Amino acid dipepetide frequency for Escherichia phage phiv142-3

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.162AlaAla: 13.162 ± 1.704
0.513AlaCys: 0.513 ± 0.204
5.812AlaAsp: 5.812 ± 0.728
7.863AlaGlu: 7.863 ± 1.581
3.504AlaPhe: 3.504 ± 0.535
7.436AlaGly: 7.436 ± 0.927
1.282AlaHis: 1.282 ± 0.33
4.444AlaIle: 4.444 ± 0.79
5.214AlaLys: 5.214 ± 0.63
8.632AlaLeu: 8.632 ± 0.763
3.59AlaMet: 3.59 ± 0.697
4.103AlaAsn: 4.103 ± 0.581
2.735AlaPro: 2.735 ± 0.58
5.47AlaGln: 5.47 ± 0.877
6.239AlaArg: 6.239 ± 0.893
5.385AlaSer: 5.385 ± 0.651
4.615AlaThr: 4.615 ± 0.617
7.094AlaVal: 7.094 ± 0.868
1.795AlaTrp: 1.795 ± 0.431
3.077AlaTyr: 3.077 ± 0.627
0.0AlaXaa: 0.0 ± 0.0
Cys
0.513CysAla: 0.513 ± 0.252
0.085CysCys: 0.085 ± 0.086
0.855CysAsp: 0.855 ± 0.342
0.513CysGlu: 0.513 ± 0.176
0.513CysPhe: 0.513 ± 0.164
1.026CysGly: 1.026 ± 0.358
0.171CysHis: 0.171 ± 0.115
0.342CysIle: 0.342 ± 0.163
0.513CysLys: 0.513 ± 0.223
0.684CysLeu: 0.684 ± 0.237
0.342CysMet: 0.342 ± 0.155
0.598CysAsn: 0.598 ± 0.209
0.342CysPro: 0.342 ± 0.189
0.342CysGln: 0.342 ± 0.206
0.427CysArg: 0.427 ± 0.216
0.342CysSer: 0.342 ± 0.179
0.598CysThr: 0.598 ± 0.237
0.342CysVal: 0.342 ± 0.169
0.256CysTrp: 0.256 ± 0.161
0.256CysTyr: 0.256 ± 0.128
0.0CysXaa: 0.0 ± 0.0
Asp
6.41AspAla: 6.41 ± 0.832
0.598AspCys: 0.598 ± 0.246
3.932AspAsp: 3.932 ± 0.557
3.932AspGlu: 3.932 ± 0.644
1.624AspPhe: 1.624 ± 0.338
4.53AspGly: 4.53 ± 0.752
0.598AspHis: 0.598 ± 0.283
3.932AspIle: 3.932 ± 0.637
3.504AspLys: 3.504 ± 0.707
4.017AspLeu: 4.017 ± 0.413
2.137AspMet: 2.137 ± 0.508
1.624AspAsn: 1.624 ± 0.365
2.393AspPro: 2.393 ± 0.462
1.966AspGln: 1.966 ± 0.334
2.906AspArg: 2.906 ± 0.527
4.017AspSer: 4.017 ± 0.447
3.248AspThr: 3.248 ± 0.559
4.53AspVal: 4.53 ± 0.609
1.197AspTrp: 1.197 ± 0.26
2.137AspTyr: 2.137 ± 0.35
0.0AspXaa: 0.0 ± 0.0
Glu
6.923GluAla: 6.923 ± 1.335
0.855GluCys: 0.855 ± 0.262
3.761GluAsp: 3.761 ± 0.497
3.846GluGlu: 3.846 ± 1.011
3.248GluPhe: 3.248 ± 0.42
3.333GluGly: 3.333 ± 0.527
1.111GluHis: 1.111 ± 0.31
3.932GluIle: 3.932 ± 0.48
4.017GluLys: 4.017 ± 0.857
5.47GluLeu: 5.47 ± 0.782
1.368GluMet: 1.368 ± 0.367
2.65GluAsn: 2.65 ± 0.415
2.137GluPro: 2.137 ± 0.67
4.872GluGln: 4.872 ± 0.7
4.957GluArg: 4.957 ± 0.904
3.419GluSer: 3.419 ± 0.607
3.504GluThr: 3.504 ± 0.48
3.675GluVal: 3.675 ± 0.636
1.026GluTrp: 1.026 ± 0.354
2.906GluTyr: 2.906 ± 0.51
0.0GluXaa: 0.0 ± 0.0
Phe
2.479PheAla: 2.479 ± 0.491
0.256PheCys: 0.256 ± 0.138
1.966PheAsp: 1.966 ± 0.479
2.137PheGlu: 2.137 ± 0.317
1.538PhePhe: 1.538 ± 0.331
2.906PheGly: 2.906 ± 0.452
0.256PheHis: 0.256 ± 0.18
2.137PheIle: 2.137 ± 0.404
1.197PheLys: 1.197 ± 0.33
1.624PheLeu: 1.624 ± 0.413
0.855PheMet: 0.855 ± 0.252
1.538PheAsn: 1.538 ± 0.343
1.368PhePro: 1.368 ± 0.329
1.026PheGln: 1.026 ± 0.304
2.991PheArg: 2.991 ± 0.518
2.735PheSer: 2.735 ± 0.491
1.538PheThr: 1.538 ± 0.349
2.308PheVal: 2.308 ± 0.417
0.342PheTrp: 0.342 ± 0.194
1.026PheTyr: 1.026 ± 0.334
0.0PheXaa: 0.0 ± 0.0
Gly
5.897GlyAla: 5.897 ± 0.913
0.598GlyCys: 0.598 ± 0.245
4.274GlyAsp: 4.274 ± 0.56
4.957GlyGlu: 4.957 ± 0.618
2.906GlyPhe: 2.906 ± 0.576
6.239GlyGly: 6.239 ± 0.773
1.453GlyHis: 1.453 ± 0.309
5.128GlyIle: 5.128 ± 0.783
5.47GlyLys: 5.47 ± 0.748
5.812GlyLeu: 5.812 ± 0.844
2.137GlyMet: 2.137 ± 0.564
4.188GlyAsn: 4.188 ± 0.789
1.624GlyPro: 1.624 ± 0.418
3.675GlyGln: 3.675 ± 0.734
3.932GlyArg: 3.932 ± 0.546
4.017GlySer: 4.017 ± 0.859
3.846GlyThr: 3.846 ± 0.532
5.556GlyVal: 5.556 ± 0.717
1.197GlyTrp: 1.197 ± 0.304
1.709GlyTyr: 1.709 ± 0.266
0.0GlyXaa: 0.0 ± 0.0
His
1.282HisAla: 1.282 ± 0.308
0.342HisCys: 0.342 ± 0.176
0.94HisAsp: 0.94 ± 0.269
1.453HisGlu: 1.453 ± 0.357
0.342HisPhe: 0.342 ± 0.166
1.368HisGly: 1.368 ± 0.327
0.427HisHis: 0.427 ± 0.169
0.94HisIle: 0.94 ± 0.235
0.256HisLys: 0.256 ± 0.152
1.368HisLeu: 1.368 ± 0.368
0.171HisMet: 0.171 ± 0.116
1.197HisAsn: 1.197 ± 0.556
0.684HisPro: 0.684 ± 0.262
0.427HisGln: 0.427 ± 0.18
0.769HisArg: 0.769 ± 0.285
0.855HisSer: 0.855 ± 0.259
0.513HisThr: 0.513 ± 0.203
0.684HisVal: 0.684 ± 0.237
0.684HisTrp: 0.684 ± 0.225
0.427HisTyr: 0.427 ± 0.248
0.0HisXaa: 0.0 ± 0.0
Ile
6.41IleAla: 6.41 ± 0.799
0.256IleCys: 0.256 ± 0.135
4.957IleAsp: 4.957 ± 0.822
3.932IleGlu: 3.932 ± 0.575
1.111IlePhe: 1.111 ± 0.279
3.59IleGly: 3.59 ± 0.542
0.684IleHis: 0.684 ± 0.235
3.248IleIle: 3.248 ± 0.604
3.077IleLys: 3.077 ± 0.561
2.308IleLeu: 2.308 ± 0.353
1.111IleMet: 1.111 ± 0.325
3.419IleAsn: 3.419 ± 0.423
2.65IlePro: 2.65 ± 0.446
2.65IleGln: 2.65 ± 0.386
3.59IleArg: 3.59 ± 0.441
4.53IleSer: 4.53 ± 0.895
4.444IleThr: 4.444 ± 0.76
2.821IleVal: 2.821 ± 0.684
0.855IleTrp: 0.855 ± 0.253
0.94IleTyr: 0.94 ± 0.246
0.0IleXaa: 0.0 ± 0.0
Lys
4.615LysAla: 4.615 ± 0.803
0.769LysCys: 0.769 ± 0.269
2.137LysAsp: 2.137 ± 0.545
2.991LysGlu: 2.991 ± 0.658
1.282LysPhe: 1.282 ± 0.297
3.675LysGly: 3.675 ± 0.551
0.94LysHis: 0.94 ± 0.259
1.795LysIle: 1.795 ± 0.464
2.222LysLys: 2.222 ± 0.499
4.359LysLeu: 4.359 ± 0.615
1.368LysMet: 1.368 ± 0.359
2.308LysAsn: 2.308 ± 0.594
2.821LysPro: 2.821 ± 0.618
2.564LysGln: 2.564 ± 0.516
4.103LysArg: 4.103 ± 0.801
3.248LysSer: 3.248 ± 0.554
3.333LysThr: 3.333 ± 0.574
3.504LysVal: 3.504 ± 0.516
1.368LysTrp: 1.368 ± 0.287
1.453LysTyr: 1.453 ± 0.365
0.0LysXaa: 0.0 ± 0.0
Leu
8.889LeuAla: 8.889 ± 0.961
0.94LeuCys: 0.94 ± 0.247
4.188LeuAsp: 4.188 ± 0.415
5.299LeuGlu: 5.299 ± 0.695
2.821LeuPhe: 2.821 ± 0.525
4.957LeuGly: 4.957 ± 0.963
1.624LeuHis: 1.624 ± 0.34
3.846LeuIle: 3.846 ± 0.596
3.59LeuLys: 3.59 ± 0.609
6.496LeuLeu: 6.496 ± 0.713
2.051LeuMet: 2.051 ± 0.384
3.675LeuAsn: 3.675 ± 0.581
2.222LeuPro: 2.222 ± 0.342
3.162LeuGln: 3.162 ± 0.455
5.043LeuArg: 5.043 ± 0.774
5.983LeuSer: 5.983 ± 0.561
4.872LeuThr: 4.872 ± 0.576
4.53LeuVal: 4.53 ± 0.562
0.94LeuTrp: 0.94 ± 0.23
1.966LeuTyr: 1.966 ± 0.403
0.0LeuXaa: 0.0 ± 0.0
Met
3.932MetAla: 3.932 ± 0.804
0.256MetCys: 0.256 ± 0.163
0.94MetAsp: 0.94 ± 0.259
1.88MetGlu: 1.88 ± 0.53
0.769MetPhe: 0.769 ± 0.256
1.368MetGly: 1.368 ± 0.35
0.171MetHis: 0.171 ± 0.109
1.368MetIle: 1.368 ± 0.398
1.282MetLys: 1.282 ± 0.305
2.65MetLeu: 2.65 ± 0.513
0.94MetMet: 0.94 ± 0.489
1.966MetAsn: 1.966 ± 0.542
1.282MetPro: 1.282 ± 0.32
0.769MetGln: 0.769 ± 0.278
2.137MetArg: 2.137 ± 0.639
2.991MetSer: 2.991 ± 0.586
1.026MetThr: 1.026 ± 0.266
1.453MetVal: 1.453 ± 0.334
0.085MetTrp: 0.085 ± 0.09
0.855MetTyr: 0.855 ± 0.317
0.0MetXaa: 0.0 ± 0.0
Asn
4.786AsnAla: 4.786 ± 0.587
0.085AsnCys: 0.085 ± 0.087
2.65AsnAsp: 2.65 ± 0.365
2.821AsnGlu: 2.821 ± 0.469
1.111AsnPhe: 1.111 ± 0.264
4.188AsnGly: 4.188 ± 0.875
0.342AsnHis: 0.342 ± 0.161
2.393AsnIle: 2.393 ± 0.463
2.137AsnLys: 2.137 ± 0.379
3.077AsnLeu: 3.077 ± 0.545
1.026AsnMet: 1.026 ± 0.322
2.308AsnAsn: 2.308 ± 0.773
2.735AsnPro: 2.735 ± 0.549
2.393AsnGln: 2.393 ± 0.419
2.906AsnArg: 2.906 ± 0.457
2.479AsnSer: 2.479 ± 0.62
2.821AsnThr: 2.821 ± 0.574
2.564AsnVal: 2.564 ± 0.462
0.769AsnTrp: 0.769 ± 0.286
1.88AsnTyr: 1.88 ± 0.421
0.0AsnXaa: 0.0 ± 0.0
Pro
2.991ProAla: 2.991 ± 0.664
0.085ProCys: 0.085 ± 0.087
3.419ProAsp: 3.419 ± 0.464
3.504ProGlu: 3.504 ± 0.662
1.111ProPhe: 1.111 ± 0.29
4.017ProGly: 4.017 ± 0.457
0.684ProHis: 0.684 ± 0.18
1.88ProIle: 1.88 ± 0.368
1.368ProLys: 1.368 ± 0.395
2.222ProLeu: 2.222 ± 0.417
0.684ProMet: 0.684 ± 0.221
1.026ProAsn: 1.026 ± 0.227
1.88ProPro: 1.88 ± 0.496
1.88ProGln: 1.88 ± 0.395
1.966ProArg: 1.966 ± 0.435
2.906ProSer: 2.906 ± 0.573
1.538ProThr: 1.538 ± 0.342
3.59ProVal: 3.59 ± 0.501
0.855ProTrp: 0.855 ± 0.25
0.769ProTyr: 0.769 ± 0.242
0.0ProXaa: 0.0 ± 0.0
Gln
6.239GlnAla: 6.239 ± 1.287
0.513GlnCys: 0.513 ± 0.228
1.966GlnAsp: 1.966 ± 0.343
3.162GlnGlu: 3.162 ± 0.456
1.709GlnPhe: 1.709 ± 0.384
2.222GlnGly: 2.222 ± 0.367
0.855GlnHis: 0.855 ± 0.282
2.051GlnIle: 2.051 ± 0.539
2.222GlnLys: 2.222 ± 0.545
4.701GlnLeu: 4.701 ± 0.891
1.88GlnMet: 1.88 ± 0.446
1.709GlnAsn: 1.709 ± 0.43
1.453GlnPro: 1.453 ± 0.303
4.444GlnGln: 4.444 ± 0.854
3.932GlnArg: 3.932 ± 0.632
2.051GlnSer: 2.051 ± 0.598
2.222GlnThr: 2.222 ± 0.496
2.735GlnVal: 2.735 ± 0.682
1.197GlnTrp: 1.197 ± 0.331
1.709GlnTyr: 1.709 ± 0.341
0.0GlnXaa: 0.0 ± 0.0
Arg
6.068ArgAla: 6.068 ± 0.814
0.513ArgCys: 0.513 ± 0.268
4.188ArgAsp: 4.188 ± 0.516
4.615ArgGlu: 4.615 ± 0.766
1.538ArgPhe: 1.538 ± 0.277
3.162ArgGly: 3.162 ± 0.426
1.111ArgHis: 1.111 ± 0.292
5.897ArgIle: 5.897 ± 0.968
4.188ArgLys: 4.188 ± 0.598
5.47ArgLeu: 5.47 ± 0.733
1.282ArgMet: 1.282 ± 0.341
2.991ArgAsn: 2.991 ± 0.427
1.453ArgPro: 1.453 ± 0.328
4.359ArgGln: 4.359 ± 0.623
4.786ArgArg: 4.786 ± 0.941
2.65ArgSer: 2.65 ± 0.576
3.248ArgThr: 3.248 ± 0.571
3.761ArgVal: 3.761 ± 0.609
1.709ArgTrp: 1.709 ± 0.408
1.624ArgTyr: 1.624 ± 0.346
0.0ArgXaa: 0.0 ± 0.0
Ser
5.299SerAla: 5.299 ± 0.679
0.513SerCys: 0.513 ± 0.23
4.103SerAsp: 4.103 ± 0.686
4.017SerGlu: 4.017 ± 0.626
2.222SerPhe: 2.222 ± 0.354
5.726SerGly: 5.726 ± 0.686
0.855SerHis: 0.855 ± 0.28
3.162SerIle: 3.162 ± 0.538
3.675SerLys: 3.675 ± 0.55
5.556SerLeu: 5.556 ± 0.53
2.222SerMet: 2.222 ± 0.426
3.162SerAsn: 3.162 ± 0.686
3.333SerPro: 3.333 ± 0.488
2.479SerGln: 2.479 ± 0.539
4.017SerArg: 4.017 ± 0.652
4.615SerSer: 4.615 ± 0.826
4.017SerThr: 4.017 ± 0.58
4.017SerVal: 4.017 ± 0.788
0.769SerTrp: 0.769 ± 0.227
2.222SerTyr: 2.222 ± 0.482
0.0SerXaa: 0.0 ± 0.0
Thr
6.496ThrAla: 6.496 ± 0.859
0.513ThrCys: 0.513 ± 0.19
3.333ThrAsp: 3.333 ± 0.719
2.821ThrGlu: 2.821 ± 0.457
1.624ThrPhe: 1.624 ± 0.419
6.581ThrGly: 6.581 ± 0.782
0.769ThrHis: 0.769 ± 0.264
3.333ThrIle: 3.333 ± 0.659
2.137ThrLys: 2.137 ± 0.378
4.017ThrLeu: 4.017 ± 0.589
1.709ThrMet: 1.709 ± 0.433
1.709ThrAsn: 1.709 ± 0.247
3.077ThrPro: 3.077 ± 0.482
1.709ThrGln: 1.709 ± 0.53
2.735ThrArg: 2.735 ± 0.614
4.188ThrSer: 4.188 ± 0.86
2.222ThrThr: 2.222 ± 0.375
3.675ThrVal: 3.675 ± 0.786
0.684ThrTrp: 0.684 ± 0.281
1.111ThrTyr: 1.111 ± 0.353
0.0ThrXaa: 0.0 ± 0.0
Val
5.556ValAla: 5.556 ± 0.649
0.598ValCys: 0.598 ± 0.241
3.675ValAsp: 3.675 ± 0.592
4.188ValGlu: 4.188 ± 0.519
1.624ValPhe: 1.624 ± 0.298
3.846ValGly: 3.846 ± 0.62
0.855ValHis: 0.855 ± 0.248
3.675ValIle: 3.675 ± 0.637
2.991ValLys: 2.991 ± 0.529
4.274ValLeu: 4.274 ± 0.58
1.966ValMet: 1.966 ± 0.301
3.504ValAsn: 3.504 ± 0.619
2.137ValPro: 2.137 ± 0.37
2.564ValGln: 2.564 ± 0.347
4.103ValArg: 4.103 ± 0.47
5.897ValSer: 5.897 ± 0.824
4.615ValThr: 4.615 ± 0.749
4.53ValVal: 4.53 ± 0.689
0.684ValTrp: 0.684 ± 0.174
2.222ValTyr: 2.222 ± 0.448
0.0ValXaa: 0.0 ± 0.0
Trp
1.795TrpAla: 1.795 ± 0.403
0.171TrpCys: 0.171 ± 0.106
0.769TrpAsp: 0.769 ± 0.283
1.282TrpGlu: 1.282 ± 0.34
0.598TrpPhe: 0.598 ± 0.24
1.453TrpGly: 1.453 ± 0.313
0.085TrpHis: 0.085 ± 0.087
0.94TrpIle: 0.94 ± 0.324
0.513TrpLys: 0.513 ± 0.248
1.966TrpLeu: 1.966 ± 0.509
0.427TrpMet: 0.427 ± 0.182
0.769TrpAsn: 0.769 ± 0.216
0.513TrpPro: 0.513 ± 0.255
0.684TrpGln: 0.684 ± 0.234
1.197TrpArg: 1.197 ± 0.284
1.624TrpSer: 1.624 ± 0.421
0.598TrpThr: 0.598 ± 0.221
0.94TrpVal: 0.94 ± 0.276
0.427TrpTrp: 0.427 ± 0.236
0.427TrpTyr: 0.427 ± 0.18
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.222TyrAla: 2.222 ± 0.391
0.598TyrCys: 0.598 ± 0.236
1.368TyrAsp: 1.368 ± 0.347
1.88TyrGlu: 1.88 ± 0.36
1.026TyrPhe: 1.026 ± 0.312
2.991TyrGly: 2.991 ± 0.588
0.855TyrHis: 0.855 ± 0.314
2.137TyrIle: 2.137 ± 0.43
1.282TyrLys: 1.282 ± 0.341
2.393TyrLeu: 2.393 ± 0.548
0.769TyrMet: 0.769 ± 0.235
1.026TyrAsn: 1.026 ± 0.318
1.538TyrPro: 1.538 ± 0.347
1.538TyrGln: 1.538 ± 0.393
1.88TyrArg: 1.88 ± 0.365
2.051TyrSer: 2.051 ± 0.402
1.624TyrThr: 1.624 ± 0.436
1.197TyrVal: 1.197 ± 0.257
0.342TyrTrp: 0.342 ± 0.153
0.855TyrTyr: 0.855 ± 0.276
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 53 proteins (11701 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski