± 0.006	0.531MetTyr: 0.531 ± 0.008	0.0MetXaa: 0.0 ± 0.0
Asn	2.706AsnAla: 2.706 ± 0.024	0.639AsnCys: 0.639 ± 0.012	2.254AsnAsp: 2.254 ± 0.019	2.683AsnGlu: 2.683 ± 0.024	1.676AsnPhe: 1.676 ± 0.016	2.835AsnGly: 2.835 ± 0.029	1.693AsnHis: 1.693 ± 0.021	2.224AsnIle: 2.224 ± 0.019	2.343AsnLys: 2.343 ± 0.021	4.729AsnLeu: 4.729 ± 0.035	0.876AsnMet: 0.876 ± 0.014	2.209AsnAsn: 2.209 ± 0.03	3.527AsnPro: 3.527 ± 0.027	2.956AsnGln: 2.956 ± 0.028	2.492AsnArg: 2.492 ± 0.021	4.485AsnSer: 4.485 ± 0.034	2.718AsnThr: 2.718 ± 0.025	2.39AsnVal: 2.39 ± 0.022	0.608AsnTrp: 0.608 ± 0.011	1.174AsnTyr: 1.174 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	4.043ProAla: 4.043 ± 0.035	0.619ProCys: 0.619 ± 0.01	3.09ProAsp: 3.09 ± 0.023	3.309ProGlu: 3.309 ± 0.026	2.026ProPhe: 2.026 ± 0.016	3.068ProGly: 3.068 ± 0.027	1.585ProHis: 1.585 ± 0.017	3.629ProIle: 3.629 ± 0.032	3.331ProLys: 3.331 ± 0.025	4.814ProLeu: 4.814 ± 0.03	1.109ProMet: 1.109 ± 0.014	3.223ProAsn: 3.223 ± 0.03	4.942ProPro: 4.942 ± 0.058	2.387ProGln: 2.387 ± 0.023	2.911ProArg: 2.911 ± 0.028	6.954ProSer: 6.954 ± 0.053	4.663ProThr: 4.663 ± 0.038	3.205ProVal: 3.205 ± 0.033	0.533ProTrp: 0.533 ± 0.01	1.403ProTyr: 1.403 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.297GlnAla: 3.297 ± 0.024	0.584GlnCys: 0.584 ± 0.011	2.316GlnAsp: 2.316 ± 0.021	2.582GlnGlu: 2.582 ± 0.022	1.482GlnPhe: 1.482 ± 0.017	2.06GlnGly: 2.06 ± 0.023	1.283GlnHis: 1.283 ± 0.019	2.579GlnIle: 2.579 ± 0.022	2.383GlnLys: 2.383 ± 0.021	4.031GlnLeu: 4.031 ± 0.027	0.928GlnMet: 0.928 ± 0.013	2.099GlnAsn: 2.099 ± 0.02	2.831GlnPro: 2.831 ± 0.028	2.303GlnGln: 2.303 ± 0.044	2.349GlnArg: 2.349 ± 0.018	4.44GlnSer: 4.44 ± 0.032	2.932GlnThr: 2.932 ± 0.027	2.365GlnVal: 2.365 ± 0.019	0.538GlnTrp: 0.538 ± 0.009	1.056GlnTyr: 1.056 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	3.56ArgAla: 3.56 ± 0.026	0.767ArgCys: 0.767 ± 0.014	2.611ArgAsp: 2.611 ± 0.023	2.919ArgGlu: 2.919 ± 0.022	2.139ArgPhe: 2.139 ± 0.018	2.818ArgGly: 2.818 ± 0.029	1.456ArgHis: 1.456 ± 0.017	2.946ArgIle: 2.946 ± 0.024	3.511ArgLys: 3.511 ± 0.027	5.276ArgLeu: 5.276 ± 0.03	1.197ArgMet: 1.197 ± 0.015	2.385ArgAsn: 2.385 ± 0.021	3.082ArgPro: 3.082 ± 0.024	2.311ArgGln: 2.311 ± 0.024	3.866ArgArg: 3.866 ± 0.033	4.947ArgSer: 4.947 ± 0.039	3.035ArgThr: 3.035 ± 0.022	2.853ArgVal: 2.853 ± 0.021	0.761ArgTrp: 0.761 ± 0.012	1.487ArgTyr: 1.487 ± 0.015	0.0ArgXaa: 0.0 ± 0.0
Ser	5.498SerAla: 5.498 ± 0.038	1.119SerCys: 1.119 ± 0.015	5.1SerAsp: 5.1 ± 0.032	4.775SerGlu: 4.775 ± 0.037	3.366SerPhe: 3.366 ± 0.027	5.174SerGly: 5.174 ± 0.036	2.649SerHis: 2.649 ± 0.024	5.445SerIle: 5.445 ± 0.034	5.589SerLys: 5.589 ± 0.037	8.36SerLeu: 8.36 ± 0.04	1.821SerMet: 1.821 ± 0.018	5.479SerAsn: 5.479 ± 0.037	5.712SerPro: 5.712 ± 0.051	4.292SerGln: 4.292 ± 0.03	4.929SerArg: 4.929 ± 0.036	11.834SerSer: 11.834 ± 0.084	7.068SerThr: 7.068 ± 0.037	4.466SerVal: 4.466 ± 0.031	1.004SerTrp: 1.004 ± 0.014	2.129SerTyr: 2.129 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	3.816ThrAla: 3.816 ± 0.027	0.908ThrCys: 0.908 ± 0.013	2.867ThrAsp: 2.867 ± 0.023	3.044ThrGlu: 3.044 ± 0.023	2.356ThrPhe: 2.356 ± 0.022	3.48ThrGly: 3.48 ± 0.026	1.695ThrHis: 1.695 ± 0.017	3.381ThrIle: 3.381 ± 0.026	3.264ThrLys: 3.264 ± 0.023	5.504ThrLeu: 5.504 ± 0.03	1.144ThrMet: 1.144 ± 0.015	3.077ThrAsn: 3.077 ± 0.028	4.511ThrPro: 4.511 ± 0.037	2.638ThrGln: 2.638 ± 0.024	3.206ThrArg: 3.206 ± 0.025	6.97ThrSer: 6.97 ± 0.041	4.569ThrThr: 4.569 ± 0.037	3.139ThrVal: 3.139 ± 0.025	0.776ThrTrp: 0.776 ± 0.011	1.594ThrTyr: 1.594 ± 0.016	0.0ThrXaa: 0.0 ± 0.0
Val	3.595ValAla: 3.595 ± 0.028	0.846ValCys: 0.846 ± 0.012	3.153ValAsp: 3.153 ± 0.026	3.524ValGlu: 3.524 ± 0.03	2.126ValPhe: 2.126 ± 0.02	3.19ValGly: 3.19 ± 0.027	1.345ValHis: 1.345 ± 0.016	3.151ValIle: 3.151 ± 0.025	3.249ValLys: 3.249 ± 0.025	4.962ValLeu: 4.962 ± 0.03	1.275ValMet: 1.275 ± 0.016	2.419ValAsn: 2.419 ± 0.021	3.083ValPro: 3.083 ± 0.027	2.24ValGln: 2.24 ± 0.022	2.544ValArg: 2.544 ± 0.02	4.375ValSer: 4.375 ± 0.028	3.205ValThr: 3.205 ± 0.027	3.307ValVal: 3.307 ± 0.028	0.746ValTrp: 0.746 ± 0.011	1.41ValTyr: 1.41 ± 0.017	0.0ValXaa: 0.0 ± 0.0
Trp	0.831TrpAla: 0.831 ± 0.012	0.22TrpCys: 0.22 ± 0.005	0.739TrpAsp: 0.739 ± 0.011	0.675TrpGlu: 0.675 ± 0.01	0.465TrpPhe: 0.465 ± 0.009	0.672TrpGly: 0.672 ± 0.012	0.313TrpHis: 0.313 ± 0.007	0.801TrpIle: 0.801 ± 0.012	0.902TrpLys: 0.902 ± 0.012	1.188TrpLeu: 1.188 ± 0.014	0.331TrpMet: 0.331 ± 0.007	0.766TrpAsn: 0.766 ± 0.012	0.56TrpPro: 0.56 ± 0.01	0.438TrpGln: 0.438 ± 0.009	0.763TrpArg: 0.763 ± 0.012	1.037TrpSer: 1.037 ± 0.014	0.768TrpThr: 0.768 ± 0.011	0.693TrpVal: 0.693 ± 0.011	0.196TrpTrp: 0.196 ± 0.006	0.377TrpTyr: 0.377 ± 0.007	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.533TyrAla: 1.533 ± 0.015	0.452TyrCys: 0.452 ± 0.009	1.466TyrAsp: 1.466 ± 0.017	1.43TyrGlu: 1.43 ± 0.017	1.076TyrPhe: 1.076 ± 0.014	1.514TyrGly: 1.514 ± 0.019	0.903TyrHis: 0.903 ± 0.014	1.297TyrIle: 1.297 ± 0.014	1.303TyrLys: 1.303 ± 0.015	2.673TyrLeu: 2.673 ± 0.021	0.51TyrMet: 0.51 ± 0.009	1.187TyrAsn: 1.187 ± 0.016	1.448TyrPro: 1.448 ± 0.02	1.334TyrGln: 1.334 ± 0.017	1.433TyrArg: 1.433 ± 0.016	2.001TyrSer: 2.001 ± 0.017	1.425TyrThr: 1.425 ± 0.016	1.373TyrVal: 1.373 ± 0.017	0.361TyrTrp: 0.361 ± 0.008	0.802TyrTyr: 0.802 ± 0.011	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 16237 proteins (6087715 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---