Amino acid dipepetide frequency for Aspergillus versicolor CBS 583.65

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.59AlaAla: 8.59 ± 0.05	1.189AlaCys: 1.189 ± 0.015	4.234AlaAsp: 4.234 ± 0.029	4.94AlaGlu: 4.94 ± 0.032	3.291AlaPhe: 3.291 ± 0.029	5.981AlaGly: 5.981 ± 0.039	1.786AlaHis: 1.786 ± 0.02	4.415AlaIle: 4.415 ± 0.03	3.535AlaLys: 3.535 ± 0.028	7.954AlaLeu: 7.954 ± 0.046	1.95AlaMet: 1.95 ± 0.018	2.849AlaAsn: 2.849 ± 0.024	4.489AlaPro: 4.489 ± 0.039	3.287AlaGln: 3.287 ± 0.025	4.849AlaArg: 4.849 ± 0.031	6.976AlaSer: 6.976 ± 0.037	5.032AlaThr: 5.032 ± 0.029	5.644AlaVal: 5.644 ± 0.037	1.228AlaTrp: 1.228 ± 0.015	2.26AlaTyr: 2.26 ± 0.018	0.0AlaXaa: 0.0 ± 0.0
Cys	1.05CysAla: 1.05 ± 0.013	0.284CysCys: 0.284 ± 0.008	0.748CysAsp: 0.748 ± 0.011	0.635CysGlu: 0.635 ± 0.011	0.597CysPhe: 0.597 ± 0.009	0.984CysGly: 0.984 ± 0.014	0.362CysHis: 0.362 ± 0.007	0.79CysIle: 0.79 ± 0.012	0.495CysLys: 0.495 ± 0.01	1.407CysLeu: 1.407 ± 0.016	0.301CysMet: 0.301 ± 0.007	0.444CysAsn: 0.444 ± 0.009	0.69CysPro: 0.69 ± 0.013	0.484CysGln: 0.484 ± 0.011	0.859CysArg: 0.859 ± 0.012	1.034CysSer: 1.034 ± 0.014	0.772CysThr: 0.772 ± 0.013	0.868CysVal: 0.868 ± 0.014	0.22CysTrp: 0.22 ± 0.006	0.39CysTyr: 0.39 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	4.587AspAla: 4.587 ± 0.027	0.661AspCys: 0.661 ± 0.011	3.817AspAsp: 3.817 ± 0.037	4.163AspGlu: 4.163 ± 0.03	2.17AspPhe: 2.17 ± 0.019	4.101AspGly: 4.101 ± 0.036	1.248AspHis: 1.248 ± 0.015	3.279AspIle: 3.279 ± 0.021	2.255AspLys: 2.255 ± 0.021	5.051AspLeu: 5.051 ± 0.031	1.233AspMet: 1.233 ± 0.013	1.924AspAsn: 1.924 ± 0.02	3.326AspPro: 3.326 ± 0.022	1.902AspGln: 1.902 ± 0.017	3.078AspArg: 3.078 ± 0.024	4.255AspSer: 4.255 ± 0.027	3.088AspThr: 3.088 ± 0.024	3.641AspVal: 3.641 ± 0.024	0.915AspTrp: 0.915 ± 0.013	1.651AspTyr: 1.651 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	5.027GluAla: 5.027 ± 0.034	0.676GluCys: 0.676 ± 0.012	3.889GluAsp: 3.889 ± 0.035	4.957GluGlu: 4.957 ± 0.05	2.011GluPhe: 2.011 ± 0.019	3.734GluGly: 3.734 ± 0.028	1.355GluHis: 1.355 ± 0.016	3.091GluIle: 3.091 ± 0.022	3.333GluLys: 3.333 ± 0.027	5.098GluLeu: 5.098 ± 0.034	1.397GluMet: 1.397 ± 0.013	2.34GluAsn: 2.34 ± 0.017	2.805GluPro: 2.805 ± 0.031	2.423GluGln: 2.423 ± 0.023	3.795GluArg: 3.795 ± 0.029	4.369GluSer: 4.369 ± 0.029	3.565GluThr: 3.565 ± 0.026	3.433GluVal: 3.433 ± 0.027	0.9GluTrp: 0.9 ± 0.011	1.788GluTyr: 1.788 ± 0.016	0.0GluXaa: 0.0 ± 0.0
Phe	3.153PheAla: 3.153 ± 0.024	0.621PheCys: 0.621 ± 0.01	2.3PheAsp: 2.3 ± 0.02	2.119PheGlu: 2.119 ± 0.019	1.762PhePhe: 1.762 ± 0.02	3.01PheGly: 3.01 ± 0.028	0.966PheHis: 0.966 ± 0.011	1.974PheIle: 1.974 ± 0.022	1.407PheLys: 1.407 ± 0.016	3.734PheLeu: 3.734 ± 0.031	0.794PheMet: 0.794 ± 0.012	1.48PheAsn: 1.48 ± 0.018	2.109PhePro: 2.109 ± 0.019	1.436PheGln: 1.436 ± 0.015	2.007PheArg: 2.007 ± 0.018	3.111PheSer: 3.111 ± 0.026	2.249PheThr: 2.249 ± 0.02	2.476PheVal: 2.476 ± 0.022	0.709PheTrp: 0.709 ± 0.011	1.192PheTyr: 1.192 ± 0.015	0.0PheXaa: 0.0 ± 0.0
Gly	5.461GlyAla: 5.461 ± 0.036	1.003GlyCys: 1.003 ± 0.014	3.737GlyAsp: 3.737 ± 0.031	3.724GlyGlu: 3.724 ± 0.027	2.975GlyPhe: 2.975 ± 0.027	5.723GlyGly: 5.723 ± 0.055	1.699GlyHis: 1.699 ± 0.018	3.854GlyIle: 3.854 ± 0.027	3.25GlyLys: 3.25 ± 0.025	6.507GlyLeu: 6.507 ± 0.035	1.579GlyMet: 1.579 ± 0.016	2.572GlyAsn: 2.572 ± 0.021	3.457GlyPro: 3.457 ± 0.026	2.565GlyGln: 2.565 ± 0.022	4.098GlyArg: 4.098 ± 0.027	5.785GlySer: 5.785 ± 0.037	3.996GlyThr: 3.996 ± 0.027	4.747GlyVal: 4.747 ± 0.032	1.245GlyTrp: 1.245 ± 0.015	2.304GlyTyr: 2.304 ± 0.019	0.0GlyXaa: 0.0 ± 0.0
His	1.845HisAla: 1.845 ± 0.018	0.36HisCys: 0.36 ± 0.008	1.313HisAsp: 1.313 ± 0.016	1.296HisGlu: 1.296 ± 0.014	0.94HisPhe: 0.94 ± 0.013	1.753HisGly: 1.753 ± 0.017	0.821HisHis: 0.821 ± 0.015	1.269HisIle: 1.269 ± 0.014	0.837HisLys: 0.837 ± 0.012	2.303HisLeu: 2.303 ± 0.02	0.468HisMet: 0.468 ± 0.009	0.843HisAsn: 0.843 ± 0.012	1.692HisPro: 1.692 ± 0.019	0.956HisGln: 0.956 ± 0.015	1.579HisArg: 1.579 ± 0.02	1.906HisSer: 1.906 ± 0.021	1.268HisThr: 1.268 ± 0.016	1.397HisVal: 1.397 ± 0.014	0.392HisTrp: 0.392 ± 0.009	0.726HisTyr: 0.726 ± 0.013	0.0HisXaa: 0.0 ± 0.0
Ile	4.339IleAla: 4.339 ± 0.029	0.834IleCys: 0.834 ± 0.014	2.86IleAsp: 2.86 ± 0.022	2.84IleGlu: 2.84 ± 0.023	2.117IlePhe: 2.117 ± 0.021	3.414IleGly: 3.414 ± 0.03	1.287IleHis: 1.287 ± 0.015	2.623IleIle: 2.623 ± 0.025	1.988IleLys: 1.988 ± 0.02	4.86IleLeu: 4.86 ± 0.037	1.025IleMet: 1.025 ± 0.012	1.823IleAsn: 1.823 ± 0.018	3.319IlePro: 3.319 ± 0.023	2.039IleGln: 2.039 ± 0.017	2.809IleArg: 2.809 ± 0.024	4.078IleSer: 4.078 ± 0.029	2.954IleThr: 2.954 ± 0.026	3.302IleVal: 3.302 ± 0.025	0.759IleTrp: 0.759 ± 0.01	1.545IleTyr: 1.545 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	3.819LysAla: 3.819 ± 0.031	0.523LysCys: 0.523 ± 0.011	2.581LysAsp: 2.581 ± 0.023	3.029LysGlu: 3.029 ± 0.025	1.337LysPhe: 1.337 ± 0.015	2.835LysGly: 2.835 ± 0.022	1.051LysHis: 1.051 ± 0.012	2.068LysIle: 2.068 ± 0.019	2.74LysLys: 2.74 ± 0.035	3.793LysLeu: 3.793 ± 0.026	0.868LysMet: 0.868 ± 0.013	1.558LysAsn: 1.558 ± 0.018	2.561LysPro: 2.561 ± 0.024	1.742LysGln: 1.742 ± 0.021	3.1LysArg: 3.1 ± 0.028	3.225LysSer: 3.225 ± 0.026	2.598LysThr: 2.598 ± 0.023	2.558LysVal: 2.558 ± 0.024	0.656LysTrp: 0.656 ± 0.01	1.347LysTyr: 1.347 ± 0.016	0.0LysXaa: 0.0 ± 0.0
Leu	7.995LeuAla: 7.995 ± 0.04	1.293LeuCys: 1.293 ± 0.016	5.349LeuAsp: 5.349 ± 0.036	5.406LeuGlu: 5.406 ± 0.031	3.588LeuPhe: 3.588 ± 0.028	6.355LeuGly: 6.355 ± 0.039	2.33LeuHis: 2.33 ± 0.019	4.127LeuIle: 4.127 ± 0.031	3.864LeuLys: 3.864 ± 0.028	8.7LeuLeu: 8.7 ± 0.062	1.81LeuMet: 1.81 ± 0.017	3.278LeuAsn: 3.278 ± 0.026	5.54LeuPro: 5.54 ± 0.037	3.924LeuGln: 3.924 ± 0.034	5.758LeuArg: 5.758 ± 0.031	7.643LeuSer: 7.643 ± 0.038	4.882LeuThr: 4.882 ± 0.035	5.751LeuVal: 5.751 ± 0.039	1.284LeuTrp: 1.284 ± 0.017	2.594LeuTyr: 2.594 ± 0.023	0.0LeuXaa: 0.0 ± 0.0
Met	2.165MetAla: 2.165 ± 0.017	0.252MetCys: 0.252 ± 0.007	1.219MetAsp: 1.219 ± 0.014	1.235MetGlu: 1.235 ± 0.014	0.746MetPhe: 0.746 ± 0.01	1.514MetGly: 1.514 ± 0.018	0.473MetHis: 0.473 ± 0.009	0.995MetIle: 0.995 ± 0.011	0.936MetLys: 0.936 ± 0.011	1.826MetLeu: 1.826 ± 0.019	0.525MetMet: 0.525 ± 0.01	0.783MetAsn: 0.783 ± 0.011	1.188MetPro: 1.188 ± 0.013	0.854MetGln: 0.854 ± 0.012	1.212MetArg: 1.212 ± 0.013	1.783MetSer: 1.783 ± 0.018	1.233MetThr: 1.233 ± 0.013	1.379MetVal: 1.379 ± 0.014	0.274MetTrp: 0.274 ± 0.007	0.528MetTyr: 0.528 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	3.074AsnAla: 3.074 ± 0.021	0.481AsnCys: 0.481 ± 0.01	1.915AsnAsp: 1.915 ± 0.019	2.019AsnGlu: 2.019 ± 0.019	1.335AsnPhe: 1.335 ± 0.015	2.927AsnGly: 2.927 ± 0.024	0.843AsnHis: 0.843 ± 0.013	2.144AsnIle: 2.144 ± 0.021	1.48AsnLys: 1.48 ± 0.015	3.226AsnLeu: 3.226 ± 0.025	0.808AsnMet: 0.808 ± 0.013	1.46AsnAsn: 1.46 ± 0.017	2.54AsnPro: 2.54 ± 0.024	1.342AsnGln: 1.342 ± 0.017	2.005AsnArg: 2.005 ± 0.017	2.786AsnSer: 2.786 ± 0.023	2.238AsnThr: 2.238 ± 0.019	2.31AsnVal: 2.31 ± 0.021	0.58AsnTrp: 0.58 ± 0.012	1.094AsnTyr: 1.094 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.011ProAla: 5.011 ± 0.039	0.618ProCys: 0.618 ± 0.012	3.348ProAsp: 3.348 ± 0.023	3.922ProGlu: 3.922 ± 0.032	2.168ProPhe: 2.168 ± 0.023	4.185ProGly: 4.185 ± 0.034	1.276ProHis: 1.276 ± 0.016	2.565ProIle: 2.565 ± 0.021	2.417ProLys: 2.417 ± 0.023	4.773ProLeu: 4.773 ± 0.03	1.021ProMet: 1.021 ± 0.014	2.208ProAsn: 2.208 ± 0.022	4.586ProPro: 4.586 ± 0.065	2.429ProGln: 2.429 ± 0.03	3.364ProArg: 3.364 ± 0.029	6.0ProSer: 6.0 ± 0.044	3.874ProThr: 3.874 ± 0.031	3.684ProVal: 3.684 ± 0.026	0.815ProTrp: 0.815 ± 0.011	1.56ProTyr: 1.56 ± 0.018	0.0ProXaa: 0.0 ± 0.0
Gln	3.299GlnAla: 3.299 ± 0.026	0.482GlnCys: 0.482 ± 0.009	2.088GlnAsp: 2.088 ± 0.02	2.325GlnGlu: 2.325 ± 0.018	1.333GlnPhe: 1.333 ± 0.013	2.511GlnGly: 2.511 ± 0.021	1.024GlnHis: 1.024 ± 0.016	1.905GlnIle: 1.905 ± 0.018	1.843GlnLys: 1.843 ± 0.019	3.504GlnLeu: 3.504 ± 0.024	0.855GlnMet: 0.855 ± 0.013	1.562GlnAsn: 1.562 ± 0.016	2.519GlnPro: 2.519 ± 0.029	2.183GlnGln: 2.183 ± 0.037	2.612GlnArg: 2.612 ± 0.024	3.199GlnSer: 3.199 ± 0.025	2.377GlnThr: 2.377 ± 0.019	2.235GlnVal: 2.235 ± 0.023	0.596GlnTrp: 0.596 ± 0.01	1.197GlnTyr: 1.197 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	4.639ArgAla: 4.639 ± 0.028	0.798ArgCys: 0.798 ± 0.013	3.335ArgAsp: 3.335 ± 0.026	3.767ArgGlu: 3.767 ± 0.028	2.238ArgPhe: 2.238 ± 0.02	3.728ArgGly: 3.728 ± 0.026	1.543ArgHis: 1.543 ± 0.018	2.932ArgIle: 2.932 ± 0.023	3.17ArgLys: 3.17 ± 0.023	5.624ArgLeu: 5.624 ± 0.035	1.269ArgMet: 1.269 ± 0.016	2.269ArgAsn: 2.269 ± 0.02	3.406ArgPro: 3.406 ± 0.03	2.501ArgGln: 2.501 ± 0.021	4.936ArgArg: 4.936 ± 0.042	4.681ArgSer: 4.681 ± 0.034	3.281ArgThr: 3.281 ± 0.022	3.557ArgVal: 3.557 ± 0.024	1.001ArgTrp: 1.001 ± 0.014	1.749ArgTyr: 1.749 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.503SerAla: 6.503 ± 0.038	0.974SerCys: 0.974 ± 0.014	4.283SerAsp: 4.283 ± 0.026	4.173SerGlu: 4.173 ± 0.028	3.192SerPhe: 3.192 ± 0.022	5.713SerGly: 5.713 ± 0.032	1.994SerHis: 1.994 ± 0.019	4.161SerIle: 4.161 ± 0.029	3.449SerLys: 3.449 ± 0.029	7.563SerLeu: 7.563 ± 0.041	1.678SerMet: 1.678 ± 0.017	3.011SerAsn: 3.011 ± 0.024	5.482SerPro: 5.482 ± 0.047	3.334SerGln: 3.334 ± 0.03	5.006SerArg: 5.006 ± 0.038	8.45SerSer: 8.45 ± 0.07	5.492SerThr: 5.492 ± 0.039	4.716SerVal: 4.716 ± 0.028	1.223SerTrp: 1.223 ± 0.014	2.169SerTyr: 2.169 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.233ThrAla: 5.233 ± 0.027	0.781ThrCys: 0.781 ± 0.011	2.956ThrAsp: 2.956 ± 0.027	3.207ThrGlu: 3.207 ± 0.026	2.268ThrPhe: 2.268 ± 0.019	4.386ThrGly: 4.386 ± 0.031	1.288ThrHis: 1.288 ± 0.014	3.074ThrIle: 3.074 ± 0.025	2.39ThrLys: 2.39 ± 0.021	5.331ThrLeu: 5.331 ± 0.029	1.164ThrMet: 1.164 ± 0.012	2.043ThrAsn: 2.043 ± 0.018	4.215ThrPro: 4.215 ± 0.036	2.109ThrGln: 2.109 ± 0.022	3.1ThrArg: 3.1 ± 0.023	5.058ThrSer: 5.058 ± 0.036	4.083ThrThr: 4.083 ± 0.035	3.934ThrVal: 3.934 ± 0.031	0.915ThrTrp: 0.915 ± 0.013	1.644ThrTyr: 1.644 ± 0.018	0.0ThrXaa: 0.0 ± 0.0
Val	5.238ValAla: 5.238 ± 0.032	0.914ValCys: 0.914 ± 0.012	3.779ValAsp: 3.779 ± 0.028	3.764ValGlu: 3.764 ± 0.025	2.673ValPhe: 2.673 ± 0.025	4.219ValGly: 4.219 ± 0.03	1.448ValHis: 1.448 ± 0.016	3.129ValIle: 3.129 ± 0.028	2.71ValLys: 2.71 ± 0.024	5.931ValLeu: 5.931 ± 0.041	1.322ValMet: 1.322 ± 0.015	2.315ValAsn: 2.315 ± 0.02	3.607ValPro: 3.607 ± 0.023	2.441ValGln: 2.441 ± 0.019	3.506ValArg: 3.506 ± 0.026	4.936ValSer: 4.936 ± 0.032	3.484ValThr: 3.484 ± 0.027	4.468ValVal: 4.468 ± 0.035	0.928ValTrp: 0.928 ± 0.012	1.917ValTyr: 1.917 ± 0.016	0.0ValXaa: 0.0 ± 0.0
Trp	1.212TrpAla: 1.212 ± 0.015	0.218TrpCys: 0.218 ± 0.006	0.941TrpAsp: 0.941 ± 0.013	0.889TrpGlu: 0.889 ± 0.013	0.579TrpPhe: 0.579 ± 0.01	1.009TrpGly: 1.009 ± 0.012	0.375TrpHis: 0.375 ± 0.009	0.838TrpIle: 0.838 ± 0.013	0.821TrpLys: 0.821 ± 0.013	1.441TrpLeu: 1.441 ± 0.016	0.397TrpMet: 0.397 ± 0.008	0.66TrpAsn: 0.66 ± 0.01	0.663TrpPro: 0.663 ± 0.011	0.572TrpGln: 0.572 ± 0.01	1.025TrpArg: 1.025 ± 0.013	1.111TrpSer: 1.111 ± 0.013	0.951TrpThr: 0.951 ± 0.013	0.952TrpVal: 0.952 ± 0.012	0.294TrpTrp: 0.294 ± 0.008	0.476TrpTyr: 0.476 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.02	0.45TyrCys: 0.45 ± 0.008	1.654TyrAsp: 1.654 ± 0.019	1.576TyrGlu: 1.576 ± 0.016	1.29TyrPhe: 1.29 ± 0.013	2.2TyrGly: 2.2 ± 0.022	0.796TyrHis: 0.796 ± 0.012	1.584TyrIle: 1.584 ± 0.016	1.07TyrLys: 1.07 ± 0.015	2.843TyrLeu: 2.843 ± 0.024	0.654TyrMet: 0.654 ± 0.012	1.186TyrAsn: 1.186 ± 0.015	1.633TyrPro: 1.633 ± 0.018	1.127TyrGln: 1.127 ± 0.014	1.724TyrArg: 1.724 ± 0.015	2.178TyrSer: 2.178 ± 0.021	1.759TyrThr: 1.759 ± 0.019	1.677TyrVal: 1.677 ± 0.019	0.489TyrTrp: 0.489 ± 0.009	1.0TyrTyr: 1.0 ± 0.013	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 13222 proteins (6349617 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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