Amino acid dipepetide frequency for Chondrus crispus (Carrageen Irish moss) (Polymorpha crispa)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.961AlaAla: 9.961 ± 0.085	1.548AlaCys: 1.548 ± 0.026	4.559AlaAsp: 4.559 ± 0.044	5.467AlaGlu: 5.467 ± 0.069	3.244AlaPhe: 3.244 ± 0.033	5.821AlaGly: 5.821 ± 0.043	2.114AlaHis: 2.114 ± 0.026	4.075AlaIle: 4.075 ± 0.043	4.181AlaLys: 4.181 ± 0.047	8.649AlaLeu: 8.649 ± 0.062	2.362AlaMet: 2.362 ± 0.034	2.692AlaAsn: 2.692 ± 0.028	4.721AlaPro: 4.721 ± 0.054	2.996AlaGln: 2.996 ± 0.037	6.507AlaArg: 6.507 ± 0.057	7.416AlaSer: 7.416 ± 0.059	4.989AlaThr: 4.989 ± 0.039	6.772AlaVal: 6.772 ± 0.055	1.004AlaTrp: 1.004 ± 0.018	1.749AlaTyr: 1.749 ± 0.026	0.005AlaXaa: 0.005 ± 0.001
Cys	1.539CysAla: 1.539 ± 0.025	0.402CysCys: 0.402 ± 0.014	0.863CysAsp: 0.863 ± 0.018	0.88CysGlu: 0.88 ± 0.019	0.749CysPhe: 0.749 ± 0.017	1.339CysGly: 1.339 ± 0.022	0.466CysHis: 0.466 ± 0.013	0.84CysIle: 0.84 ± 0.017	0.753CysLys: 0.753 ± 0.017	1.552CysLeu: 1.552 ± 0.024	0.411CysMet: 0.411 ± 0.012	0.59CysAsn: 0.59 ± 0.013	0.961CysPro: 0.961 ± 0.023	0.481CysGln: 0.481 ± 0.013	1.31CysArg: 1.31 ± 0.023	1.409CysSer: 1.409 ± 0.024	1.015CysThr: 1.015 ± 0.017	1.323CysVal: 1.323 ± 0.022	0.205CysTrp: 0.205 ± 0.008	0.398CysTyr: 0.398 ± 0.011	0.001CysXaa: 0.001 ± 0.0
Asp	5.221AspAla: 5.221 ± 0.047	0.775AspCys: 0.775 ± 0.017	3.762AspAsp: 3.762 ± 0.057	4.014AspGlu: 4.014 ± 0.043	2.001AspPhe: 2.001 ± 0.023	4.515AspGly: 4.515 ± 0.063	1.174AspHis: 1.174 ± 0.02	2.728AspIle: 2.728 ± 0.03	2.267AspLys: 2.267 ± 0.027	4.561AspLeu: 4.561 ± 0.039	1.302AspMet: 1.302 ± 0.02	1.615AspAsn: 1.615 ± 0.021	2.664AspPro: 2.664 ± 0.032	1.363AspGln: 1.363 ± 0.022	3.29AspArg: 3.29 ± 0.038	3.827AspSer: 3.827 ± 0.037	2.642AspThr: 2.642 ± 0.028	4.429AspVal: 4.429 ± 0.041	0.638AspTrp: 0.638 ± 0.017	1.203AspTyr: 1.203 ± 0.02	0.001AspXaa: 0.001 ± 0.001
Glu	5.572GluAla: 5.572 ± 0.06	0.904GluCys: 0.904 ± 0.02	3.7GluAsp: 3.7 ± 0.037	5.155GluGlu: 5.155 ± 0.065	1.864GluPhe: 1.864 ± 0.024	4.029GluGly: 4.029 ± 0.046	1.414GluHis: 1.414 ± 0.021	2.743GluIle: 2.743 ± 0.034	3.67GluLys: 3.67 ± 0.041	5.252GluLeu: 5.252 ± 0.042	1.634GluMet: 1.634 ± 0.023	2.351GluAsn: 2.351 ± 0.029	2.235GluPro: 2.235 ± 0.037	2.224GluGln: 2.224 ± 0.028	4.818GluArg: 4.818 ± 0.047	4.246GluSer: 4.246 ± 0.04	3.282GluThr: 3.282 ± 0.037	3.989GluVal: 3.989 ± 0.039	0.753GluTrp: 0.753 ± 0.017	1.395GluTyr: 1.395 ± 0.022	0.003GluXaa: 0.003 ± 0.001
Phe	3.198PheAla: 3.198 ± 0.035	0.782PheCys: 0.782 ± 0.015	2.104PheAsp: 2.104 ± 0.025	2.17PheGlu: 2.17 ± 0.027	1.564PhePhe: 1.564 ± 0.024	2.586PheGly: 2.586 ± 0.035	0.842PheHis: 0.842 ± 0.016	1.572PheIle: 1.572 ± 0.024	1.409PheLys: 1.409 ± 0.023	3.497PheLeu: 3.497 ± 0.04	0.768PheMet: 0.768 ± 0.018	1.142PheAsn: 1.142 ± 0.018	1.874PhePro: 1.874 ± 0.029	1.268PheGln: 1.268 ± 0.021	2.397PheArg: 2.397 ± 0.03	3.122PheSer: 3.122 ± 0.035	1.801PheThr: 1.801 ± 0.027	2.699PheVal: 2.699 ± 0.034	0.463PheTrp: 0.463 ± 0.011	0.926PheTyr: 0.926 ± 0.017	0.001PheXaa: 0.001 ± 0.0
Gly	5.711GlyAla: 5.711 ± 0.05	1.099GlyCys: 1.099 ± 0.019	3.935GlyAsp: 3.935 ± 0.048	4.217GlyGlu: 4.217 ± 0.049	2.346GlyPhe: 2.346 ± 0.028	5.765GlyGly: 5.765 ± 0.08	1.768GlyHis: 1.768 ± 0.032	3.099GlyIle: 3.099 ± 0.035	3.737GlyLys: 3.737 ± 0.043	5.541GlyLeu: 5.541 ± 0.045	1.782GlyMet: 1.782 ± 0.029	2.394GlyAsn: 2.394 ± 0.027	2.789GlyPro: 2.789 ± 0.036	2.105GlyGln: 2.105 ± 0.028	5.301GlyArg: 5.301 ± 0.056	5.327GlySer: 5.327 ± 0.05	3.739GlyThr: 3.739 ± 0.033	4.841GlyVal: 4.841 ± 0.049	0.823GlyTrp: 0.823 ± 0.016	1.555GlyTyr: 1.555 ± 0.026	0.007GlyXaa: 0.007 ± 0.001
His	2.379HisAla: 2.379 ± 0.031	0.523HisCys: 0.523 ± 0.014	1.254HisAsp: 1.254 ± 0.02	1.28HisGlu: 1.28 ± 0.02	0.945HisPhe: 0.945 ± 0.016	1.759HisGly: 1.759 ± 0.026	0.867HisHis: 0.867 ± 0.024	1.164HisIle: 1.164 ± 0.019	0.908HisLys: 0.908 ± 0.018	2.325HisLeu: 2.325 ± 0.03	0.555HisMet: 0.555 ± 0.013	0.8HisAsn: 0.8 ± 0.015	1.771HisPro: 1.771 ± 0.03	0.822HisGln: 0.822 ± 0.018	1.836HisArg: 1.836 ± 0.026	1.922HisSer: 1.922 ± 0.028	1.384HisThr: 1.384 ± 0.027	1.965HisVal: 1.965 ± 0.027	0.262HisTrp: 0.262 ± 0.009	0.588HisTyr: 0.588 ± 0.014	0.002HisXaa: 0.002 ± 0.001
Ile	4.231IleAla: 4.231 ± 0.038	0.835IleCys: 0.835 ± 0.017	2.576IleAsp: 2.576 ± 0.031	2.638IleGlu: 2.638 ± 0.029	1.56IlePhe: 1.56 ± 0.024	2.875IleGly: 2.875 ± 0.032	1.063IleHis: 1.063 ± 0.016	1.883IleIle: 1.883 ± 0.031	1.736IleLys: 1.736 ± 0.025	4.044IleLeu: 4.044 ± 0.039	0.886IleMet: 0.886 ± 0.016	1.346IleAsn: 1.346 ± 0.023	2.561IlePro: 2.561 ± 0.026	1.441IleGln: 1.441 ± 0.019	3.004IleArg: 3.004 ± 0.032	3.68IleSer: 3.68 ± 0.038	2.267IleThr: 2.267 ± 0.026	3.174IleVal: 3.174 ± 0.036	0.507IleTrp: 0.507 ± 0.012	1.009IleTyr: 1.009 ± 0.016	0.002IleXaa: 0.002 ± 0.001
Lys	4.034LysAla: 4.034 ± 0.04	0.731LysCys: 0.731 ± 0.019	2.444LysAsp: 2.444 ± 0.028	3.3LysGlu: 3.3 ± 0.042	1.39LysPhe: 1.39 ± 0.022	3.029LysGly: 3.029 ± 0.034	1.132LysHis: 1.132 ± 0.016	2.097LysIle: 2.097 ± 0.026	3.304LysLys: 3.304 ± 0.054	4.11LysLeu: 4.11 ± 0.041	1.165LysMet: 1.165 ± 0.021	1.727LysAsn: 1.727 ± 0.025	2.303LysPro: 2.303 ± 0.036	1.773LysGln: 1.773 ± 0.025	3.975LysArg: 3.975 ± 0.044	3.513LysSer: 3.513 ± 0.038	2.706LysThr: 2.706 ± 0.03	3.058LysVal: 3.058 ± 0.03	0.576LysTrp: 0.576 ± 0.015	1.259LysTyr: 1.259 ± 0.02	0.002LysXaa: 0.002 ± 0.001
Leu	7.907LeuAla: 7.907 ± 0.054	1.756LeuCys: 1.756 ± 0.022	4.697LeuAsp: 4.697 ± 0.038	5.133LeuGlu: 5.133 ± 0.056	3.517LeuPhe: 3.517 ± 0.041	5.395LeuGly: 5.395 ± 0.053	2.521LeuHis: 2.521 ± 0.026	3.396LeuIle: 3.396 ± 0.038	4.02LeuLys: 4.02 ± 0.043	8.913LeuLeu: 8.913 ± 0.068	1.82LeuMet: 1.82 ± 0.023	2.879LeuAsn: 2.879 ± 0.029	5.478LeuPro: 5.478 ± 0.046	3.684LeuGln: 3.684 ± 0.035	7.324LeuArg: 7.324 ± 0.057	7.617LeuSer: 7.617 ± 0.054	4.662LeuThr: 4.662 ± 0.036	5.945LeuVal: 5.945 ± 0.054	1.046LeuTrp: 1.046 ± 0.02	2.231LeuTyr: 2.231 ± 0.029	0.003LeuXaa: 0.003 ± 0.001
Met	2.058MetAla: 2.058 ± 0.026	0.397MetCys: 0.397 ± 0.011	1.215MetAsp: 1.215 ± 0.019	1.397MetGlu: 1.397 ± 0.023	0.788MetPhe: 0.788 ± 0.015	1.476MetGly: 1.476 ± 0.024	0.634MetHis: 0.634 ± 0.013	0.861MetIle: 0.861 ± 0.015	1.208MetLys: 1.208 ± 0.023	2.091MetLeu: 2.091 ± 0.024	0.579MetMet: 0.579 ± 0.014	0.794MetAsn: 0.794 ± 0.017	1.395MetPro: 1.395 ± 0.02	0.995MetGln: 0.995 ± 0.02	1.773MetArg: 1.773 ± 0.023	1.99MetSer: 1.99 ± 0.03	1.338MetThr: 1.338 ± 0.021	1.408MetVal: 1.408 ± 0.021	0.271MetTrp: 0.271 ± 0.009	0.614MetTyr: 0.614 ± 0.015	0.001MetXaa: 0.001 ± 0.0
Asn	2.993AsnAla: 2.993 ± 0.034	0.573AsnCys: 0.573 ± 0.013	1.718AsnAsp: 1.718 ± 0.024	1.972AsnGlu: 1.972 ± 0.027	1.217AsnPhe: 1.217 ± 0.022	2.564AsnGly: 2.564 ± 0.031	0.739AsnHis: 0.739 ± 0.017	1.728AsnIle: 1.728 ± 0.025	1.4AsnLys: 1.4 ± 0.017	2.973AsnLeu: 2.973 ± 0.033	0.816AsnMet: 0.816 ± 0.016	1.102AsnAsn: 1.102 ± 0.022	1.966AsnPro: 1.966 ± 0.026	1.035AsnGln: 1.035 ± 0.017	2.227AsnArg: 2.227 ± 0.029	2.491AsnSer: 2.491 ± 0.031	1.726AsnThr: 1.726 ± 0.022	2.574AsnVal: 2.574 ± 0.032	0.387AsnTrp: 0.387 ± 0.01	0.745AsnTyr: 0.745 ± 0.017	0.001AsnXaa: 0.001 ± 0.0
Pro	4.784ProAla: 4.784 ± 0.052	0.912ProCys: 0.912 ± 0.019	2.835ProAsp: 2.835 ± 0.034	3.032ProGlu: 3.032 ± 0.034	2.04ProPhe: 2.04 ± 0.025	3.335ProGly: 3.335 ± 0.039	1.598ProHis: 1.598 ± 0.03	2.087ProIle: 2.087 ± 0.026	2.188ProLys: 2.188 ± 0.031	4.707ProLeu: 4.707 ± 0.042	1.021ProMet: 1.021 ± 0.02	1.806ProAsn: 1.806 ± 0.025	4.757ProPro: 4.757 ± 0.074	1.938ProGln: 1.938 ± 0.032	3.959ProArg: 3.959 ± 0.048	5.568ProSer: 5.568 ± 0.103	3.341ProThr: 3.341 ± 0.045	3.543ProVal: 3.543 ± 0.037	0.55ProTrp: 0.55 ± 0.013	1.184ProTyr: 1.184 ± 0.022	0.006ProXaa: 0.006 ± 0.001
Gln	2.913GlnAla: 2.913 ± 0.037	0.543GlnCys: 0.543 ± 0.014	1.641GlnAsp: 1.641 ± 0.023	2.071GlnGlu: 2.071 ± 0.025	1.149GlnPhe: 1.149 ± 0.021	2.116GlnGly: 2.116 ± 0.024	0.938GlnHis: 0.938 ± 0.021	1.593GlnIle: 1.593 ± 0.02	1.774GlnLys: 1.774 ± 0.028	3.163GlnLeu: 3.163 ± 0.034	0.904GlnMet: 0.904 ± 0.016	1.283GlnAsn: 1.283 ± 0.02	1.855GlnPro: 1.855 ± 0.034	1.695GlnGln: 1.695 ± 0.05	2.629GlnArg: 2.629 ± 0.025	2.6GlnSer: 2.6 ± 0.032	1.98GlnThr: 1.98 ± 0.029	2.309GlnVal: 2.309 ± 0.027	0.405GlnTrp: 0.405 ± 0.011	0.897GlnTyr: 0.897 ± 0.018	0.001GlnXaa: 0.001 ± 0.0
Arg	6.684ArgAla: 6.684 ± 0.053	1.278ArgCys: 1.278 ± 0.024	3.803ArgAsp: 3.803 ± 0.041	4.487ArgGlu: 4.487 ± 0.038	2.608ArgPhe: 2.608 ± 0.032	4.8ArgGly: 4.8 ± 0.047	1.976ArgHis: 1.976 ± 0.027	3.159ArgIle: 3.159 ± 0.03	4.179ArgLys: 4.179 ± 0.046	6.655ArgLeu: 6.655 ± 0.051	1.719ArgMet: 1.719 ± 0.022	2.653ArgAsn: 2.653 ± 0.032	4.016ArgPro: 4.016 ± 0.047	2.726ArgGln: 2.726 ± 0.034	7.065ArgArg: 7.065 ± 0.064	5.526ArgSer: 5.526 ± 0.052	3.969ArgThr: 3.969 ± 0.041	4.861ArgVal: 4.861 ± 0.049	0.889ArgTrp: 0.889 ± 0.018	1.803ArgTyr: 1.803 ± 0.025	0.009ArgXaa: 0.009 ± 0.002
Ser	7.245SerAla: 7.245 ± 0.062	1.339SerCys: 1.339 ± 0.022	4.076SerAsp: 4.076 ± 0.045	4.437SerGlu: 4.437 ± 0.041	3.131SerPhe: 3.131 ± 0.036	5.664SerGly: 5.664 ± 0.054	2.061SerHis: 2.061 ± 0.025	3.418SerIle: 3.418 ± 0.04	3.696SerLys: 3.696 ± 0.036	7.293SerLeu: 7.293 ± 0.061	1.842SerMet: 1.842 ± 0.024	2.637SerAsn: 2.637 ± 0.026	5.01SerPro: 5.01 ± 0.063	2.637SerGln: 2.637 ± 0.036	6.0SerArg: 6.0 ± 0.059	8.092SerSer: 8.092 ± 0.088	4.822SerThr: 4.822 ± 0.043	5.41SerVal: 5.41 ± 0.046	0.919SerTrp: 0.919 ± 0.017	1.68SerTyr: 1.68 ± 0.023	0.004SerXaa: 0.004 ± 0.001
Thr	5.104ThrAla: 5.104 ± 0.038	1.037ThrCys: 1.037 ± 0.021	2.706ThrAsp: 2.706 ± 0.031	3.047ThrGlu: 3.047 ± 0.038	1.954ThrPhe: 1.954 ± 0.028	3.842ThrGly: 3.842 ± 0.049	1.308ThrHis: 1.308 ± 0.02	2.367ThrIle: 2.367 ± 0.029	2.482ThrLys: 2.482 ± 0.027	4.844ThrLeu: 4.844 ± 0.039	1.234ThrMet: 1.234 ± 0.021	1.748ThrAsn: 1.748 ± 0.023	3.516ThrPro: 3.516 ± 0.076	1.643ThrGln: 1.643 ± 0.024	3.712ThrArg: 3.712 ± 0.038	4.804ThrSer: 4.804 ± 0.048	3.216ThrThr: 3.216 ± 0.042	3.871ThrVal: 3.871 ± 0.037	0.596ThrTrp: 0.596 ± 0.012	1.21ThrTyr: 1.21 ± 0.019	0.003ThrXaa: 0.003 ± 0.001
Val	6.476ValAla: 6.476 ± 0.049	1.331ValCys: 1.331 ± 0.025	3.96ValAsp: 3.96 ± 0.036	4.464ValGlu: 4.464 ± 0.044	2.701ValPhe: 2.701 ± 0.03	4.603ValGly: 4.603 ± 0.05	1.769ValHis: 1.769 ± 0.025	2.908ValIle: 2.908 ± 0.033	3.064ValLys: 3.064 ± 0.029	6.582ValLeu: 6.582 ± 0.049	1.597ValMet: 1.597 ± 0.022	2.092ValAsn: 2.092 ± 0.027	3.743ValPro: 3.743 ± 0.039	2.475ValGln: 2.475 ± 0.029	5.12ValArg: 5.12 ± 0.046	5.614ValSer: 5.614 ± 0.047	3.542ValThr: 3.542 ± 0.034	5.514ValVal: 5.514 ± 0.047	0.961ValTrp: 0.961 ± 0.028	1.693ValTyr: 1.693 ± 0.023	0.002ValXaa: 0.002 ± 0.001
Trp	0.879TrpAla: 0.879 ± 0.018	0.227TrpCys: 0.227 ± 0.009	0.808TrpAsp: 0.808 ± 0.026	0.674TrpGlu: 0.674 ± 0.014	0.432TrpPhe: 0.432 ± 0.011	0.7TrpGly: 0.7 ± 0.016	0.329TrpHis: 0.329 ± 0.009	0.518TrpIle: 0.518 ± 0.014	0.627TrpLys: 0.627 ± 0.014	1.045TrpLeu: 1.045 ± 0.017	0.322TrpMet: 0.322 ± 0.009	0.465TrpAsn: 0.465 ± 0.014	0.456TrpPro: 0.456 ± 0.013	0.412TrpGln: 0.412 ± 0.012	1.009TrpArg: 1.009 ± 0.019	0.893TrpSer: 0.893 ± 0.019	0.634TrpThr: 0.634 ± 0.016	0.778TrpVal: 0.778 ± 0.014	0.163TrpTrp: 0.163 ± 0.007	0.339TrpTyr: 0.339 ± 0.011	0.001TrpXaa: 0.001 ± 0.0
Tyr	1.938TyrAla: 1.938 ± 0.023	0.495TyrCys: 0.495 ± 0.011	1.335TyrAsp: 1.335 ± 0.023	1.392TyrGlu: 1.392 ± 0.025	0.982TyrPhe: 0.982 ± 0.018	1.665TyrGly: 1.665 ± 0.022	0.598TyrHis: 0.598 ± 0.015	1.082TyrIle: 1.082 ± 0.018	1.022TyrLys: 1.022 ± 0.022	2.144TyrLeu: 2.144 ± 0.027	0.564TyrMet: 0.564 ± 0.014	0.829TyrAsn: 0.829 ± 0.019	1.112TyrPro: 1.112 ± 0.02	0.748TyrGln: 0.748 ± 0.017	1.602TyrArg: 1.602 ± 0.025	1.75TyrSer: 1.75 ± 0.023	1.186TyrThr: 1.186 ± 0.021	1.743TyrVal: 1.743 ± 0.022	0.293TyrTrp: 0.293 ± 0.01	0.673TyrTyr: 0.673 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.002XaaAsp: 0.002 ± 0.001	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.006XaaGly: 0.006 ± 0.001	0.001XaaHis: 0.001 ± 0.001	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.006XaaLeu: 0.006 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.007XaaPro: 0.007 ± 0.001	0.002XaaGln: 0.002 ± 0.001	0.006XaaArg: 0.006 ± 0.001	0.005XaaSer: 0.005 ± 0.001	0.003XaaThr: 0.003 ± 0.001	0.002XaaVal: 0.002 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	4.671XaaXaa: 4.671 ± 0.478

Statistics based on 9598 proteins (3411166 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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