Amino acid dipepetide frequency for Dickeya phage vB_DsoM_JA33

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.633AlaAla: 6.633 ± 0.374
0.627AlaCys: 0.627 ± 0.092
4.928AlaAsp: 4.928 ± 0.255
5.141AlaGlu: 5.141 ± 0.308
3.26AlaPhe: 3.26 ± 0.193
4.238AlaGly: 4.238 ± 0.291
1.542AlaHis: 1.542 ± 0.135
5.016AlaIle: 5.016 ± 0.28
6.006AlaLys: 6.006 ± 0.396
6.357AlaLeu: 6.357 ± 0.315
1.931AlaMet: 1.931 ± 0.146
3.787AlaAsn: 3.787 ± 0.259
3.085AlaPro: 3.085 ± 0.228
2.922AlaGln: 2.922 ± 0.2
4.213AlaArg: 4.213 ± 0.242
4.464AlaSer: 4.464 ± 0.233
4.351AlaThr: 4.351 ± 0.284
4.577AlaVal: 4.577 ± 0.244
0.614AlaTrp: 0.614 ± 0.082
2.483AlaTyr: 2.483 ± 0.191
0.0AlaXaa: 0.0 ± 0.0
Cys
0.74CysAla: 0.74 ± 0.097
0.138CysCys: 0.138 ± 0.039
0.727CysAsp: 0.727 ± 0.098
0.853CysGlu: 0.853 ± 0.11
0.539CysPhe: 0.539 ± 0.087
0.878CysGly: 0.878 ± 0.098
0.276CysHis: 0.276 ± 0.06
0.652CysIle: 0.652 ± 0.091
0.665CysLys: 0.665 ± 0.102
0.978CysLeu: 0.978 ± 0.113
0.326CysMet: 0.326 ± 0.07
0.326CysAsn: 0.326 ± 0.064
0.752CysPro: 0.752 ± 0.106
0.238CysGln: 0.238 ± 0.055
0.577CysArg: 0.577 ± 0.093
0.665CysSer: 0.665 ± 0.094
0.552CysThr: 0.552 ± 0.088
0.715CysVal: 0.715 ± 0.095
0.075CysTrp: 0.075 ± 0.028
0.376CysTyr: 0.376 ± 0.066
0.0CysXaa: 0.0 ± 0.0
Asp
4.69AspAla: 4.69 ± 0.273
0.614AspCys: 0.614 ± 0.081
5.166AspAsp: 5.166 ± 0.575
5.317AspGlu: 5.317 ± 0.548
3.335AspPhe: 3.335 ± 0.197
4.627AspGly: 4.627 ± 0.315
0.928AspHis: 0.928 ± 0.103
4.125AspIle: 4.125 ± 0.235
3.448AspLys: 3.448 ± 0.253
5.843AspLeu: 5.843 ± 0.301
1.517AspMet: 1.517 ± 0.156
2.508AspAsn: 2.508 ± 0.163
3.386AspPro: 3.386 ± 0.203
2.082AspGln: 2.082 ± 0.148
2.997AspArg: 2.997 ± 0.158
4.627AspSer: 4.627 ± 0.248
3.223AspThr: 3.223 ± 0.18
4.125AspVal: 4.125 ± 0.252
0.915AspTrp: 0.915 ± 0.111
2.408AspTyr: 2.408 ± 0.185
0.0AspXaa: 0.0 ± 0.0
Glu
4.991GluAla: 4.991 ± 0.303
0.552GluCys: 0.552 ± 0.086
5.43GluAsp: 5.43 ± 0.59
6.006GluGlu: 6.006 ± 0.699
2.984GluPhe: 2.984 ± 0.203
3.223GluGly: 3.223 ± 0.259
1.455GluHis: 1.455 ± 0.141
4.665GluIle: 4.665 ± 0.233
4.602GluLys: 4.602 ± 0.288
5.793GluLeu: 5.793 ± 0.333
1.969GluMet: 1.969 ± 0.179
3.549GluAsn: 3.549 ± 0.188
1.881GluPro: 1.881 ± 0.15
2.458GluGln: 2.458 ± 0.186
3.11GluArg: 3.11 ± 0.208
4.414GluSer: 4.414 ± 0.318
3.461GluThr: 3.461 ± 0.264
4.477GluVal: 4.477 ± 0.225
0.903GluTrp: 0.903 ± 0.101
2.382GluTyr: 2.382 ± 0.167
0.0GluXaa: 0.0 ± 0.0
Phe
3.135PheAla: 3.135 ± 0.215
0.64PheCys: 0.64 ± 0.085
3.624PheAsp: 3.624 ± 0.257
3.273PheGlu: 3.273 ± 0.214
1.517PhePhe: 1.517 ± 0.162
3.06PheGly: 3.06 ± 0.2
0.702PheHis: 0.702 ± 0.107
2.721PheIle: 2.721 ± 0.176
2.37PheLys: 2.37 ± 0.173
3.097PheLeu: 3.097 ± 0.195
0.953PheMet: 0.953 ± 0.101
2.332PheAsn: 2.332 ± 0.162
1.756PhePro: 1.756 ± 0.148
1.053PheGln: 1.053 ± 0.103
2.332PheArg: 2.332 ± 0.152
3.11PheSer: 3.11 ± 0.213
2.633PheThr: 2.633 ± 0.21
3.009PheVal: 3.009 ± 0.191
0.364PheTrp: 0.364 ± 0.063
1.555PheTyr: 1.555 ± 0.153
0.0PheXaa: 0.0 ± 0.0
Gly
4.426GlyAla: 4.426 ± 0.274
0.577GlyCys: 0.577 ± 0.092
3.624GlyAsp: 3.624 ± 0.246
3.85GlyGlu: 3.85 ± 0.225
2.683GlyPhe: 2.683 ± 0.182
3.799GlyGly: 3.799 ± 0.33
0.815GlyHis: 0.815 ± 0.104
3.636GlyIle: 3.636 ± 0.218
5.279GlyLys: 5.279 ± 0.297
4.1GlyLeu: 4.1 ± 0.227
1.705GlyMet: 1.705 ± 0.14
2.997GlyAsn: 2.997 ± 0.265
1.154GlyPro: 1.154 ± 0.245
1.73GlyGln: 1.73 ± 0.144
2.834GlyArg: 2.834 ± 0.2
4.665GlySer: 4.665 ± 0.291
4.288GlyThr: 4.288 ± 0.299
4.063GlyVal: 4.063 ± 0.245
0.765GlyTrp: 0.765 ± 0.096
2.495GlyTyr: 2.495 ± 0.202
0.0GlyXaa: 0.0 ± 0.0
His
1.342HisAla: 1.342 ± 0.114
0.389HisCys: 0.389 ± 0.075
0.853HisAsp: 0.853 ± 0.09
1.342HisGlu: 1.342 ± 0.131
0.928HisPhe: 0.928 ± 0.11
1.229HisGly: 1.229 ± 0.12
0.301HisHis: 0.301 ± 0.071
1.103HisIle: 1.103 ± 0.122
1.354HisLys: 1.354 ± 0.121
1.354HisLeu: 1.354 ± 0.142
0.489HisMet: 0.489 ± 0.065
0.928HisAsn: 0.928 ± 0.108
0.74HisPro: 0.74 ± 0.1
0.288HisGln: 0.288 ± 0.055
1.166HisArg: 1.166 ± 0.118
1.053HisSer: 1.053 ± 0.101
0.915HisThr: 0.915 ± 0.112
1.442HisVal: 1.442 ± 0.133
0.213HisTrp: 0.213 ± 0.057
0.89HisTyr: 0.89 ± 0.115
0.0HisXaa: 0.0 ± 0.0
Ile
4.865IleAla: 4.865 ± 0.239
0.777IleCys: 0.777 ± 0.099
4.0IleAsp: 4.0 ± 0.222
4.489IleGlu: 4.489 ± 0.234
2.169IlePhe: 2.169 ± 0.182
3.674IleGly: 3.674 ± 0.26
1.354IleHis: 1.354 ± 0.125
2.734IleIle: 2.734 ± 0.199
3.762IleLys: 3.762 ± 0.246
4.627IleLeu: 4.627 ± 0.237
1.354IleMet: 1.354 ± 0.138
2.934IleAsn: 2.934 ± 0.188
3.386IlePro: 3.386 ± 0.201
2.47IleGln: 2.47 ± 0.141
3.674IleArg: 3.674 ± 0.188
4.803IleSer: 4.803 ± 0.219
3.348IleThr: 3.348 ± 0.179
4.502IleVal: 4.502 ± 0.215
0.564IleTrp: 0.564 ± 0.077
1.818IleTyr: 1.818 ± 0.14
0.0IleXaa: 0.0 ± 0.0
Lys
5.166LysAla: 5.166 ± 0.353
0.439LysCys: 0.439 ± 0.059
3.636LysAsp: 3.636 ± 0.258
4.414LysGlu: 4.414 ± 0.278
2.922LysPhe: 2.922 ± 0.179
3.511LysGly: 3.511 ± 0.243
1.292LysHis: 1.292 ± 0.123
3.937LysIle: 3.937 ± 0.238
6.784LysLys: 6.784 ± 0.611
6.057LysLeu: 6.057 ± 0.352
1.781LysMet: 1.781 ± 0.159
3.21LysAsn: 3.21 ± 0.199
2.734LysPro: 2.734 ± 0.217
2.658LysGln: 2.658 ± 0.175
3.636LysArg: 3.636 ± 0.281
4.514LysSer: 4.514 ± 0.339
4.477LysThr: 4.477 ± 0.237
4.602LysVal: 4.602 ± 0.264
0.577LysTrp: 0.577 ± 0.087
2.495LysTyr: 2.495 ± 0.167
0.0LysXaa: 0.0 ± 0.0
Leu
6.383LeuAla: 6.383 ± 0.273
0.89LeuCys: 0.89 ± 0.104
5.154LeuAsp: 5.154 ± 0.238
5.605LeuGlu: 5.605 ± 0.279
3.498LeuPhe: 3.498 ± 0.214
4.125LeuGly: 4.125 ± 0.235
1.705LeuHis: 1.705 ± 0.143
4.665LeuIle: 4.665 ± 0.23
5.317LeuLys: 5.317 ± 0.396
6.383LeuLeu: 6.383 ± 0.308
2.169LeuMet: 2.169 ± 0.165
4.777LeuAsn: 4.777 ± 0.2
4.163LeuPro: 4.163 ± 0.246
2.37LeuGln: 2.37 ± 0.157
5.053LeuArg: 5.053 ± 0.25
6.834LeuSer: 6.834 ± 0.343
4.451LeuThr: 4.451 ± 0.277
5.216LeuVal: 5.216 ± 0.231
0.765LeuTrp: 0.765 ± 0.097
2.683LeuTyr: 2.683 ± 0.222
0.0LeuXaa: 0.0 ± 0.0
Met
1.881MetAla: 1.881 ± 0.158
0.401MetCys: 0.401 ± 0.083
1.455MetAsp: 1.455 ± 0.115
1.793MetGlu: 1.793 ± 0.166
1.129MetPhe: 1.129 ± 0.113
0.991MetGly: 0.991 ± 0.108
0.351MetHis: 0.351 ± 0.068
1.417MetIle: 1.417 ± 0.116
1.893MetLys: 1.893 ± 0.158
2.082MetLeu: 2.082 ± 0.163
0.652MetMet: 0.652 ± 0.094
0.978MetAsn: 0.978 ± 0.111
1.304MetPro: 1.304 ± 0.147
1.141MetGln: 1.141 ± 0.106
1.655MetArg: 1.655 ± 0.147
2.069MetSer: 2.069 ± 0.167
1.392MetThr: 1.392 ± 0.138
1.279MetVal: 1.279 ± 0.113
0.238MetTrp: 0.238 ± 0.059
0.828MetTyr: 0.828 ± 0.08
0.0MetXaa: 0.0 ± 0.0
Asn
4.113AsnAla: 4.113 ± 0.209
0.564AsnCys: 0.564 ± 0.089
2.683AsnAsp: 2.683 ± 0.19
2.708AsnGlu: 2.708 ± 0.17
2.37AsnPhe: 2.37 ± 0.163
3.536AsnGly: 3.536 ± 0.207
0.577AsnHis: 0.577 ± 0.091
3.31AsnIle: 3.31 ± 0.218
3.122AsnLys: 3.122 ± 0.194
3.975AsnLeu: 3.975 ± 0.21
1.229AsnMet: 1.229 ± 0.126
2.056AsnAsn: 2.056 ± 0.165
2.408AsnPro: 2.408 ± 0.147
1.718AsnGln: 1.718 ± 0.16
2.056AsnArg: 2.056 ± 0.177
3.31AsnSer: 3.31 ± 0.221
2.746AsnThr: 2.746 ± 0.217
3.511AsnVal: 3.511 ± 0.225
0.564AsnTrp: 0.564 ± 0.084
1.605AsnTyr: 1.605 ± 0.149
0.0AsnXaa: 0.0 ± 0.0
Pro
2.922ProAla: 2.922 ± 0.247
0.552ProCys: 0.552 ± 0.09
3.223ProAsp: 3.223 ± 0.185
3.361ProGlu: 3.361 ± 0.202
1.969ProPhe: 1.969 ± 0.139
1.981ProGly: 1.981 ± 0.179
0.677ProHis: 0.677 ± 0.097
2.683ProIle: 2.683 ± 0.163
3.486ProLys: 3.486 ± 0.269
3.185ProLeu: 3.185 ± 0.215
0.978ProMet: 0.978 ± 0.099
2.044ProAsn: 2.044 ± 0.152
1.204ProPro: 1.204 ± 0.126
1.166ProGln: 1.166 ± 0.126
1.944ProArg: 1.944 ± 0.145
2.884ProSer: 2.884 ± 0.203
2.884ProThr: 2.884 ± 0.232
3.386ProVal: 3.386 ± 0.194
0.301ProTrp: 0.301 ± 0.069
1.342ProTyr: 1.342 ± 0.139
0.0ProXaa: 0.0 ± 0.0
Gln
2.52GlnAla: 2.52 ± 0.172
0.276GlnCys: 0.276 ± 0.051
1.856GlnAsp: 1.856 ± 0.146
2.019GlnGlu: 2.019 ± 0.155
1.392GlnPhe: 1.392 ± 0.128
1.555GlnGly: 1.555 ± 0.139
0.677GlnHis: 0.677 ± 0.092
2.922GlnIle: 2.922 ± 0.192
2.332GlnLys: 2.332 ± 0.163
3.072GlnLeu: 3.072 ± 0.243
0.765GlnMet: 0.765 ± 0.091
1.856GlnAsn: 1.856 ± 0.157
1.229GlnPro: 1.229 ± 0.119
1.354GlnGln: 1.354 ± 0.127
1.793GlnArg: 1.793 ± 0.173
2.169GlnSer: 2.169 ± 0.142
2.144GlnThr: 2.144 ± 0.145
2.031GlnVal: 2.031 ± 0.178
0.464GlnTrp: 0.464 ± 0.082
1.442GlnTyr: 1.442 ± 0.107
0.0GlnXaa: 0.0 ± 0.0
Arg
3.737ArgAla: 3.737 ± 0.23
0.652ArgCys: 0.652 ± 0.081
3.285ArgAsp: 3.285 ± 0.212
3.06ArgGlu: 3.06 ± 0.196
2.32ArgPhe: 2.32 ± 0.151
2.984ArgGly: 2.984 ± 0.209
0.991ArgHis: 0.991 ± 0.116
3.824ArgIle: 3.824 ± 0.227
3.887ArgLys: 3.887 ± 0.26
4.677ArgLeu: 4.677 ± 0.24
1.605ArgMet: 1.605 ± 0.132
2.872ArgAsn: 2.872 ± 0.24
1.756ArgPro: 1.756 ± 0.163
1.893ArgGln: 1.893 ± 0.19
3.035ArgArg: 3.035 ± 0.232
3.298ArgSer: 3.298 ± 0.199
2.984ArgThr: 2.984 ± 0.169
3.774ArgVal: 3.774 ± 0.227
0.577ArgTrp: 0.577 ± 0.079
1.994ArgTyr: 1.994 ± 0.148
0.0ArgXaa: 0.0 ± 0.0
Ser
5.806SerAla: 5.806 ± 0.269
0.727SerCys: 0.727 ± 0.109
4.915SerAsp: 4.915 ± 0.266
4.815SerGlu: 4.815 ± 0.342
2.947SerPhe: 2.947 ± 0.218
4.878SerGly: 4.878 ± 0.283
1.216SerHis: 1.216 ± 0.122
4.163SerIle: 4.163 ± 0.274
4.188SerLys: 4.188 ± 0.287
5.919SerLeu: 5.919 ± 0.257
1.781SerMet: 1.781 ± 0.145
3.398SerAsn: 3.398 ± 0.185
2.909SerPro: 2.909 ± 0.208
2.107SerGln: 2.107 ± 0.136
3.097SerArg: 3.097 ± 0.175
4.702SerSer: 4.702 ± 0.318
3.975SerThr: 3.975 ± 0.24
5.066SerVal: 5.066 ± 0.25
0.589SerTrp: 0.589 ± 0.092
2.408SerTyr: 2.408 ± 0.188
0.0SerXaa: 0.0 ± 0.0
Thr
4.577ThrAla: 4.577 ± 0.261
0.652ThrCys: 0.652 ± 0.096
3.524ThrAsp: 3.524 ± 0.254
3.21ThrGlu: 3.21 ± 0.201
2.52ThrPhe: 2.52 ± 0.182
4.351ThrGly: 4.351 ± 0.322
1.179ThrHis: 1.179 ± 0.113
3.787ThrIle: 3.787 ± 0.241
3.586ThrLys: 3.586 ± 0.234
5.593ThrLeu: 5.593 ± 0.269
1.028ThrMet: 1.028 ± 0.098
2.508ThrAsn: 2.508 ± 0.183
3.035ThrPro: 3.035 ± 0.198
1.956ThrGln: 1.956 ± 0.159
2.633ThrArg: 2.633 ± 0.173
3.549ThrSer: 3.549 ± 0.215
2.872ThrThr: 2.872 ± 0.209
4.765ThrVal: 4.765 ± 0.293
0.702ThrTrp: 0.702 ± 0.104
1.944ThrTyr: 1.944 ± 0.201
0.0ThrXaa: 0.0 ± 0.0
Val
4.878ValAla: 4.878 ± 0.263
0.765ValCys: 0.765 ± 0.1
4.803ValAsp: 4.803 ± 0.245
4.589ValGlu: 4.589 ± 0.252
2.683ValPhe: 2.683 ± 0.165
3.912ValGly: 3.912 ± 0.219
1.129ValHis: 1.129 ± 0.116
3.511ValIle: 3.511 ± 0.226
4.176ValLys: 4.176 ± 0.259
5.643ValLeu: 5.643 ± 0.277
1.404ValMet: 1.404 ± 0.151
2.984ValAsn: 2.984 ± 0.183
3.461ValPro: 3.461 ± 0.242
2.52ValGln: 2.52 ± 0.198
4.477ValArg: 4.477 ± 0.211
5.279ValSer: 5.279 ± 0.247
4.326ValThr: 4.326 ± 0.292
5.756ValVal: 5.756 ± 0.337
0.89ValTrp: 0.89 ± 0.091
2.408ValTyr: 2.408 ± 0.184
0.0ValXaa: 0.0 ± 0.0
Trp
0.702TrpAla: 0.702 ± 0.083
0.176TrpCys: 0.176 ± 0.042
0.489TrpAsp: 0.489 ± 0.073
0.627TrpGlu: 0.627 ± 0.091
0.464TrpPhe: 0.464 ± 0.079
0.564TrpGly: 0.564 ± 0.094
0.401TrpHis: 0.401 ± 0.071
0.665TrpIle: 0.665 ± 0.083
0.64TrpLys: 0.64 ± 0.093
0.84TrpLeu: 0.84 ± 0.106
0.339TrpMet: 0.339 ± 0.059
0.502TrpAsn: 0.502 ± 0.083
0.414TrpPro: 0.414 ± 0.066
0.464TrpGln: 0.464 ± 0.078
0.727TrpArg: 0.727 ± 0.094
0.577TrpSer: 0.577 ± 0.076
0.777TrpThr: 0.777 ± 0.117
0.74TrpVal: 0.74 ± 0.098
0.05TrpTrp: 0.05 ± 0.024
0.339TrpTyr: 0.339 ± 0.057
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.683TyrAla: 2.683 ± 0.225
0.64TyrCys: 0.64 ± 0.091
2.508TyrAsp: 2.508 ± 0.194
1.831TyrGlu: 1.831 ± 0.172
1.605TyrPhe: 1.605 ± 0.128
2.37TyrGly: 2.37 ± 0.152
0.752TyrHis: 0.752 ± 0.093
1.768TyrIle: 1.768 ± 0.145
1.944TyrLys: 1.944 ± 0.159
2.633TyrLeu: 2.633 ± 0.186
0.94TyrMet: 0.94 ± 0.119
1.618TyrAsn: 1.618 ± 0.136
1.417TyrPro: 1.417 ± 0.13
1.279TyrGln: 1.279 ± 0.135
2.194TyrArg: 2.194 ± 0.155
2.621TyrSer: 2.621 ± 0.169
2.169TyrThr: 2.169 ± 0.196
2.558TyrVal: 2.558 ± 0.186
0.364TyrTrp: 0.364 ± 0.065
1.304TyrTyr: 1.304 ± 0.129
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 321 proteins (79750 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski