Amino acid dipepetide frequency for Indibacter alkaliphilus LW1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.629AlaAla: 4.629 ± 0.067	0.56AlaCys: 0.56 ± 0.022	3.399AlaAsp: 3.399 ± 0.051	4.458AlaGlu: 4.458 ± 0.063	3.594AlaPhe: 3.594 ± 0.046	4.809AlaGly: 4.809 ± 0.067	1.121AlaHis: 1.121 ± 0.033	4.825AlaIle: 4.825 ± 0.067	4.205AlaLys: 4.205 ± 0.068	6.363AlaLeu: 6.363 ± 0.075	1.711AlaMet: 1.711 ± 0.038	3.028AlaAsn: 3.028 ± 0.057	2.082AlaPro: 2.082 ± 0.041	2.399AlaGln: 2.399 ± 0.041	2.328AlaArg: 2.328 ± 0.047	4.12AlaSer: 4.12 ± 0.053	2.866AlaThr: 2.866 ± 0.05	4.254AlaVal: 4.254 ± 0.066	0.79AlaTrp: 0.79 ± 0.025	2.566AlaTyr: 2.566 ± 0.044	0.001AlaXaa: 0.001 ± 0.001
Cys	0.406CysAla: 0.406 ± 0.016	0.089CysCys: 0.089 ± 0.008	0.341CysAsp: 0.341 ± 0.016	0.429CysGlu: 0.429 ± 0.022	0.413CysPhe: 0.413 ± 0.019	0.543CysGly: 0.543 ± 0.021	0.192CysHis: 0.192 ± 0.011	0.476CysIle: 0.476 ± 0.018	0.38CysLys: 0.38 ± 0.018	0.622CysLeu: 0.622 ± 0.023	0.158CysMet: 0.158 ± 0.011	0.301CysAsn: 0.301 ± 0.016	0.303CysPro: 0.303 ± 0.016	0.262CysGln: 0.262 ± 0.012	0.244CysArg: 0.244 ± 0.013	0.447CysSer: 0.447 ± 0.018	0.333CysThr: 0.333 ± 0.015	0.354CysVal: 0.354 ± 0.016	0.065CysTrp: 0.065 ± 0.007	0.234CysTyr: 0.234 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.209AspAla: 3.209 ± 0.054	0.357AspCys: 0.357 ± 0.018	2.476AspAsp: 2.476 ± 0.044	3.739AspGlu: 3.739 ± 0.056	3.902AspPhe: 3.902 ± 0.057	3.9AspGly: 3.9 ± 0.064	1.094AspHis: 1.094 ± 0.028	4.073AspIle: 4.073 ± 0.057	3.578AspLys: 3.578 ± 0.058	5.764AspLeu: 5.764 ± 0.068	1.309AspMet: 1.309 ± 0.033	2.467AspAsn: 2.467 ± 0.044	2.488AspPro: 2.488 ± 0.044	2.142AspGln: 2.142 ± 0.04	2.401AspArg: 2.401 ± 0.046	2.948AspSer: 2.948 ± 0.048	2.152AspThr: 2.152 ± 0.035	2.959AspVal: 2.959 ± 0.046	0.91AspTrp: 0.91 ± 0.022	2.438AspTyr: 2.438 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.796GluAla: 4.796 ± 0.067	0.285GluCys: 0.285 ± 0.017	3.909GluAsp: 3.909 ± 0.061	6.108GluGlu: 6.108 ± 0.083	3.447GluPhe: 3.447 ± 0.054	4.79GluGly: 4.79 ± 0.06	1.065GluHis: 1.065 ± 0.028	5.78GluIle: 5.78 ± 0.071	6.408GluLys: 6.408 ± 0.087	6.847GluLeu: 6.847 ± 0.08	1.901GluMet: 1.901 ± 0.041	4.638GluAsn: 4.638 ± 0.059	1.953GluPro: 1.953 ± 0.042	2.262GluGln: 2.262 ± 0.036	3.083GluArg: 3.083 ± 0.055	4.004GluSer: 4.004 ± 0.056	3.138GluThr: 3.138 ± 0.048	4.834GluVal: 4.834 ± 0.063	0.83GluTrp: 0.83 ± 0.028	2.276GluTyr: 2.276 ± 0.044	0.001GluXaa: 0.001 ± 0.001
Phe	3.282PheAla: 3.282 ± 0.051	0.405PheCys: 0.405 ± 0.017	3.381PheAsp: 3.381 ± 0.05	4.061PheGlu: 4.061 ± 0.056	3.219PhePhe: 3.219 ± 0.052	4.067PheGly: 4.067 ± 0.06	1.077PheHis: 1.077 ± 0.029	3.551PheIle: 3.551 ± 0.055	3.101PheLys: 3.101 ± 0.048	5.411PheLeu: 5.411 ± 0.072	1.215PheMet: 1.215 ± 0.028	2.82PheAsn: 2.82 ± 0.051	2.103PhePro: 2.103 ± 0.042	2.118PheGln: 2.118 ± 0.04	2.333PheArg: 2.333 ± 0.046	4.236PheSer: 4.236 ± 0.057	2.798PheThr: 2.798 ± 0.046	3.155PheVal: 3.155 ± 0.047	0.756PheTrp: 0.756 ± 0.028	2.15PheTyr: 2.15 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	4.317GlyAla: 4.317 ± 0.057	0.506GlyCys: 0.506 ± 0.021	3.47GlyAsp: 3.47 ± 0.05	4.548GlyGlu: 4.548 ± 0.064	4.103GlyPhe: 4.103 ± 0.047	5.053GlyGly: 5.053 ± 0.096	1.269GlyHis: 1.269 ± 0.031	5.535GlyIle: 5.535 ± 0.07	5.214GlyLys: 5.214 ± 0.077	6.932GlyLeu: 6.932 ± 0.083	1.996GlyMet: 1.996 ± 0.038	3.821GlyAsn: 3.821 ± 0.065	1.885GlyPro: 1.885 ± 0.043	2.361GlyGln: 2.361 ± 0.044	2.948GlyArg: 2.948 ± 0.046	4.328GlySer: 4.328 ± 0.059	3.644GlyThr: 3.644 ± 0.059	4.693GlyVal: 4.693 ± 0.066	0.908GlyTrp: 0.908 ± 0.026	2.869GlyTyr: 2.869 ± 0.043	0.001GlyXaa: 0.001 ± 0.001
His	1.145HisAla: 1.145 ± 0.034	0.165HisCys: 0.165 ± 0.012	0.891HisAsp: 0.891 ± 0.026	1.13HisGlu: 1.13 ± 0.027	1.209HisPhe: 1.209 ± 0.032	1.23HisGly: 1.23 ± 0.03	0.54HisHis: 0.54 ± 0.021	1.289HisIle: 1.289 ± 0.035	1.003HisLys: 1.003 ± 0.026	1.976HisLeu: 1.976 ± 0.043	0.393HisMet: 0.393 ± 0.017	0.747HisAsn: 0.747 ± 0.025	1.103HisPro: 1.103 ± 0.028	0.85HisGln: 0.85 ± 0.024	0.762HisArg: 0.762 ± 0.023	1.123HisSer: 1.123 ± 0.03	0.864HisThr: 0.864 ± 0.027	1.064HisVal: 1.064 ± 0.022	0.252HisTrp: 0.252 ± 0.014	0.824HisTyr: 0.824 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	4.936IleAla: 4.936 ± 0.066	0.606IleCys: 0.606 ± 0.025	4.091IleAsp: 4.091 ± 0.058	4.857IleGlu: 4.857 ± 0.062	3.739IlePhe: 3.739 ± 0.051	5.08IleGly: 5.08 ± 0.067	1.557IleHis: 1.557 ± 0.038	4.911IleIle: 4.911 ± 0.069	4.781IleLys: 4.781 ± 0.065	7.245IleLeu: 7.245 ± 0.089	1.472IleMet: 1.472 ± 0.033	3.886IleAsn: 3.886 ± 0.053	3.42IlePro: 3.42 ± 0.051	2.954IleGln: 2.954 ± 0.044	3.165IleArg: 3.165 ± 0.054	5.54IleSer: 5.54 ± 0.068	3.615IleThr: 3.615 ± 0.054	3.822IleVal: 3.822 ± 0.064	0.878IleTrp: 0.878 ± 0.025	2.544IleTyr: 2.544 ± 0.04	0.001IleXaa: 0.001 ± 0.001
Lys	4.618LysAla: 4.618 ± 0.066	0.293LysCys: 0.293 ± 0.013	3.886LysAsp: 3.886 ± 0.052	5.725LysGlu: 5.725 ± 0.083	2.722LysPhe: 2.722 ± 0.047	4.512LysGly: 4.512 ± 0.057	1.138LysHis: 1.138 ± 0.031	5.392LysIle: 5.392 ± 0.066	5.493LysLys: 5.493 ± 0.089	6.074LysLeu: 6.074 ± 0.075	1.862LysMet: 1.862 ± 0.038	4.007LysAsn: 4.007 ± 0.063	2.41LysPro: 2.41 ± 0.041	1.97LysGln: 1.97 ± 0.039	2.703LysArg: 2.703 ± 0.046	4.61LysSer: 4.61 ± 0.059	3.399LysThr: 3.399 ± 0.053	4.581LysVal: 4.581 ± 0.057	0.793LysTrp: 0.793 ± 0.022	2.531LysTyr: 2.531 ± 0.043	0.001LysXaa: 0.001 ± 0.001
Leu	6.41LeuAla: 6.41 ± 0.07	0.596LeuCys: 0.596 ± 0.02	5.631LeuAsp: 5.631 ± 0.069	7.522LeuGlu: 7.522 ± 0.094	5.106LeuPhe: 5.106 ± 0.07	6.824LeuGly: 6.824 ± 0.081	1.691LeuHis: 1.691 ± 0.035	7.276LeuIle: 7.276 ± 0.095	6.864LeuLys: 6.864 ± 0.081	9.181LeuLeu: 9.181 ± 0.112	2.396LeuMet: 2.396 ± 0.044	5.042LeuAsn: 5.042 ± 0.064	4.046LeuPro: 4.046 ± 0.055	3.371LeuGln: 3.371 ± 0.046	3.965LeuArg: 3.965 ± 0.048	7.015LeuSer: 7.015 ± 0.077	4.733LeuThr: 4.733 ± 0.06	5.858LeuVal: 5.858 ± 0.069	0.989LeuTrp: 0.989 ± 0.03	3.05LeuTyr: 3.05 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	1.907MetAla: 1.907 ± 0.042	0.13MetCys: 0.13 ± 0.01	1.582MetAsp: 1.582 ± 0.031	1.943MetGlu: 1.943 ± 0.04	0.865MetPhe: 0.865 ± 0.022	1.852MetGly: 1.852 ± 0.039	0.42MetHis: 0.42 ± 0.016	1.701MetIle: 1.701 ± 0.035	2.019MetLys: 2.019 ± 0.037	2.192MetLeu: 2.192 ± 0.046	0.71MetMet: 0.71 ± 0.023	1.299MetAsn: 1.299 ± 0.031	1.046MetPro: 1.046 ± 0.026	0.843MetGln: 0.843 ± 0.024	1.044MetArg: 1.044 ± 0.026	1.358MetSer: 1.358 ± 0.031	1.141MetThr: 1.141 ± 0.029	1.699MetVal: 1.699 ± 0.034	0.192MetTrp: 0.192 ± 0.011	0.666MetTyr: 0.666 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.223AsnAla: 3.223 ± 0.053	0.328AsnCys: 0.328 ± 0.015	2.424AsnAsp: 2.424 ± 0.044	3.303AsnGlu: 3.303 ± 0.049	3.076AsnPhe: 3.076 ± 0.056	3.538AsnGly: 3.538 ± 0.064	1.079AsnHis: 1.079 ± 0.026	3.825AsnIle: 3.825 ± 0.057	3.007AsnLys: 3.007 ± 0.052	5.436AsnLeu: 5.436 ± 0.077	1.195AsnMet: 1.195 ± 0.03	2.692AsnAsn: 2.692 ± 0.058	3.077AsnPro: 3.077 ± 0.053	2.326AsnGln: 2.326 ± 0.043	2.466AsnArg: 2.466 ± 0.045	3.381AsnSer: 3.381 ± 0.054	2.651AsnThr: 2.651 ± 0.049	2.867AsnVal: 2.867 ± 0.051	0.805AsnTrp: 0.805 ± 0.023	2.262AsnTyr: 2.262 ± 0.041	0.001AsnXaa: 0.001 ± 0.001
Pro	2.33ProAla: 2.33 ± 0.042	0.21ProCys: 0.21 ± 0.013	2.668ProAsp: 2.668 ± 0.05	3.673ProGlu: 3.673 ± 0.063	2.201ProPhe: 2.201 ± 0.043	2.774ProGly: 2.774 ± 0.049	0.697ProHis: 0.697 ± 0.021	2.706ProIle: 2.706 ± 0.046	2.427ProLys: 2.427 ± 0.043	3.393ProLeu: 3.393 ± 0.055	0.907ProMet: 0.907 ± 0.025	2.174ProAsn: 2.174 ± 0.042	0.976ProPro: 0.976 ± 0.028	1.3ProGln: 1.3 ± 0.027	1.297ProArg: 1.297 ± 0.031	2.542ProSer: 2.542 ± 0.05	1.74ProThr: 1.74 ± 0.036	2.765ProVal: 2.765 ± 0.046	0.457ProTrp: 0.457 ± 0.019	1.486ProTyr: 1.486 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.421GlnAla: 2.421 ± 0.04	0.165GlnCys: 0.165 ± 0.012	1.804GlnAsp: 1.804 ± 0.036	2.85GlnGlu: 2.85 ± 0.044	1.727GlnPhe: 1.727 ± 0.039	2.207GlnGly: 2.207 ± 0.039	0.6GlnHis: 0.6 ± 0.021	2.643GlnIle: 2.643 ± 0.044	2.79GlnLys: 2.79 ± 0.045	3.549GlnLeu: 3.549 ± 0.055	0.996GlnMet: 0.996 ± 0.025	2.107GlnAsn: 2.107 ± 0.037	1.213GlnPro: 1.213 ± 0.025	1.358GlnGln: 1.358 ± 0.034	1.574GlnArg: 1.574 ± 0.038	2.212GlnSer: 2.212 ± 0.042	1.783GlnThr: 1.783 ± 0.031	2.481GlnVal: 2.481 ± 0.041	0.421GlnTrp: 0.421 ± 0.017	1.288GlnTyr: 1.288 ± 0.03	0.001GlnXaa: 0.001 ± 0.001
Arg	2.429ArgAla: 2.429 ± 0.049	0.192ArgCys: 0.192 ± 0.012	2.265ArgAsp: 2.265 ± 0.041	2.985ArgGlu: 2.985 ± 0.05	2.369ArgPhe: 2.369 ± 0.042	2.475ArgGly: 2.475 ± 0.048	0.694ArgHis: 0.694 ± 0.023	3.184ArgIle: 3.184 ± 0.047	3.044ArgLys: 3.044 ± 0.046	4.047ArgLeu: 4.047 ± 0.058	1.161ArgMet: 1.161 ± 0.03	2.477ArgAsn: 2.477 ± 0.042	1.574ArgPro: 1.574 ± 0.032	1.472ArgGln: 1.472 ± 0.033	1.793ArgArg: 1.793 ± 0.044	2.435ArgSer: 2.435 ± 0.034	2.054ArgThr: 2.054 ± 0.038	2.635ArgVal: 2.635 ± 0.045	0.527ArgTrp: 0.527 ± 0.02	1.682ArgTyr: 1.682 ± 0.038	0.0ArgXaa: 0.0 ± 0.0
Ser	3.799SerAla: 3.799 ± 0.051	0.566SerCys: 0.566 ± 0.018	3.276SerAsp: 3.276 ± 0.053	4.409SerGlu: 4.409 ± 0.058	3.938SerPhe: 3.938 ± 0.051	5.214SerGly: 5.214 ± 0.075	1.219SerHis: 1.219 ± 0.029	4.86SerIle: 4.86 ± 0.064	4.411SerLys: 4.411 ± 0.06	6.582SerLeu: 6.582 ± 0.078	1.584SerMet: 1.584 ± 0.034	3.314SerAsn: 3.314 ± 0.057	2.667SerPro: 2.667 ± 0.052	2.411SerGln: 2.411 ± 0.04	2.66SerArg: 2.66 ± 0.045	4.402SerSer: 4.402 ± 0.063	3.123SerThr: 3.123 ± 0.048	3.688SerVal: 3.688 ± 0.056	0.876SerTrp: 0.876 ± 0.027	2.482SerTyr: 2.482 ± 0.044	0.001SerXaa: 0.001 ± 0.001
Thr	3.318ThrAla: 3.318 ± 0.05	0.316ThrCys: 0.316 ± 0.017	2.637ThrAsp: 2.637 ± 0.049	3.093ThrGlu: 3.093 ± 0.045	2.761ThrPhe: 2.761 ± 0.043	3.986ThrGly: 3.986 ± 0.05	0.913ThrHis: 0.913 ± 0.027	3.38ThrIle: 3.38 ± 0.05	2.726ThrLys: 2.726 ± 0.042	4.763ThrLeu: 4.763 ± 0.06	0.96ThrMet: 0.96 ± 0.027	2.158ThrAsn: 2.158 ± 0.044	2.101ThrPro: 2.101 ± 0.034	1.662ThrGln: 1.662 ± 0.033	1.684ThrArg: 1.684 ± 0.041	3.104ThrSer: 3.104 ± 0.055	2.231ThrThr: 2.231 ± 0.044	3.362ThrVal: 3.362 ± 0.062	0.646ThrTrp: 0.646 ± 0.022	2.013ThrTyr: 2.013 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	3.917ValAla: 3.917 ± 0.061	0.475ValCys: 0.475 ± 0.02	3.414ValAsp: 3.414 ± 0.043	4.228ValGlu: 4.228 ± 0.056	3.69ValPhe: 3.69 ± 0.048	4.055ValGly: 4.055 ± 0.066	1.09ValHis: 1.09 ± 0.029	4.467ValIle: 4.467 ± 0.055	4.145ValLys: 4.145 ± 0.062	6.039ValLeu: 6.039 ± 0.067	1.485ValMet: 1.485 ± 0.034	3.443ValAsn: 3.443 ± 0.05	2.365ValPro: 2.365 ± 0.043	2.008ValGln: 2.008 ± 0.033	2.6ValArg: 2.6 ± 0.044	4.373ValSer: 4.373 ± 0.062	2.981ValThr: 2.981 ± 0.052	3.767ValVal: 3.767 ± 0.057	0.735ValTrp: 0.735 ± 0.023	2.264ValTyr: 2.264 ± 0.036	0.002ValXaa: 0.002 ± 0.002
Trp	0.772TrpAla: 0.772 ± 0.025	0.08TrpCys: 0.08 ± 0.007	0.745TrpAsp: 0.745 ± 0.024	0.931TrpGlu: 0.931 ± 0.026	0.606TrpPhe: 0.606 ± 0.023	0.855TrpGly: 0.855 ± 0.025	0.239TrpHis: 0.239 ± 0.012	0.921TrpIle: 0.921 ± 0.031	0.915TrpLys: 0.915 ± 0.03	1.132TrpLeu: 1.132 ± 0.029	0.407TrpMet: 0.407 ± 0.017	0.677TrpAsn: 0.677 ± 0.02	0.351TrpPro: 0.351 ± 0.014	0.469TrpGln: 0.469 ± 0.019	0.557TrpArg: 0.557 ± 0.02	0.738TrpSer: 0.738 ± 0.025	0.678TrpThr: 0.678 ± 0.023	0.811TrpVal: 0.811 ± 0.025	0.197TrpTrp: 0.197 ± 0.011	0.471TrpTyr: 0.471 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.245TyrAla: 2.245 ± 0.037	0.268TyrCys: 0.268 ± 0.013	2.013TyrAsp: 2.013 ± 0.042	2.363TyrGlu: 2.363 ± 0.044	2.552TyrPhe: 2.552 ± 0.045	2.637TyrGly: 2.637 ± 0.045	0.865TyrHis: 0.865 ± 0.025	2.301TyrIle: 2.301 ± 0.044	2.209TyrLys: 2.209 ± 0.038	4.021TyrLeu: 4.021 ± 0.056	0.792TyrMet: 0.792 ± 0.024	1.864TyrAsn: 1.864 ± 0.045	1.56TyrPro: 1.56 ± 0.033	1.652TyrGln: 1.652 ± 0.035	1.885TyrArg: 1.885 ± 0.035	2.563TyrSer: 2.563 ± 0.042	1.888TyrThr: 1.888 ± 0.036	1.891TyrVal: 1.891 ± 0.037	0.527TyrTrp: 0.527 ± 0.018	1.585TyrTyr: 1.585 ± 0.038	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.001	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.002XaaSer: 0.002 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 4650 proteins (1482599 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---