Amino acid dipepetide frequency for Streptobacillus moniliformis (strain ATCC 14647 / DSM 12112 / NCTC 10651 / 9901)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.562AlaAla: 2.562 ± 0.098
0.293AlaCys: 0.293 ± 0.029
2.081AlaAsp: 2.081 ± 0.072
2.643AlaGlu: 2.643 ± 0.081
2.071AlaPhe: 2.071 ± 0.078
3.365AlaGly: 3.365 ± 0.095
0.632AlaHis: 0.632 ± 0.041
5.562AlaIle: 5.562 ± 0.151
4.67AlaLys: 4.67 ± 0.111
4.891AlaLeu: 4.891 ± 0.12
1.268AlaMet: 1.268 ± 0.055
2.917AlaAsn: 2.917 ± 0.1
0.954AlaPro: 0.954 ± 0.049
1.1AlaGln: 1.1 ± 0.049
1.813AlaArg: 1.813 ± 0.065
3.014AlaSer: 3.014 ± 0.087
2.591AlaThr: 2.591 ± 0.087
2.791AlaVal: 2.791 ± 0.103
0.244AlaTrp: 0.244 ± 0.026
1.873AlaTyr: 1.873 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.268CysAla: 0.268 ± 0.025
0.047CysCys: 0.047 ± 0.01
0.273CysAsp: 0.273 ± 0.024
0.337CysGlu: 0.337 ± 0.026
0.283CysPhe: 0.283 ± 0.025
0.512CysGly: 0.512 ± 0.04
0.078CysHis: 0.078 ± 0.015
0.502CysIle: 0.502 ± 0.032
0.454CysLys: 0.454 ± 0.034
0.411CysLeu: 0.411 ± 0.031
0.14CysMet: 0.14 ± 0.02
0.355CysAsn: 0.355 ± 0.034
0.206CysPro: 0.206 ± 0.021
0.107CysGln: 0.107 ± 0.017
0.169CysArg: 0.169 ± 0.02
0.407CysSer: 0.407 ± 0.03
0.223CysThr: 0.223 ± 0.02
0.314CysVal: 0.314 ± 0.027
0.031CysTrp: 0.031 ± 0.007
0.209CysTyr: 0.209 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
2.224AspAla: 2.224 ± 0.078
0.262AspCys: 0.262 ± 0.025
2.907AspAsp: 2.907 ± 0.088
4.951AspGlu: 4.951 ± 0.115
3.037AspPhe: 3.037 ± 0.082
3.089AspGly: 3.089 ± 0.107
0.535AspHis: 0.535 ± 0.038
6.718AspIle: 6.718 ± 0.136
6.669AspLys: 6.669 ± 0.157
5.11AspLeu: 5.11 ± 0.123
1.241AspMet: 1.241 ± 0.052
4.02AspAsn: 4.02 ± 0.128
1.107AspPro: 1.107 ± 0.054
0.702AspGln: 0.702 ± 0.037
1.914AspArg: 1.914 ± 0.072
3.054AspSer: 3.054 ± 0.092
2.164AspThr: 2.164 ± 0.066
3.405AspVal: 3.405 ± 0.085
0.31AspTrp: 0.31 ± 0.027
2.676AspTyr: 2.676 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
3.522GluAla: 3.522 ± 0.103
0.341GluCys: 0.341 ± 0.032
4.14GluAsp: 4.14 ± 0.092
6.398GluGlu: 6.398 ± 0.161
3.535GluPhe: 3.535 ± 0.099
3.429GluGly: 3.429 ± 0.085
0.921GluHis: 0.921 ± 0.04
8.806GluIle: 8.806 ± 0.166
10.107GluLys: 10.107 ± 0.164
7.536GluLeu: 7.536 ± 0.148
1.885GluMet: 1.885 ± 0.07
7.076GluAsn: 7.076 ± 0.129
1.024GluPro: 1.024 ± 0.05
1.435GluGln: 1.435 ± 0.06
2.5GluArg: 2.5 ± 0.096
3.196GluSer: 3.196 ± 0.095
3.087GluThr: 3.087 ± 0.098
4.59GluVal: 4.59 ± 0.11
0.427GluTrp: 0.427 ± 0.031
4.212GluTyr: 4.212 ± 0.104
0.0GluXaa: 0.0 ± 0.0
Phe
2.228PheAla: 2.228 ± 0.074
0.301PheCys: 0.301 ± 0.026
2.975PheAsp: 2.975 ± 0.093
3.69PheGlu: 3.69 ± 0.103
2.292PhePhe: 2.292 ± 0.086
3.163PheGly: 3.163 ± 0.081
0.51PheHis: 0.51 ± 0.036
4.47PheIle: 4.47 ± 0.138
4.528PheLys: 4.528 ± 0.112
4.61PheLeu: 4.61 ± 0.126
1.119PheMet: 1.119 ± 0.056
3.46PheAsn: 3.46 ± 0.1
1.041PhePro: 1.041 ± 0.051
0.768PheGln: 0.768 ± 0.04
1.33PheArg: 1.33 ± 0.053
3.77PheSer: 3.77 ± 0.106
2.29PheThr: 2.29 ± 0.075
2.668PheVal: 2.668 ± 0.092
0.233PheTrp: 0.233 ± 0.026
1.753PheTyr: 1.753 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
3.475GlyAla: 3.475 ± 0.121
0.33GlyCys: 0.33 ± 0.028
3.097GlyAsp: 3.097 ± 0.096
4.299GlyGlu: 4.299 ± 0.111
2.732GlyPhe: 2.732 ± 0.074
3.813GlyGly: 3.813 ± 0.124
1.018GlyHis: 1.018 ± 0.051
6.547GlyIle: 6.547 ± 0.128
6.004GlyLys: 6.004 ± 0.137
5.647GlyLeu: 5.647 ± 0.126
1.478GlyMet: 1.478 ± 0.057
4.045GlyAsn: 4.045 ± 0.146
1.022GlyPro: 1.022 ± 0.052
1.233GlyGln: 1.233 ± 0.057
2.094GlyArg: 2.094 ± 0.079
3.762GlySer: 3.762 ± 0.13
3.242GlyThr: 3.242 ± 0.11
4.117GlyVal: 4.117 ± 0.1
0.322GlyTrp: 0.322 ± 0.03
3.223GlyTyr: 3.223 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
0.696HisAla: 0.696 ± 0.036
0.103HisCys: 0.103 ± 0.014
0.663HisAsp: 0.663 ± 0.041
0.803HisGlu: 0.803 ± 0.042
0.675HisPhe: 0.675 ± 0.04
0.873HisGly: 0.873 ± 0.043
0.246HisHis: 0.246 ± 0.031
1.268HisIle: 1.268 ± 0.048
1.136HisLys: 1.136 ± 0.054
1.146HisLeu: 1.146 ± 0.044
0.266HisMet: 0.266 ± 0.026
0.877HisAsn: 0.877 ± 0.04
0.46HisPro: 0.46 ± 0.038
0.264HisGln: 0.264 ± 0.022
0.469HisArg: 0.469 ± 0.029
0.995HisSer: 0.995 ± 0.05
0.588HisThr: 0.588 ± 0.034
0.652HisVal: 0.652 ± 0.037
0.068HisTrp: 0.068 ± 0.013
0.508HisTyr: 0.508 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.31IleAla: 5.31 ± 0.138
0.659IleCys: 0.659 ± 0.04
6.316IleAsp: 6.316 ± 0.124
7.988IleGlu: 7.988 ± 0.147
5.277IlePhe: 5.277 ± 0.139
6.386IleGly: 6.386 ± 0.18
1.34IleHis: 1.34 ± 0.055
9.301IleIle: 9.301 ± 0.199
10.175IleLys: 10.175 ± 0.15
10.563IleLeu: 10.563 ± 0.184
1.968IleMet: 1.968 ± 0.061
7.389IleAsn: 7.389 ± 0.164
2.651IlePro: 2.651 ± 0.08
1.899IleGln: 1.899 ± 0.063
3.171IleArg: 3.171 ± 0.09
7.959IleSer: 7.959 ± 0.149
5.001IleThr: 5.001 ± 0.116
5.585IleVal: 5.585 ± 0.114
0.537IleTrp: 0.537 ± 0.035
4.563IleTyr: 4.563 ± 0.138
0.0IleXaa: 0.0 ± 0.0
Lys
4.402LysAla: 4.402 ± 0.116
0.396LysCys: 0.396 ± 0.033
6.694LysAsp: 6.694 ± 0.162
10.243LysGlu: 10.243 ± 0.188
4.055LysPhe: 4.055 ± 0.099
5.527LysGly: 5.527 ± 0.115
1.222LysHis: 1.222 ± 0.057
11.151LysIle: 11.151 ± 0.189
10.107LysLys: 10.107 ± 0.167
9.483LysLeu: 9.483 ± 0.171
2.68LysMet: 2.68 ± 0.081
8.067LysAsn: 8.067 ± 0.144
1.902LysPro: 1.902 ± 0.075
1.914LysGln: 1.914 ± 0.07
3.138LysArg: 3.138 ± 0.085
5.515LysSer: 5.515 ± 0.136
4.701LysThr: 4.701 ± 0.116
6.126LysVal: 6.126 ± 0.117
0.615LysTrp: 0.615 ± 0.039
5.713LysTyr: 5.713 ± 0.115
0.0LysXaa: 0.0 ± 0.0
Leu
4.423LeuAla: 4.423 ± 0.12
0.496LeuCys: 0.496 ± 0.03
5.779LeuAsp: 5.779 ± 0.132
7.889LeuGlu: 7.889 ± 0.153
4.098LeuPhe: 4.098 ± 0.134
6.869LeuGly: 6.869 ± 0.152
1.088LeuHis: 1.088 ± 0.051
9.095LeuIle: 9.095 ± 0.196
9.919LeuLys: 9.919 ± 0.156
8.426LeuLeu: 8.426 ± 0.184
2.063LeuMet: 2.063 ± 0.072
7.241LeuAsn: 7.241 ± 0.144
2.463LeuPro: 2.463 ± 0.08
1.763LeuGln: 1.763 ± 0.065
2.969LeuArg: 2.969 ± 0.078
7.255LeuSer: 7.255 ± 0.129
4.703LeuThr: 4.703 ± 0.108
4.672LeuVal: 4.672 ± 0.124
0.479LeuTrp: 0.479 ± 0.036
3.062LeuTyr: 3.062 ± 0.074
0.0LeuXaa: 0.0 ± 0.0
Met
1.154MetAla: 1.154 ± 0.059
0.109MetCys: 0.109 ± 0.016
1.092MetAsp: 1.092 ± 0.054
1.579MetGlu: 1.579 ± 0.061
1.109MetPhe: 1.109 ± 0.054
1.321MetGly: 1.321 ± 0.062
0.233MetHis: 0.233 ± 0.024
2.131MetIle: 2.131 ± 0.079
2.831MetLys: 2.831 ± 0.082
2.343MetLeu: 2.343 ± 0.079
0.535MetMet: 0.535 ± 0.038
1.522MetAsn: 1.522 ± 0.053
0.69MetPro: 0.69 ± 0.042
0.487MetGln: 0.487 ± 0.031
0.749MetArg: 0.749 ± 0.045
1.528MetSer: 1.528 ± 0.061
0.898MetThr: 0.898 ± 0.044
1.117MetVal: 1.117 ± 0.054
0.14MetTrp: 0.14 ± 0.019
1.018MetTyr: 1.018 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
2.986AsnAla: 2.986 ± 0.087
0.293AsnCys: 0.293 ± 0.026
3.816AsnAsp: 3.816 ± 0.095
5.314AsnGlu: 5.314 ± 0.119
3.248AsnPhe: 3.248 ± 0.085
4.288AsnGly: 4.288 ± 0.14
0.89AsnHis: 0.89 ± 0.046
8.709AsnIle: 8.709 ± 0.17
8.226AsnLys: 8.226 ± 0.198
6.888AsnLeu: 6.888 ± 0.141
1.536AsnMet: 1.536 ± 0.063
5.661AsnAsn: 5.661 ± 0.156
2.001AsnPro: 2.001 ± 0.064
1.301AsnGln: 1.301 ± 0.047
2.253AsnArg: 2.253 ± 0.074
4.468AsnSer: 4.468 ± 0.15
3.18AsnThr: 3.18 ± 0.094
4.592AsnVal: 4.592 ± 0.123
0.429AsnTrp: 0.429 ± 0.033
2.932AsnTyr: 2.932 ± 0.085
0.0AsnXaa: 0.0 ± 0.0
Pro
0.977ProAla: 0.977 ± 0.055
0.118ProCys: 0.118 ± 0.017
1.098ProAsp: 1.098 ± 0.054
1.893ProGlu: 1.893 ± 0.073
1.226ProPhe: 1.226 ± 0.056
1.142ProGly: 1.142 ± 0.054
0.388ProHis: 0.388 ± 0.034
2.257ProIle: 2.257 ± 0.072
2.133ProLys: 2.133 ± 0.07
1.957ProLeu: 1.957 ± 0.071
0.471ProMet: 0.471 ± 0.033
1.511ProAsn: 1.511 ± 0.059
0.386ProPro: 0.386 ± 0.031
0.535ProGln: 0.535 ± 0.038
0.716ProArg: 0.716 ± 0.035
1.377ProSer: 1.377 ± 0.065
1.365ProThr: 1.365 ± 0.062
1.456ProVal: 1.456 ± 0.067
0.159ProTrp: 0.159 ± 0.017
1.136ProTyr: 1.136 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
1.028GlnAla: 1.028 ± 0.044
0.091GlnCys: 0.091 ± 0.013
0.948GlnAsp: 0.948 ± 0.042
1.464GlnGlu: 1.464 ± 0.06
0.785GlnPhe: 0.785 ± 0.04
1.193GlnGly: 1.193 ± 0.048
0.235GlnHis: 0.235 ± 0.02
2.081GlnIle: 2.081 ± 0.064
1.906GlnLys: 1.906 ± 0.059
1.582GlnLeu: 1.582 ± 0.06
0.448GlnMet: 0.448 ± 0.028
1.402GlnAsn: 1.402 ± 0.061
0.374GlnPro: 0.374 ± 0.03
0.423GlnGln: 0.423 ± 0.029
0.754GlnArg: 0.754 ± 0.044
1.078GlnSer: 1.078 ± 0.051
0.809GlnThr: 0.809 ± 0.044
1.233GlnVal: 1.233 ± 0.048
0.151GlnTrp: 0.151 ± 0.018
0.811GlnTyr: 0.811 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
1.674ArgAla: 1.674 ± 0.057
0.194ArgCys: 0.194 ± 0.023
1.712ArgAsp: 1.712 ± 0.069
2.872ArgGlu: 2.872 ± 0.091
1.398ArgPhe: 1.398 ± 0.063
1.84ArgGly: 1.84 ± 0.062
0.496ArgHis: 0.496 ± 0.033
3.252ArgIle: 3.252 ± 0.09
3.242ArgLys: 3.242 ± 0.091
3.163ArgLeu: 3.163 ± 0.097
0.853ArgMet: 0.853 ± 0.042
2.232ArgAsn: 2.232 ± 0.071
0.671ArgPro: 0.671 ± 0.036
0.665ArgGln: 0.665 ± 0.041
1.239ArgArg: 1.239 ± 0.057
1.534ArgSer: 1.534 ± 0.051
1.315ArgThr: 1.315 ± 0.061
1.959ArgVal: 1.959 ± 0.068
0.206ArgTrp: 0.206 ± 0.021
1.848ArgTyr: 1.848 ± 0.065
0.0ArgXaa: 0.0 ± 0.0
Ser
2.75SerAla: 2.75 ± 0.087
0.407SerCys: 0.407 ± 0.032
3.285SerAsp: 3.285 ± 0.084
4.288SerGlu: 4.288 ± 0.103
3.452SerPhe: 3.452 ± 0.088
4.412SerGly: 4.412 ± 0.131
0.869SerHis: 0.869 ± 0.044
7.096SerIle: 7.096 ± 0.16
6.985SerLys: 6.985 ± 0.141
5.996SerLeu: 5.996 ± 0.116
1.299SerMet: 1.299 ± 0.054
4.548SerAsn: 4.548 ± 0.118
1.41SerPro: 1.41 ± 0.058
1.288SerGln: 1.288 ± 0.059
1.827SerArg: 1.827 ± 0.065
4.557SerSer: 4.557 ± 0.127
3.175SerThr: 3.175 ± 0.093
3.644SerVal: 3.644 ± 0.094
0.37SerTrp: 0.37 ± 0.03
2.709SerTyr: 2.709 ± 0.083
0.0SerXaa: 0.0 ± 0.0
Thr
2.213ThrAla: 2.213 ± 0.077
0.254ThrCys: 0.254 ± 0.023
2.645ThrAsp: 2.645 ± 0.099
3.045ThrGlu: 3.045 ± 0.082
2.449ThrPhe: 2.449 ± 0.075
3.502ThrGly: 3.502 ± 0.102
0.756ThrHis: 0.756 ± 0.036
4.453ThrIle: 4.453 ± 0.101
4.4ThrLys: 4.4 ± 0.119
4.968ThrLeu: 4.968 ± 0.108
0.898ThrMet: 0.898 ± 0.043
2.963ThrAsn: 2.963 ± 0.104
1.458ThrPro: 1.458 ± 0.053
0.913ThrGln: 0.913 ± 0.042
1.489ThrArg: 1.489 ± 0.049
3.0ThrSer: 3.0 ± 0.105
2.542ThrThr: 2.542 ± 0.096
2.847ThrVal: 2.847 ± 0.09
0.312ThrTrp: 0.312 ± 0.027
2.003ThrTyr: 2.003 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
3.349ValAla: 3.349 ± 0.12
0.365ValCys: 0.365 ± 0.03
3.648ValAsp: 3.648 ± 0.083
4.778ValGlu: 4.778 ± 0.115
2.734ValPhe: 2.734 ± 0.085
3.811ValGly: 3.811 ± 0.093
0.663ValHis: 0.663 ± 0.042
5.409ValIle: 5.409 ± 0.132
5.637ValLys: 5.637 ± 0.11
5.271ValLeu: 5.271 ± 0.13
1.243ValMet: 1.243 ± 0.054
3.979ValAsn: 3.979 ± 0.113
1.292ValPro: 1.292 ± 0.06
0.892ValGln: 0.892 ± 0.048
1.827ValArg: 1.827 ± 0.057
4.102ValSer: 4.102 ± 0.084
2.668ValThr: 2.668 ± 0.078
3.481ValVal: 3.481 ± 0.105
0.324ValTrp: 0.324 ± 0.025
2.469ValTyr: 2.469 ± 0.072
0.0ValXaa: 0.0 ± 0.0
Trp
0.31TrpAla: 0.31 ± 0.027
0.031TrpCys: 0.031 ± 0.008
0.345TrpAsp: 0.345 ± 0.026
0.44TrpGlu: 0.44 ± 0.031
0.256TrpPhe: 0.256 ± 0.024
0.37TrpGly: 0.37 ± 0.026
0.083TrpHis: 0.083 ± 0.012
0.512TrpIle: 0.512 ± 0.034
0.551TrpLys: 0.551 ± 0.032
0.508TrpLeu: 0.508 ± 0.033
0.202TrpMet: 0.202 ± 0.02
0.442TrpAsn: 0.442 ± 0.034
0.103TrpPro: 0.103 ± 0.016
0.169TrpGln: 0.169 ± 0.02
0.175TrpArg: 0.175 ± 0.02
0.345TrpSer: 0.345 ± 0.026
0.277TrpThr: 0.277 ± 0.028
0.256TrpVal: 0.256 ± 0.027
0.078TrpTrp: 0.078 ± 0.013
0.244TrpTyr: 0.244 ± 0.029
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.786TyrAla: 1.786 ± 0.063
0.235TyrCys: 0.235 ± 0.025
2.581TyrAsp: 2.581 ± 0.07
3.252TyrGlu: 3.252 ± 0.096
2.488TyrPhe: 2.488 ± 0.083
2.591TyrGly: 2.591 ± 0.076
0.555TyrHis: 0.555 ± 0.035
4.718TyrIle: 4.718 ± 0.128
3.974TyrLys: 3.974 ± 0.107
4.253TyrLeu: 4.253 ± 0.123
0.993TyrMet: 0.993 ± 0.047
3.301TyrAsn: 3.301 ± 0.098
1.086TyrPro: 1.086 ± 0.051
0.935TyrGln: 0.935 ± 0.047
1.769TyrArg: 1.769 ± 0.062
3.452TyrSer: 3.452 ± 0.085
2.29TyrThr: 2.29 ± 0.078
2.438TyrVal: 2.438 ± 0.06
0.26TyrTrp: 0.26 ± 0.023
2.052TyrTyr: 2.052 ± 0.069
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1431 proteins (484340 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski