Amino acid dipepetide frequency for Mycoplasma mobile (strain ATCC 43663 / 163K / NCTC 11711)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.596AlaAla: 2.596 ± 0.139
0.193AlaCys: 0.193 ± 0.028
1.651AlaAsp: 1.651 ± 0.095
2.283AlaGlu: 2.283 ± 0.113
2.94AlaPhe: 2.94 ± 0.138
2.502AlaGly: 2.502 ± 0.133
0.597AlaHis: 0.597 ± 0.062
5.739AlaIle: 5.739 ± 0.17
4.823AlaLys: 4.823 ± 0.215
4.793AlaLeu: 4.793 ± 0.172
0.877AlaMet: 0.877 ± 0.067
3.925AlaAsn: 3.925 ± 0.189
1.225AlaPro: 1.225 ± 0.094
1.358AlaGln: 1.358 ± 0.082
1.651AlaArg: 1.651 ± 0.092
3.899AlaSer: 3.899 ± 0.151
3.138AlaThr: 3.138 ± 0.143
2.038AlaVal: 2.038 ± 0.097
0.4AlaTrp: 0.4 ± 0.044
1.44AlaTyr: 1.44 ± 0.086
0.0AlaXaa: 0.0 ± 0.0
Cys
0.155CysAla: 0.155 ± 0.027
0.009CysCys: 0.009 ± 0.006
0.172CysAsp: 0.172 ± 0.03
0.172CysGlu: 0.172 ± 0.024
0.224CysPhe: 0.224 ± 0.031
0.232CysGly: 0.232 ± 0.037
0.069CysHis: 0.069 ± 0.017
0.181CysIle: 0.181 ± 0.048
0.245CysLys: 0.245 ± 0.034
0.219CysLeu: 0.219 ± 0.033
0.03CysMet: 0.03 ± 0.012
0.138CysAsn: 0.138 ± 0.029
0.129CysPro: 0.129 ± 0.02
0.047CysGln: 0.047 ± 0.015
0.086CysArg: 0.086 ± 0.021
0.193CysSer: 0.193 ± 0.034
0.069CysThr: 0.069 ± 0.017
0.185CysVal: 0.185 ± 0.028
0.013CysTrp: 0.013 ± 0.008
0.112CysTyr: 0.112 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
2.209AspAla: 2.209 ± 0.102
0.069AspCys: 0.069 ± 0.018
2.063AspAsp: 2.063 ± 0.135
3.624AspGlu: 3.624 ± 0.171
4.161AspPhe: 4.161 ± 0.13
2.141AspGly: 2.141 ± 0.09
0.533AspHis: 0.533 ± 0.045
4.251AspIle: 4.251 ± 0.139
4.367AspLys: 4.367 ± 0.183
5.618AspLeu: 5.618 ± 0.147
0.58AspMet: 0.58 ± 0.05
2.824AspAsn: 2.824 ± 0.129
1.444AspPro: 1.444 ± 0.09
1.307AspGln: 1.307 ± 0.084
1.255AspArg: 1.255 ± 0.07
3.237AspSer: 3.237 ± 0.128
2.003AspThr: 2.003 ± 0.109
3.052AspVal: 3.052 ± 0.117
0.361AspTrp: 0.361 ± 0.042
1.857AspTyr: 1.857 ± 0.104
0.0AspXaa: 0.0 ± 0.0
Glu
3.099GluAla: 3.099 ± 0.116
0.15GluCys: 0.15 ± 0.026
3.073GluAsp: 3.073 ± 0.173
5.042GluGlu: 5.042 ± 0.224
4.015GluPhe: 4.015 ± 0.159
2.519GluGly: 2.519 ± 0.127
0.821GluHis: 0.821 ± 0.06
8.993GluIle: 8.993 ± 0.296
9.199GluLys: 9.199 ± 0.359
6.263GluLeu: 6.263 ± 0.23
1.216GluMet: 1.216 ± 0.076
7.123GluAsn: 7.123 ± 0.216
0.933GluPro: 0.933 ± 0.066
1.84GluGln: 1.84 ± 0.099
1.737GluArg: 1.737 ± 0.118
3.598GluSer: 3.598 ± 0.142
3.194GluThr: 3.194 ± 0.122
3.654GluVal: 3.654 ± 0.128
0.408GluTrp: 0.408 ± 0.042
2.454GluTyr: 2.454 ± 0.144
0.0GluXaa: 0.0 ± 0.0
Phe
2.975PheAla: 2.975 ± 0.138
0.284PheCys: 0.284 ± 0.038
3.469PheAsp: 3.469 ± 0.137
4.694PheGlu: 4.694 ± 0.179
3.993PhePhe: 3.993 ± 0.165
3.048PheGly: 3.048 ± 0.141
0.757PheHis: 0.757 ± 0.071
6.022PheIle: 6.022 ± 0.201
5.515PheLys: 5.515 ± 0.181
6.388PheLeu: 6.388 ± 0.234
0.8PheMet: 0.8 ± 0.061
4.832PheAsn: 4.832 ± 0.156
1.599PhePro: 1.599 ± 0.088
2.055PheGln: 2.055 ± 0.095
1.689PheArg: 1.689 ± 0.095
5.451PheSer: 5.451 ± 0.188
3.073PheThr: 3.073 ± 0.131
3.46PheVal: 3.46 ± 0.152
0.739PheTrp: 0.739 ± 0.066
2.386PheTyr: 2.386 ± 0.125
0.0PheXaa: 0.0 ± 0.0
Gly
2.682GlyAla: 2.682 ± 0.144
0.12GlyCys: 0.12 ± 0.026
2.059GlyAsp: 2.059 ± 0.113
2.553GlyGlu: 2.553 ± 0.136
3.594GlyPhe: 3.594 ± 0.157
2.781GlyGly: 2.781 ± 0.149
0.722GlyHis: 0.722 ± 0.061
5.322GlyIle: 5.322 ± 0.158
4.213GlyLys: 4.213 ± 0.187
4.213GlyLeu: 4.213 ± 0.185
0.774GlyMet: 0.774 ± 0.065
3.009GlyAsn: 3.009 ± 0.208
1.023GlyPro: 1.023 ± 0.08
1.621GlyGln: 1.621 ± 0.104
1.586GlyArg: 1.586 ± 0.091
3.495GlySer: 3.495 ± 0.138
3.198GlyThr: 3.198 ± 0.164
3.065GlyVal: 3.065 ± 0.148
0.46GlyTrp: 0.46 ± 0.056
1.603GlyTyr: 1.603 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
0.666HisAla: 0.666 ± 0.058
0.047HisCys: 0.047 ± 0.014
0.55HisAsp: 0.55 ± 0.052
0.894HisGlu: 0.894 ± 0.073
0.941HisPhe: 0.941 ± 0.073
0.666HisGly: 0.666 ± 0.063
0.224HisHis: 0.224 ± 0.034
1.066HisIle: 1.066 ± 0.073
1.088HisLys: 1.088 ± 0.077
1.337HisLeu: 1.337 ± 0.078
0.112HisMet: 0.112 ± 0.02
0.843HisAsn: 0.843 ± 0.066
0.503HisPro: 0.503 ± 0.049
0.481HisGln: 0.481 ± 0.046
0.417HisArg: 0.417 ± 0.046
0.821HisSer: 0.821 ± 0.063
0.666HisThr: 0.666 ± 0.062
0.658HisVal: 0.658 ± 0.051
0.077HisTrp: 0.077 ± 0.017
0.477HisTyr: 0.477 ± 0.049
0.0HisXaa: 0.0 ± 0.0
Ile
5.408IleAla: 5.408 ± 0.174
0.357IleCys: 0.357 ± 0.045
5.833IleAsp: 5.833 ± 0.181
7.363IleGlu: 7.363 ± 0.256
6.916IlePhe: 6.916 ± 0.247
5.167IleGly: 5.167 ± 0.188
1.255IleHis: 1.255 ± 0.07
10.291IleIle: 10.291 ± 0.255
9.508IleLys: 9.508 ± 0.281
10.536IleLeu: 10.536 ± 0.223
1.401IleMet: 1.401 ± 0.087
8.842IleAsn: 8.842 ± 0.304
3.366IlePro: 3.366 ± 0.141
3.013IleGln: 3.013 ± 0.116
2.768IleArg: 2.768 ± 0.103
9.281IleSer: 9.281 ± 0.241
5.094IleThr: 5.094 ± 0.238
5.984IleVal: 5.984 ± 0.174
0.731IleTrp: 0.731 ± 0.058
3.228IleTyr: 3.228 ± 0.138
0.0IleXaa: 0.0 ± 0.0
Lys
3.959LysAla: 3.959 ± 0.168
0.185LysCys: 0.185 ± 0.033
4.823LysAsp: 4.823 ± 0.207
8.021LysGlu: 8.021 ± 0.299
4.72LysPhe: 4.72 ± 0.202
3.641LysGly: 3.641 ± 0.153
1.182LysHis: 1.182 ± 0.086
12.492LysIle: 12.492 ± 0.375
10.935LysLys: 10.935 ± 0.43
8.189LysLeu: 8.189 ± 0.287
2.39LysMet: 2.39 ± 0.121
10.183LysAsn: 10.183 ± 0.308
2.072LysPro: 2.072 ± 0.108
2.811LysGln: 2.811 ± 0.142
2.76LysArg: 2.76 ± 0.133
6.37LysSer: 6.37 ± 0.219
5.567LysThr: 5.567 ± 0.19
4.595LysVal: 4.595 ± 0.19
0.959LysTrp: 0.959 ± 0.07
4.157LysTyr: 4.157 ± 0.198
0.0LysXaa: 0.0 ± 0.0
Leu
5.107LeuAla: 5.107 ± 0.173
0.267LeuCys: 0.267 ± 0.047
5.158LeuAsp: 5.158 ± 0.175
7.862LeuGlu: 7.862 ± 0.265
5.206LeuPhe: 5.206 ± 0.217
4.986LeuGly: 4.986 ± 0.167
1.212LeuHis: 1.212 ± 0.091
10.347LeuIle: 10.347 ± 0.244
10.579LeuLys: 10.579 ± 0.354
7.823LeuLeu: 7.823 ± 0.227
1.315LeuMet: 1.315 ± 0.079
8.515LeuAsn: 8.515 ± 0.256
2.859LeuPro: 2.859 ± 0.107
2.523LeuGln: 2.523 ± 0.129
2.944LeuArg: 2.944 ± 0.108
7.191LeuSer: 7.191 ± 0.216
4.599LeuThr: 4.599 ± 0.195
5.218LeuVal: 5.218 ± 0.163
0.602LeuTrp: 0.602 ± 0.048
2.351LeuTyr: 2.351 ± 0.106
0.0LeuXaa: 0.0 ± 0.0
Met
0.86MetAla: 0.86 ± 0.08
0.043MetCys: 0.043 ± 0.013
0.606MetAsp: 0.606 ± 0.055
0.954MetGlu: 0.954 ± 0.073
0.701MetPhe: 0.701 ± 0.054
0.675MetGly: 0.675 ± 0.064
0.232MetHis: 0.232 ± 0.034
1.509MetIle: 1.509 ± 0.081
1.913MetLys: 1.913 ± 0.103
1.29MetLeu: 1.29 ± 0.097
0.249MetMet: 0.249 ± 0.031
1.539MetAsn: 1.539 ± 0.083
0.572MetPro: 0.572 ± 0.055
0.593MetGln: 0.593 ± 0.048
0.404MetArg: 0.404 ± 0.041
1.062MetSer: 1.062 ± 0.067
0.653MetThr: 0.653 ± 0.057
0.705MetVal: 0.705 ± 0.055
0.103MetTrp: 0.103 ± 0.022
0.447MetTyr: 0.447 ± 0.049
0.0MetXaa: 0.0 ± 0.0
Asn
3.68AsnAla: 3.68 ± 0.176
0.155AsnCys: 0.155 ± 0.027
3.916AsnAsp: 3.916 ± 0.145
5.988AsnGlu: 5.988 ± 0.2
6.168AsnPhe: 6.168 ± 0.212
3.972AsnGly: 3.972 ± 0.225
1.057AsnHis: 1.057 ± 0.068
7.832AsnIle: 7.832 ± 0.247
7.6AsnLys: 7.6 ± 0.274
9.504AsnLeu: 9.504 ± 0.301
1.023AsnMet: 1.023 ± 0.072
7.2AsnAsn: 7.2 ± 0.36
2.841AsnPro: 2.841 ± 0.196
2.987AsnGln: 2.987 ± 0.155
2.158AsnArg: 2.158 ± 0.113
7.058AsnSer: 7.058 ± 0.324
3.886AsnThr: 3.886 ± 0.234
4.023AsnVal: 4.023 ± 0.133
0.821AsnTrp: 0.821 ± 0.068
3.048AsnTyr: 3.048 ± 0.128
0.0AsnXaa: 0.0 ± 0.0
Pro
1.152ProAla: 1.152 ± 0.08
0.056ProCys: 0.056 ± 0.017
1.014ProAsp: 1.014 ± 0.078
1.853ProGlu: 1.853 ± 0.081
1.672ProPhe: 1.672 ± 0.078
1.388ProGly: 1.388 ± 0.096
0.361ProHis: 0.361 ± 0.045
2.919ProIle: 2.919 ± 0.136
2.467ProLys: 2.467 ± 0.136
2.472ProLeu: 2.472 ± 0.095
0.37ProMet: 0.37 ± 0.043
2.523ProAsn: 2.523 ± 0.196
0.49ProPro: 0.49 ± 0.045
0.821ProGln: 0.821 ± 0.062
0.658ProArg: 0.658 ± 0.052
2.111ProSer: 2.111 ± 0.131
1.672ProThr: 1.672 ± 0.133
1.423ProVal: 1.423 ± 0.096
0.245ProTrp: 0.245 ± 0.031
0.795ProTyr: 0.795 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
1.547GlnAla: 1.547 ± 0.081
0.039GlnCys: 0.039 ± 0.013
1.337GlnAsp: 1.337 ± 0.073
2.231GlnGlu: 2.231 ± 0.107
1.535GlnPhe: 1.535 ± 0.106
1.354GlnGly: 1.354 ± 0.077
0.279GlnHis: 0.279 ± 0.034
3.585GlnIle: 3.585 ± 0.13
3.263GlnLys: 3.263 ± 0.124
2.429GlnLeu: 2.429 ± 0.118
0.537GlnMet: 0.537 ± 0.048
3.336GlnAsn: 3.336 ± 0.176
0.632GlnPro: 0.632 ± 0.054
0.877GlnGln: 0.877 ± 0.08
1.143GlnArg: 1.143 ± 0.084
1.689GlnSer: 1.689 ± 0.087
1.56GlnThr: 1.56 ± 0.081
1.453GlnVal: 1.453 ± 0.091
0.284GlnTrp: 0.284 ± 0.04
1.032GlnTyr: 1.032 ± 0.075
0.0GlnXaa: 0.0 ± 0.0
Arg
1.56ArgAla: 1.56 ± 0.086
0.047ArgCys: 0.047 ± 0.014
1.423ArgAsp: 1.423 ± 0.077
1.93ArgGlu: 1.93 ± 0.081
1.496ArgPhe: 1.496 ± 0.079
1.333ArgGly: 1.333 ± 0.08
0.395ArgHis: 0.395 ± 0.042
3.129ArgIle: 3.129 ± 0.119
3.022ArgLys: 3.022 ± 0.153
2.442ArgLeu: 2.442 ± 0.107
0.46ArgMet: 0.46 ± 0.051
2.459ArgAsn: 2.459 ± 0.112
0.787ArgPro: 0.787 ± 0.067
0.937ArgGln: 0.937 ± 0.064
1.066ArgArg: 1.066 ± 0.073
1.801ArgSer: 1.801 ± 0.116
1.711ArgThr: 1.711 ± 0.106
1.526ArgVal: 1.526 ± 0.1
0.245ArgTrp: 0.245 ± 0.038
1.019ArgTyr: 1.019 ± 0.07
0.0ArgXaa: 0.0 ± 0.0
Ser
3.22SerAla: 3.22 ± 0.132
0.185SerCys: 0.185 ± 0.029
3.164SerAsp: 3.164 ± 0.121
4.647SerGlu: 4.647 ± 0.15
5.463SerPhe: 5.463 ± 0.18
3.894SerGly: 3.894 ± 0.144
0.933SerHis: 0.933 ± 0.069
7.948SerIle: 7.948 ± 0.24
7.926SerLys: 7.926 ± 0.24
7.909SerLeu: 7.909 ± 0.246
0.941SerMet: 0.941 ± 0.062
6.138SerAsn: 6.138 ± 0.32
1.762SerPro: 1.762 ± 0.1
2.399SerGln: 2.399 ± 0.119
2.192SerArg: 2.192 ± 0.094
5.872SerSer: 5.872 ± 0.277
3.74SerThr: 3.74 ± 0.16
3.469SerVal: 3.469 ± 0.159
0.52SerTrp: 0.52 ± 0.048
2.558SerTyr: 2.558 ± 0.116
0.0SerXaa: 0.0 ± 0.0
Thr
2.038ThrAla: 2.038 ± 0.121
0.15ThrCys: 0.15 ± 0.03
1.909ThrAsp: 1.909 ± 0.096
2.454ThrGlu: 2.454 ± 0.12
3.202ThrPhe: 3.202 ± 0.119
2.79ThrGly: 2.79 ± 0.139
0.757ThrHis: 0.757 ± 0.061
5.876ThrIle: 5.876 ± 0.233
4.758ThrLys: 4.758 ± 0.166
5.451ThrLeu: 5.451 ± 0.217
0.572ThrMet: 0.572 ± 0.044
4.72ThrAsn: 4.72 ± 0.272
1.651ThrPro: 1.651 ± 0.1
1.737ThrGln: 1.737 ± 0.109
1.547ThrArg: 1.547 ± 0.074
4.157ThrSer: 4.157 ± 0.177
3.404ThrThr: 3.404 ± 0.21
2.235ThrVal: 2.235 ± 0.122
0.413ThrTrp: 0.413 ± 0.043
1.775ThrTyr: 1.775 ± 0.09
0.0ThrXaa: 0.0 ± 0.0
Val
3.138ValAla: 3.138 ± 0.145
0.176ValCys: 0.176 ± 0.031
2.515ValAsp: 2.515 ± 0.119
3.757ValGlu: 3.757 ± 0.141
3.301ValPhe: 3.301 ± 0.14
2.992ValGly: 2.992 ± 0.16
0.683ValHis: 0.683 ± 0.053
4.909ValIle: 4.909 ± 0.178
4.612ValLys: 4.612 ± 0.176
5.18ValLeu: 5.18 ± 0.183
0.804ValMet: 0.804 ± 0.066
3.864ValAsn: 3.864 ± 0.16
1.586ValPro: 1.586 ± 0.111
1.427ValGln: 1.427 ± 0.087
1.397ValArg: 1.397 ± 0.087
4.436ValSer: 4.436 ± 0.173
2.545ValThr: 2.545 ± 0.141
3.396ValVal: 3.396 ± 0.136
0.327ValTrp: 0.327 ± 0.037
1.388ValTyr: 1.388 ± 0.071
0.0ValXaa: 0.0 ± 0.0
Trp
0.37TrpAla: 0.37 ± 0.039
0.021TrpCys: 0.021 ± 0.009
0.404TrpAsp: 0.404 ± 0.05
0.529TrpGlu: 0.529 ± 0.051
0.533TrpPhe: 0.533 ± 0.058
0.344TrpGly: 0.344 ± 0.037
0.073TrpHis: 0.073 ± 0.016
0.95TrpIle: 0.95 ± 0.071
0.791TrpLys: 0.791 ± 0.061
0.769TrpLeu: 0.769 ± 0.065
0.133TrpMet: 0.133 ± 0.021
0.8TrpAsn: 0.8 ± 0.059
0.12TrpPro: 0.12 ± 0.022
0.236TrpGln: 0.236 ± 0.035
0.215TrpArg: 0.215 ± 0.033
0.464TrpSer: 0.464 ± 0.05
0.383TrpThr: 0.383 ± 0.046
0.542TrpVal: 0.542 ± 0.059
0.09TrpTrp: 0.09 ± 0.023
0.335TrpTyr: 0.335 ± 0.04
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.646TyrAla: 1.646 ± 0.104
0.125TyrCys: 0.125 ± 0.023
1.818TyrAsp: 1.818 ± 0.09
2.48TyrGlu: 2.48 ± 0.138
2.446TyrPhe: 2.446 ± 0.119
1.668TyrGly: 1.668 ± 0.083
0.391TyrHis: 0.391 ± 0.044
2.983TyrIle: 2.983 ± 0.119
3.19TyrLys: 3.19 ± 0.157
3.843TyrLeu: 3.843 ± 0.146
0.52TyrMet: 0.52 ± 0.055
2.106TyrAsn: 2.106 ± 0.111
0.868TyrPro: 0.868 ± 0.069
1.07TyrGln: 1.07 ± 0.083
1.113TyrArg: 1.113 ± 0.073
2.695TyrSer: 2.695 ± 0.123
1.44TyrThr: 1.44 ± 0.083
1.754TyrVal: 1.754 ± 0.089
0.305TyrTrp: 0.305 ± 0.042
1.208TyrTyr: 1.208 ± 0.087
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 628 proteins (232639 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski