Amino acid dipepetide frequency for Cognatiyoonia sediminum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.326AlaAla: 13.326 ± 0.164	1.052AlaCys: 1.052 ± 0.036	6.716AlaAsp: 6.716 ± 0.105	7.761AlaGlu: 7.761 ± 0.113	4.257AlaPhe: 4.257 ± 0.071	8.928AlaGly: 8.928 ± 0.106	1.997AlaHis: 1.997 ± 0.049	6.153AlaIle: 6.153 ± 0.087	4.656AlaLys: 4.656 ± 0.08	11.542AlaLeu: 11.542 ± 0.128	3.576AlaMet: 3.576 ± 0.064	3.139AlaAsn: 3.139 ± 0.055	4.667AlaPro: 4.667 ± 0.088	4.021AlaGln: 4.021 ± 0.072	6.124AlaArg: 6.124 ± 0.097	5.748AlaSer: 5.748 ± 0.076	5.939AlaThr: 5.939 ± 0.072	7.552AlaVal: 7.552 ± 0.108	1.26AlaTrp: 1.26 ± 0.037	2.488AlaTyr: 2.488 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.999CysAla: 0.999 ± 0.035	0.121CysCys: 0.121 ± 0.011	0.673CysAsp: 0.673 ± 0.028	0.522CysGlu: 0.522 ± 0.022	0.375CysPhe: 0.375 ± 0.019	1.025CysGly: 1.025 ± 0.034	0.242CysHis: 0.242 ± 0.017	0.456CysIle: 0.456 ± 0.023	0.261CysLys: 0.261 ± 0.015	0.841CysLeu: 0.841 ± 0.029	0.183CysMet: 0.183 ± 0.014	0.281CysAsn: 0.281 ± 0.017	0.453CysPro: 0.453 ± 0.022	0.26CysGln: 0.26 ± 0.014	0.478CysArg: 0.478 ± 0.021	0.51CysSer: 0.51 ± 0.021	0.482CysThr: 0.482 ± 0.021	0.638CysVal: 0.638 ± 0.026	0.108CysTrp: 0.108 ± 0.01	0.23CysTyr: 0.23 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	7.288AspAla: 7.288 ± 0.105	0.555AspCys: 0.555 ± 0.023	3.873AspAsp: 3.873 ± 0.087	4.074AspGlu: 4.074 ± 0.071	2.562AspPhe: 2.562 ± 0.054	5.844AspGly: 5.844 ± 0.097	1.455AspHis: 1.455 ± 0.042	3.529AspIle: 3.529 ± 0.069	1.981AspLys: 1.981 ± 0.045	6.631AspLeu: 6.631 ± 0.103	1.74AspMet: 1.74 ± 0.042	1.536AspAsn: 1.536 ± 0.044	3.491AspPro: 3.491 ± 0.064	2.314AspGln: 2.314 ± 0.042	3.829AspArg: 3.829 ± 0.064	2.302AspSer: 2.302 ± 0.048	3.181AspThr: 3.181 ± 0.064	5.002AspVal: 5.002 ± 0.085	1.163AspTrp: 1.163 ± 0.037	1.659AspTyr: 1.659 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.706GluAla: 7.706 ± 0.11	0.408GluCys: 0.408 ± 0.02	3.952GluAsp: 3.952 ± 0.067	4.129GluGlu: 4.129 ± 0.082	2.131GluPhe: 2.131 ± 0.047	4.93GluGly: 4.93 ± 0.078	1.195GluHis: 1.195 ± 0.038	3.965GluIle: 3.965 ± 0.057	2.501GluLys: 2.501 ± 0.062	5.627GluLeu: 5.627 ± 0.087	1.892GluMet: 1.892 ± 0.049	2.325GluAsn: 2.325 ± 0.047	2.604GluPro: 2.604 ± 0.061	2.115GluGln: 2.115 ± 0.054	4.099GluArg: 4.099 ± 0.072	2.384GluSer: 2.384 ± 0.054	4.139GluThr: 4.139 ± 0.059	4.74GluVal: 4.74 ± 0.072	0.815GluTrp: 0.815 ± 0.028	1.199GluTyr: 1.199 ± 0.036	0.0GluXaa: 0.0 ± 0.0
Phe	4.389PheAla: 4.389 ± 0.063	0.455PheCys: 0.455 ± 0.023	3.259PheAsp: 3.259 ± 0.058	2.717PheGlu: 2.717 ± 0.057	1.699PhePhe: 1.699 ± 0.046	4.019PheGly: 4.019 ± 0.07	0.781PheHis: 0.781 ± 0.027	1.961PheIle: 1.961 ± 0.048	1.205PheLys: 1.205 ± 0.032	3.578PheLeu: 3.578 ± 0.07	0.953PheMet: 0.953 ± 0.03	1.183PheAsn: 1.183 ± 0.032	1.595PhePro: 1.595 ± 0.039	1.183PheGln: 1.183 ± 0.034	2.045PheArg: 2.045 ± 0.046	2.363PheSer: 2.363 ± 0.049	2.118PheThr: 2.118 ± 0.043	2.959PheVal: 2.959 ± 0.057	0.62PheTrp: 0.62 ± 0.026	1.033PheTyr: 1.033 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.63GlyAla: 8.63 ± 0.105	0.9GlyCys: 0.9 ± 0.031	4.826GlyAsp: 4.826 ± 0.091	4.768GlyGlu: 4.768 ± 0.072	3.788GlyPhe: 3.788 ± 0.064	6.998GlyGly: 6.998 ± 0.111	1.818GlyHis: 1.818 ± 0.049	4.665GlyIle: 4.665 ± 0.073	3.36GlyLys: 3.36 ± 0.066	8.462GlyLeu: 8.462 ± 0.098	2.477GlyMet: 2.477 ± 0.058	2.309GlyAsn: 2.309 ± 0.06	3.464GlyPro: 3.464 ± 0.063	3.123GlyGln: 3.123 ± 0.059	4.903GlyArg: 4.903 ± 0.071	4.634GlySer: 4.634 ± 0.079	4.634GlyThr: 4.634 ± 0.085	6.419GlyVal: 6.419 ± 0.084	1.4GlyTrp: 1.4 ± 0.04	2.415GlyTyr: 2.415 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	2.015HisAla: 2.015 ± 0.053	0.257HisCys: 0.257 ± 0.016	1.282HisAsp: 1.282 ± 0.045	1.037HisGlu: 1.037 ± 0.035	0.853HisPhe: 0.853 ± 0.034	1.733HisGly: 1.733 ± 0.048	0.538HisHis: 0.538 ± 0.031	1.09HisIle: 1.09 ± 0.029	0.638HisLys: 0.638 ± 0.026	2.012HisLeu: 2.012 ± 0.049	0.577HisMet: 0.577 ± 0.025	0.516HisAsn: 0.516 ± 0.022	1.267HisPro: 1.267 ± 0.04	0.634HisGln: 0.634 ± 0.027	1.118HisArg: 1.118 ± 0.036	0.962HisSer: 0.962 ± 0.034	0.867HisThr: 0.867 ± 0.034	1.462HisVal: 1.462 ± 0.043	0.35HisTrp: 0.35 ± 0.019	0.555HisTyr: 0.555 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	6.996IleAla: 6.996 ± 0.092	0.647IleCys: 0.647 ± 0.024	3.973IleAsp: 3.973 ± 0.082	4.113IleGlu: 4.113 ± 0.065	2.137IlePhe: 2.137 ± 0.057	5.273IleGly: 5.273 ± 0.079	0.961IleHis: 0.961 ± 0.032	2.828IleIle: 2.828 ± 0.06	1.898IleLys: 1.898 ± 0.043	5.126IleLeu: 5.126 ± 0.086	1.29IleMet: 1.29 ± 0.039	1.687IleAsn: 1.687 ± 0.042	2.556IlePro: 2.556 ± 0.052	1.477IleGln: 1.477 ± 0.035	3.025IleArg: 3.025 ± 0.054	3.556IleSer: 3.556 ± 0.072	3.067IleThr: 3.067 ± 0.068	4.165IleVal: 4.165 ± 0.068	0.791IleTrp: 0.791 ± 0.029	1.283IleTyr: 1.283 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	4.264LysAla: 4.264 ± 0.075	0.211LysCys: 0.211 ± 0.012	2.405LysAsp: 2.405 ± 0.055	2.199LysGlu: 2.199 ± 0.049	1.212LysPhe: 1.212 ± 0.037	2.997LysGly: 2.997 ± 0.063	0.739LysHis: 0.739 ± 0.027	2.087LysIle: 2.087 ± 0.045	1.54LysLys: 1.54 ± 0.049	3.409LysLeu: 3.409 ± 0.061	1.041LysMet: 1.041 ± 0.033	1.056LysAsn: 1.056 ± 0.034	1.949LysPro: 1.949 ± 0.045	1.095LysGln: 1.095 ± 0.03	2.446LysArg: 2.446 ± 0.055	2.316LysSer: 2.316 ± 0.056	2.258LysThr: 2.258 ± 0.053	2.741LysVal: 2.741 ± 0.065	0.449LysTrp: 0.449 ± 0.021	0.75LysTyr: 0.75 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	10.866LeuAla: 10.866 ± 0.125	0.938LeuCys: 0.938 ± 0.03	6.091LeuAsp: 6.091 ± 0.09	5.642LeuGlu: 5.642 ± 0.088	3.583LeuPhe: 3.583 ± 0.061	7.851LeuGly: 7.851 ± 0.108	1.676LeuHis: 1.676 ± 0.046	5.575LeuIle: 5.575 ± 0.08	3.776LeuLys: 3.776 ± 0.075	8.204LeuLeu: 8.204 ± 0.111	2.615LeuMet: 2.615 ± 0.061	3.131LeuAsn: 3.131 ± 0.056	4.898LeuPro: 4.898 ± 0.071	2.797LeuGln: 2.797 ± 0.057	5.83LeuArg: 5.83 ± 0.082	6.711LeuSer: 6.711 ± 0.092	5.971LeuThr: 5.971 ± 0.084	6.358LeuVal: 6.358 ± 0.111	1.285LeuTrp: 1.285 ± 0.042	1.982LeuTyr: 1.982 ± 0.044	0.0LeuXaa: 0.0 ± 0.0
Met	3.225MetAla: 3.225 ± 0.064	0.231MetCys: 0.231 ± 0.014	1.52MetAsp: 1.52 ± 0.044	1.482MetGlu: 1.482 ± 0.048	0.95MetPhe: 0.95 ± 0.031	2.282MetGly: 2.282 ± 0.064	0.48MetHis: 0.48 ± 0.027	1.803MetIle: 1.803 ± 0.046	1.254MetLys: 1.254 ± 0.035	2.439MetLeu: 2.439 ± 0.049	0.832MetMet: 0.832 ± 0.032	0.988MetAsn: 0.988 ± 0.03	1.433MetPro: 1.433 ± 0.04	0.924MetGln: 0.924 ± 0.028	1.728MetArg: 1.728 ± 0.049	1.985MetSer: 1.985 ± 0.042	2.15MetThr: 2.15 ± 0.046	1.895MetVal: 1.895 ± 0.047	0.278MetTrp: 0.278 ± 0.016	0.38MetTyr: 0.38 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.441AsnAla: 3.441 ± 0.065	0.325AsnCys: 0.325 ± 0.018	1.867AsnAsp: 1.867 ± 0.056	1.606AsnGlu: 1.606 ± 0.043	1.201AsnPhe: 1.201 ± 0.039	2.894AsnGly: 2.894 ± 0.065	0.579AsnHis: 0.579 ± 0.024	1.735AsnIle: 1.735 ± 0.043	0.839AsnLys: 0.839 ± 0.032	2.91AsnLeu: 2.91 ± 0.06	0.817AsnMet: 0.817 ± 0.026	0.847AsnAsn: 0.847 ± 0.03	2.061AsnPro: 2.061 ± 0.043	0.901AsnGln: 0.901 ± 0.032	1.798AsnArg: 1.798 ± 0.041	1.527AsnSer: 1.527 ± 0.036	1.593AsnThr: 1.593 ± 0.042	2.226AsnVal: 2.226 ± 0.05	0.545AsnTrp: 0.545 ± 0.025	0.82AsnTyr: 0.82 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.538ProAla: 4.538 ± 0.07	0.337ProCys: 0.337 ± 0.02	3.609ProAsp: 3.609 ± 0.067	3.859ProGlu: 3.859 ± 0.061	2.044ProPhe: 2.044 ± 0.046	3.242ProGly: 3.242 ± 0.064	1.025ProHis: 1.025 ± 0.036	2.727ProIle: 2.727 ± 0.054	2.005ProLys: 2.005 ± 0.052	4.262ProLeu: 4.262 ± 0.07	1.342ProMet: 1.342 ± 0.037	1.789ProAsn: 1.789 ± 0.043	1.8ProPro: 1.8 ± 0.051	1.597ProGln: 1.597 ± 0.044	2.202ProArg: 2.202 ± 0.045	2.704ProSer: 2.704 ± 0.057	2.735ProThr: 2.735 ± 0.067	3.637ProVal: 3.637 ± 0.063	0.626ProTrp: 0.626 ± 0.024	1.188ProTyr: 1.188 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	3.619GlnAla: 3.619 ± 0.055	0.224GlnCys: 0.224 ± 0.015	1.846GlnAsp: 1.846 ± 0.047	1.767GlnGlu: 1.767 ± 0.043	1.28GlnPhe: 1.28 ± 0.035	2.403GlnGly: 2.403 ± 0.052	0.603GlnHis: 0.603 ± 0.026	2.221GlnIle: 2.221 ± 0.046	1.237GlnLys: 1.237 ± 0.039	2.948GlnLeu: 2.948 ± 0.056	1.139GlnMet: 1.139 ± 0.036	1.142GlnAsn: 1.142 ± 0.038	1.49GlnPro: 1.49 ± 0.04	1.091GlnGln: 1.091 ± 0.035	2.115GlnArg: 2.115 ± 0.05	2.066GlnSer: 2.066 ± 0.054	2.021GlnThr: 2.021 ± 0.046	2.435GlnVal: 2.435 ± 0.051	0.406GlnTrp: 0.406 ± 0.024	0.68GlnTyr: 0.68 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.036ArgAla: 6.036 ± 0.087	0.444ArgCys: 0.444 ± 0.021	3.704ArgAsp: 3.704 ± 0.068	3.397ArgGlu: 3.397 ± 0.059	2.472ArgPhe: 2.472 ± 0.05	3.953ArgGly: 3.953 ± 0.074	1.23ArgHis: 1.23 ± 0.037	3.444ArgIle: 3.444 ± 0.057	2.355ArgLys: 2.355 ± 0.053	5.977ArgLeu: 5.977 ± 0.093	1.809ArgMet: 1.809 ± 0.042	1.786ArgAsn: 1.786 ± 0.039	2.691ArgPro: 2.691 ± 0.056	2.078ArgGln: 2.078 ± 0.045	3.901ArgArg: 3.901 ± 0.07	3.252ArgSer: 3.252 ± 0.059	2.831ArgThr: 2.831 ± 0.05	4.084ArgVal: 4.084 ± 0.073	0.829ArgTrp: 0.829 ± 0.033	1.507ArgTyr: 1.507 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.795SerAla: 5.795 ± 0.077	0.498SerCys: 0.498 ± 0.022	3.802SerAsp: 3.802 ± 0.057	3.429SerGlu: 3.429 ± 0.059	2.548SerPhe: 2.548 ± 0.057	5.487SerGly: 5.487 ± 0.088	1.119SerHis: 1.119 ± 0.032	3.128SerIle: 3.128 ± 0.06	2.141SerLys: 2.141 ± 0.049	5.237SerLeu: 5.237 ± 0.084	1.53SerMet: 1.53 ± 0.04	1.806SerAsn: 1.806 ± 0.047	2.442SerPro: 2.442 ± 0.048	1.805SerGln: 1.805 ± 0.048	2.956SerArg: 2.956 ± 0.062	3.003SerSer: 3.003 ± 0.061	2.805SerThr: 2.805 ± 0.048	4.084SerVal: 4.084 ± 0.076	0.774SerTrp: 0.774 ± 0.028	1.405SerTyr: 1.405 ± 0.033	0.0SerXaa: 0.0 ± 0.0
Thr	5.845ThrAla: 5.845 ± 0.087	0.5ThrCys: 0.5 ± 0.024	3.503ThrAsp: 3.503 ± 0.071	3.26ThrGlu: 3.26 ± 0.052	2.352ThrPhe: 2.352 ± 0.053	5.106ThrGly: 5.106 ± 0.078	1.16ThrHis: 1.16 ± 0.036	3.207ThrIle: 3.207 ± 0.075	1.949ThrLys: 1.949 ± 0.044	5.87ThrLeu: 5.87 ± 0.08	1.417ThrMet: 1.417 ± 0.036	1.656ThrAsn: 1.656 ± 0.044	3.26ThrPro: 3.26 ± 0.049	1.723ThrGln: 1.723 ± 0.042	2.96ThrArg: 2.96 ± 0.056	3.043ThrSer: 3.043 ± 0.055	3.105ThrThr: 3.105 ± 0.061	4.379ThrVal: 4.379 ± 0.066	0.717ThrTrp: 0.717 ± 0.028	1.446ThrTyr: 1.446 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.189ValAla: 8.189 ± 0.095	0.661ValCys: 0.661 ± 0.024	4.529ValAsp: 4.529 ± 0.072	4.892ValGlu: 4.892 ± 0.083	3.01ValPhe: 3.01 ± 0.063	5.809ValGly: 5.809 ± 0.083	1.278ValHis: 1.278 ± 0.037	4.357ValIle: 4.357 ± 0.066	2.388ValLys: 2.388 ± 0.062	6.962ValLeu: 6.962 ± 0.09	2.109ValMet: 2.109 ± 0.045	2.166ValAsn: 2.166 ± 0.042	3.385ValPro: 3.385 ± 0.065	2.181ValGln: 2.181 ± 0.044	3.814ValArg: 3.814 ± 0.062	4.524ValSer: 4.524 ± 0.076	4.61ValThr: 4.61 ± 0.073	5.644ValVal: 5.644 ± 0.094	0.937ValTrp: 0.937 ± 0.031	1.594ValTyr: 1.594 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.303TrpAla: 1.303 ± 0.04	0.143TrpCys: 0.143 ± 0.011	0.881TrpAsp: 0.881 ± 0.029	0.743TrpGlu: 0.743 ± 0.03	0.608TrpPhe: 0.608 ± 0.025	1.014TrpGly: 1.014 ± 0.038	0.322TrpHis: 0.322 ± 0.018	0.798TrpIle: 0.798 ± 0.028	0.49TrpLys: 0.49 ± 0.023	1.487TrpLeu: 1.487 ± 0.049	0.395TrpMet: 0.395 ± 0.021	0.48TrpAsn: 0.48 ± 0.022	0.695TrpPro: 0.695 ± 0.026	0.584TrpGln: 0.584 ± 0.026	0.895TrpArg: 0.895 ± 0.037	0.853TrpSer: 0.853 ± 0.032	0.777TrpThr: 0.777 ± 0.033	0.964TrpVal: 0.964 ± 0.032	0.238TrpTrp: 0.238 ± 0.016	0.313TrpTyr: 0.313 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.431TyrAla: 2.431 ± 0.048	0.229TyrCys: 0.229 ± 0.016	1.7TyrAsp: 1.7 ± 0.041	1.46TyrGlu: 1.46 ± 0.04	1.055TyrPhe: 1.055 ± 0.036	2.204TyrGly: 2.204 ± 0.05	0.566TyrHis: 0.566 ± 0.023	1.12TyrIle: 1.12 ± 0.032	0.689TyrLys: 0.689 ± 0.024	2.256TyrLeu: 2.256 ± 0.047	0.524TyrMet: 0.524 ± 0.024	0.709TyrAsn: 0.709 ± 0.025	1.067TyrPro: 1.067 ± 0.036	0.831TyrGln: 0.831 ± 0.027	1.514TyrArg: 1.514 ± 0.041	1.35TyrSer: 1.35 ± 0.041	1.174TyrThr: 1.174 ± 0.036	1.656TyrVal: 1.656 ± 0.044	0.392TyrTrp: 0.392 ± 0.02	0.667TyrTyr: 0.667 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3230 proteins (985169 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---