Amino acid dipepetide frequency for Salinarchaeum sp. Harcht-Bsk1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.115AlaAla: 15.115 ± 0.195
0.688AlaCys: 0.688 ± 0.029
10.871AlaAsp: 10.871 ± 0.133
9.89AlaGlu: 9.89 ± 0.143
3.937AlaPhe: 3.937 ± 0.075
10.343AlaGly: 10.343 ± 0.13
1.885AlaHis: 1.885 ± 0.05
6.203AlaIle: 6.203 ± 0.093
1.708AlaLys: 1.708 ± 0.046
10.442AlaLeu: 10.442 ± 0.138
2.221AlaMet: 2.221 ± 0.046
2.521AlaAsn: 2.521 ± 0.061
4.506AlaPro: 4.506 ± 0.081
2.363AlaGln: 2.363 ± 0.056
5.948AlaArg: 5.948 ± 0.094
6.183AlaSer: 6.183 ± 0.101
7.825AlaThr: 7.825 ± 0.121
10.246AlaVal: 10.246 ± 0.14
1.107AlaTrp: 1.107 ± 0.035
2.58AlaTyr: 2.58 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.558CysAla: 0.558 ± 0.029
0.076CysCys: 0.076 ± 0.009
0.552CysAsp: 0.552 ± 0.022
0.577CysGlu: 0.577 ± 0.029
0.224CysPhe: 0.224 ± 0.015
0.797CysGly: 0.797 ± 0.035
0.166CysHis: 0.166 ± 0.014
0.217CysIle: 0.217 ± 0.016
0.106CysLys: 0.106 ± 0.011
0.469CysLeu: 0.469 ± 0.024
0.105CysMet: 0.105 ± 0.011
0.194CysAsn: 0.194 ± 0.016
0.546CysPro: 0.546 ± 0.026
0.151CysGln: 0.151 ± 0.014
0.435CysArg: 0.435 ± 0.022
0.508CysSer: 0.508 ± 0.023
0.401CysThr: 0.401 ± 0.022
0.464CysVal: 0.464 ± 0.025
0.093CysTrp: 0.093 ± 0.01
0.219CysTyr: 0.219 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
12.211AspAla: 12.211 ± 0.141
0.637AspCys: 0.637 ± 0.026
8.235AspAsp: 8.235 ± 0.127
8.007AspGlu: 8.007 ± 0.115
1.968AspPhe: 1.968 ± 0.046
9.114AspGly: 9.114 ± 0.136
1.851AspHis: 1.851 ± 0.051
1.89AspIle: 1.89 ± 0.051
0.707AspLys: 0.707 ± 0.029
7.783AspLeu: 7.783 ± 0.11
1.124AspMet: 1.124 ± 0.036
1.05AspAsn: 1.05 ± 0.039
5.272AspPro: 5.272 ± 0.086
1.78AspGln: 1.78 ± 0.048
7.118AspArg: 7.118 ± 0.093
3.844AspSer: 3.844 ± 0.076
3.752AspThr: 3.752 ± 0.069
9.192AspVal: 9.192 ± 0.108
1.122AspTrp: 1.122 ± 0.038
1.772AspTyr: 1.772 ± 0.048
0.0AspXaa: 0.0 ± 0.0
Glu
9.751GluAla: 9.751 ± 0.127
0.571GluCys: 0.571 ± 0.027
6.737GluAsp: 6.737 ± 0.101
7.539GluGlu: 7.539 ± 0.13
2.711GluPhe: 2.711 ± 0.057
5.942GluGly: 5.942 ± 0.085
2.458GluHis: 2.458 ± 0.061
4.088GluIle: 4.088 ± 0.082
1.424GluLys: 1.424 ± 0.047
7.533GluLeu: 7.533 ± 0.107
1.666GluMet: 1.666 ± 0.037
2.021GluAsn: 2.021 ± 0.05
4.562GluPro: 4.562 ± 0.076
3.053GluGln: 3.053 ± 0.064
7.857GluArg: 7.857 ± 0.13
5.159GluSer: 5.159 ± 0.104
5.979GluThr: 5.979 ± 0.091
5.974GluVal: 5.974 ± 0.086
1.186GluTrp: 1.186 ± 0.039
2.595GluTyr: 2.595 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
3.595PheAla: 3.595 ± 0.064
0.242PheCys: 0.242 ± 0.016
3.154PheAsp: 3.154 ± 0.057
3.25PheGlu: 3.25 ± 0.068
0.905PhePhe: 0.905 ± 0.04
3.065PheGly: 3.065 ± 0.07
0.635PheHis: 0.635 ± 0.028
0.689PheIle: 0.689 ± 0.031
0.365PheLys: 0.365 ± 0.022
2.746PheLeu: 2.746 ± 0.062
0.415PheMet: 0.415 ± 0.021
0.597PheAsn: 0.597 ± 0.024
1.277PhePro: 1.277 ± 0.039
0.869PheGln: 0.869 ± 0.026
1.664PheArg: 1.664 ± 0.041
1.511PheSer: 1.511 ± 0.041
1.653PheThr: 1.653 ± 0.045
3.291PheVal: 3.291 ± 0.064
0.362PheTrp: 0.362 ± 0.021
0.823PheTyr: 0.823 ± 0.031
0.0PheXaa: 0.0 ± 0.0
Gly
9.125GlyAla: 9.125 ± 0.113
0.651GlyCys: 0.651 ± 0.027
7.595GlyAsp: 7.595 ± 0.109
7.533GlyGlu: 7.533 ± 0.104
3.021GlyPhe: 3.021 ± 0.061
8.215GlyGly: 8.215 ± 0.128
1.869GlyHis: 1.869 ± 0.052
4.399GlyIle: 4.399 ± 0.078
1.571GlyLys: 1.571 ± 0.042
7.229GlyLeu: 7.229 ± 0.111
1.662GlyMet: 1.662 ± 0.051
1.93GlyAsn: 1.93 ± 0.052
3.677GlyPro: 3.677 ± 0.071
2.197GlyGln: 2.197 ± 0.052
4.762GlyArg: 4.762 ± 0.083
5.648GlySer: 5.648 ± 0.098
6.036GlyThr: 6.036 ± 0.088
7.513GlyVal: 7.513 ± 0.109
1.169GlyTrp: 1.169 ± 0.04
2.529GlyTyr: 2.529 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.128HisAla: 2.128 ± 0.055
0.227HisCys: 0.227 ± 0.013
1.978HisAsp: 1.978 ± 0.054
1.819HisGlu: 1.819 ± 0.052
0.597HisPhe: 0.597 ± 0.027
2.078HisGly: 2.078 ± 0.051
0.555HisHis: 0.555 ± 0.027
0.464HisIle: 0.464 ± 0.025
0.257HisLys: 0.257 ± 0.017
1.798HisLeu: 1.798 ± 0.052
0.288HisMet: 0.288 ± 0.018
0.389HisAsn: 0.389 ± 0.02
1.238HisPro: 1.238 ± 0.041
0.5HisGln: 0.5 ± 0.023
1.337HisArg: 1.337 ± 0.033
0.88HisSer: 0.88 ± 0.033
0.986HisThr: 0.986 ± 0.033
2.113HisVal: 2.113 ± 0.045
0.264HisTrp: 0.264 ± 0.016
0.585HisTyr: 0.585 ± 0.03
0.0HisXaa: 0.0 ± 0.0
Ile
5.29IleAla: 5.29 ± 0.092
0.252IleCys: 0.252 ± 0.016
4.132IleAsp: 4.132 ± 0.08
4.596IleGlu: 4.596 ± 0.078
0.927IlePhe: 0.927 ± 0.036
4.078IleGly: 4.078 ± 0.065
0.792IleHis: 0.792 ± 0.029
0.838IleIle: 0.838 ± 0.035
0.545IleLys: 0.545 ± 0.029
2.734IleLeu: 2.734 ± 0.058
0.478IleMet: 0.478 ± 0.021
0.746IleAsn: 0.746 ± 0.029
1.969IlePro: 1.969 ± 0.048
1.077IleGln: 1.077 ± 0.037
2.32IleArg: 2.32 ± 0.055
1.864IleSer: 1.864 ± 0.052
2.145IleThr: 2.145 ± 0.045
4.137IleVal: 4.137 ± 0.083
0.349IleTrp: 0.349 ± 0.022
0.865IleTyr: 0.865 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
1.488LysAla: 1.488 ± 0.044
0.097LysCys: 0.097 ± 0.012
0.88LysAsp: 0.88 ± 0.028
1.098LysGlu: 1.098 ± 0.035
0.393LysPhe: 0.393 ± 0.02
1.102LysGly: 1.102 ± 0.039
0.373LysHis: 0.373 ± 0.018
0.626LysIle: 0.626 ± 0.033
0.344LysLys: 0.344 ± 0.021
1.504LysLeu: 1.504 ± 0.047
0.254LysMet: 0.254 ± 0.018
0.388LysAsn: 0.388 ± 0.024
0.751LysPro: 0.751 ± 0.027
0.633LysGln: 0.633 ± 0.03
1.327LysArg: 1.327 ± 0.045
0.861LysSer: 0.861 ± 0.031
1.038LysThr: 1.038 ± 0.035
1.019LysVal: 1.019 ± 0.033
0.173LysTrp: 0.173 ± 0.013
0.441LysTyr: 0.441 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
11.399LeuAla: 11.399 ± 0.152
0.535LeuCys: 0.535 ± 0.024
8.043LeuAsp: 8.043 ± 0.099
7.588LeuGlu: 7.588 ± 0.108
2.785LeuPhe: 2.785 ± 0.061
7.885LeuGly: 7.885 ± 0.125
1.576LeuHis: 1.576 ± 0.04
2.737LeuIle: 2.737 ± 0.066
1.148LeuLys: 1.148 ± 0.038
8.808LeuLeu: 8.808 ± 0.145
1.136LeuMet: 1.136 ± 0.034
1.447LeuAsn: 1.447 ± 0.05
4.242LeuPro: 4.242 ± 0.07
2.401LeuGln: 2.401 ± 0.056
5.485LeuArg: 5.485 ± 0.082
4.826LeuSer: 4.826 ± 0.082
4.856LeuThr: 4.856 ± 0.092
8.144LeuVal: 8.144 ± 0.111
0.849LeuTrp: 0.849 ± 0.034
2.052LeuTyr: 2.052 ± 0.057
0.0LeuXaa: 0.0 ± 0.0
Met
1.872MetAla: 1.872 ± 0.046
0.102MetCys: 0.102 ± 0.01
1.303MetAsp: 1.303 ± 0.04
1.152MetGlu: 1.152 ± 0.038
0.406MetPhe: 0.406 ± 0.024
1.319MetGly: 1.319 ± 0.045
0.366MetHis: 0.366 ± 0.023
0.639MetIle: 0.639 ± 0.029
0.314MetLys: 0.314 ± 0.022
1.45MetLeu: 1.45 ± 0.046
0.286MetMet: 0.286 ± 0.018
0.488MetAsn: 0.488 ± 0.025
0.896MetPro: 0.896 ± 0.037
0.537MetGln: 0.537 ± 0.023
0.926MetArg: 0.926 ± 0.031
1.229MetSer: 1.229 ± 0.039
1.365MetThr: 1.365 ± 0.036
1.231MetVal: 1.231 ± 0.036
0.145MetTrp: 0.145 ± 0.012
0.343MetTyr: 0.343 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
2.533AsnAla: 2.533 ± 0.073
0.185AsnCys: 0.185 ± 0.014
1.62AsnAsp: 1.62 ± 0.044
1.648AsnGlu: 1.648 ± 0.046
0.622AsnPhe: 0.622 ± 0.03
1.912AsnGly: 1.912 ± 0.057
0.442AsnHis: 0.442 ± 0.024
0.562AsnIle: 0.562 ± 0.027
0.311AsnLys: 0.311 ± 0.019
1.696AsnLeu: 1.696 ± 0.039
0.335AsnMet: 0.335 ± 0.02
0.464AsnAsn: 0.464 ± 0.025
1.341AsnPro: 1.341 ± 0.037
0.578AsnGln: 0.578 ± 0.026
1.474AsnArg: 1.474 ± 0.039
0.826AsnSer: 0.826 ± 0.035
1.045AsnThr: 1.045 ± 0.034
2.312AsnVal: 2.312 ± 0.059
0.297AsnTrp: 0.297 ± 0.019
0.587AsnTyr: 0.587 ± 0.026
0.0AsnXaa: 0.0 ± 0.0
Pro
5.491ProAla: 5.491 ± 0.093
0.243ProCys: 0.243 ± 0.016
5.173ProAsp: 5.173 ± 0.089
4.966ProGlu: 4.966 ± 0.082
1.551ProPhe: 1.551 ± 0.04
4.14ProGly: 4.14 ± 0.071
0.931ProHis: 0.931 ± 0.04
2.281ProIle: 2.281 ± 0.056
0.724ProLys: 0.724 ± 0.028
3.636ProLeu: 3.636 ± 0.069
0.88ProMet: 0.88 ± 0.03
1.119ProAsn: 1.119 ± 0.037
2.3ProPro: 2.3 ± 0.062
0.963ProGln: 0.963 ± 0.042
2.222ProArg: 2.222 ± 0.053
2.66ProSer: 2.66 ± 0.058
3.212ProThr: 3.212 ± 0.064
4.0ProVal: 4.0 ± 0.073
0.536ProTrp: 0.536 ± 0.026
1.118ProTyr: 1.118 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
2.733GlnAla: 2.733 ± 0.058
0.178GlnCys: 0.178 ± 0.014
1.619GlnAsp: 1.619 ± 0.049
1.857GlnGlu: 1.857 ± 0.052
1.038GlnPhe: 1.038 ± 0.036
1.692GlnGly: 1.692 ± 0.046
0.581GlnHis: 0.581 ± 0.025
1.178GlnIle: 1.178 ± 0.04
0.455GlnLys: 0.455 ± 0.021
2.41GlnLeu: 2.41 ± 0.053
0.492GlnMet: 0.492 ± 0.023
0.669GlnAsn: 0.669 ± 0.031
1.299GlnPro: 1.299 ± 0.042
1.065GlnGln: 1.065 ± 0.073
2.127GlnArg: 2.127 ± 0.05
1.631GlnSer: 1.631 ± 0.044
1.733GlnThr: 1.733 ± 0.056
1.89GlnVal: 1.89 ± 0.05
0.349GlnTrp: 0.349 ± 0.023
0.78GlnTyr: 0.78 ± 0.029
0.0GlnXaa: 0.0 ± 0.0
Arg
6.354ArgAla: 6.354 ± 0.087
0.461ArgCys: 0.461 ± 0.025
5.024ArgAsp: 5.024 ± 0.074
6.496ArgGlu: 6.496 ± 0.102
2.243ArgPhe: 2.243 ± 0.048
4.438ArgGly: 4.438 ± 0.082
1.262ArgHis: 1.262 ± 0.038
3.324ArgIle: 3.324 ± 0.067
1.153ArgLys: 1.153 ± 0.04
5.616ArgLeu: 5.616 ± 0.092
1.241ArgMet: 1.241 ± 0.032
1.533ArgAsn: 1.533 ± 0.045
2.563ArgPro: 2.563 ± 0.067
1.767ArgGln: 1.767 ± 0.047
4.806ArgArg: 4.806 ± 0.094
4.113ArgSer: 4.113 ± 0.072
3.907ArgThr: 3.907 ± 0.06
4.781ArgVal: 4.781 ± 0.069
0.717ArgTrp: 0.717 ± 0.031
1.75ArgTyr: 1.75 ± 0.039
0.0ArgXaa: 0.0 ± 0.0
Ser
5.683SerAla: 5.683 ± 0.092
0.302SerCys: 0.302 ± 0.02
4.566SerAsp: 4.566 ± 0.083
4.22SerGlu: 4.22 ± 0.078
1.856SerPhe: 1.856 ± 0.044
5.521SerGly: 5.521 ± 0.093
0.96SerHis: 0.96 ± 0.034
2.653SerIle: 2.653 ± 0.055
0.978SerLys: 0.978 ± 0.036
4.653SerLeu: 4.653 ± 0.075
1.027SerMet: 1.027 ± 0.044
1.254SerAsn: 1.254 ± 0.039
2.72SerPro: 2.72 ± 0.057
1.306SerGln: 1.306 ± 0.04
2.905SerArg: 2.905 ± 0.054
3.02SerSer: 3.02 ± 0.088
3.535SerThr: 3.535 ± 0.074
4.899SerVal: 4.899 ± 0.086
0.635SerTrp: 0.635 ± 0.029
1.284SerTyr: 1.284 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
7.005ThrAla: 7.005 ± 0.099
0.409ThrCys: 0.409 ± 0.022
5.439ThrAsp: 5.439 ± 0.086
4.493ThrGlu: 4.493 ± 0.083
2.015ThrPhe: 2.015 ± 0.048
5.776ThrGly: 5.776 ± 0.085
1.153ThrHis: 1.153 ± 0.043
3.346ThrIle: 3.346 ± 0.066
0.938ThrLys: 0.938 ± 0.033
5.379ThrLeu: 5.379 ± 0.078
1.009ThrMet: 1.009 ± 0.038
1.327ThrAsn: 1.327 ± 0.047
3.015ThrPro: 3.015 ± 0.058
1.305ThrGln: 1.305 ± 0.039
2.936ThrArg: 2.936 ± 0.063
2.831ThrSer: 2.831 ± 0.069
4.052ThrThr: 4.052 ± 0.089
6.791ThrVal: 6.791 ± 0.107
0.68ThrTrp: 0.68 ± 0.032
1.641ThrTyr: 1.641 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
10.622ValAla: 10.622 ± 0.135
0.639ValCys: 0.639 ± 0.03
8.125ValAsp: 8.125 ± 0.109
8.76ValGlu: 8.76 ± 0.114
2.667ValPhe: 2.667 ± 0.063
7.847ValGly: 7.847 ± 0.116
1.726ValHis: 1.726 ± 0.047
2.96ValIle: 2.96 ± 0.064
1.178ValLys: 1.178 ± 0.041
8.477ValLeu: 8.477 ± 0.135
1.203ValMet: 1.203 ± 0.038
1.777ValAsn: 1.777 ± 0.055
4.373ValPro: 4.373 ± 0.066
2.138ValGln: 2.138 ± 0.052
5.288ValArg: 5.288 ± 0.073
4.59ValSer: 4.59 ± 0.072
5.892ValThr: 5.892 ± 0.094
8.777ValVal: 8.777 ± 0.123
0.829ValTrp: 0.829 ± 0.034
2.022ValTyr: 2.022 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.986TrpAla: 0.986 ± 0.037
0.098TrpCys: 0.098 ± 0.01
0.805TrpAsp: 0.805 ± 0.033
0.894TrpGlu: 0.894 ± 0.036
0.449TrpPhe: 0.449 ± 0.022
0.785TrpGly: 0.785 ± 0.025
0.253TrpHis: 0.253 ± 0.017
0.594TrpIle: 0.594 ± 0.026
0.229TrpLys: 0.229 ± 0.017
1.225TrpLeu: 1.225 ± 0.04
0.214TrpMet: 0.214 ± 0.016
0.365TrpAsn: 0.365 ± 0.022
0.465TrpPro: 0.465 ± 0.021
0.412TrpGln: 0.412 ± 0.021
0.854TrpArg: 0.854 ± 0.031
0.636TrpSer: 0.636 ± 0.029
0.824TrpThr: 0.824 ± 0.03
0.751TrpVal: 0.751 ± 0.031
0.199TrpTrp: 0.199 ± 0.014
0.36TrpTyr: 0.36 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.642TyrAla: 2.642 ± 0.065
0.267TyrCys: 0.267 ± 0.017
2.578TyrAsp: 2.578 ± 0.052
2.423TyrGlu: 2.423 ± 0.055
0.795TyrPhe: 0.795 ± 0.029
2.279TyrGly: 2.279 ± 0.049
0.647TyrHis: 0.647 ± 0.028
0.445TyrIle: 0.445 ± 0.024
0.335TyrLys: 0.335 ± 0.018
2.356TyrLeu: 2.356 ± 0.053
0.332TyrMet: 0.332 ± 0.019
0.511TyrAsn: 0.511 ± 0.024
1.133TyrPro: 1.133 ± 0.04
0.678TyrGln: 0.678 ± 0.026
1.76TyrArg: 1.76 ± 0.043
1.157TyrSer: 1.157 ± 0.038
1.304TyrThr: 1.304 ± 0.041
2.366TyrVal: 2.366 ± 0.06
0.338TyrTrp: 0.338 ± 0.02
0.76TyrTyr: 0.76 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3013 proteins (911803 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski