Amino acid dipepetide frequency for Salinimonas sediminis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.601AlaAla: 9.601 ± 0.102	1.118AlaCys: 1.118 ± 0.029	5.431AlaAsp: 5.431 ± 0.074	5.246AlaGlu: 5.246 ± 0.096	3.668AlaPhe: 3.668 ± 0.062	7.351AlaGly: 7.351 ± 0.084	2.075AlaHis: 2.075 ± 0.043	6.003AlaIle: 6.003 ± 0.082	4.207AlaLys: 4.207 ± 0.061	11.149AlaLeu: 11.149 ± 0.127	2.868AlaMet: 2.868 ± 0.043	3.756AlaAsn: 3.756 ± 0.054	3.702AlaPro: 3.702 ± 0.06	5.374AlaGln: 5.374 ± 0.066	5.047AlaArg: 5.047 ± 0.074	6.011AlaSer: 6.011 ± 0.077	5.368AlaThr: 5.368 ± 0.069	6.622AlaVal: 6.622 ± 0.079	1.052AlaTrp: 1.052 ± 0.036	2.732AlaTyr: 2.732 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.958CysAla: 0.958 ± 0.033	0.176CysCys: 0.176 ± 0.013	0.588CysAsp: 0.588 ± 0.022	0.608CysGlu: 0.608 ± 0.022	0.417CysPhe: 0.417 ± 0.02	0.788CysGly: 0.788 ± 0.027	0.335CysHis: 0.335 ± 0.016	0.62CysIle: 0.62 ± 0.027	0.385CysLys: 0.385 ± 0.019	0.941CysLeu: 0.941 ± 0.029	0.222CysMet: 0.222 ± 0.013	0.349CysAsn: 0.349 ± 0.018	0.461CysPro: 0.461 ± 0.02	0.516CysGln: 0.516 ± 0.024	0.51CysArg: 0.51 ± 0.021	0.599CysSer: 0.599 ± 0.019	0.494CysThr: 0.494 ± 0.021	0.62CysVal: 0.62 ± 0.023	0.141CysTrp: 0.141 ± 0.01	0.326CysTyr: 0.326 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.178AspAla: 5.178 ± 0.067	0.515AspCys: 0.515 ± 0.021	3.389AspAsp: 3.389 ± 0.072	3.825AspGlu: 3.825 ± 0.072	2.443AspPhe: 2.443 ± 0.046	3.732AspGly: 3.732 ± 0.06	1.091AspHis: 1.091 ± 0.028	4.187AspIle: 4.187 ± 0.058	2.975AspLys: 2.975 ± 0.06	4.544AspLeu: 4.544 ± 0.066	1.499AspMet: 1.499 ± 0.038	2.722AspAsn: 2.722 ± 0.053	2.119AspPro: 2.119 ± 0.042	1.788AspGln: 1.788 ± 0.036	2.283AspArg: 2.283 ± 0.044	3.284AspSer: 3.284 ± 0.067	3.547AspThr: 3.547 ± 0.054	3.818AspVal: 3.818 ± 0.059	0.851AspTrp: 0.851 ± 0.029	2.201AspTyr: 2.201 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.474GluAla: 5.474 ± 0.072	0.396GluCys: 0.396 ± 0.02	2.889GluAsp: 2.889 ± 0.053	3.131GluGlu: 3.131 ± 0.07	2.073GluPhe: 2.073 ± 0.043	3.482GluGly: 3.482 ± 0.058	1.619GluHis: 1.619 ± 0.04	3.056GluIle: 3.056 ± 0.054	2.928GluLys: 2.928 ± 0.055	5.9GluLeu: 5.9 ± 0.088	1.368GluMet: 1.368 ± 0.037	2.278GluAsn: 2.278 ± 0.047	2.163GluPro: 2.163 ± 0.077	4.125GluGln: 4.125 ± 0.069	3.107GluArg: 3.107 ± 0.051	2.92GluSer: 2.92 ± 0.05	2.921GluThr: 2.921 ± 0.049	3.98GluVal: 3.98 ± 0.059	0.65GluTrp: 0.65 ± 0.026	1.625GluTyr: 1.625 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.97PheAla: 3.97 ± 0.068	0.513PheCys: 0.513 ± 0.019	2.824PheAsp: 2.824 ± 0.052	2.234PheGlu: 2.234 ± 0.036	1.74PhePhe: 1.74 ± 0.048	3.106PheGly: 3.106 ± 0.057	0.829PheHis: 0.829 ± 0.027	2.59PheIle: 2.59 ± 0.048	1.667PheLys: 1.667 ± 0.038	3.199PheLeu: 3.199 ± 0.059	1.0PheMet: 1.0 ± 0.028	1.916PheAsn: 1.916 ± 0.036	1.284PhePro: 1.284 ± 0.035	1.042PheGln: 1.042 ± 0.029	1.58PheArg: 1.58 ± 0.042	3.3PheSer: 3.3 ± 0.053	2.713PheThr: 2.713 ± 0.051	2.738PheVal: 2.738 ± 0.044	0.545PheTrp: 0.545 ± 0.024	1.387PheTyr: 1.387 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	5.898GlyAla: 5.898 ± 0.081	0.849GlyCys: 0.849 ± 0.029	3.618GlyAsp: 3.618 ± 0.06	4.03GlyGlu: 4.03 ± 0.056	3.326GlyPhe: 3.326 ± 0.058	4.711GlyGly: 4.711 ± 0.082	1.622GlyHis: 1.622 ± 0.038	4.506GlyIle: 4.506 ± 0.063	3.581GlyLys: 3.581 ± 0.063	7.166GlyLeu: 7.166 ± 0.085	2.11GlyMet: 2.11 ± 0.044	2.605GlyAsn: 2.605 ± 0.052	2.007GlyPro: 2.007 ± 0.042	3.247GlyGln: 3.247 ± 0.054	3.263GlyArg: 3.263 ± 0.056	4.045GlySer: 4.045 ± 0.071	3.575GlyThr: 3.575 ± 0.058	4.988GlyVal: 4.988 ± 0.071	1.044GlyTrp: 1.044 ± 0.031	2.708GlyTyr: 2.708 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.019HisAla: 2.019 ± 0.051	0.321HisCys: 0.321 ± 0.017	1.183HisAsp: 1.183 ± 0.036	1.198HisGlu: 1.198 ± 0.032	1.131HisPhe: 1.131 ± 0.033	1.675HisGly: 1.675 ± 0.036	0.789HisHis: 0.789 ± 0.032	1.471HisIle: 1.471 ± 0.038	1.016HisLys: 1.016 ± 0.031	2.218HisLeu: 2.218 ± 0.05	0.543HisMet: 0.543 ± 0.021	0.982HisAsn: 0.982 ± 0.027	1.255HisPro: 1.255 ± 0.035	1.279HisGln: 1.279 ± 0.04	1.283HisArg: 1.283 ± 0.032	1.558HisSer: 1.558 ± 0.037	1.399HisThr: 1.399 ± 0.032	1.372HisVal: 1.372 ± 0.035	0.404HisTrp: 0.404 ± 0.019	1.009HisTyr: 1.009 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	6.32IleAla: 6.32 ± 0.079	0.641IleCys: 0.641 ± 0.021	4.04IleAsp: 4.04 ± 0.055	3.901IleGlu: 3.901 ± 0.069	1.921IlePhe: 1.921 ± 0.04	4.325IleGly: 4.325 ± 0.065	1.169IleHis: 1.169 ± 0.029	3.239IleIle: 3.239 ± 0.058	2.668IleLys: 2.668 ± 0.05	4.71IleLeu: 4.71 ± 0.07	1.307IleMet: 1.307 ± 0.032	2.763IleAsn: 2.763 ± 0.047	2.353IlePro: 2.353 ± 0.038	2.018IleGln: 2.018 ± 0.038	2.757IleArg: 2.757 ± 0.051	4.184IleSer: 4.184 ± 0.061	3.732IleThr: 3.732 ± 0.06	3.987IleVal: 3.987 ± 0.069	0.577IleTrp: 0.577 ± 0.021	1.554IleTyr: 1.554 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.498LysAla: 4.498 ± 0.069	0.264LysCys: 0.264 ± 0.017	2.24LysAsp: 2.24 ± 0.048	2.362LysGlu: 2.362 ± 0.05	1.298LysPhe: 1.298 ± 0.034	2.806LysGly: 2.806 ± 0.054	1.168LysHis: 1.168 ± 0.029	2.33LysIle: 2.33 ± 0.044	2.133LysLys: 2.133 ± 0.054	4.477LysLeu: 4.477 ± 0.071	1.186LysMet: 1.186 ± 0.031	1.745LysAsn: 1.745 ± 0.036	2.171LysPro: 2.171 ± 0.048	2.612LysGln: 2.612 ± 0.053	2.575LysArg: 2.575 ± 0.054	2.437LysSer: 2.437 ± 0.055	2.601LysThr: 2.601 ± 0.043	3.278LysVal: 3.278 ± 0.053	0.469LysTrp: 0.469 ± 0.02	1.14LysTyr: 1.14 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.019LeuAla: 11.019 ± 0.114	1.145LeuCys: 1.145 ± 0.031	5.566LeuAsp: 5.566 ± 0.075	5.294LeuGlu: 5.294 ± 0.068	4.154LeuPhe: 4.154 ± 0.073	6.636LeuGly: 6.636 ± 0.082	2.384LeuHis: 2.384 ± 0.049	5.581LeuIle: 5.581 ± 0.072	4.455LeuLys: 4.455 ± 0.07	10.684LeuLeu: 10.684 ± 0.137	2.449LeuMet: 2.449 ± 0.046	4.362LeuAsn: 4.362 ± 0.057	5.087LeuPro: 5.087 ± 0.065	4.353LeuGln: 4.353 ± 0.069	4.779LeuArg: 4.779 ± 0.07	7.531LeuSer: 7.531 ± 0.093	6.391LeuThr: 6.391 ± 0.074	6.764LeuVal: 6.764 ± 0.087	1.092LeuTrp: 1.092 ± 0.033	2.87LeuTyr: 2.87 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.789MetAla: 2.789 ± 0.056	0.204MetCys: 0.204 ± 0.014	1.252MetAsp: 1.252 ± 0.031	1.208MetGlu: 1.208 ± 0.032	0.873MetPhe: 0.873 ± 0.03	1.685MetGly: 1.685 ± 0.039	0.569MetHis: 0.569 ± 0.021	1.156MetIle: 1.156 ± 0.034	1.212MetLys: 1.212 ± 0.028	2.869MetLeu: 2.869 ± 0.048	0.703MetMet: 0.703 ± 0.03	0.996MetAsn: 0.996 ± 0.026	1.302MetPro: 1.302 ± 0.034	1.419MetGln: 1.419 ± 0.033	1.245MetArg: 1.245 ± 0.032	1.731MetSer: 1.731 ± 0.043	1.519MetThr: 1.519 ± 0.034	1.749MetVal: 1.749 ± 0.04	0.245MetTrp: 0.245 ± 0.014	0.535MetTyr: 0.535 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.706AsnAla: 3.706 ± 0.058	0.358AsnCys: 0.358 ± 0.016	2.211AsnAsp: 2.211 ± 0.044	2.203AsnGlu: 2.203 ± 0.041	1.467AsnPhe: 1.467 ± 0.039	2.734AsnGly: 2.734 ± 0.058	0.896AsnHis: 0.896 ± 0.029	2.537AsnIle: 2.537 ± 0.048	1.878AsnLys: 1.878 ± 0.041	3.673AsnLeu: 3.673 ± 0.056	0.913AsnMet: 0.913 ± 0.026	1.81AsnAsn: 1.81 ± 0.046	2.028AsnPro: 2.028 ± 0.037	2.093AsnGln: 2.093 ± 0.042	2.135AsnArg: 2.135 ± 0.043	2.26AsnSer: 2.26 ± 0.046	2.489AsnThr: 2.489 ± 0.043	2.6AsnVal: 2.6 ± 0.055	0.636AsnTrp: 0.636 ± 0.023	1.301AsnTyr: 1.301 ± 0.035	0.0AsnXaa: 0.0 ± 0.0
Pro	4.744ProAla: 4.744 ± 0.069	0.317ProCys: 0.317 ± 0.017	2.844ProAsp: 2.844 ± 0.046	2.89ProGlu: 2.89 ± 0.083	1.698ProPhe: 1.698 ± 0.034	3.132ProGly: 3.132 ± 0.058	0.974ProHis: 0.974 ± 0.032	2.091ProIle: 2.091 ± 0.041	1.525ProLys: 1.525 ± 0.036	4.245ProLeu: 4.245 ± 0.067	0.975ProMet: 0.975 ± 0.032	1.381ProAsn: 1.381 ± 0.033	1.514ProPro: 1.514 ± 0.037	2.034ProGln: 2.034 ± 0.04	1.651ProArg: 1.651 ± 0.042	2.304ProSer: 2.304 ± 0.043	2.213ProThr: 2.213 ± 0.042	3.697ProVal: 3.697 ± 0.061	0.529ProTrp: 0.529 ± 0.02	1.301ProTyr: 1.301 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	5.471GlnAla: 5.471 ± 0.072	0.456GlnCys: 0.456 ± 0.021	2.259GlnAsp: 2.259 ± 0.049	2.218GlnGlu: 2.218 ± 0.049	1.887GlnPhe: 1.887 ± 0.038	3.118GlnGly: 3.118 ± 0.059	1.567GlnHis: 1.567 ± 0.045	2.548GlnIle: 2.548 ± 0.044	1.864GlnLys: 1.864 ± 0.042	5.478GlnLeu: 5.478 ± 0.092	1.133GlnMet: 1.133 ± 0.031	1.621GlnAsn: 1.621 ± 0.04	2.319GlnPro: 2.319 ± 0.048	3.988GlnGln: 3.988 ± 0.075	2.974GlnArg: 2.974 ± 0.053	2.796GlnSer: 2.796 ± 0.054	2.686GlnThr: 2.686 ± 0.051	3.484GlnVal: 3.484 ± 0.052	0.903GlnTrp: 0.903 ± 0.026	1.537GlnTyr: 1.537 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	4.119ArgAla: 4.119 ± 0.064	0.484ArgCys: 0.484 ± 0.024	2.544ArgAsp: 2.544 ± 0.044	3.043ArgGlu: 3.043 ± 0.047	2.459ArgPhe: 2.459 ± 0.044	2.759ArgGly: 2.759 ± 0.047	1.487ArgHis: 1.487 ± 0.035	3.034ArgIle: 3.034 ± 0.048	2.24ArgLys: 2.24 ± 0.05	5.593ArgLeu: 5.593 ± 0.066	1.276ArgMet: 1.276 ± 0.033	1.829ArgAsn: 1.829 ± 0.035	1.937ArgPro: 1.937 ± 0.041	2.96ArgGln: 2.96 ± 0.052	2.795ArgArg: 2.795 ± 0.05	2.739ArgSer: 2.739 ± 0.046	2.39ArgThr: 2.39 ± 0.044	3.257ArgVal: 3.257 ± 0.05	0.763ArgTrp: 0.763 ± 0.028	2.129ArgTyr: 2.129 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.408SerAla: 6.408 ± 0.075	0.573SerCys: 0.573 ± 0.023	3.415SerAsp: 3.415 ± 0.065	3.452SerGlu: 3.452 ± 0.054	2.536SerPhe: 2.536 ± 0.054	4.82SerGly: 4.82 ± 0.067	1.533SerHis: 1.533 ± 0.037	3.461SerIle: 3.461 ± 0.056	2.417SerLys: 2.417 ± 0.05	6.639SerLeu: 6.639 ± 0.086	1.605SerMet: 1.605 ± 0.041	2.198SerAsn: 2.198 ± 0.044	2.513SerPro: 2.513 ± 0.047	3.264SerGln: 3.264 ± 0.052	3.25SerArg: 3.25 ± 0.054	3.889SerSer: 3.889 ± 0.066	3.305SerThr: 3.305 ± 0.048	4.656SerVal: 4.656 ± 0.056	0.845SerTrp: 0.845 ± 0.023	1.922SerTyr: 1.922 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.483ThrAla: 5.483 ± 0.065	0.469ThrCys: 0.469 ± 0.02	3.279ThrAsp: 3.279 ± 0.055	2.958ThrGlu: 2.958 ± 0.051	2.179ThrPhe: 2.179 ± 0.043	4.524ThrGly: 4.524 ± 0.065	1.343ThrHis: 1.343 ± 0.037	3.195ThrIle: 3.195 ± 0.056	1.872ThrLys: 1.872 ± 0.046	7.102ThrLeu: 7.102 ± 0.097	1.222ThrMet: 1.222 ± 0.035	1.939ThrAsn: 1.939 ± 0.041	3.057ThrPro: 3.057 ± 0.051	2.759ThrGln: 2.759 ± 0.056	2.783ThrArg: 2.783 ± 0.046	3.389ThrSer: 3.389 ± 0.054	3.144ThrThr: 3.144 ± 0.044	4.293ThrVal: 4.293 ± 0.064	0.632ThrTrp: 0.632 ± 0.021	1.696ThrTyr: 1.696 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	6.957ValAla: 6.957 ± 0.082	0.748ValCys: 0.748 ± 0.024	4.007ValAsp: 4.007 ± 0.064	4.098ValGlu: 4.098 ± 0.066	2.848ValPhe: 2.848 ± 0.048	4.554ValGly: 4.554 ± 0.064	1.399ValHis: 1.399 ± 0.033	4.286ValIle: 4.286 ± 0.062	3.227ValLys: 3.227 ± 0.055	6.81ValLeu: 6.81 ± 0.084	1.893ValMet: 1.893 ± 0.04	3.105ValAsn: 3.105 ± 0.052	2.785ValPro: 2.785 ± 0.048	2.369ValGln: 2.369 ± 0.043	3.12ValArg: 3.12 ± 0.041	5.049ValSer: 5.049 ± 0.064	4.506ValThr: 4.506 ± 0.064	5.328ValVal: 5.328 ± 0.077	0.793ValTrp: 0.793 ± 0.024	2.012ValTyr: 2.012 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.96TrpAla: 0.96 ± 0.028	0.161TrpCys: 0.161 ± 0.011	0.645TrpAsp: 0.645 ± 0.026	0.561TrpGlu: 0.561 ± 0.022	0.592TrpPhe: 0.592 ± 0.023	0.77TrpGly: 0.77 ± 0.024	0.417TrpHis: 0.417 ± 0.017	0.641TrpIle: 0.641 ± 0.024	0.379TrpLys: 0.379 ± 0.019	1.807TrpLeu: 1.807 ± 0.045	0.356TrpMet: 0.356 ± 0.017	0.398TrpAsn: 0.398 ± 0.02	0.556TrpPro: 0.556 ± 0.021	1.172TrpGln: 1.172 ± 0.035	0.746TrpArg: 0.746 ± 0.025	0.665TrpSer: 0.665 ± 0.022	0.506TrpThr: 0.506 ± 0.023	0.845TrpVal: 0.845 ± 0.022	0.22TrpTrp: 0.22 ± 0.013	0.476TrpTyr: 0.476 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.807TyrAla: 2.807 ± 0.046	0.344TyrCys: 0.344 ± 0.018	1.765TyrAsp: 1.765 ± 0.04	1.627TyrGlu: 1.627 ± 0.033	1.467TyrPhe: 1.467 ± 0.032	2.192TyrGly: 2.192 ± 0.044	0.839TyrHis: 0.839 ± 0.026	1.635TyrIle: 1.635 ± 0.038	1.161TyrLys: 1.161 ± 0.029	3.39TyrLeu: 3.39 ± 0.063	0.633TyrMet: 0.633 ± 0.023	1.178TyrAsn: 1.178 ± 0.034	1.444TyrPro: 1.444 ± 0.036	1.894TyrGln: 1.894 ± 0.045	1.956TyrArg: 1.956 ± 0.041	2.009TyrSer: 2.009 ± 0.044	1.818TyrThr: 1.818 ± 0.038	1.819TyrVal: 1.819 ± 0.04	0.482TyrTrp: 0.482 ± 0.017	1.128TyrTyr: 1.128 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3700 proteins (1236480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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