Amino acid dipepetide frequency for Poseidonibacter parvus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.743AlaAla: 3.743 ± 0.155
0.609AlaCys: 0.609 ± 0.031
2.8AlaAsp: 2.8 ± 0.135
2.437AlaGlu: 2.437 ± 0.082
2.934AlaPhe: 2.934 ± 0.082
3.749AlaGly: 3.749 ± 0.159
0.964AlaHis: 0.964 ± 0.033
5.742AlaIle: 5.742 ± 0.095
5.572AlaLys: 5.572 ± 0.13
6.253AlaLeu: 6.253 ± 0.12
1.605AlaMet: 1.605 ± 0.055
3.57AlaAsn: 3.57 ± 0.085
1.458AlaPro: 1.458 ± 0.054
1.988AlaGln: 1.988 ± 0.065
1.72AlaArg: 1.72 ± 0.062
4.304AlaSer: 4.304 ± 0.084
3.185AlaThr: 3.185 ± 0.12
3.663AlaVal: 3.663 ± 0.087
0.446AlaTrp: 0.446 ± 0.028
2.22AlaTyr: 2.22 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.507CysAla: 0.507 ± 0.023
0.099CysCys: 0.099 ± 0.012
0.624CysAsp: 0.624 ± 0.03
0.637CysGlu: 0.637 ± 0.031
0.364CysPhe: 0.364 ± 0.023
0.656CysGly: 0.656 ± 0.031
0.211CysHis: 0.211 ± 0.016
0.66CysIle: 0.66 ± 0.026
0.7CysLys: 0.7 ± 0.029
0.607CysLeu: 0.607 ± 0.029
0.167CysMet: 0.167 ± 0.015
0.515CysAsn: 0.515 ± 0.026
0.363CysPro: 0.363 ± 0.024
0.211CysGln: 0.211 ± 0.015
0.196CysArg: 0.196 ± 0.015
0.661CysSer: 0.661 ± 0.03
0.451CysThr: 0.451 ± 0.026
0.479CysVal: 0.479 ± 0.025
0.058CysTrp: 0.058 ± 0.009
0.285CysTyr: 0.285 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.428AspAla: 3.428 ± 0.118
0.491AspCys: 0.491 ± 0.026
3.722AspAsp: 3.722 ± 0.273
5.284AspGlu: 5.284 ± 0.129
3.627AspPhe: 3.627 ± 0.065
3.731AspGly: 3.731 ± 0.307
0.593AspHis: 0.593 ± 0.024
6.634AspIle: 6.634 ± 0.138
5.31AspLys: 5.31 ± 0.105
5.722AspLeu: 5.722 ± 0.096
1.319AspMet: 1.319 ± 0.042
3.523AspAsn: 3.523 ± 0.108
1.188AspPro: 1.188 ± 0.047
0.947AspGln: 0.947 ± 0.035
1.375AspArg: 1.375 ± 0.049
3.591AspSer: 3.591 ± 0.134
3.481AspThr: 3.481 ± 0.382
3.585AspVal: 3.585 ± 0.131
0.421AspTrp: 0.421 ± 0.023
2.667AspTyr: 2.667 ± 0.099
0.0AspXaa: 0.0 ± 0.0
Glu
4.155GluAla: 4.155 ± 0.144
0.48GluCys: 0.48 ± 0.024
4.519GluAsp: 4.519 ± 0.16
6.103GluGlu: 6.103 ± 0.116
3.448GluPhe: 3.448 ± 0.068
3.121GluGly: 3.121 ± 0.119
1.124GluHis: 1.124 ± 0.037
6.734GluIle: 6.734 ± 0.123
7.158GluLys: 7.158 ± 0.169
7.156GluLeu: 7.156 ± 0.116
1.524GluMet: 1.524 ± 0.054
5.332GluAsn: 5.332 ± 0.114
1.361GluPro: 1.361 ± 0.049
2.191GluGln: 2.191 ± 0.057
1.597GluArg: 1.597 ± 0.059
3.407GluSer: 3.407 ± 0.072
3.0GluThr: 3.0 ± 0.075
4.6GluVal: 4.6 ± 0.09
0.388GluTrp: 0.388 ± 0.022
2.912GluTyr: 2.912 ± 0.071
0.0GluXaa: 0.0 ± 0.0
Phe
3.027PheAla: 3.027 ± 0.075
0.527PheCys: 0.527 ± 0.024
3.4PheAsp: 3.4 ± 0.068
3.566PheGlu: 3.566 ± 0.071
2.83PhePhe: 2.83 ± 0.097
2.874PheGly: 2.874 ± 0.075
0.676PheHis: 0.676 ± 0.026
4.964PheIle: 4.964 ± 0.111
4.213PheLys: 4.213 ± 0.094
4.857PheLeu: 4.857 ± 0.123
1.111PheMet: 1.111 ± 0.039
3.019PheAsn: 3.019 ± 0.067
1.206PhePro: 1.206 ± 0.041
1.094PheGln: 1.094 ± 0.044
1.208PheArg: 1.208 ± 0.043
3.66PheSer: 3.66 ± 0.074
2.959PheThr: 2.959 ± 0.075
2.899PheVal: 2.899 ± 0.071
0.403PheTrp: 0.403 ± 0.026
1.977PheTyr: 1.977 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
3.48GlyAla: 3.48 ± 0.108
0.609GlyCys: 0.609 ± 0.03
3.033GlyAsp: 3.033 ± 0.336
3.278GlyGlu: 3.278 ± 0.118
3.121GlyPhe: 3.121 ± 0.07
3.632GlyGly: 3.632 ± 0.244
0.951GlyHis: 0.951 ± 0.037
5.014GlyIle: 5.014 ± 0.08
4.42GlyLys: 4.42 ± 0.094
5.176GlyLeu: 5.176 ± 0.092
1.507GlyMet: 1.507 ± 0.053
2.782GlyAsn: 2.782 ± 0.239
0.921GlyPro: 0.921 ± 0.038
1.406GlyGln: 1.406 ± 0.043
1.615GlyArg: 1.615 ± 0.05
3.621GlySer: 3.621 ± 0.165
3.222GlyThr: 3.222 ± 0.224
3.854GlyVal: 3.854 ± 0.089
0.484GlyTrp: 0.484 ± 0.027
2.359GlyTyr: 2.359 ± 0.059
0.0GlyXaa: 0.0 ± 0.0
His
0.773HisAla: 0.773 ± 0.034
0.161HisCys: 0.161 ± 0.015
0.801HisAsp: 0.801 ± 0.03
0.968HisGlu: 0.968 ± 0.037
0.831HisPhe: 0.831 ± 0.032
0.919HisGly: 0.919 ± 0.036
0.355HisHis: 0.355 ± 0.022
1.343HisIle: 1.343 ± 0.044
1.246HisLys: 1.246 ± 0.045
1.458HisLeu: 1.458 ± 0.052
0.398HisMet: 0.398 ± 0.024
0.895HisAsn: 0.895 ± 0.04
0.682HisPro: 0.682 ± 0.034
0.519HisGln: 0.519 ± 0.027
0.509HisArg: 0.509 ± 0.028
0.999HisSer: 0.999 ± 0.038
0.837HisThr: 0.837 ± 0.033
0.718HisVal: 0.718 ± 0.029
0.146HisTrp: 0.146 ± 0.013
0.576HisTyr: 0.576 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
6.001IleAla: 6.001 ± 0.108
0.763IleCys: 0.763 ± 0.034
6.359IleAsp: 6.359 ± 0.15
6.994IleGlu: 6.994 ± 0.103
4.47IlePhe: 4.47 ± 0.115
5.098IleGly: 5.098 ± 0.084
1.281IleHis: 1.281 ± 0.046
8.236IleIle: 8.236 ± 0.128
8.984IleLys: 8.984 ± 0.169
8.744IleLeu: 8.744 ± 0.149
1.696IleMet: 1.696 ± 0.048
6.164IleAsn: 6.164 ± 0.1
2.812IlePro: 2.812 ± 0.065
2.428IleGln: 2.428 ± 0.065
2.32IleArg: 2.32 ± 0.069
7.285IleSer: 7.285 ± 0.107
5.367IleThr: 5.367 ± 0.203
5.4IleVal: 5.4 ± 0.088
0.532IleTrp: 0.532 ± 0.027
3.314IleTyr: 3.314 ± 0.08
0.0IleXaa: 0.0 ± 0.0
Lys
5.172LysAla: 5.172 ± 0.112
0.53LysCys: 0.53 ± 0.03
6.609LysAsp: 6.609 ± 0.124
8.772LysGlu: 8.772 ± 0.169
3.432LysPhe: 3.432 ± 0.088
3.879LysGly: 3.879 ± 0.081
1.31LysHis: 1.31 ± 0.049
8.303LysIle: 8.303 ± 0.167
9.284LysLys: 9.284 ± 0.206
8.064LysLeu: 8.064 ± 0.15
2.364LysMet: 2.364 ± 0.065
6.931LysAsn: 6.931 ± 0.159
2.187LysPro: 2.187 ± 0.065
3.021LysGln: 3.021 ± 0.088
2.994LysArg: 2.994 ± 0.095
5.424LysSer: 5.424 ± 0.112
4.819LysThr: 4.819 ± 0.103
5.415LysVal: 5.415 ± 0.119
0.554LysTrp: 0.554 ± 0.029
4.013LysTyr: 4.013 ± 0.106
0.0LysXaa: 0.0 ± 0.0
Leu
5.65LeuAla: 5.65 ± 0.115
0.79LeuCys: 0.79 ± 0.033
5.981LeuAsp: 5.981 ± 0.113
7.193LeuGlu: 7.193 ± 0.119
4.823LeuPhe: 4.823 ± 0.126
5.39LeuGly: 5.39 ± 0.101
1.313LeuHis: 1.313 ± 0.047
8.275LeuIle: 8.275 ± 0.162
9.229LeuLys: 9.229 ± 0.181
9.128LeuLeu: 9.128 ± 0.18
2.013LeuMet: 2.013 ± 0.063
6.558LeuAsn: 6.558 ± 0.107
2.899LeuPro: 2.899 ± 0.074
2.679LeuGln: 2.679 ± 0.071
2.595LeuArg: 2.595 ± 0.07
7.285LeuSer: 7.285 ± 0.108
5.069LeuThr: 5.069 ± 0.116
5.412LeuVal: 5.412 ± 0.084
0.614LeuTrp: 0.614 ± 0.031
3.389LeuTyr: 3.389 ± 0.081
0.0LeuXaa: 0.0 ± 0.0
Met
1.506MetAla: 1.506 ± 0.047
0.188MetCys: 0.188 ± 0.016
1.177MetAsp: 1.177 ± 0.036
1.179MetGlu: 1.179 ± 0.048
1.137MetPhe: 1.137 ± 0.04
1.359MetGly: 1.359 ± 0.05
0.372MetHis: 0.372 ± 0.021
2.137MetIle: 2.137 ± 0.065
2.214MetLys: 2.214 ± 0.062
2.147MetLeu: 2.147 ± 0.064
0.616MetMet: 0.616 ± 0.033
1.465MetAsn: 1.465 ± 0.049
0.907MetPro: 0.907 ± 0.045
0.866MetGln: 0.866 ± 0.034
0.587MetArg: 0.587 ± 0.028
1.756MetSer: 1.756 ± 0.049
1.108MetThr: 1.108 ± 0.042
1.195MetVal: 1.195 ± 0.045
0.149MetTrp: 0.149 ± 0.013
0.75MetTyr: 0.75 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.442AsnAla: 3.442 ± 0.082
0.492AsnCys: 0.492 ± 0.026
4.067AsnAsp: 4.067 ± 0.209
4.978AsnGlu: 4.978 ± 0.095
3.009AsnPhe: 3.009 ± 0.074
3.053AsnGly: 3.053 ± 0.094
1.009AsnHis: 1.009 ± 0.045
7.115AsnIle: 7.115 ± 0.162
6.273AsnLys: 6.273 ± 0.13
5.826AsnLeu: 5.826 ± 0.112
1.35AsnMet: 1.35 ± 0.049
4.079AsnAsn: 4.079 ± 0.09
2.083AsnPro: 2.083 ± 0.066
1.84AsnGln: 1.84 ± 0.048
1.759AsnArg: 1.759 ± 0.064
4.562AsnSer: 4.562 ± 0.106
3.644AsnThr: 3.644 ± 0.091
3.222AsnVal: 3.222 ± 0.085
0.439AsnTrp: 0.439 ± 0.024
2.494AsnTyr: 2.494 ± 0.07
0.0AsnXaa: 0.0 ± 0.0
Pro
1.425ProAla: 1.425 ± 0.081
0.207ProCys: 0.207 ± 0.015
1.377ProAsp: 1.377 ± 0.07
1.649ProGlu: 1.649 ± 0.073
1.512ProPhe: 1.512 ± 0.048
1.206ProGly: 1.206 ± 0.05
0.509ProHis: 0.509 ± 0.027
2.527ProIle: 2.527 ± 0.066
2.376ProLys: 2.376 ± 0.068
2.693ProLeu: 2.693 ± 0.071
0.626ProMet: 0.626 ± 0.031
1.663ProAsn: 1.663 ± 0.052
0.552ProPro: 0.552 ± 0.038
0.734ProGln: 0.734 ± 0.033
0.733ProArg: 0.733 ± 0.032
2.023ProSer: 2.023 ± 0.051
1.614ProThr: 1.614 ± 0.076
1.619ProVal: 1.619 ± 0.055
0.244ProTrp: 0.244 ± 0.018
1.218ProTyr: 1.218 ± 0.043
0.0ProXaa: 0.0 ± 0.0
Gln
1.702GlnAla: 1.702 ± 0.043
0.176GlnCys: 0.176 ± 0.014
1.618GlnAsp: 1.618 ± 0.046
2.181GlnGlu: 2.181 ± 0.058
1.124GlnPhe: 1.124 ± 0.04
1.311GlnGly: 1.311 ± 0.042
0.354GlnHis: 0.354 ± 0.021
2.661GlnIle: 2.661 ± 0.066
2.889GlnLys: 2.889 ± 0.079
2.368GlnLeu: 2.368 ± 0.06
0.733GlnMet: 0.733 ± 0.034
2.121GlnAsn: 2.121 ± 0.057
0.578GlnPro: 0.578 ± 0.025
0.689GlnGln: 0.689 ± 0.035
1.129GlnArg: 1.129 ± 0.045
1.766GlnSer: 1.766 ± 0.05
1.697GlnThr: 1.697 ± 0.058
1.615GlnVal: 1.615 ± 0.047
0.294GlnTrp: 0.294 ± 0.019
0.987GlnTyr: 0.987 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
1.737ArgAla: 1.737 ± 0.054
0.228ArgCys: 0.228 ± 0.015
1.632ArgAsp: 1.632 ± 0.043
1.895ArgGlu: 1.895 ± 0.063
1.498ArgPhe: 1.498 ± 0.049
1.497ArgGly: 1.497 ± 0.049
0.474ArgHis: 0.474 ± 0.026
2.438ArgIle: 2.438 ± 0.076
2.311ArgLys: 2.311 ± 0.072
2.595ArgLeu: 2.595 ± 0.078
0.698ArgMet: 0.698 ± 0.031
1.67ArgAsn: 1.67 ± 0.05
0.729ArgPro: 0.729 ± 0.033
0.724ArgGln: 0.724 ± 0.033
1.028ArgArg: 1.028 ± 0.043
1.448ArgSer: 1.448 ± 0.048
1.374ArgThr: 1.374 ± 0.049
2.005ArgVal: 2.005 ± 0.062
0.229ArgTrp: 0.229 ± 0.015
1.172ArgTyr: 1.172 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
3.607SerAla: 3.607 ± 0.066
0.62SerCys: 0.62 ± 0.026
3.572SerAsp: 3.572 ± 0.147
3.464SerGlu: 3.464 ± 0.08
4.021SerPhe: 4.021 ± 0.091
3.82SerGly: 3.82 ± 0.149
1.112SerHis: 1.112 ± 0.034
6.612SerIle: 6.612 ± 0.099
6.652SerLys: 6.652 ± 0.129
7.147SerLeu: 7.147 ± 0.128
1.657SerMet: 1.657 ± 0.047
4.701SerAsn: 4.701 ± 0.112
1.482SerPro: 1.482 ± 0.052
2.058SerGln: 2.058 ± 0.054
1.868SerArg: 1.868 ± 0.056
5.529SerSer: 5.529 ± 0.129
3.654SerThr: 3.654 ± 0.103
3.742SerVal: 3.742 ± 0.093
0.52SerTrp: 0.52 ± 0.028
2.822SerTyr: 2.822 ± 0.067
0.0SerXaa: 0.0 ± 0.0
Thr
3.366ThrAla: 3.366 ± 0.12
0.415ThrCys: 0.415 ± 0.022
2.63ThrAsp: 2.63 ± 0.187
2.222ThrGlu: 2.222 ± 0.095
2.756ThrPhe: 2.756 ± 0.078
3.151ThrGly: 3.151 ± 0.207
0.865ThrHis: 0.865 ± 0.035
5.522ThrIle: 5.522 ± 0.185
4.805ThrLys: 4.805 ± 0.102
5.705ThrLeu: 5.705 ± 0.178
1.054ThrMet: 1.054 ± 0.04
3.464ThrAsn: 3.464 ± 0.093
2.041ThrPro: 2.041 ± 0.099
1.729ThrGln: 1.729 ± 0.046
1.338ThrArg: 1.338 ± 0.053
3.901ThrSer: 3.901 ± 0.099
3.283ThrThr: 3.283 ± 0.157
3.42ThrVal: 3.42 ± 0.25
0.428ThrTrp: 0.428 ± 0.027
2.188ThrTyr: 2.188 ± 0.059
0.0ThrXaa: 0.0 ± 0.0
Val
3.721ValAla: 3.721 ± 0.12
0.627ValCys: 0.627 ± 0.028
3.826ValAsp: 3.826 ± 0.204
4.039ValGlu: 4.039 ± 0.093
2.813ValPhe: 2.813 ± 0.065
3.449ValGly: 3.449 ± 0.071
0.88ValHis: 0.88 ± 0.033
5.315ValIle: 5.315 ± 0.078
4.893ValLys: 4.893 ± 0.097
5.877ValLeu: 5.877 ± 0.103
1.348ValMet: 1.348 ± 0.048
3.51ValAsn: 3.51 ± 0.082
1.727ValPro: 1.727 ± 0.067
1.63ValGln: 1.63 ± 0.044
1.55ValArg: 1.55 ± 0.042
4.193ValSer: 4.193 ± 0.068
3.136ValThr: 3.136 ± 0.171
3.895ValVal: 3.895 ± 0.096
0.392ValTrp: 0.392 ± 0.02
2.19ValTyr: 2.19 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.413TrpAla: 0.413 ± 0.027
0.079TrpCys: 0.079 ± 0.01
0.4TrpAsp: 0.4 ± 0.023
0.464TrpGlu: 0.464 ± 0.025
0.404TrpPhe: 0.404 ± 0.024
0.468TrpGly: 0.468 ± 0.023
0.15TrpHis: 0.15 ± 0.016
0.628TrpIle: 0.628 ± 0.03
0.529TrpLys: 0.529 ± 0.028
0.717TrpLeu: 0.717 ± 0.033
0.231TrpMet: 0.231 ± 0.021
0.429TrpAsn: 0.429 ± 0.022
0.162TrpPro: 0.162 ± 0.014
0.24TrpGln: 0.24 ± 0.015
0.25TrpArg: 0.25 ± 0.016
0.395TrpSer: 0.395 ± 0.022
0.321TrpThr: 0.321 ± 0.021
0.483TrpVal: 0.483 ± 0.025
0.061TrpTrp: 0.061 ± 0.009
0.308TrpTyr: 0.308 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.107TyrAla: 2.107 ± 0.057
0.359TyrCys: 0.359 ± 0.025
2.494TyrAsp: 2.494 ± 0.068
3.005TyrGlu: 3.005 ± 0.059
2.318TyrPhe: 2.318 ± 0.076
2.122TyrGly: 2.122 ± 0.089
0.633TyrHis: 0.633 ± 0.03
3.385TyrIle: 3.385 ± 0.067
4.019TyrLys: 4.019 ± 0.11
4.043TyrLeu: 4.043 ± 0.101
0.797TyrMet: 0.797 ± 0.038
2.345TyrAsn: 2.345 ± 0.055
1.169TyrPro: 1.169 ± 0.045
0.999TyrGln: 0.999 ± 0.04
1.01TyrArg: 1.01 ± 0.035
2.849TyrSer: 2.849 ± 0.06
2.064TyrThr: 2.064 ± 0.06
1.789TyrVal: 1.789 ± 0.057
0.332TyrTrp: 0.332 ± 0.021
1.57TyrTyr: 1.57 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2691 proteins (878469 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski