Amino acid dipepetide frequency for Endozoicomonas numazuensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.937AlaAla: 6.937 ± 0.11	1.001AlaCys: 1.001 ± 0.026	4.174AlaAsp: 4.174 ± 0.077	5.483AlaGlu: 5.483 ± 0.071	3.305AlaPhe: 3.305 ± 0.053	6.142AlaGly: 6.142 ± 0.079	1.592AlaHis: 1.592 ± 0.04	5.098AlaIle: 5.098 ± 0.065	3.667AlaLys: 3.667 ± 0.059	9.182AlaLeu: 9.182 ± 0.098	2.538AlaMet: 2.538 ± 0.044	2.762AlaAsn: 2.762 ± 0.042	2.869AlaPro: 2.869 ± 0.056	3.136AlaGln: 3.136 ± 0.057	4.228AlaArg: 4.228 ± 0.066	5.448AlaSer: 5.448 ± 0.067	3.952AlaThr: 3.952 ± 0.061	5.575AlaVal: 5.575 ± 0.075	0.951AlaTrp: 0.951 ± 0.026	2.115AlaTyr: 2.115 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.72CysAla: 0.72 ± 0.025	0.181CysCys: 0.181 ± 0.011	0.578CysAsp: 0.578 ± 0.021	0.626CysGlu: 0.626 ± 0.023	0.503CysPhe: 0.503 ± 0.021	0.841CysGly: 0.841 ± 0.025	0.366CysHis: 0.366 ± 0.015	0.637CysIle: 0.637 ± 0.024	0.527CysLys: 0.527 ± 0.02	1.201CysLeu: 1.201 ± 0.032	0.276CysMet: 0.276 ± 0.014	0.391CysAsn: 0.391 ± 0.017	0.538CysPro: 0.538 ± 0.022	0.548CysGln: 0.548 ± 0.02	0.658CysArg: 0.658 ± 0.023	0.898CysSer: 0.898 ± 0.027	0.504CysThr: 0.504 ± 0.019	0.62CysVal: 0.62 ± 0.023	0.161CysTrp: 0.161 ± 0.012	0.349CysTyr: 0.349 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	4.016AspAla: 4.016 ± 0.073	0.668AspCys: 0.668 ± 0.024	3.19AspAsp: 3.19 ± 0.065	3.894AspGlu: 3.894 ± 0.057	2.463AspPhe: 2.463 ± 0.045	3.844AspGly: 3.844 ± 0.102	1.372AspHis: 1.372 ± 0.034	3.632AspIle: 3.632 ± 0.057	2.957AspLys: 2.957 ± 0.052	5.42AspLeu: 5.42 ± 0.07	1.312AspMet: 1.312 ± 0.035	2.192AspAsn: 2.192 ± 0.043	2.359AspPro: 2.359 ± 0.047	2.704AspGln: 2.704 ± 0.044	2.957AspArg: 2.957 ± 0.054	3.864AspSer: 3.864 ± 0.075	2.798AspThr: 2.798 ± 0.059	3.335AspVal: 3.335 ± 0.062	0.871AspTrp: 0.871 ± 0.026	2.04AspTyr: 2.04 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	5.82GluAla: 5.82 ± 0.082	0.611GluCys: 0.611 ± 0.024	3.338GluAsp: 3.338 ± 0.059	4.758GluGlu: 4.758 ± 0.083	2.345GluPhe: 2.345 ± 0.036	4.451GluGly: 4.451 ± 0.063	1.543GluHis: 1.543 ± 0.04	3.609GluIle: 3.609 ± 0.056	4.527GluLys: 4.527 ± 0.072	7.423GluLeu: 7.423 ± 0.106	1.664GluMet: 1.664 ± 0.038	2.795GluAsn: 2.795 ± 0.05	2.515GluPro: 2.515 ± 0.04	3.767GluGln: 3.767 ± 0.071	3.534GluArg: 3.534 ± 0.068	4.424GluSer: 4.424 ± 0.063	3.412GluThr: 3.412 ± 0.048	4.434GluVal: 4.434 ± 0.059	0.847GluTrp: 0.847 ± 0.024	1.888GluTyr: 1.888 ± 0.038	0.002GluXaa: 0.002 ± 0.001
Phe	2.767PheAla: 2.767 ± 0.054	0.522PheCys: 0.522 ± 0.02	2.48PheAsp: 2.48 ± 0.048	2.434PheGlu: 2.434 ± 0.043	1.745PhePhe: 1.745 ± 0.046	2.75PheGly: 2.75 ± 0.055	0.88PheHis: 0.88 ± 0.025	2.414PheIle: 2.414 ± 0.05	2.104PheLys: 2.104 ± 0.035	3.786PheLeu: 3.786 ± 0.059	1.028PheMet: 1.028 ± 0.031	1.834PheAsn: 1.834 ± 0.036	1.57PhePro: 1.57 ± 0.036	1.56PheGln: 1.56 ± 0.035	1.967PheArg: 1.967 ± 0.036	3.497PheSer: 3.497 ± 0.052	2.142PheThr: 2.142 ± 0.045	2.348PheVal: 2.348 ± 0.045	0.531PheTrp: 0.531 ± 0.022	1.303PheTyr: 1.303 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	5.154GlyAla: 5.154 ± 0.09	0.913GlyCys: 0.913 ± 0.024	3.546GlyAsp: 3.546 ± 0.068	4.27GlyGlu: 4.27 ± 0.056	3.138GlyPhe: 3.138 ± 0.056	4.955GlyGly: 4.955 ± 0.087	1.67GlyHis: 1.67 ± 0.039	4.524GlyIle: 4.524 ± 0.062	4.048GlyLys: 4.048 ± 0.063	7.14GlyLeu: 7.14 ± 0.081	2.04GlyMet: 2.04 ± 0.039	2.729GlyAsn: 2.729 ± 0.058	1.781GlyPro: 1.781 ± 0.042	3.254GlyGln: 3.254 ± 0.056	3.539GlyArg: 3.539 ± 0.051	4.809GlySer: 4.809 ± 0.078	3.459GlyThr: 3.459 ± 0.072	4.904GlyVal: 4.904 ± 0.077	1.054GlyTrp: 1.054 ± 0.027	2.502GlyTyr: 2.502 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.44HisAla: 1.44 ± 0.028	0.361HisCys: 0.361 ± 0.018	1.178HisAsp: 1.178 ± 0.028	1.367HisGlu: 1.367 ± 0.037	1.149HisPhe: 1.149 ± 0.033	1.467HisGly: 1.467 ± 0.032	0.686HisHis: 0.686 ± 0.025	1.279HisIle: 1.279 ± 0.029	1.112HisLys: 1.112 ± 0.029	2.533HisLeu: 2.533 ± 0.046	0.528HisMet: 0.528 ± 0.019	0.858HisAsn: 0.858 ± 0.025	1.306HisPro: 1.306 ± 0.033	1.191HisGln: 1.191 ± 0.032	1.238HisArg: 1.238 ± 0.032	1.626HisSer: 1.626 ± 0.035	1.13HisThr: 1.13 ± 0.032	1.126HisVal: 1.126 ± 0.029	0.416HisTrp: 0.416 ± 0.018	0.916HisTyr: 0.916 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.906IleAla: 4.906 ± 0.074	0.723IleCys: 0.723 ± 0.025	3.587IleAsp: 3.587 ± 0.05	4.184IleGlu: 4.184 ± 0.056	2.019IlePhe: 2.019 ± 0.041	3.638IleGly: 3.638 ± 0.054	1.376IleHis: 1.376 ± 0.032	3.159IleIle: 3.159 ± 0.057	3.276IleLys: 3.276 ± 0.052	5.19IleLeu: 5.19 ± 0.077	1.249IleMet: 1.249 ± 0.03	2.773IleAsn: 2.773 ± 0.049	2.862IlePro: 2.862 ± 0.043	2.483IleGln: 2.483 ± 0.039	3.28IleArg: 3.28 ± 0.048	4.215IleSer: 4.215 ± 0.071	3.229IleThr: 3.229 ± 0.057	3.31IleVal: 3.31 ± 0.058	0.611IleTrp: 0.611 ± 0.023	1.649IleTyr: 1.649 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	5.041LysAla: 5.041 ± 0.066	0.381LysCys: 0.381 ± 0.018	2.966LysAsp: 2.966 ± 0.055	3.836LysGlu: 3.836 ± 0.066	1.358LysPhe: 1.358 ± 0.032	3.727LysGly: 3.727 ± 0.05	1.203LysHis: 1.203 ± 0.03	2.653LysIle: 2.653 ± 0.052	3.637LysLys: 3.637 ± 0.071	5.396LysLeu: 5.396 ± 0.07	1.31LysMet: 1.31 ± 0.033	2.178LysAsn: 2.178 ± 0.045	2.661LysPro: 2.661 ± 0.049	2.596LysGln: 2.596 ± 0.052	2.693LysArg: 2.693 ± 0.056	3.489LysSer: 3.489 ± 0.058	3.147LysThr: 3.147 ± 0.054	3.829LysVal: 3.829 ± 0.057	0.517LysTrp: 0.517 ± 0.021	1.311LysTyr: 1.311 ± 0.034	0.0LysXaa: 0.0 ± 0.0
Leu	8.783LeuAla: 8.783 ± 0.089	1.118LeuCys: 1.118 ± 0.031	5.933LeuAsp: 5.933 ± 0.079	7.14LeuGlu: 7.14 ± 0.11	4.043LeuPhe: 4.043 ± 0.068	6.894LeuGly: 6.894 ± 0.079	2.017LeuHis: 2.017 ± 0.039	5.931LeuIle: 5.931 ± 0.085	6.449LeuLys: 6.449 ± 0.084	10.348LeuLeu: 10.348 ± 0.126	2.8LeuMet: 2.8 ± 0.046	4.737LeuAsn: 4.737 ± 0.06	5.073LeuPro: 5.073 ± 0.071	4.055LeuGln: 4.055 ± 0.077	4.721LeuArg: 4.721 ± 0.063	8.442LeuSer: 8.442 ± 0.089	5.895LeuThr: 5.895 ± 0.061	6.412LeuVal: 6.412 ± 0.085	1.087LeuTrp: 1.087 ± 0.028	2.783LeuTyr: 2.783 ± 0.054	0.001LeuXaa: 0.001 ± 0.001
Met	2.511MetAla: 2.511 ± 0.048	0.177MetCys: 0.177 ± 0.011	1.459MetAsp: 1.459 ± 0.03	1.573MetGlu: 1.573 ± 0.037	0.775MetPhe: 0.775 ± 0.025	1.926MetGly: 1.926 ± 0.046	0.509MetHis: 0.509 ± 0.02	1.496MetIle: 1.496 ± 0.036	1.562MetLys: 1.562 ± 0.035	2.584MetLeu: 2.584 ± 0.044	0.764MetMet: 0.764 ± 0.029	1.151MetAsn: 1.151 ± 0.032	1.301MetPro: 1.301 ± 0.027	0.996MetGln: 0.996 ± 0.027	1.094MetArg: 1.094 ± 0.027	1.92MetSer: 1.92 ± 0.038	1.733MetThr: 1.733 ± 0.039	1.758MetVal: 1.758 ± 0.034	0.171MetTrp: 0.171 ± 0.011	0.445MetTyr: 0.445 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.937AsnAla: 2.937 ± 0.046	0.401AsnCys: 0.401 ± 0.019	2.198AsnAsp: 2.198 ± 0.058	2.356AsnGlu: 2.356 ± 0.046	1.409AsnPhe: 1.409 ± 0.031	2.816AsnGly: 2.816 ± 0.063	1.031AsnHis: 1.031 ± 0.025	2.451AsnIle: 2.451 ± 0.04	2.053AsnLys: 2.053 ± 0.044	3.852AsnLeu: 3.852 ± 0.061	0.921AsnMet: 0.921 ± 0.026	1.779AsnAsn: 1.779 ± 0.049	2.394AsnPro: 2.394 ± 0.04	1.98AsnGln: 1.98 ± 0.036	2.197AsnArg: 2.197 ± 0.042	2.623AsnSer: 2.623 ± 0.052	2.323AsnThr: 2.323 ± 0.045	2.204AsnVal: 2.204 ± 0.047	0.572AsnTrp: 0.572 ± 0.023	1.199AsnTyr: 1.199 ± 0.032	0.001AsnXaa: 0.001 ± 0.001
Pro	3.562ProAla: 3.562 ± 0.06	0.394ProCys: 0.394 ± 0.017	3.331ProAsp: 3.331 ± 0.053	4.372ProGlu: 4.372 ± 0.057	1.726ProPhe: 1.726 ± 0.036	3.194ProGly: 3.194 ± 0.05	0.856ProHis: 0.856 ± 0.028	2.013ProIle: 2.013 ± 0.038	1.903ProLys: 1.903 ± 0.038	4.322ProLeu: 4.322 ± 0.06	1.068ProMet: 1.068 ± 0.027	1.403ProAsn: 1.403 ± 0.036	1.675ProPro: 1.675 ± 0.047	1.515ProGln: 1.515 ± 0.034	1.693ProArg: 1.693 ± 0.043	2.825ProSer: 2.825 ± 0.054	1.868ProThr: 1.868 ± 0.04	3.947ProVal: 3.947 ± 0.057	0.571ProTrp: 0.571 ± 0.021	1.232ProTyr: 1.232 ± 0.031	0.001ProXaa: 0.001 ± 0.001
Gln	4.028GlnAla: 4.028 ± 0.059	0.468GlnCys: 0.468 ± 0.017	1.93GlnAsp: 1.93 ± 0.042	2.852GlnGlu: 2.852 ± 0.058	1.623GlnPhe: 1.623 ± 0.037	2.927GlnGly: 2.927 ± 0.042	1.166GlnHis: 1.166 ± 0.032	2.322GlnIle: 2.322 ± 0.031	2.64GlnLys: 2.64 ± 0.05	4.994GlnLeu: 4.994 ± 0.089	1.099GlnMet: 1.099 ± 0.027	1.682GlnAsn: 1.682 ± 0.034	2.02GlnPro: 2.02 ± 0.033	2.672GlnGln: 2.672 ± 0.06	2.256GlnArg: 2.256 ± 0.047	3.054GlnSer: 3.054 ± 0.051	2.239GlnThr: 2.239 ± 0.045	2.963GlnVal: 2.963 ± 0.046	0.764GlnTrp: 0.764 ± 0.025	1.333GlnTyr: 1.333 ± 0.034	0.002GlnXaa: 0.002 ± 0.001
Arg	3.586ArgAla: 3.586 ± 0.056	0.519ArgCys: 0.519 ± 0.02	2.645ArgAsp: 2.645 ± 0.052	3.545ArgGlu: 3.545 ± 0.05	2.461ArgPhe: 2.461 ± 0.044	2.74ArgGly: 2.74 ± 0.048	1.274ArgHis: 1.274 ± 0.036	3.16ArgIle: 3.16 ± 0.054	3.12ArgLys: 3.12 ± 0.064	5.648ArgLeu: 5.648 ± 0.082	1.398ArgMet: 1.398 ± 0.032	2.049ArgAsn: 2.049 ± 0.041	1.975ArgPro: 1.975 ± 0.041	2.504ArgGln: 2.504 ± 0.05	2.755ArgArg: 2.755 ± 0.056	3.283ArgSer: 3.283 ± 0.058	2.328ArgThr: 2.328 ± 0.04	3.44ArgVal: 3.44 ± 0.055	0.702ArgTrp: 0.702 ± 0.024	1.762ArgTyr: 1.762 ± 0.039	0.001ArgXaa: 0.001 ± 0.001
Ser	5.342SerAla: 5.342 ± 0.066	0.778SerCys: 0.778 ± 0.026	4.254SerAsp: 4.254 ± 0.064	4.772SerGlu: 4.772 ± 0.066	2.917SerPhe: 2.917 ± 0.049	5.768SerGly: 5.768 ± 0.085	1.695SerHis: 1.695 ± 0.035	4.049SerIle: 4.049 ± 0.066	3.121SerLys: 3.121 ± 0.046	7.707SerLeu: 7.707 ± 0.09	1.89SerMet: 1.89 ± 0.044	2.498SerAsn: 2.498 ± 0.054	3.111SerPro: 3.111 ± 0.049	3.153SerGln: 3.153 ± 0.056	3.663SerArg: 3.663 ± 0.053	5.407SerSer: 5.407 ± 0.088	3.385SerThr: 3.385 ± 0.061	4.782SerVal: 4.782 ± 0.065	0.944SerTrp: 0.944 ± 0.03	2.104SerTyr: 2.104 ± 0.042	0.001SerXaa: 0.001 ± 0.001
Thr	4.377ThrAla: 4.377 ± 0.072	0.518ThrCys: 0.518 ± 0.02	2.955ThrAsp: 2.955 ± 0.052	3.372ThrGlu: 3.372 ± 0.051	2.035ThrPhe: 2.035 ± 0.048	4.435ThrGly: 4.435 ± 0.066	1.32ThrHis: 1.32 ± 0.035	2.843ThrIle: 2.843 ± 0.061	1.734ThrLys: 1.734 ± 0.036	6.334ThrLeu: 6.334 ± 0.073	1.143ThrMet: 1.143 ± 0.036	1.61ThrAsn: 1.61 ± 0.039	2.93ThrPro: 2.93 ± 0.06	2.062ThrGln: 2.062 ± 0.041	2.71ThrArg: 2.71 ± 0.047	3.499ThrSer: 3.499 ± 0.062	2.765ThrThr: 2.765 ± 0.063	3.754ThrVal: 3.754 ± 0.065	0.569ThrTrp: 0.569 ± 0.018	1.332ThrTyr: 1.332 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	5.619ValAla: 5.619 ± 0.075	0.78ValCys: 0.78 ± 0.025	3.831ValAsp: 3.831 ± 0.057	4.434ValGlu: 4.434 ± 0.059	2.695ValPhe: 2.695 ± 0.049	4.032ValGly: 4.032 ± 0.066	1.276ValHis: 1.276 ± 0.035	4.253ValIle: 4.253 ± 0.059	3.371ValLys: 3.371 ± 0.048	6.546ValLeu: 6.546 ± 0.073	1.867ValMet: 1.867 ± 0.04	2.68ValAsn: 2.68 ± 0.048	2.68ValPro: 2.68 ± 0.049	2.349ValGln: 2.349 ± 0.051	3.26ValArg: 3.26 ± 0.052	5.027ValSer: 5.027 ± 0.06	3.909ValThr: 3.909 ± 0.068	4.858ValVal: 4.858 ± 0.077	0.743ValTrp: 0.743 ± 0.021	1.876ValTyr: 1.876 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.743TrpAla: 0.743 ± 0.023	0.176TrpCys: 0.176 ± 0.011	0.598TrpAsp: 0.598 ± 0.023	0.651TrpGlu: 0.651 ± 0.024	0.565TrpPhe: 0.565 ± 0.023	0.825TrpGly: 0.825 ± 0.029	0.351TrpHis: 0.351 ± 0.017	0.673TrpIle: 0.673 ± 0.022	0.652TrpLys: 0.652 ± 0.023	1.769TrpLeu: 1.769 ± 0.042	0.365TrpMet: 0.365 ± 0.016	0.533TrpAsn: 0.533 ± 0.019	0.523TrpPro: 0.523 ± 0.018	0.839TrpGln: 0.839 ± 0.025	0.61TrpArg: 0.61 ± 0.021	0.844TrpSer: 0.844 ± 0.025	0.612TrpThr: 0.612 ± 0.025	0.83TrpVal: 0.83 ± 0.027	0.139TrpTrp: 0.139 ± 0.011	0.362TrpTyr: 0.362 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.866TyrAla: 1.866 ± 0.041	0.432TyrCys: 0.432 ± 0.016	1.718TyrAsp: 1.718 ± 0.046	1.785TyrGlu: 1.785 ± 0.04	1.386TyrPhe: 1.386 ± 0.029	2.055TyrGly: 2.055 ± 0.044	0.725TyrHis: 0.725 ± 0.023	1.523TyrIle: 1.523 ± 0.035	1.466TyrLys: 1.466 ± 0.033	3.287TyrLeu: 3.287 ± 0.047	0.643TyrMet: 0.643 ± 0.021	1.061TyrAsn: 1.061 ± 0.033	1.331TyrPro: 1.331 ± 0.036	1.671TyrGln: 1.671 ± 0.035	1.841TyrArg: 1.841 ± 0.042	2.147TyrSer: 2.147 ± 0.043	1.469TyrThr: 1.469 ± 0.034	1.658TyrVal: 1.658 ± 0.04	0.44TyrTrp: 0.44 ± 0.017	0.911TyrTyr: 0.911 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.002XaaGlu: 0.002 ± 0.001	0.001XaaPhe: 0.001 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.001XaaIle: 0.001 ± 0.001	0.001XaaLys: 0.001 ± 0.001	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4400 proteins (1400203 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---