Amino acid dipepetide frequency for Oceanisphaera psychrotolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.238AlaAla: 11.238 ± 0.161	1.176AlaCys: 1.176 ± 0.034	5.769AlaAsp: 5.769 ± 0.098	7.1AlaGlu: 7.1 ± 0.087	3.485AlaPhe: 3.485 ± 0.065	8.831AlaGly: 8.831 ± 0.137	1.956AlaHis: 1.956 ± 0.049	5.457AlaIle: 5.457 ± 0.086	3.184AlaLys: 3.184 ± 0.071	12.662AlaLeu: 12.662 ± 0.132	3.118AlaMet: 3.118 ± 0.054	2.865AlaAsn: 2.865 ± 0.054	3.807AlaPro: 3.807 ± 0.064	4.072AlaGln: 4.072 ± 0.076	6.824AlaArg: 6.824 ± 0.098	5.421AlaSer: 5.421 ± 0.075	4.541AlaThr: 4.541 ± 0.071	6.994AlaVal: 6.994 ± 0.082	1.269AlaTrp: 1.269 ± 0.038	2.149AlaTyr: 2.149 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	0.889CysAla: 0.889 ± 0.029	0.198CysCys: 0.198 ± 0.015	0.591CysAsp: 0.591 ± 0.026	0.57CysGlu: 0.57 ± 0.024	0.459CysPhe: 0.459 ± 0.022	0.984CysGly: 0.984 ± 0.032	0.372CysHis: 0.372 ± 0.021	0.498CysIle: 0.498 ± 0.025	0.312CysLys: 0.312 ± 0.018	1.069CysLeu: 1.069 ± 0.036	0.232CysMet: 0.232 ± 0.015	0.289CysAsn: 0.289 ± 0.017	0.507CysPro: 0.507 ± 0.027	0.426CysGln: 0.426 ± 0.021	0.736CysArg: 0.736 ± 0.034	0.603CysSer: 0.603 ± 0.022	0.493CysThr: 0.493 ± 0.026	0.643CysVal: 0.643 ± 0.03	0.151CysTrp: 0.151 ± 0.012	0.354CysTyr: 0.354 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.287AspAla: 5.287 ± 0.083	0.573AspCys: 0.573 ± 0.024	3.128AspAsp: 3.128 ± 0.067	3.602AspGlu: 3.602 ± 0.067	2.192AspPhe: 2.192 ± 0.05	4.196AspGly: 4.196 ± 0.101	1.221AspHis: 1.221 ± 0.038	3.486AspIle: 3.486 ± 0.065	2.331AspLys: 2.331 ± 0.056	4.995AspLeu: 4.995 ± 0.109	1.556AspMet: 1.556 ± 0.041	1.985AspAsn: 1.985 ± 0.051	2.439AspPro: 2.439 ± 0.049	2.014AspGln: 2.014 ± 0.048	2.847AspArg: 2.847 ± 0.06	2.824AspSer: 2.824 ± 0.065	2.92AspThr: 2.92 ± 0.07	3.255AspVal: 3.255 ± 0.065	1.042AspTrp: 1.042 ± 0.037	1.943AspTyr: 1.943 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	6.088GluAla: 6.088 ± 0.089	0.478GluCys: 0.478 ± 0.025	2.555GluAsp: 2.555 ± 0.05	3.184GluGlu: 3.184 ± 0.072	1.894GluPhe: 1.894 ± 0.046	3.826GluGly: 3.826 ± 0.061	1.739GluHis: 1.739 ± 0.042	2.78GluIle: 2.78 ± 0.062	2.234GluLys: 2.234 ± 0.062	8.096GluLeu: 8.096 ± 0.112	1.477GluMet: 1.477 ± 0.039	1.601GluAsn: 1.601 ± 0.047	2.564GluPro: 2.564 ± 0.049	5.282GluGln: 5.282 ± 0.095	4.252GluArg: 4.252 ± 0.086	2.739GluSer: 2.739 ± 0.055	2.5GluThr: 2.5 ± 0.042	4.306GluVal: 4.306 ± 0.075	0.743GluTrp: 0.743 ± 0.026	1.391GluTyr: 1.391 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	3.528PheAla: 3.528 ± 0.073	0.495PheCys: 0.495 ± 0.02	2.534PheAsp: 2.534 ± 0.059	2.224PheGlu: 2.224 ± 0.048	1.492PhePhe: 1.492 ± 0.044	3.527PheGly: 3.527 ± 0.073	0.787PheHis: 0.787 ± 0.027	2.248PheIle: 2.248 ± 0.052	1.26PheLys: 1.26 ± 0.035	3.015PheLeu: 3.015 ± 0.068	0.993PheMet: 0.993 ± 0.033	1.549PheAsn: 1.549 ± 0.038	1.411PhePro: 1.411 ± 0.035	1.099PheGln: 1.099 ± 0.035	1.887PheArg: 1.887 ± 0.044	2.616PheSer: 2.616 ± 0.061	2.084PheThr: 2.084 ± 0.063	2.616PheVal: 2.616 ± 0.061	0.567PheTrp: 0.567 ± 0.026	1.146PheTyr: 1.146 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	6.787GlyAla: 6.787 ± 0.123	1.026GlyCys: 1.026 ± 0.036	4.041GlyAsp: 4.041 ± 0.095	4.895GlyGlu: 4.895 ± 0.073	3.488GlyPhe: 3.488 ± 0.068	5.829GlyGly: 5.829 ± 0.136	1.919GlyHis: 1.919 ± 0.056	4.718GlyIle: 4.718 ± 0.08	3.463GlyLys: 3.463 ± 0.069	9.077GlyLeu: 9.077 ± 0.093	2.41GlyMet: 2.41 ± 0.062	2.442GlyAsn: 2.442 ± 0.075	2.504GlyPro: 2.504 ± 0.056	3.684GlyGln: 3.684 ± 0.064	4.595GlyArg: 4.595 ± 0.081	4.407GlySer: 4.407 ± 0.11	3.752GlyThr: 3.752 ± 0.082	5.723GlyVal: 5.723 ± 0.094	1.281GlyTrp: 1.281 ± 0.039	2.482GlyTyr: 2.482 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	1.915HisAla: 1.915 ± 0.046	0.365HisCys: 0.365 ± 0.02	1.199HisAsp: 1.199 ± 0.036	1.179HisGlu: 1.179 ± 0.035	1.074HisPhe: 1.074 ± 0.033	1.917HisGly: 1.917 ± 0.059	0.87HisHis: 0.87 ± 0.037	1.271HisIle: 1.271 ± 0.037	0.814HisLys: 0.814 ± 0.039	2.419HisLeu: 2.419 ± 0.06	0.529HisMet: 0.529 ± 0.023	0.733HisAsn: 0.733 ± 0.027	1.439HisPro: 1.439 ± 0.044	1.282HisGln: 1.282 ± 0.044	1.622HisArg: 1.622 ± 0.045	1.332HisSer: 1.332 ± 0.039	1.057HisThr: 1.057 ± 0.03	1.194HisVal: 1.194 ± 0.037	0.502HisTrp: 0.502 ± 0.023	0.899HisTyr: 0.899 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.497IleAla: 5.497 ± 0.084	0.58IleCys: 0.58 ± 0.025	3.323IleAsp: 3.323 ± 0.063	3.398IleGlu: 3.398 ± 0.062	1.651IlePhe: 1.651 ± 0.05	4.473IleGly: 4.473 ± 0.083	1.177IleHis: 1.177 ± 0.038	2.69IleIle: 2.69 ± 0.062	2.148IleLys: 2.148 ± 0.047	4.693IleLeu: 4.693 ± 0.069	1.276IleMet: 1.276 ± 0.035	2.084IleAsn: 2.084 ± 0.047	2.437IlePro: 2.437 ± 0.056	1.678IleGln: 1.678 ± 0.043	3.216IleArg: 3.216 ± 0.061	3.338IleSer: 3.338 ± 0.06	3.061IleThr: 3.061 ± 0.062	3.185IleVal: 3.185 ± 0.06	0.587IleTrp: 0.587 ± 0.023	1.319IleTyr: 1.319 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.87LysAla: 3.87 ± 0.066	0.213LysCys: 0.213 ± 0.015	1.887LysAsp: 1.887 ± 0.047	2.108LysGlu: 2.108 ± 0.055	0.915LysPhe: 0.915 ± 0.034	2.727LysGly: 2.727 ± 0.064	0.762LysHis: 0.762 ± 0.031	1.663LysIle: 1.663 ± 0.055	1.591LysLys: 1.591 ± 0.058	3.787LysLeu: 3.787 ± 0.075	0.91LysMet: 0.91 ± 0.031	1.089LysAsn: 1.089 ± 0.031	1.915LysPro: 1.915 ± 0.043	1.802LysGln: 1.802 ± 0.046	2.238LysArg: 2.238 ± 0.055	1.872LysSer: 1.872 ± 0.045	1.989LysThr: 1.989 ± 0.042	2.851LysVal: 2.851 ± 0.06	0.375LysTrp: 0.375 ± 0.018	0.768LysTyr: 0.768 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	13.804LeuAla: 13.804 ± 0.161	1.279LeuCys: 1.279 ± 0.037	6.656LeuAsp: 6.656 ± 0.104	6.757LeuGlu: 6.757 ± 0.095	4.366LeuPhe: 4.366 ± 0.085	8.76LeuGly: 8.76 ± 0.112	2.376LeuHis: 2.376 ± 0.053	5.418LeuIle: 5.418 ± 0.082	4.275LeuLys: 4.275 ± 0.069	14.399LeuLeu: 14.399 ± 0.222	3.037LeuMet: 3.037 ± 0.058	4.113LeuAsn: 4.113 ± 0.073	5.996LeuPro: 5.996 ± 0.093	4.891LeuGln: 4.891 ± 0.085	5.921LeuArg: 5.921 ± 0.108	7.775LeuSer: 7.775 ± 0.1	6.572LeuThr: 6.572 ± 0.099	8.454LeuVal: 8.454 ± 0.11	1.455LeuTrp: 1.455 ± 0.045	2.622LeuTyr: 2.622 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	3.198MetAla: 3.198 ± 0.064	0.181MetCys: 0.181 ± 0.013	1.297MetAsp: 1.297 ± 0.043	1.395MetGlu: 1.395 ± 0.041	0.815MetPhe: 0.815 ± 0.033	1.957MetGly: 1.957 ± 0.05	0.488MetHis: 0.488 ± 0.025	1.32MetIle: 1.32 ± 0.036	1.178MetLys: 1.178 ± 0.033	3.047MetLeu: 3.047 ± 0.06	0.876MetMet: 0.876 ± 0.037	0.962MetAsn: 0.962 ± 0.028	1.288MetPro: 1.288 ± 0.039	1.042MetGln: 1.042 ± 0.033	1.203MetArg: 1.203 ± 0.035	1.89MetSer: 1.89 ± 0.043	1.703MetThr: 1.703 ± 0.042	2.011MetVal: 2.011 ± 0.044	0.182MetTrp: 0.182 ± 0.014	0.43MetTyr: 0.43 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.833AsnAla: 2.833 ± 0.057	0.3AsnCys: 0.3 ± 0.018	1.685AsnAsp: 1.685 ± 0.052	1.739AsnGlu: 1.739 ± 0.04	1.071AsnPhe: 1.071 ± 0.04	2.675AsnGly: 2.675 ± 0.067	0.721AsnHis: 0.721 ± 0.027	1.927AsnIle: 1.927 ± 0.054	1.317AsnLys: 1.317 ± 0.041	3.312AsnLeu: 3.312 ± 0.077	0.793AsnMet: 0.793 ± 0.032	1.164AsnAsn: 1.164 ± 0.045	1.851AsnPro: 1.851 ± 0.037	1.454AsnGln: 1.454 ± 0.037	2.054AsnArg: 2.054 ± 0.043	1.659AsnSer: 1.659 ± 0.049	1.692AsnThr: 1.692 ± 0.048	1.815AsnVal: 1.815 ± 0.052	0.462AsnTrp: 0.462 ± 0.022	0.856AsnTyr: 0.856 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	5.047ProAla: 5.047 ± 0.085	0.379ProCys: 0.379 ± 0.022	2.85ProAsp: 2.85 ± 0.059	3.756ProGlu: 3.756 ± 0.071	1.744ProPhe: 1.744 ± 0.046	3.881ProGly: 3.881 ± 0.067	1.043ProHis: 1.043 ± 0.039	1.9ProIle: 1.9 ± 0.045	1.317ProLys: 1.317 ± 0.038	5.573ProLeu: 5.573 ± 0.086	1.191ProMet: 1.191 ± 0.035	1.222ProAsn: 1.222 ± 0.036	1.761ProPro: 1.761 ± 0.051	1.762ProGln: 1.762 ± 0.05	2.298ProArg: 2.298 ± 0.06	2.285ProSer: 2.285 ± 0.054	2.001ProThr: 2.001 ± 0.046	4.1ProVal: 4.1 ± 0.067	0.717ProTrp: 0.717 ± 0.029	1.165ProTyr: 1.165 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	5.792GlnAla: 5.792 ± 0.092	0.377GlnCys: 0.377 ± 0.02	2.258GlnAsp: 2.258 ± 0.044	2.367GlnGlu: 2.367 ± 0.053	1.377GlnPhe: 1.377 ± 0.041	3.775GlnGly: 3.775 ± 0.066	1.277GlnHis: 1.277 ± 0.036	2.041GlnIle: 2.041 ± 0.043	1.313GlnLys: 1.313 ± 0.044	6.247GlnLeu: 6.247 ± 0.115	1.038GlnMet: 1.038 ± 0.031	1.121GlnAsn: 1.121 ± 0.036	2.406GlnPro: 2.406 ± 0.052	3.834GlnGln: 3.834 ± 0.103	2.953GlnArg: 2.953 ± 0.069	2.45GlnSer: 2.45 ± 0.054	2.095GlnThr: 2.095 ± 0.05	3.284GlnVal: 3.284 ± 0.059	0.684GlnTrp: 0.684 ± 0.025	1.068GlnTyr: 1.068 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.084ArgAla: 5.084 ± 0.088	0.543ArgCys: 0.543 ± 0.025	2.998ArgAsp: 2.998 ± 0.058	3.88ArgGlu: 3.88 ± 0.083	2.694ArgPhe: 2.694 ± 0.054	3.527ArgGly: 3.527 ± 0.056	1.954ArgHis: 1.954 ± 0.055	3.408ArgIle: 3.408 ± 0.058	2.048ArgLys: 2.048 ± 0.052	8.518ArgLeu: 8.518 ± 0.119	1.537ArgMet: 1.537 ± 0.042	1.767ArgAsn: 1.767 ± 0.043	2.581ArgPro: 2.581 ± 0.052	3.677ArgGln: 3.677 ± 0.081	4.251ArgArg: 4.251 ± 0.084	2.8ArgSer: 2.8 ± 0.051	2.446ArgThr: 2.446 ± 0.052	4.331ArgVal: 4.331 ± 0.069	0.968ArgTrp: 0.968 ± 0.034	2.002ArgTyr: 2.002 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.459SerAla: 5.459 ± 0.076	0.553SerCys: 0.553 ± 0.026	2.707SerAsp: 2.707 ± 0.053	2.923SerGlu: 2.923 ± 0.061	2.273SerPhe: 2.273 ± 0.058	5.222SerGly: 5.222 ± 0.1	1.404SerHis: 1.404 ± 0.04	2.745SerIle: 2.745 ± 0.059	1.716SerLys: 1.716 ± 0.042	7.084SerLeu: 7.084 ± 0.096	1.477SerMet: 1.477 ± 0.041	1.587SerAsn: 1.587 ± 0.047	2.784SerPro: 2.784 ± 0.057	2.479SerGln: 2.479 ± 0.052	4.07SerArg: 4.07 ± 0.064	3.215SerSer: 3.215 ± 0.061	2.663SerThr: 2.663 ± 0.065	3.737SerVal: 3.737 ± 0.068	0.897SerTrp: 0.897 ± 0.033	1.554SerTyr: 1.554 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.896ThrAla: 4.896 ± 0.079	0.393ThrCys: 0.393 ± 0.019	2.691ThrAsp: 2.691 ± 0.07	2.837ThrGlu: 2.837 ± 0.044	1.705ThrPhe: 1.705 ± 0.046	4.611ThrGly: 4.611 ± 0.108	1.041ThrHis: 1.041 ± 0.032	2.495ThrIle: 2.495 ± 0.049	1.281ThrLys: 1.281 ± 0.041	7.142ThrLeu: 7.142 ± 0.095	1.072ThrMet: 1.072 ± 0.034	1.326ThrAsn: 1.326 ± 0.032	3.013ThrPro: 3.013 ± 0.064	1.88ThrGln: 1.88 ± 0.047	3.151ThrArg: 3.151 ± 0.058	2.587ThrSer: 2.587 ± 0.056	2.605ThrThr: 2.605 ± 0.066	3.527ThrVal: 3.527 ± 0.07	0.571ThrTrp: 0.571 ± 0.025	1.02ThrTyr: 1.02 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.48ValAla: 7.48 ± 0.092	0.778ValCys: 0.778 ± 0.029	3.751ValAsp: 3.751 ± 0.069	4.104ValGlu: 4.104 ± 0.08	2.701ValPhe: 2.701 ± 0.062	4.887ValGly: 4.887 ± 0.074	1.35ValHis: 1.35 ± 0.042	4.014ValIle: 4.014 ± 0.074	2.464ValLys: 2.464 ± 0.059	7.917ValLeu: 7.917 ± 0.105	2.061ValMet: 2.061 ± 0.05	2.371ValAsn: 2.371 ± 0.052	3.178ValPro: 3.178 ± 0.061	2.559ValGln: 2.559 ± 0.052	3.872ValArg: 3.872 ± 0.065	4.501ValSer: 4.501 ± 0.076	4.005ValThr: 4.005 ± 0.074	5.441ValVal: 5.441 ± 0.081	0.787ValTrp: 0.787 ± 0.029	1.685ValTyr: 1.685 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.031TrpAla: 1.031 ± 0.035	0.171TrpCys: 0.171 ± 0.013	0.557TrpAsp: 0.557 ± 0.025	0.508TrpGlu: 0.508 ± 0.022	0.573TrpPhe: 0.573 ± 0.029	0.793TrpGly: 0.793 ± 0.029	0.388TrpHis: 0.388 ± 0.018	0.576TrpIle: 0.576 ± 0.025	0.346TrpLys: 0.346 ± 0.018	2.601TrpLeu: 2.601 ± 0.063	0.345TrpMet: 0.345 ± 0.019	0.392TrpAsn: 0.392 ± 0.019	0.696TrpPro: 0.696 ± 0.025	1.22TrpGln: 1.22 ± 0.043	0.941TrpArg: 0.941 ± 0.032	0.786TrpSer: 0.786 ± 0.03	0.528TrpThr: 0.528 ± 0.027	0.875TrpVal: 0.875 ± 0.03	0.252TrpTrp: 0.252 ± 0.018	0.337TrpTyr: 0.337 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.194TyrAla: 2.194 ± 0.042	0.318TyrCys: 0.318 ± 0.016	1.359TyrAsp: 1.359 ± 0.042	1.207TyrGlu: 1.207 ± 0.036	1.106TyrPhe: 1.106 ± 0.037	2.124TyrGly: 2.124 ± 0.049	0.768TyrHis: 0.768 ± 0.031	1.155TyrIle: 1.155 ± 0.035	0.738TyrLys: 0.738 ± 0.03	3.275TyrLeu: 3.275 ± 0.066	0.534TyrMet: 0.534 ± 0.023	0.719TyrAsn: 0.719 ± 0.028	1.419TyrPro: 1.419 ± 0.042	1.62TyrGln: 1.62 ± 0.04	2.082TyrArg: 2.082 ± 0.051	1.449TyrSer: 1.449 ± 0.038	1.138TyrThr: 1.138 ± 0.038	1.562TyrVal: 1.562 ± 0.038	0.424TyrTrp: 0.424 ± 0.023	0.846TyrTyr: 0.846 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3066 proteins (968909 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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