Amino acid dipepetide frequency for Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek s disease herpesvirus type 1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.257AlaAla: 6.257 ± 0.554
1.377AlaCys: 1.377 ± 0.206
3.665AlaAsp: 3.665 ± 0.274
3.899AlaGlu: 3.899 ± 0.395
2.965AlaPhe: 2.965 ± 0.29
3.829AlaGly: 3.829 ± 0.391
1.424AlaHis: 1.424 ± 0.145
5.206AlaIle: 5.206 ± 0.39
2.358AlaLys: 2.358 ± 0.246
7.33AlaLeu: 7.33 ± 0.427
1.844AlaMet: 1.844 ± 0.226
3.268AlaAsn: 3.268 ± 0.272
4.062AlaPro: 4.062 ± 0.591
1.798AlaGln: 1.798 ± 0.199
4.249AlaArg: 4.249 ± 0.242
5.813AlaSer: 5.813 ± 0.435
4.576AlaThr: 4.576 ± 0.301
4.529AlaVal: 4.529 ± 0.371
0.864AlaTrp: 0.864 ± 0.164
2.381AlaTyr: 2.381 ± 0.258
0.0AlaXaa: 0.0 ± 0.0
Cys
1.517CysAla: 1.517 ± 0.263
0.584CysCys: 0.584 ± 0.118
1.541CysAsp: 1.541 ± 0.27
1.284CysGlu: 1.284 ± 0.152
0.794CysPhe: 0.794 ± 0.136
1.541CysGly: 1.541 ± 0.242
0.607CysHis: 0.607 ± 0.162
2.008CysIle: 2.008 ± 0.212
0.957CysLys: 0.957 ± 0.132
2.335CysLeu: 2.335 ± 0.252
0.864CysMet: 0.864 ± 0.159
1.004CysAsn: 1.004 ± 0.21
1.214CysPro: 1.214 ± 0.172
0.303CysGln: 0.303 ± 0.082
1.564CysArg: 1.564 ± 0.236
1.844CysSer: 1.844 ± 0.208
1.564CysThr: 1.564 ± 0.257
1.401CysVal: 1.401 ± 0.16
0.163CysTrp: 0.163 ± 0.059
0.77CysTyr: 0.77 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
4.272AspAla: 4.272 ± 0.337
1.191AspCys: 1.191 ± 0.16
3.315AspAsp: 3.315 ± 0.269
3.478AspGlu: 3.478 ± 0.273
1.868AspPhe: 1.868 ± 0.204
3.175AspGly: 3.175 ± 0.266
1.167AspHis: 1.167 ± 0.165
4.412AspIle: 4.412 ± 0.333
1.891AspLys: 1.891 ± 0.25
5.183AspLeu: 5.183 ± 0.385
1.704AspMet: 1.704 ± 0.165
2.101AspAsn: 2.101 ± 0.191
3.082AspPro: 3.082 ± 0.376
0.84AspGln: 0.84 ± 0.099
3.035AspArg: 3.035 ± 0.267
4.179AspSer: 4.179 ± 0.395
3.759AspThr: 3.759 ± 0.345
3.782AspVal: 3.782 ± 0.263
0.84AspTrp: 0.84 ± 0.18
1.798AspTyr: 1.798 ± 0.182
0.0AspXaa: 0.0 ± 0.0
Glu
3.969GluAla: 3.969 ± 0.364
1.517GluCys: 1.517 ± 0.217
3.082GluAsp: 3.082 ± 0.324
3.175GluGlu: 3.175 ± 0.252
2.148GluPhe: 2.148 ± 0.228
2.778GluGly: 2.778 ± 0.329
1.681GluHis: 1.681 ± 0.217
2.988GluIle: 2.988 ± 0.187
2.451GluLys: 2.451 ± 0.272
5.58GluLeu: 5.58 ± 0.447
1.494GluMet: 1.494 ± 0.183
2.638GluAsn: 2.638 ± 0.296
2.171GluPro: 2.171 ± 0.267
1.144GluGln: 1.144 ± 0.15
3.969GluArg: 3.969 ± 0.323
4.529GluSer: 4.529 ± 0.377
3.245GluThr: 3.245 ± 0.29
2.475GluVal: 2.475 ± 0.211
0.747GluTrp: 0.747 ± 0.138
1.774GluTyr: 1.774 ± 0.203
0.0GluXaa: 0.0 ± 0.0
Phe
2.615PheAla: 2.615 ± 0.255
0.934PheCys: 0.934 ± 0.182
2.591PheAsp: 2.591 ± 0.275
2.008PheGlu: 2.008 ± 0.176
1.447PhePhe: 1.447 ± 0.242
2.358PheGly: 2.358 ± 0.263
0.91PheHis: 0.91 ± 0.153
2.521PheIle: 2.521 ± 0.312
1.891PheLys: 1.891 ± 0.208
3.782PheLeu: 3.782 ± 0.452
0.981PheMet: 0.981 ± 0.177
1.167PheAsn: 1.167 ± 0.136
1.891PhePro: 1.891 ± 0.247
1.027PheGln: 1.027 ± 0.154
1.728PheArg: 1.728 ± 0.213
3.712PheSer: 3.712 ± 0.325
1.984PheThr: 1.984 ± 0.209
2.521PheVal: 2.521 ± 0.229
0.467PheTrp: 0.467 ± 0.088
1.494PheTyr: 1.494 ± 0.182
0.0PheXaa: 0.0 ± 0.0
Gly
3.595GlyAla: 3.595 ± 0.387
1.284GlyCys: 1.284 ± 0.201
2.965GlyAsp: 2.965 ± 0.216
3.455GlyGlu: 3.455 ± 0.29
1.658GlyPhe: 1.658 ± 0.223
3.292GlyGly: 3.292 ± 0.4
1.424GlyHis: 1.424 ± 0.229
3.735GlyIle: 3.735 ± 0.34
2.381GlyLys: 2.381 ± 0.279
4.716GlyLeu: 4.716 ± 0.353
1.634GlyMet: 1.634 ± 0.17
2.568GlyAsn: 2.568 ± 0.173
2.591GlyPro: 2.591 ± 0.466
1.704GlyGln: 1.704 ± 0.249
4.319GlyArg: 4.319 ± 0.491
4.903GlySer: 4.903 ± 0.342
4.366GlyThr: 4.366 ± 0.295
2.965GlyVal: 2.965 ± 0.341
0.654GlyTrp: 0.654 ± 0.124
1.984GlyTyr: 1.984 ± 0.249
0.0GlyXaa: 0.0 ± 0.0
His
1.868HisAla: 1.868 ± 0.189
0.514HisCys: 0.514 ± 0.1
1.377HisAsp: 1.377 ± 0.226
1.331HisGlu: 1.331 ± 0.165
0.864HisPhe: 0.864 ± 0.16
1.611HisGly: 1.611 ± 0.179
0.864HisHis: 0.864 ± 0.123
1.844HisIle: 1.844 ± 0.204
1.004HisLys: 1.004 ± 0.166
2.311HisLeu: 2.311 ± 0.191
0.724HisMet: 0.724 ± 0.148
1.027HisAsn: 1.027 ± 0.158
1.354HisPro: 1.354 ± 0.22
0.374HisGln: 0.374 ± 0.108
2.078HisArg: 2.078 ± 0.262
2.148HisSer: 2.148 ± 0.186
1.167HisThr: 1.167 ± 0.157
1.891HisVal: 1.891 ± 0.258
0.093HisTrp: 0.093 ± 0.052
0.49HisTyr: 0.49 ± 0.107
0.0HisXaa: 0.0 ± 0.0
Ile
4.436IleAla: 4.436 ± 0.294
1.587IleCys: 1.587 ± 0.211
3.945IleAsp: 3.945 ± 0.405
3.385IleGlu: 3.385 ± 0.27
2.615IlePhe: 2.615 ± 0.262
3.408IleGly: 3.408 ± 0.351
1.634IleHis: 1.634 ± 0.219
4.319IleIle: 4.319 ± 0.351
2.475IleLys: 2.475 ± 0.274
5.58IleLeu: 5.58 ± 0.408
1.377IleMet: 1.377 ± 0.151
2.801IleAsn: 2.801 ± 0.267
4.015IlePro: 4.015 ± 0.352
2.031IleGln: 2.031 ± 0.221
3.829IleArg: 3.829 ± 0.312
5.883IleSer: 5.883 ± 0.369
4.552IleThr: 4.552 ± 0.309
3.922IleVal: 3.922 ± 0.424
0.747IleTrp: 0.747 ± 0.114
2.918IleTyr: 2.918 ± 0.273
0.0IleXaa: 0.0 ± 0.0
Lys
2.615LysAla: 2.615 ± 0.227
1.074LysCys: 1.074 ± 0.165
2.054LysAsp: 2.054 ± 0.193
2.101LysGlu: 2.101 ± 0.239
1.658LysPhe: 1.658 ± 0.211
1.401LysGly: 1.401 ± 0.204
1.191LysHis: 1.191 ± 0.175
2.358LysIle: 2.358 ± 0.305
2.265LysLys: 2.265 ± 0.285
4.015LysLeu: 4.015 ± 0.375
1.167LysMet: 1.167 ± 0.163
2.124LysAsn: 2.124 ± 0.294
2.545LysPro: 2.545 ± 0.887
1.564LysGln: 1.564 ± 0.216
3.362LysArg: 3.362 ± 0.295
3.292LysSer: 3.292 ± 0.305
3.082LysThr: 3.082 ± 0.277
2.218LysVal: 2.218 ± 0.254
0.537LysTrp: 0.537 ± 0.122
1.868LysTyr: 1.868 ± 0.188
0.0LysXaa: 0.0 ± 0.0
Leu
6.91LeuAla: 6.91 ± 0.372
2.871LeuCys: 2.871 ± 0.257
4.762LeuAsp: 4.762 ± 0.473
5.323LeuGlu: 5.323 ± 0.367
4.436LeuPhe: 4.436 ± 0.338
4.949LeuGly: 4.949 ± 0.396
2.358LeuHis: 2.358 ± 0.263
5.58LeuIle: 5.58 ± 0.424
4.155LeuLys: 4.155 ± 0.49
9.572LeuLeu: 9.572 ± 0.547
2.498LeuMet: 2.498 ± 0.303
3.245LeuAsn: 3.245 ± 0.286
4.412LeuPro: 4.412 ± 0.456
2.755LeuGln: 2.755 ± 0.226
6.14LeuArg: 6.14 ± 0.43
7.681LeuSer: 7.681 ± 0.415
5.136LeuThr: 5.136 ± 0.291
4.669LeuVal: 4.669 ± 0.449
1.377LeuTrp: 1.377 ± 0.197
3.222LeuTyr: 3.222 ± 0.3
0.0LeuXaa: 0.0 ± 0.0
Met
1.914MetAla: 1.914 ± 0.217
0.374MetCys: 0.374 ± 0.101
1.494MetAsp: 1.494 ± 0.184
1.377MetGlu: 1.377 ± 0.22
1.027MetPhe: 1.027 ± 0.172
1.938MetGly: 1.938 ± 0.221
0.677MetHis: 0.677 ± 0.118
1.587MetIle: 1.587 ± 0.22
1.237MetLys: 1.237 ± 0.191
2.265MetLeu: 2.265 ± 0.237
0.724MetMet: 0.724 ± 0.152
1.191MetAsn: 1.191 ± 0.174
1.167MetPro: 1.167 ± 0.2
0.747MetGln: 0.747 ± 0.123
1.587MetArg: 1.587 ± 0.324
2.381MetSer: 2.381 ± 0.21
1.587MetThr: 1.587 ± 0.175
1.354MetVal: 1.354 ± 0.186
0.397MetTrp: 0.397 ± 0.103
1.004MetTyr: 1.004 ± 0.173
0.0MetXaa: 0.0 ± 0.0
Asn
3.058AsnAla: 3.058 ± 0.275
0.957AsnCys: 0.957 ± 0.142
2.148AsnAsp: 2.148 ± 0.208
1.844AsnGlu: 1.844 ± 0.223
1.517AsnPhe: 1.517 ± 0.215
2.615AsnGly: 2.615 ± 0.22
1.004AsnHis: 1.004 ± 0.161
3.782AsnIle: 3.782 ± 0.313
1.984AsnLys: 1.984 ± 0.198
3.408AsnLeu: 3.408 ± 0.277
1.261AsnMet: 1.261 ± 0.155
2.265AsnAsn: 2.265 ± 0.227
2.078AsnPro: 2.078 ± 0.205
1.307AsnGln: 1.307 ± 0.19
2.638AsnArg: 2.638 ± 0.231
3.735AsnSer: 3.735 ± 0.273
2.801AsnThr: 2.801 ± 0.229
3.128AsnVal: 3.128 ± 0.255
0.444AsnTrp: 0.444 ± 0.106
1.401AsnTyr: 1.401 ± 0.138
0.0AsnXaa: 0.0 ± 0.0
Pro
3.502ProAla: 3.502 ± 0.637
1.284ProCys: 1.284 ± 0.139
2.942ProAsp: 2.942 ± 0.438
2.988ProGlu: 2.988 ± 0.404
1.728ProPhe: 1.728 ± 0.238
2.801ProGly: 2.801 ± 0.353
1.704ProHis: 1.704 ± 0.279
3.455ProIle: 3.455 ± 0.294
2.241ProLys: 2.241 ± 0.665
4.202ProLeu: 4.202 ± 0.49
1.307ProMet: 1.307 ± 0.139
1.984ProAsn: 1.984 ± 0.22
5.253ProPro: 5.253 ± 0.945
1.564ProGln: 1.564 ± 0.237
3.875ProArg: 3.875 ± 0.605
5.416ProSer: 5.416 ± 0.705
4.062ProThr: 4.062 ± 0.448
3.455ProVal: 3.455 ± 0.401
0.607ProTrp: 0.607 ± 0.119
1.331ProTyr: 1.331 ± 0.155
0.0ProXaa: 0.0 ± 0.0
Gln
1.541GlnAla: 1.541 ± 0.171
0.677GlnCys: 0.677 ± 0.13
1.261GlnAsp: 1.261 ± 0.209
1.307GlnGlu: 1.307 ± 0.191
1.074GlnPhe: 1.074 ± 0.215
1.377GlnGly: 1.377 ± 0.189
0.607GlnHis: 0.607 ± 0.104
1.704GlnIle: 1.704 ± 0.189
1.237GlnLys: 1.237 ± 0.16
2.405GlnLeu: 2.405 ± 0.21
0.794GlnMet: 0.794 ± 0.159
1.284GlnAsn: 1.284 ± 0.166
1.541GlnPro: 1.541 ± 0.193
1.027GlnGln: 1.027 ± 0.173
1.914GlnArg: 1.914 ± 0.212
2.638GlnSer: 2.638 ± 0.318
1.798GlnThr: 1.798 ± 0.219
1.307GlnVal: 1.307 ± 0.171
0.233GlnTrp: 0.233 ± 0.073
1.097GlnTyr: 1.097 ± 0.144
0.0GlnXaa: 0.0 ± 0.0
Arg
4.692ArgAla: 4.692 ± 0.513
1.634ArgCys: 1.634 ± 0.257
3.572ArgAsp: 3.572 ± 0.315
3.175ArgGlu: 3.175 ± 0.279
2.335ArgPhe: 2.335 ± 0.268
4.272ArgGly: 4.272 ± 0.469
1.984ArgHis: 1.984 ± 0.19
3.198ArgIle: 3.198 ± 0.21
3.152ArgLys: 3.152 ± 0.348
6.303ArgLeu: 6.303 ± 0.366
1.494ArgMet: 1.494 ± 0.225
3.175ArgAsn: 3.175 ± 0.274
3.689ArgPro: 3.689 ± 0.486
1.891ArgGln: 1.891 ± 0.213
6.28ArgArg: 6.28 ± 0.678
4.996ArgSer: 4.996 ± 0.482
4.319ArgThr: 4.319 ± 0.35
3.549ArgVal: 3.549 ± 0.282
0.724ArgTrp: 0.724 ± 0.186
2.218ArgTyr: 2.218 ± 0.215
0.0ArgXaa: 0.0 ± 0.0
Ser
6.093SerAla: 6.093 ± 0.415
1.914SerCys: 1.914 ± 0.25
4.552SerAsp: 4.552 ± 0.401
4.389SerGlu: 4.389 ± 0.483
2.708SerPhe: 2.708 ± 0.273
4.949SerGly: 4.949 ± 0.342
1.844SerHis: 1.844 ± 0.189
5.393SerIle: 5.393 ± 0.365
3.455SerLys: 3.455 ± 0.382
7.447SerLeu: 7.447 ± 0.387
1.821SerMet: 1.821 ± 0.184
3.782SerAsn: 3.782 ± 0.3
5.65SerPro: 5.65 ± 1.099
2.451SerGln: 2.451 ± 0.287
5.813SerArg: 5.813 ± 0.462
8.988SerSer: 8.988 ± 1.036
6.677SerThr: 6.677 ± 0.325
4.762SerVal: 4.762 ± 0.273
0.677SerTrp: 0.677 ± 0.12
2.988SerTyr: 2.988 ± 0.255
0.0SerXaa: 0.0 ± 0.0
Thr
5.253ThrAla: 5.253 ± 0.362
1.541ThrCys: 1.541 ± 0.227
3.338ThrAsp: 3.338 ± 0.317
3.665ThrGlu: 3.665 ± 0.279
2.942ThrPhe: 2.942 ± 0.286
3.525ThrGly: 3.525 ± 0.299
1.587ThrHis: 1.587 ± 0.196
4.506ThrIle: 4.506 ± 0.324
2.685ThrLys: 2.685 ± 0.322
5.603ThrLeu: 5.603 ± 0.403
1.284ThrMet: 1.284 ± 0.166
3.338ThrAsn: 3.338 ± 0.324
3.665ThrPro: 3.665 ± 0.451
1.564ThrGln: 1.564 ± 0.165
3.852ThrArg: 3.852 ± 0.432
6.093ThrSer: 6.093 ± 0.496
5.393ThrThr: 5.393 ± 0.41
4.366ThrVal: 4.366 ± 0.386
0.794ThrTrp: 0.794 ± 0.114
1.961ThrTyr: 1.961 ± 0.208
0.0ThrXaa: 0.0 ± 0.0
Val
4.109ValAla: 4.109 ± 0.302
1.564ValCys: 1.564 ± 0.208
3.595ValAsp: 3.595 ± 0.327
3.385ValGlu: 3.385 ± 0.393
2.428ValPhe: 2.428 ± 0.291
3.222ValGly: 3.222 ± 0.343
0.934ValHis: 0.934 ± 0.171
3.665ValIle: 3.665 ± 0.295
2.451ValLys: 2.451 ± 0.255
5.883ValLeu: 5.883 ± 0.4
1.658ValMet: 1.658 ± 0.221
2.498ValAsn: 2.498 ± 0.216
2.988ValPro: 2.988 ± 0.354
1.728ValGln: 1.728 ± 0.202
3.642ValArg: 3.642 ± 0.347
4.436ValSer: 4.436 ± 0.279
3.829ValThr: 3.829 ± 0.237
3.362ValVal: 3.362 ± 0.298
0.49ValTrp: 0.49 ± 0.097
2.568ValTyr: 2.568 ± 0.233
0.0ValXaa: 0.0 ± 0.0
Trp
0.654TrpAla: 0.654 ± 0.106
0.14TrpCys: 0.14 ± 0.057
0.7TrpAsp: 0.7 ± 0.112
0.607TrpGlu: 0.607 ± 0.108
0.49TrpPhe: 0.49 ± 0.132
0.77TrpGly: 0.77 ± 0.156
0.303TrpHis: 0.303 ± 0.095
0.794TrpIle: 0.794 ± 0.148
0.677TrpLys: 0.677 ± 0.112
0.981TrpLeu: 0.981 ± 0.133
0.35TrpMet: 0.35 ± 0.087
0.56TrpAsn: 0.56 ± 0.124
0.584TrpPro: 0.584 ± 0.121
0.28TrpGln: 0.28 ± 0.071
0.817TrpArg: 0.817 ± 0.163
1.027TrpSer: 1.027 ± 0.148
0.654TrpThr: 0.654 ± 0.129
0.397TrpVal: 0.397 ± 0.086
0.233TrpTrp: 0.233 ± 0.077
0.35TrpTyr: 0.35 ± 0.083
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.825TyrAla: 2.825 ± 0.233
0.84TyrCys: 0.84 ± 0.144
2.171TyrAsp: 2.171 ± 0.236
1.377TyrGlu: 1.377 ± 0.179
1.331TyrPhe: 1.331 ± 0.201
2.381TyrGly: 2.381 ± 0.205
1.027TyrHis: 1.027 ± 0.173
2.405TyrIle: 2.405 ± 0.271
1.541TyrLys: 1.541 ± 0.192
3.152TyrLeu: 3.152 ± 0.271
1.027TyrMet: 1.027 ± 0.174
1.354TyrAsn: 1.354 ± 0.145
1.751TyrPro: 1.751 ± 0.281
0.747TyrGln: 0.747 ± 0.122
1.961TyrArg: 1.961 ± 0.21
2.661TyrSer: 2.661 ± 0.252
2.405TyrThr: 2.405 ± 0.286
2.381TyrVal: 2.381 ± 0.235
0.28TyrTrp: 0.28 ± 0.076
1.354TyrTyr: 1.354 ± 0.164
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 91 proteins (42836 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski