Amino acid dipepetide frequency for Bifidobacterium hapali

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.553AlaAla: 13.553 ± 0.216	1.136AlaCys: 1.136 ± 0.045	7.855AlaAsp: 7.855 ± 0.129	5.483AlaGlu: 5.483 ± 0.093	3.455AlaPhe: 3.455 ± 0.067	8.448AlaGly: 8.448 ± 0.128	2.423AlaHis: 2.423 ± 0.06	6.021AlaIle: 6.021 ± 0.092	4.234AlaLys: 4.234 ± 0.107	9.737AlaLeu: 9.737 ± 0.133	3.095AlaMet: 3.095 ± 0.069	3.695AlaAsn: 3.695 ± 0.069	3.71AlaPro: 3.71 ± 0.078	4.54AlaGln: 4.54 ± 0.108	6.126AlaArg: 6.126 ± 0.11	6.341AlaSer: 6.341 ± 0.097	6.572AlaThr: 6.572 ± 0.101	8.047AlaVal: 8.047 ± 0.101	1.538AlaTrp: 1.538 ± 0.046	2.678AlaTyr: 2.678 ± 0.058	0.009AlaXaa: 0.009 ± 0.006
Cys	1.241CysAla: 1.241 ± 0.039	0.176CysCys: 0.176 ± 0.015	0.687CysAsp: 0.687 ± 0.03	0.498CysGlu: 0.498 ± 0.027	0.306CysPhe: 0.306 ± 0.019	0.994CysGly: 0.994 ± 0.038	0.256CysHis: 0.256 ± 0.02	0.467CysIle: 0.467 ± 0.025	0.215CysLys: 0.215 ± 0.016	0.77CysLeu: 0.77 ± 0.033	0.27CysMet: 0.27 ± 0.019	0.274CysAsn: 0.274 ± 0.017	0.438CysPro: 0.438 ± 0.024	0.232CysGln: 0.232 ± 0.016	0.537CysArg: 0.537 ± 0.027	0.568CysSer: 0.568 ± 0.027	0.536CysThr: 0.536 ± 0.027	0.823CysVal: 0.823 ± 0.038	0.133CysTrp: 0.133 ± 0.012	0.269CysTyr: 0.269 ± 0.021	0.002CysXaa: 0.002 ± 0.002
Asp	7.377AspAla: 7.377 ± 0.104	0.639AspCys: 0.639 ± 0.029	5.108AspAsp: 5.108 ± 0.103	4.742AspGlu: 4.742 ± 0.104	2.141AspPhe: 2.141 ± 0.053	5.906AspGly: 5.906 ± 0.097	1.544AspHis: 1.544 ± 0.053	3.526AspIle: 3.526 ± 0.07	2.4AspLys: 2.4 ± 0.064	5.242AspLeu: 5.242 ± 0.085	1.706AspMet: 1.706 ± 0.051	2.238AspAsn: 2.238 ± 0.055	3.322AspPro: 3.322 ± 0.064	2.101AspGln: 2.101 ± 0.05	3.85AspArg: 3.85 ± 0.083	3.47AspSer: 3.47 ± 0.064	3.954AspThr: 3.954 ± 0.078	5.176AspVal: 5.176 ± 0.089	1.112AspTrp: 1.112 ± 0.043	1.978AspTyr: 1.978 ± 0.048	0.002AspXaa: 0.002 ± 0.003
Glu	5.197GluAla: 5.197 ± 0.097	0.454GluCys: 0.454 ± 0.028	2.789GluAsp: 2.789 ± 0.062	2.75GluGlu: 2.75 ± 0.07	1.82GluPhe: 1.82 ± 0.049	3.154GluGly: 3.154 ± 0.074	1.862GluHis: 1.862 ± 0.054	2.659GluIle: 2.659 ± 0.054	1.69GluLys: 1.69 ± 0.054	5.17GluLeu: 5.17 ± 0.1	1.159GluMet: 1.159 ± 0.041	1.687GluAsn: 1.687 ± 0.046	2.535GluPro: 2.535 ± 0.055	2.724GluGln: 2.724 ± 0.072	4.267GluArg: 4.267 ± 0.077	3.376GluSer: 3.376 ± 0.072	3.36GluThr: 3.36 ± 0.066	3.145GluVal: 3.145 ± 0.064	0.67GluTrp: 0.67 ± 0.028	1.768GluTyr: 1.768 ± 0.047	0.002GluXaa: 0.002 ± 0.002
Phe	4.101PheAla: 4.101 ± 0.068	0.384PheCys: 0.384 ± 0.024	2.717PheAsp: 2.717 ± 0.057	1.7PheGlu: 1.7 ± 0.056	1.252PhePhe: 1.252 ± 0.048	3.187PheGly: 3.187 ± 0.073	0.791PheHis: 0.791 ± 0.036	1.874PheIle: 1.874 ± 0.059	1.055PheLys: 1.055 ± 0.046	2.624PheLeu: 2.624 ± 0.072	0.805PheMet: 0.805 ± 0.032	1.301PheAsn: 1.301 ± 0.042	1.396PhePro: 1.396 ± 0.044	0.878PheGln: 0.878 ± 0.027	1.689PheArg: 1.689 ± 0.047	2.09PheSer: 2.09 ± 0.053	2.361PheThr: 2.361 ± 0.062	2.729PheVal: 2.729 ± 0.073	0.478PheTrp: 0.478 ± 0.024	0.915PheTyr: 0.915 ± 0.036	0.001PheXaa: 0.001 ± 0.001
Gly	6.915GlyAla: 6.915 ± 0.113	0.835GlyCys: 0.835 ± 0.036	4.584GlyAsp: 4.584 ± 0.087	4.255GlyGlu: 4.255 ± 0.081	3.106GlyPhe: 3.106 ± 0.068	5.659GlyGly: 5.659 ± 0.118	1.715GlyHis: 1.715 ± 0.046	4.566GlyIle: 4.566 ± 0.092	3.409GlyLys: 3.409 ± 0.073	6.919GlyLeu: 6.919 ± 0.109	2.115GlyMet: 2.115 ± 0.065	2.716GlyAsn: 2.716 ± 0.074	2.281GlyPro: 2.281 ± 0.054	2.407GlyGln: 2.407 ± 0.06	4.463GlyArg: 4.463 ± 0.079	4.984GlySer: 4.984 ± 0.097	5.112GlyThr: 5.112 ± 0.109	6.142GlyVal: 6.142 ± 0.093	1.236GlyTrp: 1.236 ± 0.044	2.622GlyTyr: 2.622 ± 0.062	0.006GlyXaa: 0.006 ± 0.005
His	2.483HisAla: 2.483 ± 0.06	0.229HisCys: 0.229 ± 0.017	1.888HisAsp: 1.888 ± 0.052	1.327HisGlu: 1.327 ± 0.042	0.651HisPhe: 0.651 ± 0.028	2.057HisGly: 2.057 ± 0.048	0.698HisHis: 0.698 ± 0.03	1.329HisIle: 1.329 ± 0.043	0.604HisLys: 0.604 ± 0.028	1.672HisLeu: 1.672 ± 0.05	0.651HisMet: 0.651 ± 0.028	0.832HisAsn: 0.832 ± 0.034	1.336HisPro: 1.336 ± 0.044	0.695HisGln: 0.695 ± 0.027	1.522HisArg: 1.522 ± 0.044	1.08HisSer: 1.08 ± 0.037	1.487HisThr: 1.487 ± 0.045	2.03HisVal: 2.03 ± 0.049	0.379HisTrp: 0.379 ± 0.023	0.701HisTyr: 0.701 ± 0.03	0.002HisXaa: 0.002 ± 0.002
Ile	7.3IleAla: 7.3 ± 0.121	0.669IleCys: 0.669 ± 0.03	4.332IleAsp: 4.332 ± 0.075	3.189IleGlu: 3.189 ± 0.069	1.537IlePhe: 1.537 ± 0.049	4.697IleGly: 4.697 ± 0.084	1.084IleHis: 1.084 ± 0.036	3.225IleIle: 3.225 ± 0.08	1.708IleLys: 1.708 ± 0.061	3.996IleLeu: 3.996 ± 0.08	1.311IleMet: 1.311 ± 0.042	1.97IleAsn: 1.97 ± 0.054	2.75IlePro: 2.75 ± 0.058	1.445IleGln: 1.445 ± 0.044	3.152IleArg: 3.152 ± 0.072	3.228IleSer: 3.228 ± 0.071	3.7IleThr: 3.7 ± 0.079	4.945IleVal: 4.945 ± 0.091	0.693IleTrp: 0.693 ± 0.03	1.315IleTyr: 1.315 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.172LysAla: 4.172 ± 0.117	0.157LysCys: 0.157 ± 0.015	2.196LysAsp: 2.196 ± 0.07	1.688LysGlu: 1.688 ± 0.056	0.952LysPhe: 0.952 ± 0.036	2.391LysGly: 2.391 ± 0.06	0.821LysHis: 0.821 ± 0.034	1.779LysIle: 1.779 ± 0.055	1.427LysLys: 1.427 ± 0.058	2.96LysLeu: 2.96 ± 0.081	0.758LysMet: 0.758 ± 0.032	1.319LysAsn: 1.319 ± 0.048	2.125LysPro: 2.125 ± 0.062	1.527LysGln: 1.527 ± 0.045	2.39LysArg: 2.39 ± 0.062	2.124LysSer: 2.124 ± 0.06	2.462LysThr: 2.462 ± 0.066	2.411LysVal: 2.411 ± 0.068	0.42LysTrp: 0.42 ± 0.027	1.074LysTyr: 1.074 ± 0.04	0.007LysXaa: 0.007 ± 0.004
Leu	10.035LeuAla: 10.035 ± 0.124	0.941LeuCys: 0.941 ± 0.037	6.143LeuAsp: 6.143 ± 0.104	4.059LeuGlu: 4.059 ± 0.074	3.175LeuPhe: 3.175 ± 0.075	6.519LeuGly: 6.519 ± 0.109	1.981LeuHis: 1.981 ± 0.053	5.012LeuIle: 5.012 ± 0.101	3.366LeuLys: 3.366 ± 0.072	7.799LeuLeu: 7.799 ± 0.138	2.156LeuMet: 2.156 ± 0.051	3.101LeuAsn: 3.101 ± 0.061	4.584LeuPro: 4.584 ± 0.096	2.391LeuGln: 2.391 ± 0.057	5.264LeuArg: 5.264 ± 0.087	5.624LeuSer: 5.624 ± 0.105	5.886LeuThr: 5.886 ± 0.086	6.239LeuVal: 6.239 ± 0.1	1.1LeuTrp: 1.1 ± 0.047	2.177LeuTyr: 2.177 ± 0.061	0.006LeuXaa: 0.006 ± 0.004
Met	2.518MetAla: 2.518 ± 0.058	0.251MetCys: 0.251 ± 0.017	1.321MetAsp: 1.321 ± 0.045	0.928MetGlu: 0.928 ± 0.034	0.914MetPhe: 0.914 ± 0.034	1.599MetGly: 1.599 ± 0.044	0.618MetHis: 0.618 ± 0.027	1.611MetIle: 1.611 ± 0.053	0.847MetLys: 0.847 ± 0.035	2.615MetLeu: 2.615 ± 0.061	0.783MetMet: 0.783 ± 0.034	0.987MetAsn: 0.987 ± 0.039	1.477MetPro: 1.477 ± 0.041	0.814MetGln: 0.814 ± 0.035	1.763MetArg: 1.763 ± 0.05	2.0MetSer: 2.0 ± 0.048	2.042MetThr: 2.042 ± 0.047	1.68MetVal: 1.68 ± 0.05	0.354MetTrp: 0.354 ± 0.018	0.555MetTyr: 0.555 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.043AsnAla: 4.043 ± 0.091	0.228AsnCys: 0.228 ± 0.018	2.404AsnAsp: 2.404 ± 0.061	1.932AsnGlu: 1.932 ± 0.057	0.935AsnPhe: 0.935 ± 0.035	3.491AsnGly: 3.491 ± 0.091	0.728AsnHis: 0.728 ± 0.027	1.755AsnIle: 1.755 ± 0.047	1.207AsnLys: 1.207 ± 0.046	2.712AsnLeu: 2.712 ± 0.059	0.903AsnMet: 0.903 ± 0.034	1.392AsnAsn: 1.392 ± 0.058	2.194AsnPro: 2.194 ± 0.054	1.096AsnGln: 1.096 ± 0.039	1.994AsnArg: 1.994 ± 0.048	1.829AsnSer: 1.829 ± 0.056	2.4AsnThr: 2.4 ± 0.067	2.66AsnVal: 2.66 ± 0.06	0.487AsnTrp: 0.487 ± 0.024	0.958AsnTyr: 0.958 ± 0.035	0.004AsnXaa: 0.004 ± 0.002
Pro	4.592ProAla: 4.592 ± 0.085	0.333ProCys: 0.333 ± 0.019	3.522ProAsp: 3.522 ± 0.063	2.794ProGlu: 2.794 ± 0.057	1.704ProPhe: 1.704 ± 0.044	3.149ProGly: 3.149 ± 0.072	1.059ProHis: 1.059 ± 0.036	2.473ProIle: 2.473 ± 0.047	1.612ProLys: 1.612 ± 0.043	3.813ProLeu: 3.813 ± 0.071	1.095ProMet: 1.095 ± 0.031	1.693ProAsn: 1.693 ± 0.05	1.243ProPro: 1.243 ± 0.045	1.905ProGln: 1.905 ± 0.052	2.259ProArg: 2.259 ± 0.06	3.116ProSer: 3.116 ± 0.064	2.999ProThr: 2.999 ± 0.064	3.849ProVal: 3.849 ± 0.068	0.64ProTrp: 0.64 ± 0.03	1.427ProTyr: 1.427 ± 0.049	0.002ProXaa: 0.002 ± 0.002
Gln	3.537GlnAla: 3.537 ± 0.077	0.327GlnCys: 0.327 ± 0.02	1.498GlnAsp: 1.498 ± 0.042	1.432GlnGlu: 1.432 ± 0.048	1.201GlnPhe: 1.201 ± 0.037	2.152GlnGly: 2.152 ± 0.058	1.012GlnHis: 1.012 ± 0.042	2.059GlnIle: 2.059 ± 0.056	0.962GlnLys: 0.962 ± 0.041	3.634GlnLeu: 3.634 ± 0.068	0.936GlnMet: 0.936 ± 0.034	0.941GlnAsn: 0.941 ± 0.041	1.892GlnPro: 1.892 ± 0.061	1.846GlnGln: 1.846 ± 0.055	2.498GlnArg: 2.498 ± 0.062	2.52GlnSer: 2.52 ± 0.067	2.199GlnThr: 2.199 ± 0.053	2.472GlnVal: 2.472 ± 0.053	0.644GlnTrp: 0.644 ± 0.029	1.258GlnTyr: 1.258 ± 0.041	0.0GlnXaa: 0.0 ± 0.0
Arg	5.446ArgAla: 5.446 ± 0.097	0.557ArgCys: 0.557 ± 0.028	3.961ArgAsp: 3.961 ± 0.084	3.833ArgGlu: 3.833 ± 0.074	2.285ArgPhe: 2.285 ± 0.057	3.831ArgGly: 3.831 ± 0.076	1.627ArgHis: 1.627 ± 0.045	3.934ArgIle: 3.934 ± 0.073	2.265ArgLys: 2.265 ± 0.054	5.551ArgLeu: 5.551 ± 0.105	1.896ArgMet: 1.896 ± 0.049	2.178ArgAsn: 2.178 ± 0.055	2.441ArgPro: 2.441 ± 0.061	2.191ArgGln: 2.191 ± 0.05	4.765ArgArg: 4.765 ± 0.113	3.372ArgSer: 3.372 ± 0.078	3.605ArgThr: 3.605 ± 0.069	4.214ArgVal: 4.214 ± 0.082	0.897ArgTrp: 0.897 ± 0.035	2.12ArgTyr: 2.12 ± 0.057	0.011ArgXaa: 0.011 ± 0.007
Ser	6.592SerAla: 6.592 ± 0.103	0.502SerCys: 0.502 ± 0.028	4.12SerAsp: 4.12 ± 0.082	2.875SerGlu: 2.875 ± 0.058	2.207SerPhe: 2.207 ± 0.057	5.268SerGly: 5.268 ± 0.091	1.402SerHis: 1.402 ± 0.042	3.303SerIle: 3.303 ± 0.067	1.992SerLys: 1.992 ± 0.047	5.527SerLeu: 5.527 ± 0.103	1.604SerMet: 1.604 ± 0.045	2.234SerAsn: 2.234 ± 0.055	2.451SerPro: 2.451 ± 0.054	2.267SerGln: 2.267 ± 0.054	3.561SerArg: 3.561 ± 0.08	4.6SerSer: 4.6 ± 0.11	4.117SerThr: 4.117 ± 0.081	4.842SerVal: 4.842 ± 0.087	0.888SerTrp: 0.888 ± 0.034	1.672SerTyr: 1.672 ± 0.051	0.007SerXaa: 0.007 ± 0.007
Thr	7.024ThrAla: 7.024 ± 0.126	0.51ThrCys: 0.51 ± 0.023	4.41ThrAsp: 4.41 ± 0.087	2.676ThrGlu: 2.676 ± 0.067	2.229ThrPhe: 2.229 ± 0.072	5.227ThrGly: 5.227 ± 0.089	1.445ThrHis: 1.445 ± 0.043	4.067ThrIle: 4.067 ± 0.084	2.095ThrLys: 2.095 ± 0.061	6.023ThrLeu: 6.023 ± 0.097	1.464ThrMet: 1.464 ± 0.045	2.324ThrAsn: 2.324 ± 0.066	3.408ThrPro: 3.408 ± 0.064	2.114ThrGln: 2.114 ± 0.059	3.423ThrArg: 3.423 ± 0.075	4.013ThrSer: 4.013 ± 0.083	4.434ThrThr: 4.434 ± 0.095	5.967ThrVal: 5.967 ± 0.112	0.82ThrTrp: 0.82 ± 0.033	1.698ThrTyr: 1.698 ± 0.054	0.006ThrXaa: 0.006 ± 0.003
Val	8.293ValAla: 8.293 ± 0.133	0.858ValCys: 0.858 ± 0.035	5.09ValAsp: 5.09 ± 0.081	3.883ValGlu: 3.883 ± 0.077	2.825ValPhe: 2.825 ± 0.068	4.94ValGly: 4.94 ± 0.087	1.601ValHis: 1.601 ± 0.044	4.602ValIle: 4.602 ± 0.086	2.692ValLys: 2.692 ± 0.068	6.779ValLeu: 6.779 ± 0.125	1.902ValMet: 1.902 ± 0.06	2.851ValAsn: 2.851 ± 0.066	3.828ValPro: 3.828 ± 0.063	2.075ValGln: 2.075 ± 0.052	4.52ValArg: 4.52 ± 0.08	5.166ValSer: 5.166 ± 0.094	5.654ValThr: 5.654 ± 0.11	5.915ValVal: 5.915 ± 0.116	1.012ValTrp: 1.012 ± 0.036	1.843ValTyr: 1.843 ± 0.053	0.004ValXaa: 0.004 ± 0.002
Trp	1.201TrpAla: 1.201 ± 0.042	0.172TrpCys: 0.172 ± 0.014	0.822TrpAsp: 0.822 ± 0.038	0.56TrpGlu: 0.56 ± 0.028	0.591TrpPhe: 0.591 ± 0.028	0.921TrpGly: 0.921 ± 0.037	0.426TrpHis: 0.426 ± 0.024	0.755TrpIle: 0.755 ± 0.031	0.541TrpLys: 0.541 ± 0.026	1.529TrpLeu: 1.529 ± 0.047	0.431TrpMet: 0.431 ± 0.027	0.666TrpAsn: 0.666 ± 0.034	0.589TrpPro: 0.589 ± 0.031	0.752TrpGln: 0.752 ± 0.031	0.942TrpArg: 0.942 ± 0.043	0.952TrpSer: 0.952 ± 0.033	0.827TrpThr: 0.827 ± 0.029	0.825TrpVal: 0.825 ± 0.035	0.285TrpTrp: 0.285 ± 0.019	0.484TrpTyr: 0.484 ± 0.024	0.001TrpXaa: 0.001 ± 0.001
Tyr	3.072TyrAla: 3.072 ± 0.066	0.336TyrCys: 0.336 ± 0.02	2.083TyrAsp: 2.083 ± 0.057	1.627TyrGlu: 1.627 ± 0.052	1.045TyrPhe: 1.045 ± 0.038	2.448TyrGly: 2.448 ± 0.059	0.557TyrHis: 0.557 ± 0.027	1.227TyrIle: 1.227 ± 0.042	0.828TyrLys: 0.828 ± 0.035	2.48TyrLeu: 2.48 ± 0.058	0.633TyrMet: 0.633 ± 0.027	0.95TyrAsn: 0.95 ± 0.036	1.271TyrPro: 1.271 ± 0.047	1.02TyrGln: 1.02 ± 0.037	1.988TyrArg: 1.988 ± 0.056	1.573TyrSer: 1.573 ± 0.045	1.669TyrThr: 1.669 ± 0.047	2.214TyrVal: 2.214 ± 0.054	0.49TyrTrp: 0.49 ± 0.026	0.931TyrTyr: 0.931 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.005XaaAla: 0.005 ± 0.003	0.0XaaCys: 0.0 ± 0.0	0.004XaaAsp: 0.004 ± 0.003	0.01XaaGlu: 0.01 ± 0.005	0.0XaaPhe: 0.0 ± 0.0	0.007XaaGly: 0.007 ± 0.004	0.002XaaHis: 0.002 ± 0.002	0.004XaaIle: 0.004 ± 0.003	0.007XaaLys: 0.007 ± 0.006	0.006XaaLeu: 0.006 ± 0.005	0.004XaaMet: 0.004 ± 0.003	0.002XaaAsn: 0.002 ± 0.003	0.005XaaPro: 0.005 ± 0.004	0.001XaaGln: 0.001 ± 0.001	0.007XaaArg: 0.007 ± 0.005	0.002XaaSer: 0.002 ± 0.003	0.0XaaThr: 0.0 ± 0.0	0.006XaaVal: 0.006 ± 0.004	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.001	0.009XaaXaa: 0.009 ± 0.006

Statistics based on 2249 proteins (807543 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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