Amino acid dipepetide frequency for Gardnerella vaginalis 00703Dmash

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.434AlaAla: 10.434 ± 0.242
1.084AlaCys: 1.084 ± 0.057
5.668AlaAsp: 5.668 ± 0.129
5.741AlaGlu: 5.741 ± 0.166
3.305AlaPhe: 3.305 ± 0.113
7.008AlaGly: 7.008 ± 0.161
2.01AlaHis: 2.01 ± 0.079
5.855AlaIle: 5.855 ± 0.133
6.497AlaLys: 6.497 ± 0.183
9.735AlaLeu: 9.735 ± 0.19
2.509AlaMet: 2.509 ± 0.079
4.462AlaAsn: 4.462 ± 0.146
3.208AlaPro: 3.208 ± 0.104
4.345AlaGln: 4.345 ± 0.121
4.783AlaArg: 4.783 ± 0.131
6.474AlaSer: 6.474 ± 0.128
4.836AlaThr: 4.836 ± 0.128
7.208AlaVal: 7.208 ± 0.164
1.185AlaTrp: 1.185 ± 0.051
2.581AlaTyr: 2.581 ± 0.101
0.0AlaXaa: 0.0 ± 0.0
Cys
1.325CysAla: 1.325 ± 0.066
0.144CysCys: 0.144 ± 0.022
0.697CysAsp: 0.697 ± 0.042
0.756CysGlu: 0.756 ± 0.05
0.362CysPhe: 0.362 ± 0.033
1.001CysGly: 1.001 ± 0.049
0.163CysHis: 0.163 ± 0.018
0.564CysIle: 0.564 ± 0.033
0.575CysLys: 0.575 ± 0.048
0.74CysLeu: 0.74 ± 0.045
0.243CysMet: 0.243 ± 0.026
0.426CysAsn: 0.426 ± 0.031
0.424CysPro: 0.424 ± 0.033
0.231CysGln: 0.231 ± 0.024
0.387CysArg: 0.387 ± 0.032
0.699CysSer: 0.699 ± 0.036
0.545CysThr: 0.545 ± 0.038
0.963CysVal: 0.963 ± 0.05
0.108CysTrp: 0.108 ± 0.016
0.266CysTyr: 0.266 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
6.355AspAla: 6.355 ± 0.189
0.678AspCys: 0.678 ± 0.041
4.052AspAsp: 4.052 ± 0.121
4.645AspGlu: 4.645 ± 0.111
2.576AspPhe: 2.576 ± 0.085
4.558AspGly: 4.558 ± 0.132
0.933AspHis: 0.933 ± 0.053
3.552AspIle: 3.552 ± 0.106
2.954AspLys: 2.954 ± 0.138
5.06AspLeu: 5.06 ± 0.12
1.425AspMet: 1.425 ± 0.065
2.448AspAsn: 2.448 ± 0.105
2.626AspPro: 2.626 ± 0.089
1.37AspGln: 1.37 ± 0.053
2.296AspArg: 2.296 ± 0.105
4.54AspSer: 4.54 ± 0.145
2.904AspThr: 2.904 ± 0.083
4.549AspVal: 4.549 ± 0.114
0.765AspTrp: 0.765 ± 0.049
1.953AspTyr: 1.953 ± 0.082
0.0AspXaa: 0.0 ± 0.0
Glu
5.814GluAla: 5.814 ± 0.17
0.513GluCys: 0.513 ± 0.036
3.836GluAsp: 3.836 ± 0.102
4.139GluGlu: 4.139 ± 0.132
1.884GluPhe: 1.884 ± 0.077
3.557GluGly: 3.557 ± 0.095
1.682GluHis: 1.682 ± 0.062
3.422GluIle: 3.422 ± 0.099
3.555GluLys: 3.555 ± 0.131
5.228GluLeu: 5.228 ± 0.121
1.32GluMet: 1.32 ± 0.055
3.667GluAsn: 3.667 ± 0.11
2.086GluPro: 2.086 ± 0.082
2.416GluGln: 2.416 ± 0.08
3.55GluArg: 3.55 ± 0.113
4.16GluSer: 4.16 ± 0.127
3.137GluThr: 3.137 ± 0.091
3.983GluVal: 3.983 ± 0.105
0.566GluTrp: 0.566 ± 0.039
1.799GluTyr: 1.799 ± 0.057
0.0GluXaa: 0.0 ± 0.0
Phe
4.144PheAla: 4.144 ± 0.114
0.41PheCys: 0.41 ± 0.033
2.503PheAsp: 2.503 ± 0.085
1.966PheGlu: 1.966 ± 0.058
1.226PhePhe: 1.226 ± 0.068
3.032PheGly: 3.032 ± 0.1
0.633PheHis: 0.633 ± 0.042
2.081PheIle: 2.081 ± 0.088
1.609PheLys: 1.609 ± 0.076
2.603PheLeu: 2.603 ± 0.088
0.914PheMet: 0.914 ± 0.05
1.666PheAsn: 1.666 ± 0.054
1.196PhePro: 1.196 ± 0.063
0.857PheGln: 0.857 ± 0.045
1.428PheArg: 1.428 ± 0.06
2.668PheSer: 2.668 ± 0.094
2.154PheThr: 2.154 ± 0.085
3.03PheVal: 3.03 ± 0.084
0.369PheTrp: 0.369 ± 0.029
0.944PheTyr: 0.944 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
5.975GlyAla: 5.975 ± 0.164
0.71GlyCys: 0.71 ± 0.033
3.777GlyAsp: 3.777 ± 0.096
4.26GlyGlu: 4.26 ± 0.128
3.018GlyPhe: 3.018 ± 0.092
4.574GlyGly: 4.574 ± 0.148
1.32GlyHis: 1.32 ± 0.062
4.462GlyIle: 4.462 ± 0.127
4.716GlyLys: 4.716 ± 0.153
5.984GlyLeu: 5.984 ± 0.139
1.849GlyMet: 1.849 ± 0.074
2.954GlyAsn: 2.954 ± 0.107
1.84GlyPro: 1.84 ± 0.068
1.813GlyGln: 1.813 ± 0.071
3.222GlyArg: 3.222 ± 0.097
5.03GlySer: 5.03 ± 0.119
3.841GlyThr: 3.841 ± 0.109
5.59GlyVal: 5.59 ± 0.114
0.91GlyTrp: 0.91 ± 0.053
2.312GlyTyr: 2.312 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.969HisAla: 1.969 ± 0.075
0.213HisCys: 0.213 ± 0.024
1.377HisAsp: 1.377 ± 0.061
1.222HisGlu: 1.222 ± 0.052
0.596HisPhe: 0.596 ± 0.037
1.545HisGly: 1.545 ± 0.071
0.543HisHis: 0.543 ± 0.04
1.318HisIle: 1.318 ± 0.06
1.015HisLys: 1.015 ± 0.053
1.499HisLeu: 1.499 ± 0.062
0.555HisMet: 0.555 ± 0.038
1.024HisAsn: 1.024 ± 0.052
1.107HisPro: 1.107 ± 0.049
0.561HisGln: 0.561 ± 0.035
1.109HisArg: 1.109 ± 0.054
1.228HisSer: 1.228 ± 0.054
1.228HisThr: 1.228 ± 0.057
1.623HisVal: 1.623 ± 0.067
0.234HisTrp: 0.234 ± 0.021
0.633HisTyr: 0.633 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.866IleAla: 6.866 ± 0.157
0.816IleCys: 0.816 ± 0.042
3.935IleAsp: 3.935 ± 0.097
3.433IleGlu: 3.433 ± 0.1
2.214IlePhe: 2.214 ± 0.092
4.29IleGly: 4.29 ± 0.121
1.089IleHis: 1.089 ± 0.044
3.791IleIle: 3.791 ± 0.125
2.677IleLys: 2.677 ± 0.096
4.758IleLeu: 4.758 ± 0.149
1.435IleMet: 1.435 ± 0.062
2.564IleAsn: 2.564 ± 0.083
2.771IlePro: 2.771 ± 0.076
1.497IleGln: 1.497 ± 0.058
2.821IleArg: 2.821 ± 0.075
4.604IleSer: 4.604 ± 0.119
3.58IleThr: 3.58 ± 0.082
5.143IleVal: 5.143 ± 0.137
0.6IleTrp: 0.6 ± 0.042
1.35IleTyr: 1.35 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.624LysAla: 5.624 ± 0.208
0.371LysCys: 0.371 ± 0.033
3.832LysAsp: 3.832 ± 0.171
3.351LysGlu: 3.351 ± 0.123
1.533LysPhe: 1.533 ± 0.063
3.238LysGly: 3.238 ± 0.116
1.348LysHis: 1.348 ± 0.054
3.206LysIle: 3.206 ± 0.084
3.784LysLys: 3.784 ± 0.152
4.95LysLeu: 4.95 ± 0.127
1.377LysMet: 1.377 ± 0.058
3.483LysAsn: 3.483 ± 0.125
2.846LysPro: 2.846 ± 0.126
2.338LysGln: 2.338 ± 0.1
3.043LysArg: 3.043 ± 0.088
4.474LysSer: 4.474 ± 0.116
3.344LysThr: 3.344 ± 0.14
3.6LysVal: 3.6 ± 0.105
0.587LysTrp: 0.587 ± 0.036
1.726LysTyr: 1.726 ± 0.067
0.0LysXaa: 0.0 ± 0.0
Leu
8.64LeuAla: 8.64 ± 0.167
1.093LeuCys: 1.093 ± 0.057
5.294LeuAsp: 5.294 ± 0.112
4.785LeuGlu: 4.785 ± 0.124
3.004LeuPhe: 3.004 ± 0.11
6.114LeuGly: 6.114 ± 0.146
2.017LeuHis: 2.017 ± 0.071
5.294LeuIle: 5.294 ± 0.136
4.749LeuLys: 4.749 ± 0.138
7.877LeuLeu: 7.877 ± 0.185
2.042LeuMet: 2.042 ± 0.092
3.8LeuAsn: 3.8 ± 0.093
4.244LeuPro: 4.244 ± 0.11
3.451LeuGln: 3.451 ± 0.1
5.14LeuArg: 5.14 ± 0.131
6.373LeuSer: 6.373 ± 0.14
4.907LeuThr: 4.907 ± 0.117
5.998LeuVal: 5.998 ± 0.146
0.885LeuTrp: 0.885 ± 0.052
1.994LeuTyr: 1.994 ± 0.078
0.0LeuXaa: 0.0 ± 0.0
Met
2.253MetAla: 2.253 ± 0.083
0.282MetCys: 0.282 ± 0.028
1.15MetAsp: 1.15 ± 0.053
1.031MetGlu: 1.031 ± 0.052
0.878MetPhe: 0.878 ± 0.053
1.409MetGly: 1.409 ± 0.063
0.527MetHis: 0.527 ± 0.034
1.476MetIle: 1.476 ± 0.067
1.247MetLys: 1.247 ± 0.054
2.521MetLeu: 2.521 ± 0.087
0.61MetMet: 0.61 ± 0.037
1.176MetAsn: 1.176 ± 0.056
1.37MetPro: 1.37 ± 0.065
1.043MetGln: 1.043 ± 0.055
1.657MetArg: 1.657 ± 0.061
1.739MetSer: 1.739 ± 0.059
1.444MetThr: 1.444 ± 0.06
1.655MetVal: 1.655 ± 0.076
0.257MetTrp: 0.257 ± 0.024
0.621MetTyr: 0.621 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
4.684AsnAla: 4.684 ± 0.158
0.438AsnCys: 0.438 ± 0.037
2.509AsnAsp: 2.509 ± 0.102
2.448AsnGlu: 2.448 ± 0.086
1.338AsnPhe: 1.338 ± 0.063
3.277AsnGly: 3.277 ± 0.109
0.91AsnHis: 0.91 ± 0.047
3.089AsnIle: 3.089 ± 0.086
3.092AsnLys: 3.092 ± 0.114
3.788AsnLeu: 3.788 ± 0.103
1.219AsnMet: 1.219 ± 0.052
3.128AsnAsn: 3.128 ± 0.136
2.746AsnPro: 2.746 ± 0.091
1.751AsnGln: 1.751 ± 0.078
2.209AsnArg: 2.209 ± 0.081
3.607AsnSer: 3.607 ± 0.139
2.645AsnThr: 2.645 ± 0.108
3.211AsnVal: 3.211 ± 0.106
0.552AsnTrp: 0.552 ± 0.033
1.281AsnTyr: 1.281 ± 0.062
0.0AsnXaa: 0.0 ± 0.0
Pro
3.587ProAla: 3.587 ± 0.104
0.325ProCys: 0.325 ± 0.028
2.427ProAsp: 2.427 ± 0.086
3.094ProGlu: 3.094 ± 0.102
1.483ProPhe: 1.483 ± 0.06
2.704ProGly: 2.704 ± 0.083
0.825ProHis: 0.825 ± 0.044
2.367ProIle: 2.367 ± 0.075
2.347ProLys: 2.347 ± 0.072
3.401ProLeu: 3.401 ± 0.097
0.974ProMet: 0.974 ± 0.08
1.923ProAsn: 1.923 ± 0.077
0.965ProPro: 0.965 ± 0.056
1.682ProGln: 1.682 ± 0.066
1.678ProArg: 1.678 ± 0.072
2.819ProSer: 2.819 ± 0.083
2.542ProThr: 2.542 ± 0.097
3.428ProVal: 3.428 ± 0.085
0.603ProTrp: 0.603 ± 0.042
1.256ProTyr: 1.256 ± 0.06
0.0ProXaa: 0.0 ± 0.0
Gln
3.419GlnAla: 3.419 ± 0.117
0.291GlnCys: 0.291 ± 0.025
1.902GlnAsp: 1.902 ± 0.07
2.09GlnGlu: 2.09 ± 0.079
1.086GlnPhe: 1.086 ± 0.054
2.152GlnGly: 2.152 ± 0.076
0.788GlnHis: 0.788 ± 0.044
2.303GlnIle: 2.303 ± 0.075
2.024GlnLys: 2.024 ± 0.087
2.988GlnLeu: 2.988 ± 0.098
0.859GlnMet: 0.859 ± 0.042
1.992GlnAsn: 1.992 ± 0.085
1.387GlnPro: 1.387 ± 0.086
1.694GlnGln: 1.694 ± 0.075
2.047GlnArg: 2.047 ± 0.07
2.374GlnSer: 2.374 ± 0.091
1.822GlnThr: 1.822 ± 0.061
2.344GlnVal: 2.344 ± 0.075
0.481GlnTrp: 0.481 ± 0.04
1.208GlnTyr: 1.208 ± 0.066
0.0GlnXaa: 0.0 ± 0.0
Arg
4.59ArgAla: 4.59 ± 0.115
0.435ArgCys: 0.435 ± 0.034
2.734ArgAsp: 2.734 ± 0.094
3.667ArgGlu: 3.667 ± 0.101
2.003ArgPhe: 2.003 ± 0.078
3.062ArgGly: 3.062 ± 0.098
1.015ArgHis: 1.015 ± 0.057
3.22ArgIle: 3.22 ± 0.095
3.259ArgLys: 3.259 ± 0.093
4.483ArgLeu: 4.483 ± 0.112
1.471ArgMet: 1.471 ± 0.061
2.294ArgAsn: 2.294 ± 0.076
1.76ArgPro: 1.76 ± 0.078
1.641ArgGln: 1.641 ± 0.066
3.133ArgArg: 3.133 ± 0.114
2.922ArgSer: 2.922 ± 0.095
2.695ArgThr: 2.695 ± 0.081
3.912ArgVal: 3.912 ± 0.116
0.633ArgTrp: 0.633 ± 0.043
1.705ArgTyr: 1.705 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
7.098SerAla: 7.098 ± 0.155
0.72SerCys: 0.72 ± 0.044
4.148SerAsp: 4.148 ± 0.125
4.111SerGlu: 4.111 ± 0.124
2.48SerPhe: 2.48 ± 0.099
5.124SerGly: 5.124 ± 0.141
1.469SerHis: 1.469 ± 0.063
4.029SerIle: 4.029 ± 0.121
4.478SerLys: 4.478 ± 0.132
6.227SerLeu: 6.227 ± 0.134
1.68SerMet: 1.68 ± 0.061
3.509SerAsn: 3.509 ± 0.128
2.069SerPro: 2.069 ± 0.064
2.784SerGln: 2.784 ± 0.099
3.5SerArg: 3.5 ± 0.102
5.757SerSer: 5.757 ± 0.188
3.907SerThr: 3.907 ± 0.127
5.273SerVal: 5.273 ± 0.124
0.891SerTrp: 0.891 ± 0.048
2.003SerTyr: 2.003 ± 0.075
0.0SerXaa: 0.0 ± 0.0
Thr
4.918ThrAla: 4.918 ± 0.137
0.612ThrCys: 0.612 ± 0.04
3.016ThrAsp: 3.016 ± 0.11
2.64ThrGlu: 2.64 ± 0.098
2.095ThrPhe: 2.095 ± 0.068
3.896ThrGly: 3.896 ± 0.104
1.185ThrHis: 1.185 ± 0.053
3.364ThrIle: 3.364 ± 0.089
3.023ThrLys: 3.023 ± 0.132
5.299ThrLeu: 5.299 ± 0.131
1.157ThrMet: 1.157 ± 0.053
2.358ThrAsn: 2.358 ± 0.087
2.894ThrPro: 2.894 ± 0.105
2.134ThrGln: 2.134 ± 0.081
2.633ThrArg: 2.633 ± 0.086
3.882ThrSer: 3.882 ± 0.109
3.213ThrThr: 3.213 ± 0.131
4.611ThrVal: 4.611 ± 0.12
0.651ThrTrp: 0.651 ± 0.039
1.533ThrTyr: 1.533 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
7.324ValAla: 7.324 ± 0.176
0.958ValCys: 0.958 ± 0.054
4.806ValAsp: 4.806 ± 0.133
4.524ValGlu: 4.524 ± 0.133
2.732ValPhe: 2.732 ± 0.091
4.62ValGly: 4.62 ± 0.135
1.375ValHis: 1.375 ± 0.067
4.712ValIle: 4.712 ± 0.117
4.162ValLys: 4.162 ± 0.112
7.194ValLeu: 7.194 ± 0.186
1.723ValMet: 1.723 ± 0.074
3.202ValAsn: 3.202 ± 0.098
3.419ValPro: 3.419 ± 0.094
2.154ValGln: 2.154 ± 0.075
3.761ValArg: 3.761 ± 0.099
5.374ValSer: 5.374 ± 0.139
4.364ValThr: 4.364 ± 0.111
5.821ValVal: 5.821 ± 0.148
0.731ValTrp: 0.731 ± 0.04
1.84ValTyr: 1.84 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.908TrpAla: 0.908 ± 0.047
0.174TrpCys: 0.174 ± 0.023
0.619TrpAsp: 0.619 ± 0.039
0.548TrpGlu: 0.548 ± 0.032
0.513TrpPhe: 0.513 ± 0.034
0.706TrpGly: 0.706 ± 0.049
0.282TrpHis: 0.282 ± 0.026
0.724TrpIle: 0.724 ± 0.051
0.644TrpLys: 0.644 ± 0.048
1.194TrpLeu: 1.194 ± 0.058
0.39TrpMet: 0.39 ± 0.032
0.616TrpAsn: 0.616 ± 0.04
0.417TrpPro: 0.417 ± 0.033
0.594TrpGln: 0.594 ± 0.04
0.752TrpArg: 0.752 ± 0.051
0.722TrpSer: 0.722 ± 0.037
0.536TrpThr: 0.536 ± 0.039
0.658TrpVal: 0.658 ± 0.043
0.241TrpTrp: 0.241 ± 0.028
0.399TrpTyr: 0.399 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.002TyrAla: 3.002 ± 0.082
0.351TyrCys: 0.351 ± 0.033
1.959TyrAsp: 1.959 ± 0.076
1.861TyrGlu: 1.861 ± 0.074
1.107TyrPhe: 1.107 ± 0.048
2.289TyrGly: 2.289 ± 0.081
0.488TyrHis: 0.488 ± 0.038
1.403TyrIle: 1.403 ± 0.06
1.65TyrLys: 1.65 ± 0.08
2.173TyrLeu: 2.173 ± 0.082
0.589TyrMet: 0.589 ± 0.038
1.231TyrAsn: 1.231 ± 0.059
1.052TyrPro: 1.052 ± 0.05
0.896TyrGln: 0.896 ± 0.06
1.485TyrArg: 1.485 ± 0.064
1.81TyrSer: 1.81 ± 0.077
1.471TyrThr: 1.471 ± 0.058
2.198TyrVal: 2.198 ± 0.086
0.387TyrTrp: 0.387 ± 0.031
0.93TyrTyr: 0.93 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1166 proteins (436347 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski