Amino acid dipepetide frequency for Desulforhopalus singaporensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.297AlaAla: 8.297 ± 0.095	1.13AlaCys: 1.13 ± 0.032	4.487AlaAsp: 4.487 ± 0.056	5.437AlaGlu: 5.437 ± 0.063	2.942AlaPhe: 2.942 ± 0.046	7.106AlaGly: 7.106 ± 0.091	1.398AlaHis: 1.398 ± 0.03	5.541AlaIle: 5.541 ± 0.072	4.389AlaLys: 4.389 ± 0.058	8.05AlaLeu: 8.05 ± 0.071	2.534AlaMet: 2.534 ± 0.038	2.615AlaAsn: 2.615 ± 0.043	2.841AlaPro: 2.841 ± 0.043	2.414AlaGln: 2.414 ± 0.039	4.404AlaArg: 4.404 ± 0.064	4.291AlaSer: 4.291 ± 0.058	4.456AlaThr: 4.456 ± 0.054	6.459AlaVal: 6.459 ± 0.078	0.766AlaTrp: 0.766 ± 0.027	2.051AlaTyr: 2.051 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	1.069CysAla: 1.069 ± 0.029	0.36CysCys: 0.36 ± 0.018	0.787CysAsp: 0.787 ± 0.026	0.697CysGlu: 0.697 ± 0.024	0.617CysPhe: 0.617 ± 0.025	1.525CysGly: 1.525 ± 0.037	0.457CysHis: 0.457 ± 0.024	0.831CysIle: 0.831 ± 0.029	0.541CysLys: 0.541 ± 0.021	1.274CysLeu: 1.274 ± 0.029	0.373CysMet: 0.373 ± 0.016	0.552CysAsn: 0.552 ± 0.022	0.843CysPro: 0.843 ± 0.026	0.448CysGln: 0.448 ± 0.019	0.981CysArg: 0.981 ± 0.028	1.06CysSer: 1.06 ± 0.03	0.685CysThr: 0.685 ± 0.024	0.888CysVal: 0.888 ± 0.027	0.168CysTrp: 0.168 ± 0.011	0.449CysTyr: 0.449 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.577AspAla: 3.577 ± 0.052	0.762AspCys: 0.762 ± 0.028	3.011AspAsp: 3.011 ± 0.061	3.514AspGlu: 3.514 ± 0.057	2.586AspPhe: 2.586 ± 0.041	4.065AspGly: 4.065 ± 0.057	1.213AspHis: 1.213 ± 0.027	4.164AspIle: 4.164 ± 0.061	2.924AspLys: 2.924 ± 0.047	5.456AspLeu: 5.456 ± 0.061	1.324AspMet: 1.324 ± 0.029	2.221AspAsn: 2.221 ± 0.042	2.604AspPro: 2.604 ± 0.046	1.827AspGln: 1.827 ± 0.035	3.354AspArg: 3.354 ± 0.055	3.121AspSer: 3.121 ± 0.045	2.679AspThr: 2.679 ± 0.045	3.329AspVal: 3.329 ± 0.054	0.676AspTrp: 0.676 ± 0.021	1.942AspTyr: 1.942 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	4.739GluAla: 4.739 ± 0.061	0.617GluCys: 0.617 ± 0.024	3.081GluAsp: 3.081 ± 0.05	4.46GluGlu: 4.46 ± 0.071	2.281GluPhe: 2.281 ± 0.043	3.793GluGly: 3.793 ± 0.051	1.253GluHis: 1.253 ± 0.033	4.833GluIle: 4.833 ± 0.055	5.462GluLys: 5.462 ± 0.073	6.697GluLeu: 6.697 ± 0.078	1.885GluMet: 1.885 ± 0.036	3.013GluAsn: 3.013 ± 0.04	2.103GluPro: 2.103 ± 0.047	2.848GluGln: 2.848 ± 0.046	3.249GluArg: 3.249 ± 0.047	3.31GluSer: 3.31 ± 0.047	3.25GluThr: 3.25 ± 0.05	4.295GluVal: 4.295 ± 0.056	0.593GluTrp: 0.593 ± 0.023	1.823GluTyr: 1.823 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	3.384PheAla: 3.384 ± 0.056	0.801PheCys: 0.801 ± 0.026	2.565PheAsp: 2.565 ± 0.048	2.138PheGlu: 2.138 ± 0.041	2.355PhePhe: 2.355 ± 0.05	3.586PheGly: 3.586 ± 0.058	0.912PheHis: 0.912 ± 0.025	2.731PheIle: 2.731 ± 0.049	1.779PheLys: 1.779 ± 0.035	4.25PheLeu: 4.25 ± 0.059	1.086PheMet: 1.086 ± 0.033	1.629PheAsn: 1.629 ± 0.032	1.779PhePro: 1.779 ± 0.037	1.171PheGln: 1.171 ± 0.028	2.051PheArg: 2.051 ± 0.037	3.321PheSer: 3.321 ± 0.057	2.567PheThr: 2.567 ± 0.046	2.817PheVal: 2.817 ± 0.049	0.53PheTrp: 0.53 ± 0.019	1.383PheTyr: 1.383 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	6.401GlyAla: 6.401 ± 0.07	1.4GlyCys: 1.4 ± 0.039	3.86GlyAsp: 3.86 ± 0.064	4.576GlyGlu: 4.576 ± 0.063	3.488GlyPhe: 3.488 ± 0.053	6.453GlyGly: 6.453 ± 0.086	1.564GlyHis: 1.564 ± 0.038	5.522GlyIle: 5.522 ± 0.062	4.654GlyLys: 4.654 ± 0.057	7.437GlyLeu: 7.437 ± 0.076	2.288GlyMet: 2.288 ± 0.052	2.698GlyAsn: 2.698 ± 0.048	2.396GlyPro: 2.396 ± 0.041	2.387GlyGln: 2.387 ± 0.04	4.227GlyArg: 4.227 ± 0.058	4.583GlySer: 4.583 ± 0.066	4.304GlyThr: 4.304 ± 0.051	5.89GlyVal: 5.89 ± 0.069	1.005GlyTrp: 1.005 ± 0.03	2.812GlyTyr: 2.812 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.347HisAla: 1.347 ± 0.03	0.383HisCys: 0.383 ± 0.018	1.055HisAsp: 1.055 ± 0.03	1.106HisGlu: 1.106 ± 0.03	0.999HisPhe: 0.999 ± 0.027	1.578HisGly: 1.578 ± 0.036	0.616HisHis: 0.616 ± 0.023	1.238HisIle: 1.238 ± 0.034	0.953HisLys: 0.953 ± 0.022	2.118HisLeu: 2.118 ± 0.038	0.468HisMet: 0.468 ± 0.02	0.803HisAsn: 0.803 ± 0.024	1.243HisPro: 1.243 ± 0.034	0.78HisGln: 0.78 ± 0.023	1.261HisArg: 1.261 ± 0.032	1.182HisSer: 1.182 ± 0.031	0.977HisThr: 0.977 ± 0.027	1.24HisVal: 1.24 ± 0.028	0.232HisTrp: 0.232 ± 0.011	0.73HisTyr: 0.73 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	5.769IleAla: 5.769 ± 0.071	1.024IleCys: 1.024 ± 0.027	4.276IleAsp: 4.276 ± 0.055	4.431IleGlu: 4.431 ± 0.059	2.89IlePhe: 2.89 ± 0.054	5.263IleGly: 5.263 ± 0.068	1.329IleHis: 1.329 ± 0.03	4.371IleIle: 4.371 ± 0.068	3.456IleLys: 3.456 ± 0.052	6.436IleLeu: 6.436 ± 0.072	1.559IleMet: 1.559 ± 0.037	2.69IleAsn: 2.69 ± 0.04	3.046IlePro: 3.046 ± 0.053	1.737IleGln: 1.737 ± 0.036	3.426IleArg: 3.426 ± 0.049	4.441IleSer: 4.441 ± 0.055	3.878IleThr: 3.878 ± 0.053	4.88IleVal: 4.88 ± 0.059	0.575IleTrp: 0.575 ± 0.022	1.911IleTyr: 1.911 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.146LysAla: 4.146 ± 0.055	0.565LysCys: 0.565 ± 0.019	2.846LysAsp: 2.846 ± 0.046	4.071LysGlu: 4.071 ± 0.061	1.73LysPhe: 1.73 ± 0.04	3.67LysGly: 3.67 ± 0.049	1.013LysHis: 1.013 ± 0.027	4.433LysIle: 4.433 ± 0.06	4.782LysLys: 4.782 ± 0.067	4.845LysLeu: 4.845 ± 0.056	1.717LysMet: 1.717 ± 0.032	2.873LysAsn: 2.873 ± 0.05	1.977LysPro: 1.977 ± 0.037	1.988LysGln: 1.988 ± 0.038	2.933LysArg: 2.933 ± 0.046	3.229LysSer: 3.229 ± 0.049	3.42LysThr: 3.42 ± 0.051	3.636LysVal: 3.636 ± 0.048	0.575LysTrp: 0.575 ± 0.021	1.705LysTyr: 1.705 ± 0.038	0.0LysXaa: 0.0 ± 0.0
Leu	9.326LeuAla: 9.326 ± 0.091	1.423LeuCys: 1.423 ± 0.036	5.476LeuAsp: 5.476 ± 0.064	6.402LeuGlu: 6.402 ± 0.072	4.578LeuPhe: 4.578 ± 0.069	7.499LeuGly: 7.499 ± 0.08	1.959LeuHis: 1.959 ± 0.04	5.736LeuIle: 5.736 ± 0.073	5.529LeuLys: 5.529 ± 0.063	10.405LeuLeu: 10.405 ± 0.114	2.376LeuMet: 2.376 ± 0.042	3.449LeuAsn: 3.449 ± 0.046	4.59LeuPro: 4.59 ± 0.052	3.519LeuGln: 3.519 ± 0.05	4.863LeuArg: 4.863 ± 0.071	6.56LeuSer: 6.56 ± 0.074	5.268LeuThr: 5.268 ± 0.068	7.315LeuVal: 7.315 ± 0.078	0.894LeuTrp: 0.894 ± 0.026	2.697LeuTyr: 2.697 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	2.713MetAla: 2.713 ± 0.047	0.286MetCys: 0.286 ± 0.014	1.457MetAsp: 1.457 ± 0.031	1.728MetGlu: 1.728 ± 0.039	0.97MetPhe: 0.97 ± 0.029	1.959MetGly: 1.959 ± 0.036	0.46MetHis: 0.46 ± 0.018	1.803MetIle: 1.803 ± 0.043	1.798MetLys: 1.798 ± 0.032	2.423MetLeu: 2.423 ± 0.04	0.734MetMet: 0.734 ± 0.023	1.082MetAsn: 1.082 ± 0.028	1.043MetPro: 1.043 ± 0.027	0.916MetGln: 0.916 ± 0.026	1.28MetArg: 1.28 ± 0.03	1.639MetSer: 1.639 ± 0.031	1.571MetThr: 1.571 ± 0.031	2.176MetVal: 2.176 ± 0.039	0.196MetTrp: 0.196 ± 0.011	0.545MetTyr: 0.545 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.309AsnAla: 2.309 ± 0.044	0.672AsnCys: 0.672 ± 0.023	1.917AsnAsp: 1.917 ± 0.037	1.987AsnGlu: 1.987 ± 0.04	1.561AsnPhe: 1.561 ± 0.032	2.752AsnGly: 2.752 ± 0.051	0.877AsnHis: 0.877 ± 0.024	2.898AsnIle: 2.898 ± 0.047	1.926AsnLys: 1.926 ± 0.038	3.98AsnLeu: 3.98 ± 0.056	0.977AsnMet: 0.977 ± 0.028	1.589AsnAsn: 1.589 ± 0.036	1.98AsnPro: 1.98 ± 0.039	1.197AsnGln: 1.197 ± 0.025	2.525AsnArg: 2.525 ± 0.04	2.498AsnSer: 2.498 ± 0.043	1.753AsnThr: 1.753 ± 0.036	2.463AsnVal: 2.463 ± 0.046	0.436AsnTrp: 0.436 ± 0.02	1.294AsnTyr: 1.294 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	3.538ProAla: 3.538 ± 0.055	0.503ProCys: 0.503 ± 0.02	2.729ProAsp: 2.729 ± 0.046	3.637ProGlu: 3.637 ± 0.055	1.915ProPhe: 1.915 ± 0.034	3.613ProGly: 3.613 ± 0.045	0.866ProHis: 0.866 ± 0.024	2.211ProIle: 2.211 ± 0.038	1.861ProLys: 1.861 ± 0.038	4.134ProLeu: 4.134 ± 0.05	1.055ProMet: 1.055 ± 0.027	1.181ProAsn: 1.181 ± 0.033	1.818ProPro: 1.818 ± 0.04	1.357ProGln: 1.357 ± 0.031	1.781ProArg: 1.781 ± 0.038	2.22ProSer: 2.22 ± 0.041	1.915ProThr: 1.915 ± 0.038	3.846ProVal: 3.846 ± 0.057	0.487ProTrp: 0.487 ± 0.017	1.305ProTyr: 1.305 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.847GlnAla: 2.847 ± 0.044	0.413GlnCys: 0.413 ± 0.018	1.608GlnAsp: 1.608 ± 0.031	2.233GlnGlu: 2.233 ± 0.044	1.243GlnPhe: 1.243 ± 0.031	2.325GlnGly: 2.325 ± 0.04	0.691GlnHis: 0.691 ± 0.021	2.077GlnIle: 2.077 ± 0.039	2.199GlnLys: 2.199 ± 0.042	3.622GlnLeu: 3.622 ± 0.058	0.978GlnMet: 0.978 ± 0.022	1.253GlnAsn: 1.253 ± 0.028	1.351GlnPro: 1.351 ± 0.028	1.816GlnGln: 1.816 ± 0.044	1.817GlnArg: 1.817 ± 0.038	1.795GlnSer: 1.795 ± 0.034	1.679GlnThr: 1.679 ± 0.032	2.317GlnVal: 2.317 ± 0.041	0.4GlnTrp: 0.4 ± 0.018	0.956GlnTyr: 0.956 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.624ArgAla: 3.624 ± 0.054	0.776ArgCys: 0.776 ± 0.028	2.803ArgAsp: 2.803 ± 0.043	3.835ArgGlu: 3.835 ± 0.059	2.473ArgPhe: 2.473 ± 0.043	3.328ArgGly: 3.328 ± 0.051	1.127ArgHis: 1.127 ± 0.026	3.955ArgIle: 3.955 ± 0.053	3.529ArgLys: 3.529 ± 0.054	5.67ArgLeu: 5.67 ± 0.07	1.545ArgMet: 1.545 ± 0.032	2.168ArgAsn: 2.168 ± 0.042	2.033ArgPro: 2.033 ± 0.041	2.259ArgGln: 2.259 ± 0.04	2.995ArgArg: 2.995 ± 0.053	3.085ArgSer: 3.085 ± 0.051	2.661ArgThr: 2.661 ± 0.048	3.609ArgVal: 3.609 ± 0.047	0.625ArgTrp: 0.625 ± 0.021	1.817ArgTyr: 1.817 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	4.687SerAla: 4.687 ± 0.058	1.016SerCys: 1.016 ± 0.028	3.111SerAsp: 3.111 ± 0.045	3.462SerGlu: 3.462 ± 0.06	2.966SerPhe: 2.966 ± 0.048	5.664SerGly: 5.664 ± 0.071	1.259SerHis: 1.259 ± 0.03	3.797SerIle: 3.797 ± 0.054	2.58SerLys: 2.58 ± 0.038	6.387SerLeu: 6.387 ± 0.075	1.629SerMet: 1.629 ± 0.033	1.811SerAsn: 1.811 ± 0.034	2.813SerPro: 2.813 ± 0.048	1.818SerGln: 1.818 ± 0.037	3.574SerArg: 3.574 ± 0.056	4.018SerSer: 4.018 ± 0.064	2.955SerThr: 2.955 ± 0.046	4.278SerVal: 4.278 ± 0.058	0.802SerTrp: 0.802 ± 0.024	2.039SerTyr: 2.039 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.531ThrAla: 4.531 ± 0.061	0.709ThrCys: 0.709 ± 0.024	2.684ThrAsp: 2.684 ± 0.044	2.911ThrGlu: 2.911 ± 0.044	2.202ThrPhe: 2.202 ± 0.037	5.293ThrGly: 5.293 ± 0.065	0.985ThrHis: 0.985 ± 0.026	3.942ThrIle: 3.942 ± 0.052	2.113ThrLys: 2.113 ± 0.038	5.335ThrLeu: 5.335 ± 0.07	1.4ThrMet: 1.4 ± 0.03	1.671ThrAsn: 1.671 ± 0.036	2.655ThrPro: 2.655 ± 0.046	1.335ThrGln: 1.335 ± 0.031	2.891ThrArg: 2.891 ± 0.04	3.155ThrSer: 3.155 ± 0.046	3.176ThrThr: 3.176 ± 0.052	4.502ThrVal: 4.502 ± 0.057	0.526ThrTrp: 0.526 ± 0.02	1.444ThrTyr: 1.444 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	6.57ValAla: 6.57 ± 0.071	1.09ValCys: 1.09 ± 0.031	4.308ValAsp: 4.308 ± 0.054	4.715ValGlu: 4.715 ± 0.061	3.073ValPhe: 3.073 ± 0.049	5.129ValGly: 5.129 ± 0.065	1.361ValHis: 1.361 ± 0.028	4.886ValIle: 4.886 ± 0.062	3.766ValLys: 3.766 ± 0.068	6.832ValLeu: 6.832 ± 0.073	1.892ValMet: 1.892 ± 0.04	2.666ValAsn: 2.666 ± 0.043	2.967ValPro: 2.967 ± 0.047	2.075ValGln: 2.075 ± 0.04	3.598ValArg: 3.598 ± 0.055	4.5ValSer: 4.5 ± 0.057	4.283ValThr: 4.283 ± 0.056	5.947ValVal: 5.947 ± 0.077	0.69ValTrp: 0.69 ± 0.022	1.946ValTyr: 1.946 ± 0.037	0.001ValXaa: 0.001 ± 0.001
Trp	0.753TrpAla: 0.753 ± 0.025	0.147TrpCys: 0.147 ± 0.011	0.534TrpAsp: 0.534 ± 0.022	0.607TrpGlu: 0.607 ± 0.022	0.507TrpPhe: 0.507 ± 0.021	0.812TrpGly: 0.812 ± 0.03	0.237TrpHis: 0.237 ± 0.014	0.711TrpIle: 0.711 ± 0.025	0.583TrpLys: 0.583 ± 0.022	1.163TrpLeu: 1.163 ± 0.029	0.312TrpMet: 0.312 ± 0.015	0.438TrpAsn: 0.438 ± 0.018	0.449TrpPro: 0.449 ± 0.018	0.539TrpGln: 0.539 ± 0.02	0.599TrpArg: 0.599 ± 0.019	0.676TrpSer: 0.676 ± 0.023	0.48TrpThr: 0.48 ± 0.017	0.683TrpVal: 0.683 ± 0.024	0.162TrpTrp: 0.162 ± 0.01	0.339TrpTyr: 0.339 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.981TyrAla: 1.981 ± 0.04	0.529TyrCys: 0.529 ± 0.019	1.755TyrAsp: 1.755 ± 0.04	1.636TyrGlu: 1.636 ± 0.032	1.458TyrPhe: 1.458 ± 0.037	2.532TyrGly: 2.532 ± 0.044	0.732TyrHis: 0.732 ± 0.023	1.712TyrIle: 1.712 ± 0.032	1.329TyrLys: 1.329 ± 0.029	3.35TyrLeu: 3.35 ± 0.051	0.644TyrMet: 0.644 ± 0.024	1.187TyrAsn: 1.187 ± 0.03	1.44TyrPro: 1.44 ± 0.032	1.187TyrGln: 1.187 ± 0.029	2.107TyrArg: 2.107 ± 0.038	1.986TyrSer: 1.986 ± 0.041	1.506TyrThr: 1.506 ± 0.031	1.722TyrVal: 1.722 ± 0.033	0.393TyrTrp: 0.393 ± 0.015	1.134TyrTyr: 1.134 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.001XaaPro: 0.001 ± 0.001	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.002XaaXaa: 0.002 ± 0.002

Statistics based on 4348 proteins (1432539 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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