Amino acid dipepetide frequency for Devosia crocina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.858AlaAla: 15.858 ± 0.166	0.748AlaCys: 0.748 ± 0.028	6.922AlaAsp: 6.922 ± 0.082	7.954AlaGlu: 7.954 ± 0.096	4.39AlaPhe: 4.39 ± 0.067	10.416AlaGly: 10.416 ± 0.117	2.118AlaHis: 2.118 ± 0.048	6.982AlaIle: 6.982 ± 0.078	3.533AlaLys: 3.533 ± 0.067	13.693AlaLeu: 13.693 ± 0.147	3.703AlaMet: 3.703 ± 0.055	3.218AlaAsn: 3.218 ± 0.058	5.479AlaPro: 5.479 ± 0.091	4.368AlaGln: 4.368 ± 0.078	7.92AlaArg: 7.92 ± 0.104	6.437AlaSer: 6.437 ± 0.084	5.885AlaThr: 5.885 ± 0.069	8.579AlaVal: 8.579 ± 0.105	1.357AlaTrp: 1.357 ± 0.039	2.519AlaTyr: 2.519 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.786CysAla: 0.786 ± 0.029	0.091CysCys: 0.091 ± 0.011	0.399CysAsp: 0.399 ± 0.02	0.341CysGlu: 0.341 ± 0.019	0.278CysPhe: 0.278 ± 0.015	0.709CysGly: 0.709 ± 0.027	0.185CysHis: 0.185 ± 0.014	0.316CysIle: 0.316 ± 0.015	0.161CysLys: 0.161 ± 0.014	0.655CysLeu: 0.655 ± 0.025	0.123CysMet: 0.123 ± 0.011	0.182CysAsn: 0.182 ± 0.013	0.303CysPro: 0.303 ± 0.02	0.216CysGln: 0.216 ± 0.014	0.461CysArg: 0.461 ± 0.021	0.389CysSer: 0.389 ± 0.02	0.328CysThr: 0.328 ± 0.017	0.478CysVal: 0.478 ± 0.023	0.099CysTrp: 0.099 ± 0.01	0.162CysTyr: 0.162 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.63AspAla: 6.63 ± 0.084	0.409AspCys: 0.409 ± 0.019	2.927AspAsp: 2.927 ± 0.06	3.451AspGlu: 3.451 ± 0.064	2.311AspPhe: 2.311 ± 0.047	4.988AspGly: 4.988 ± 0.071	1.246AspHis: 1.246 ± 0.037	3.468AspIle: 3.468 ± 0.056	1.751AspLys: 1.751 ± 0.047	6.053AspLeu: 6.053 ± 0.077	1.425AspMet: 1.425 ± 0.036	1.447AspAsn: 1.447 ± 0.05	3.262AspPro: 3.262 ± 0.063	1.927AspGln: 1.927 ± 0.041	4.079AspArg: 4.079 ± 0.077	2.201AspSer: 2.201 ± 0.051	2.806AspThr: 2.806 ± 0.052	4.124AspVal: 4.124 ± 0.053	1.022AspTrp: 1.022 ± 0.029	1.473AspTyr: 1.473 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.963GluAla: 7.963 ± 0.094	0.282GluCys: 0.282 ± 0.017	3.054GluAsp: 3.054 ± 0.059	3.496GluGlu: 3.496 ± 0.064	1.92GluPhe: 1.92 ± 0.046	4.491GluGly: 4.491 ± 0.057	1.273GluHis: 1.273 ± 0.037	3.519GluIle: 3.519 ± 0.06	2.168GluLys: 2.168 ± 0.051	5.524GluLeu: 5.524 ± 0.078	1.562GluMet: 1.562 ± 0.036	1.777GluAsn: 1.777 ± 0.045	2.885GluPro: 2.885 ± 0.061	2.218GluGln: 2.218 ± 0.054	4.68GluArg: 4.68 ± 0.071	2.502GluSer: 2.502 ± 0.044	3.778GluThr: 3.778 ± 0.059	4.04GluVal: 4.04 ± 0.058	0.739GluTrp: 0.739 ± 0.027	0.954GluTyr: 0.954 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.901PheAla: 4.901 ± 0.071	0.372PheCys: 0.372 ± 0.016	2.663PheAsp: 2.663 ± 0.049	2.267PheGlu: 2.267 ± 0.047	1.598PhePhe: 1.598 ± 0.045	3.914PheGly: 3.914 ± 0.065	0.751PheHis: 0.751 ± 0.027	1.833PheIle: 1.833 ± 0.045	0.977PheLys: 0.977 ± 0.031	3.403PheLeu: 3.403 ± 0.056	0.839PheMet: 0.839 ± 0.029	1.158PheAsn: 1.158 ± 0.032	1.625PhePro: 1.625 ± 0.038	1.043PheGln: 1.043 ± 0.029	2.142PheArg: 2.142 ± 0.041	2.444PheSer: 2.444 ± 0.045	2.069PheThr: 2.069 ± 0.036	3.023PheVal: 3.023 ± 0.055	0.629PheTrp: 0.629 ± 0.024	0.995PheTyr: 0.995 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	9.081GlyAla: 9.081 ± 0.119	0.625GlyCys: 0.625 ± 0.026	4.225GlyAsp: 4.225 ± 0.07	5.217GlyGlu: 5.217 ± 0.071	3.714GlyPhe: 3.714 ± 0.062	7.068GlyGly: 7.068 ± 0.137	1.833GlyHis: 1.833 ± 0.046	4.891GlyIle: 4.891 ± 0.07	3.225GlyLys: 3.225 ± 0.062	9.022GlyLeu: 9.022 ± 0.098	2.291GlyMet: 2.291 ± 0.04	2.448GlyAsn: 2.448 ± 0.071	3.411GlyPro: 3.411 ± 0.051	3.211GlyGln: 3.211 ± 0.056	5.533GlyArg: 5.533 ± 0.076	4.673GlySer: 4.673 ± 0.072	4.865GlyThr: 4.865 ± 0.077	6.233GlyVal: 6.233 ± 0.081	1.308GlyTrp: 1.308 ± 0.036	2.24GlyTyr: 2.24 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	2.197HisAla: 2.197 ± 0.048	0.184HisCys: 0.184 ± 0.013	1.234HisAsp: 1.234 ± 0.036	1.072HisGlu: 1.072 ± 0.032	0.888HisPhe: 0.888 ± 0.026	1.806HisGly: 1.806 ± 0.047	0.584HisHis: 0.584 ± 0.03	0.987HisIle: 0.987 ± 0.031	0.514HisLys: 0.514 ± 0.022	2.052HisLeu: 2.052 ± 0.042	0.518HisMet: 0.518 ± 0.02	0.499HisAsn: 0.499 ± 0.021	1.259HisPro: 1.259 ± 0.036	0.66HisGln: 0.66 ± 0.028	1.437HisArg: 1.437 ± 0.04	0.952HisSer: 0.952 ± 0.027	0.865HisThr: 0.865 ± 0.031	1.458HisVal: 1.458 ± 0.034	0.335HisTrp: 0.335 ± 0.019	0.581HisTyr: 0.581 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	7.654IleAla: 7.654 ± 0.084	0.473IleCys: 0.473 ± 0.021	3.795IleAsp: 3.795 ± 0.073	3.853IleGlu: 3.853 ± 0.061	1.95IlePhe: 1.95 ± 0.047	5.142IleGly: 5.142 ± 0.077	0.925IleHis: 0.925 ± 0.032	2.62IleIle: 2.62 ± 0.061	1.487IleLys: 1.487 ± 0.042	4.843IleLeu: 4.843 ± 0.083	1.139IleMet: 1.139 ± 0.031	1.548IleAsn: 1.548 ± 0.039	2.32IlePro: 2.32 ± 0.052	1.209IleGln: 1.209 ± 0.036	3.065IleArg: 3.065 ± 0.058	3.129IleSer: 3.129 ± 0.051	2.935IleThr: 2.935 ± 0.057	4.451IleVal: 4.451 ± 0.074	0.657IleTrp: 0.657 ± 0.026	1.239IleTyr: 1.239 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	3.974LysAla: 3.974 ± 0.073	0.124LysCys: 0.124 ± 0.01	1.538LysAsp: 1.538 ± 0.041	1.308LysGlu: 1.308 ± 0.043	0.874LysPhe: 0.874 ± 0.03	2.441LysGly: 2.441 ± 0.051	0.635LysHis: 0.635 ± 0.028	1.576LysIle: 1.576 ± 0.043	1.096LysLys: 1.096 ± 0.039	3.166LysLeu: 3.166 ± 0.061	0.692LysMet: 0.692 ± 0.024	0.786LysAsn: 0.786 ± 0.029	1.958LysPro: 1.958 ± 0.051	0.933LysGln: 0.933 ± 0.029	2.229LysArg: 2.229 ± 0.051	1.788LysSer: 1.788 ± 0.044	1.867LysThr: 1.867 ± 0.042	2.342LysVal: 2.342 ± 0.051	0.357LysTrp: 0.357 ± 0.017	0.527LysTyr: 0.527 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	13.879LeuAla: 13.879 ± 0.13	0.742LeuCys: 0.742 ± 0.026	6.389LeuAsp: 6.389 ± 0.079	5.67LeuGlu: 5.67 ± 0.084	3.838LeuPhe: 3.838 ± 0.065	8.709LeuGly: 8.709 ± 0.102	1.76LeuHis: 1.76 ± 0.043	5.148LeuIle: 5.148 ± 0.071	3.113LeuLys: 3.113 ± 0.058	9.786LeuLeu: 9.786 ± 0.141	2.357LeuMet: 2.357 ± 0.047	2.715LeuAsn: 2.715 ± 0.05	5.455LeuPro: 5.455 ± 0.081	2.804LeuGln: 2.804 ± 0.054	6.566LeuArg: 6.566 ± 0.083	6.676LeuSer: 6.676 ± 0.087	5.794LeuThr: 5.794 ± 0.075	8.241LeuVal: 8.241 ± 0.099	1.091LeuTrp: 1.091 ± 0.031	2.131LeuTyr: 2.131 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.252MetAla: 3.252 ± 0.059	0.13MetCys: 0.13 ± 0.01	1.218MetAsp: 1.218 ± 0.032	1.104MetGlu: 1.104 ± 0.035	0.754MetPhe: 0.754 ± 0.028	1.951MetGly: 1.951 ± 0.046	0.43MetHis: 0.43 ± 0.018	1.438MetIle: 1.438 ± 0.041	0.808MetLys: 0.808 ± 0.025	2.567MetLeu: 2.567 ± 0.056	0.619MetMet: 0.619 ± 0.026	0.785MetAsn: 0.785 ± 0.025	1.523MetPro: 1.523 ± 0.038	0.87MetGln: 0.87 ± 0.03	1.805MetArg: 1.805 ± 0.044	1.797MetSer: 1.797 ± 0.038	1.97MetThr: 1.97 ± 0.042	1.836MetVal: 1.836 ± 0.046	0.174MetTrp: 0.174 ± 0.013	0.292MetTyr: 0.292 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.312AsnAla: 3.312 ± 0.059	0.195AsnCys: 0.195 ± 0.015	1.439AsnAsp: 1.439 ± 0.039	1.449AsnGlu: 1.449 ± 0.034	1.026AsnPhe: 1.026 ± 0.027	2.629AsnGly: 2.629 ± 0.066	0.552AsnHis: 0.552 ± 0.024	1.43AsnIle: 1.43 ± 0.041	0.795AsnLys: 0.795 ± 0.027	2.787AsnLeu: 2.787 ± 0.057	0.652AsnMet: 0.652 ± 0.029	0.78AsnAsn: 0.78 ± 0.029	1.841AsnPro: 1.841 ± 0.04	0.928AsnGln: 0.928 ± 0.033	1.859AsnArg: 1.859 ± 0.042	1.447AsnSer: 1.447 ± 0.054	1.367AsnThr: 1.367 ± 0.037	1.991AsnVal: 1.991 ± 0.04	0.5AsnTrp: 0.5 ± 0.021	0.759AsnTyr: 0.759 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	5.965ProAla: 5.965 ± 0.087	0.243ProCys: 0.243 ± 0.014	3.506ProAsp: 3.506 ± 0.06	3.729ProGlu: 3.729 ± 0.066	2.041ProPhe: 2.041 ± 0.041	4.201ProGly: 4.201 ± 0.067	1.093ProHis: 1.093 ± 0.036	2.521ProIle: 2.521 ± 0.05	1.55ProLys: 1.55 ± 0.039	4.792ProLeu: 4.792 ± 0.075	1.197ProMet: 1.197 ± 0.033	1.413ProAsn: 1.413 ± 0.037	2.265ProPro: 2.265 ± 0.055	1.73ProGln: 1.73 ± 0.043	2.802ProArg: 2.802 ± 0.048	2.765ProSer: 2.765 ± 0.057	2.583ProThr: 2.583 ± 0.049	4.205ProVal: 4.205 ± 0.069	0.616ProTrp: 0.616 ± 0.023	1.121ProTyr: 1.121 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.033GlnAla: 4.033 ± 0.067	0.18GlnCys: 0.18 ± 0.013	1.497GlnAsp: 1.497 ± 0.038	1.495GlnGlu: 1.495 ± 0.039	1.294GlnPhe: 1.294 ± 0.033	2.502GlnGly: 2.502 ± 0.048	0.676GlnHis: 0.676 ± 0.025	1.883GlnIle: 1.883 ± 0.044	1.04GlnLys: 1.04 ± 0.036	3.279GlnLeu: 3.279 ± 0.061	1.023GlnMet: 1.023 ± 0.027	0.982GlnAsn: 0.982 ± 0.034	1.819GlnPro: 1.819 ± 0.045	1.356GlnGln: 1.356 ± 0.041	2.591GlnArg: 2.591 ± 0.058	2.103GlnSer: 2.103 ± 0.05	1.916GlnThr: 1.916 ± 0.046	2.458GlnVal: 2.458 ± 0.05	0.394GlnTrp: 0.394 ± 0.02	0.676GlnTyr: 0.676 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	7.105ArgAla: 7.105 ± 0.082	0.372ArgCys: 0.372 ± 0.019	3.824ArgAsp: 3.824 ± 0.06	3.846ArgGlu: 3.846 ± 0.059	2.879ArgPhe: 2.879 ± 0.049	4.507ArgGly: 4.507 ± 0.064	1.58ArgHis: 1.58 ± 0.043	3.822ArgIle: 3.822 ± 0.059	2.117ArgLys: 2.117 ± 0.054	7.413ArgLeu: 7.413 ± 0.111	1.804ArgMet: 1.804 ± 0.038	1.823ArgAsn: 1.823 ± 0.037	3.287ArgPro: 3.287 ± 0.055	2.767ArgGln: 2.767 ± 0.05	4.877ArgArg: 4.877 ± 0.09	3.691ArgSer: 3.691 ± 0.057	3.337ArgThr: 3.337 ± 0.052	4.632ArgVal: 4.632 ± 0.069	0.882ArgTrp: 0.882 ± 0.03	1.627ArgTyr: 1.627 ± 0.035	0.0ArgXaa: 0.0 ± 0.0
Ser	6.663SerAla: 6.663 ± 0.086	0.335SerCys: 0.335 ± 0.019	3.016SerAsp: 3.016 ± 0.059	3.07SerGlu: 3.07 ± 0.055	2.407SerPhe: 2.407 ± 0.049	5.653SerGly: 5.653 ± 0.081	1.144SerHis: 1.144 ± 0.031	2.954SerIle: 2.954 ± 0.054	1.509SerLys: 1.509 ± 0.039	5.656SerLeu: 5.656 ± 0.091	1.442SerMet: 1.442 ± 0.039	1.549SerAsn: 1.549 ± 0.037	2.666SerPro: 2.666 ± 0.051	1.884SerGln: 1.884 ± 0.042	3.5SerArg: 3.5 ± 0.058	3.144SerSer: 3.144 ± 0.062	2.878SerThr: 2.878 ± 0.059	4.306SerVal: 4.306 ± 0.069	0.777SerTrp: 0.777 ± 0.029	1.355SerTyr: 1.355 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	6.259ThrAla: 6.259 ± 0.081	0.332ThrCys: 0.332 ± 0.02	2.983ThrAsp: 2.983 ± 0.057	2.983ThrGlu: 2.983 ± 0.053	2.091ThrPhe: 2.091 ± 0.045	5.101ThrGly: 5.101 ± 0.071	1.098ThrHis: 1.098 ± 0.032	3.311ThrIle: 3.311 ± 0.059	1.411ThrLys: 1.411 ± 0.035	6.249ThrLeu: 6.249 ± 0.075	1.268ThrMet: 1.268 ± 0.036	1.473ThrAsn: 1.473 ± 0.041	3.2ThrPro: 3.2 ± 0.06	1.593ThrGln: 1.593 ± 0.034	3.219ThrArg: 3.219 ± 0.051	2.947ThrSer: 2.947 ± 0.053	3.025ThrThr: 3.025 ± 0.062	4.296ThrVal: 4.296 ± 0.06	0.618ThrTrp: 0.618 ± 0.024	1.215ThrTyr: 1.215 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	8.88ValAla: 8.88 ± 0.096	0.486ValCys: 0.486 ± 0.024	4.307ValAsp: 4.307 ± 0.064	4.712ValGlu: 4.712 ± 0.069	2.827ValPhe: 2.827 ± 0.051	5.823ValGly: 5.823 ± 0.083	1.399ValHis: 1.399 ± 0.038	4.186ValIle: 4.186 ± 0.066	2.057ValLys: 2.057 ± 0.048	8.018ValLeu: 8.018 ± 0.1	1.909ValMet: 1.909 ± 0.045	2.035ValAsn: 2.035 ± 0.041	4.008ValPro: 4.008 ± 0.058	2.152ValGln: 2.152 ± 0.045	4.695ValArg: 4.695 ± 0.077	4.721ValSer: 4.721 ± 0.068	4.574ValThr: 4.574 ± 0.063	6.108ValVal: 6.108 ± 0.095	0.881ValTrp: 0.881 ± 0.028	1.586ValTyr: 1.586 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.21TrpAla: 1.21 ± 0.036	0.132TrpCys: 0.132 ± 0.009	0.646TrpAsp: 0.646 ± 0.025	0.563TrpGlu: 0.563 ± 0.022	0.565TrpPhe: 0.565 ± 0.023	0.916TrpGly: 0.916 ± 0.031	0.327TrpHis: 0.327 ± 0.016	0.61TrpIle: 0.61 ± 0.022	0.357TrpLys: 0.357 ± 0.021	1.586TrpLeu: 1.586 ± 0.041	0.317TrpMet: 0.317 ± 0.015	0.467TrpAsn: 0.467 ± 0.023	0.684TrpPro: 0.684 ± 0.025	0.602TrpGln: 0.602 ± 0.023	1.029TrpArg: 1.029 ± 0.032	0.858TrpSer: 0.858 ± 0.029	0.814TrpThr: 0.814 ± 0.027	0.858TrpVal: 0.858 ± 0.029	0.239TrpTrp: 0.239 ± 0.016	0.275TrpTyr: 0.275 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.481TyrAla: 2.481 ± 0.052	0.205TyrCys: 0.205 ± 0.013	1.42TyrAsp: 1.42 ± 0.035	1.242TyrGlu: 1.242 ± 0.034	1.001TyrPhe: 1.001 ± 0.033	2.145TyrGly: 2.145 ± 0.046	0.471TyrHis: 0.471 ± 0.019	0.942TyrIle: 0.942 ± 0.031	0.538TyrLys: 0.538 ± 0.022	2.322TyrLeu: 2.322 ± 0.043	0.445TyrMet: 0.445 ± 0.022	0.655TyrAsn: 0.655 ± 0.028	1.088TyrPro: 1.088 ± 0.032	0.73TyrGln: 0.73 ± 0.026	1.705TyrArg: 1.705 ± 0.037	1.24TyrSer: 1.24 ± 0.034	1.017TyrThr: 1.017 ± 0.03	1.704TyrVal: 1.704 ± 0.038	0.38TyrTrp: 0.38 ± 0.019	0.572TyrTyr: 0.572 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3590 proteins (1108822 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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