Amino acid dipepetide frequency for Winkia neuii BV029A5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.229AlaAla: 15.229 ± 0.218
1.116AlaCys: 1.116 ± 0.047
6.75AlaAsp: 6.75 ± 0.11
6.937AlaGlu: 6.937 ± 0.136
3.576AlaPhe: 3.576 ± 0.08
10.493AlaGly: 10.493 ± 0.136
2.324AlaHis: 2.324 ± 0.06
5.803AlaIle: 5.803 ± 0.105
5.964AlaLys: 5.964 ± 0.126
12.595AlaLeu: 12.595 ± 0.182
2.809AlaMet: 2.809 ± 0.065
3.243AlaAsn: 3.243 ± 0.067
5.022AlaPro: 5.022 ± 0.104
4.835AlaGln: 4.835 ± 0.12
6.825AlaArg: 6.825 ± 0.117
6.789AlaSer: 6.789 ± 0.11
6.325AlaThr: 6.325 ± 0.108
8.661AlaVal: 8.661 ± 0.143
1.492AlaTrp: 1.492 ± 0.051
2.479AlaTyr: 2.479 ± 0.064
0.0AlaXaa: 0.0 ± 0.0
Cys
1.02CysAla: 1.02 ± 0.041
0.1CysCys: 0.1 ± 0.016
0.444CysAsp: 0.444 ± 0.028
0.446CysGlu: 0.446 ± 0.023
0.297CysPhe: 0.297 ± 0.022
0.899CysGly: 0.899 ± 0.042
0.161CysHis: 0.161 ± 0.016
0.363CysIle: 0.363 ± 0.027
0.315CysLys: 0.315 ± 0.025
0.775CysLeu: 0.775 ± 0.038
0.164CysMet: 0.164 ± 0.015
0.237CysAsn: 0.237 ± 0.018
0.433CysPro: 0.433 ± 0.029
0.294CysGln: 0.294 ± 0.022
0.452CysArg: 0.452 ± 0.025
0.564CysSer: 0.564 ± 0.027
0.509CysThr: 0.509 ± 0.03
0.593CysVal: 0.593 ± 0.032
0.115CysTrp: 0.115 ± 0.013
0.227CysTyr: 0.227 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
5.927AspAla: 5.927 ± 0.113
0.392AspCys: 0.392 ± 0.026
2.514AspAsp: 2.514 ± 0.087
3.682AspGlu: 3.682 ± 0.082
1.899AspPhe: 1.899 ± 0.056
4.746AspGly: 4.746 ± 0.099
1.017AspHis: 1.017 ± 0.041
2.579AspIle: 2.579 ± 0.072
2.608AspLys: 2.608 ± 0.083
5.572AspLeu: 5.572 ± 0.102
1.291AspMet: 1.291 ± 0.046
1.308AspAsn: 1.308 ± 0.055
3.381AspPro: 3.381 ± 0.079
2.127AspGln: 2.127 ± 0.067
3.114AspArg: 3.114 ± 0.081
3.167AspSer: 3.167 ± 0.079
2.76AspThr: 2.76 ± 0.062
4.171AspVal: 4.171 ± 0.084
0.833AspTrp: 0.833 ± 0.041
1.563AspTyr: 1.563 ± 0.051
0.0AspXaa: 0.0 ± 0.0
Glu
7.378GluAla: 7.378 ± 0.127
0.39GluCys: 0.39 ± 0.024
3.671GluAsp: 3.671 ± 0.082
4.275GluGlu: 4.275 ± 0.11
1.583GluPhe: 1.583 ± 0.049
5.142GluGly: 5.142 ± 0.096
1.254GluHis: 1.254 ± 0.042
2.617GluIle: 2.617 ± 0.061
2.843GluLys: 2.843 ± 0.076
6.052GluLeu: 6.052 ± 0.112
1.176GluMet: 1.176 ± 0.047
1.68GluAsn: 1.68 ± 0.053
2.425GluPro: 2.425 ± 0.07
2.783GluGln: 2.783 ± 0.078
3.787GluArg: 3.787 ± 0.09
2.735GluSer: 2.735 ± 0.077
2.576GluThr: 2.576 ± 0.065
4.815GluVal: 4.815 ± 0.086
0.696GluTrp: 0.696 ± 0.032
1.322GluTyr: 1.322 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
3.876PheAla: 3.876 ± 0.082
0.326PheCys: 0.326 ± 0.023
1.982PheAsp: 1.982 ± 0.071
1.787PheGlu: 1.787 ± 0.058
1.274PhePhe: 1.274 ± 0.053
3.181PheGly: 3.181 ± 0.078
0.546PheHis: 0.546 ± 0.032
1.481PheIle: 1.481 ± 0.052
1.054PheLys: 1.054 ± 0.039
2.938PheLeu: 2.938 ± 0.07
0.664PheMet: 0.664 ± 0.038
0.902PheAsn: 0.902 ± 0.037
1.458PhePro: 1.458 ± 0.047
0.876PheGln: 0.876 ± 0.034
1.571PheArg: 1.571 ± 0.053
2.242PheSer: 2.242 ± 0.06
2.201PheThr: 2.201 ± 0.055
2.556PheVal: 2.556 ± 0.058
0.446PheTrp: 0.446 ± 0.025
0.818PheTyr: 0.818 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
9.304GlyAla: 9.304 ± 0.155
0.722GlyCys: 0.722 ± 0.033
3.847GlyAsp: 3.847 ± 0.085
4.598GlyGlu: 4.598 ± 0.093
2.845GlyPhe: 2.845 ± 0.06
6.544GlyGly: 6.544 ± 0.116
1.733GlyHis: 1.733 ± 0.055
5.094GlyIle: 5.094 ± 0.106
4.941GlyLys: 4.941 ± 0.11
7.712GlyLeu: 7.712 ± 0.122
2.127GlyMet: 2.127 ± 0.056
2.322GlyAsn: 2.322 ± 0.072
3.338GlyPro: 3.338 ± 0.072
3.342GlyGln: 3.342 ± 0.084
4.936GlyArg: 4.936 ± 0.084
5.025GlySer: 5.025 ± 0.086
5.008GlyThr: 5.008 ± 0.091
6.551GlyVal: 6.551 ± 0.119
1.372GlyTrp: 1.372 ± 0.05
2.311GlyTyr: 2.311 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.886HisAla: 1.886 ± 0.061
0.187HisCys: 0.187 ± 0.016
0.977HisAsp: 0.977 ± 0.041
1.0HisGlu: 1.0 ± 0.039
0.655HisPhe: 0.655 ± 0.032
1.548HisGly: 1.548 ± 0.049
0.418HisHis: 0.418 ± 0.025
0.901HisIle: 0.901 ± 0.037
0.718HisLys: 0.718 ± 0.033
1.952HisLeu: 1.952 ± 0.057
0.436HisMet: 0.436 ± 0.028
0.547HisAsn: 0.547 ± 0.028
1.335HisPro: 1.335 ± 0.049
0.675HisGln: 0.675 ± 0.033
1.137HisArg: 1.137 ± 0.044
1.131HisSer: 1.131 ± 0.041
1.148HisThr: 1.148 ± 0.045
1.535HisVal: 1.535 ± 0.046
0.298HisTrp: 0.298 ± 0.021
0.552HisTyr: 0.552 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
6.318IleAla: 6.318 ± 0.109
0.662IleCys: 0.662 ± 0.034
3.321IleAsp: 3.321 ± 0.068
3.103IleGlu: 3.103 ± 0.071
1.812IlePhe: 1.812 ± 0.068
4.649IleGly: 4.649 ± 0.094
0.845IleHis: 0.845 ± 0.033
2.408IleIle: 2.408 ± 0.071
1.68IleLys: 1.68 ± 0.056
4.249IleLeu: 4.249 ± 0.084
1.073IleMet: 1.073 ± 0.039
1.385IleAsn: 1.385 ± 0.049
2.76IlePro: 2.76 ± 0.072
1.226IleGln: 1.226 ± 0.046
2.557IleArg: 2.557 ± 0.069
3.539IleSer: 3.539 ± 0.083
2.948IleThr: 2.948 ± 0.077
4.263IleVal: 4.263 ± 0.086
0.57IleTrp: 0.57 ± 0.029
1.165IleTyr: 1.165 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
5.463LysAla: 5.463 ± 0.132
0.277LysCys: 0.277 ± 0.02
2.609LysAsp: 2.609 ± 0.072
2.86LysGlu: 2.86 ± 0.065
1.065LysPhe: 1.065 ± 0.038
3.038LysGly: 3.038 ± 0.074
0.839LysHis: 0.839 ± 0.04
2.374LysIle: 2.374 ± 0.066
2.725LysLys: 2.725 ± 0.084
4.094LysLeu: 4.094 ± 0.084
1.359LysMet: 1.359 ± 0.04
1.478LysAsn: 1.478 ± 0.055
2.27LysPro: 2.27 ± 0.082
1.77LysGln: 1.77 ± 0.052
2.553LysArg: 2.553 ± 0.065
2.304LysSer: 2.304 ± 0.066
2.506LysThr: 2.506 ± 0.079
3.914LysVal: 3.914 ± 0.08
0.679LysTrp: 0.679 ± 0.034
1.1LysTyr: 1.1 ± 0.046
0.0LysXaa: 0.0 ± 0.0
Leu
13.112LeuAla: 13.112 ± 0.197
0.776LeuCys: 0.776 ± 0.038
5.457LeuAsp: 5.457 ± 0.093
5.305LeuGlu: 5.305 ± 0.09
2.888LeuPhe: 2.888 ± 0.078
8.337LeuGly: 8.337 ± 0.116
1.796LeuHis: 1.796 ± 0.056
4.607LeuIle: 4.607 ± 0.115
3.364LeuLys: 3.364 ± 0.086
9.514LeuLeu: 9.514 ± 0.173
1.855LeuMet: 1.855 ± 0.051
2.359LeuAsn: 2.359 ± 0.058
5.399LeuPro: 5.399 ± 0.103
3.309LeuGln: 3.309 ± 0.072
5.95LeuArg: 5.95 ± 0.099
6.264LeuSer: 6.264 ± 0.106
5.787LeuThr: 5.787 ± 0.104
8.011LeuVal: 8.011 ± 0.115
1.114LeuTrp: 1.114 ± 0.051
1.87LeuTyr: 1.87 ± 0.056
0.0LeuXaa: 0.0 ± 0.0
Met
2.815MetAla: 2.815 ± 0.066
0.192MetCys: 0.192 ± 0.018
1.145MetAsp: 1.145 ± 0.042
1.056MetGlu: 1.056 ± 0.042
0.702MetPhe: 0.702 ± 0.032
1.936MetGly: 1.936 ± 0.06
0.416MetHis: 0.416 ± 0.024
1.045MetIle: 1.045 ± 0.043
0.91MetLys: 0.91 ± 0.04
2.044MetLeu: 2.044 ± 0.056
0.515MetMet: 0.515 ± 0.027
0.756MetAsn: 0.756 ± 0.033
1.126MetPro: 1.126 ± 0.042
0.827MetGln: 0.827 ± 0.031
1.663MetArg: 1.663 ± 0.058
1.744MetSer: 1.744 ± 0.045
1.317MetThr: 1.317 ± 0.049
1.85MetVal: 1.85 ± 0.057
0.27MetTrp: 0.27 ± 0.021
0.381MetTyr: 0.381 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.021AsnAla: 3.021 ± 0.076
0.2AsnCys: 0.2 ± 0.019
1.199AsnAsp: 1.199 ± 0.048
1.495AsnGlu: 1.495 ± 0.047
0.96AsnPhe: 0.96 ± 0.041
2.096AsnGly: 2.096 ± 0.063
0.498AsnHis: 0.498 ± 0.028
1.434AsnIle: 1.434 ± 0.052
1.259AsnLys: 1.259 ± 0.048
2.755AsnLeu: 2.755 ± 0.068
0.722AsnMet: 0.722 ± 0.035
0.824AsnAsn: 0.824 ± 0.041
1.953AsnPro: 1.953 ± 0.058
1.027AsnGln: 1.027 ± 0.044
1.521AsnArg: 1.521 ± 0.051
1.654AsnSer: 1.654 ± 0.05
1.592AsnThr: 1.592 ± 0.06
2.162AsnVal: 2.162 ± 0.059
0.484AsnTrp: 0.484 ± 0.024
0.793AsnTyr: 0.793 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
6.007ProAla: 6.007 ± 0.126
0.283ProCys: 0.283 ± 0.023
2.914ProAsp: 2.914 ± 0.074
3.585ProGlu: 3.585 ± 0.082
1.584ProPhe: 1.584 ± 0.044
3.968ProGly: 3.968 ± 0.081
1.011ProHis: 1.011 ± 0.039
2.264ProIle: 2.264 ± 0.051
2.404ProLys: 2.404 ± 0.079
4.483ProLeu: 4.483 ± 0.092
0.896ProMet: 0.896 ± 0.037
1.366ProAsn: 1.366 ± 0.05
1.746ProPro: 1.746 ± 0.061
2.012ProGln: 2.012 ± 0.054
2.387ProArg: 2.387 ± 0.06
3.121ProSer: 3.121 ± 0.077
3.307ProThr: 3.307 ± 0.072
4.051ProVal: 4.051 ± 0.073
0.67ProTrp: 0.67 ± 0.032
1.249ProTyr: 1.249 ± 0.05
0.0ProXaa: 0.0 ± 0.0
Gln
4.49GlnAla: 4.49 ± 0.101
0.227GlnCys: 0.227 ± 0.019
1.735GlnAsp: 1.735 ± 0.053
2.029GlnGlu: 2.029 ± 0.066
0.967GlnPhe: 0.967 ± 0.033
2.617GlnGly: 2.617 ± 0.058
0.587GlnHis: 0.587 ± 0.029
2.656GlnIle: 2.656 ± 0.065
1.903GlnLys: 1.903 ± 0.055
3.785GlnLeu: 3.785 ± 0.078
1.113GlnMet: 1.113 ± 0.043
1.225GlnAsn: 1.225 ± 0.044
1.412GlnPro: 1.412 ± 0.047
1.623GlnGln: 1.623 ± 0.055
2.098GlnArg: 2.098 ± 0.057
1.81GlnSer: 1.81 ± 0.057
2.078GlnThr: 2.078 ± 0.055
3.84GlnVal: 3.84 ± 0.081
0.589GlnTrp: 0.589 ± 0.029
0.81GlnTyr: 0.81 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
6.465ArgAla: 6.465 ± 0.11
0.39ArgCys: 0.39 ± 0.026
2.869ArgAsp: 2.869 ± 0.068
3.716ArgGlu: 3.716 ± 0.075
1.872ArgPhe: 1.872 ± 0.051
4.163ArgGly: 4.163 ± 0.077
1.134ArgHis: 1.134 ± 0.041
3.295ArgIle: 3.295 ± 0.075
2.878ArgLys: 2.878 ± 0.072
5.462ArgLeu: 5.462 ± 0.109
1.474ArgMet: 1.474 ± 0.046
1.675ArgAsn: 1.675 ± 0.052
2.823ArgPro: 2.823 ± 0.068
2.447ArgGln: 2.447 ± 0.07
4.218ArgArg: 4.218 ± 0.103
3.464ArgSer: 3.464 ± 0.079
3.255ArgThr: 3.255 ± 0.067
4.281ArgVal: 4.281 ± 0.083
0.865ArgTrp: 0.865 ± 0.042
1.471ArgTyr: 1.471 ± 0.045
0.0ArgXaa: 0.0 ± 0.0
Ser
6.974SerAla: 6.974 ± 0.111
0.466SerCys: 0.466 ± 0.029
3.043SerAsp: 3.043 ± 0.073
3.596SerGlu: 3.596 ± 0.068
2.274SerPhe: 2.274 ± 0.061
5.488SerGly: 5.488 ± 0.085
1.163SerHis: 1.163 ± 0.036
2.825SerIle: 2.825 ± 0.074
2.795SerLys: 2.795 ± 0.063
5.961SerLeu: 5.961 ± 0.095
1.272SerMet: 1.272 ± 0.045
1.541SerAsn: 1.541 ± 0.041
3.123SerPro: 3.123 ± 0.074
2.296SerGln: 2.296 ± 0.062
3.424SerArg: 3.424 ± 0.076
3.96SerSer: 3.96 ± 0.091
3.409SerThr: 3.409 ± 0.08
4.421SerVal: 4.421 ± 0.085
0.97SerTrp: 0.97 ± 0.039
1.466SerTyr: 1.466 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.921ThrAla: 5.921 ± 0.092
0.523ThrCys: 0.523 ± 0.028
3.207ThrAsp: 3.207 ± 0.08
3.0ThrGlu: 3.0 ± 0.066
1.959ThrPhe: 1.959 ± 0.061
5.059ThrGly: 5.059 ± 0.105
1.106ThrHis: 1.106 ± 0.045
2.998ThrIle: 2.998 ± 0.07
2.462ThrLys: 2.462 ± 0.062
5.431ThrLeu: 5.431 ± 0.102
1.223ThrMet: 1.223 ± 0.045
1.583ThrAsn: 1.583 ± 0.057
3.321ThrPro: 3.321 ± 0.083
1.889ThrGln: 1.889 ± 0.057
2.803ThrArg: 2.803 ± 0.073
3.485ThrSer: 3.485 ± 0.081
3.263ThrThr: 3.263 ± 0.07
4.944ThrVal: 4.944 ± 0.094
0.894ThrTrp: 0.894 ± 0.043
1.478ThrTyr: 1.478 ± 0.049
0.0ThrXaa: 0.0 ± 0.0
Val
9.972ValAla: 9.972 ± 0.142
0.799ValCys: 0.799 ± 0.036
4.812ValAsp: 4.812 ± 0.085
4.661ValGlu: 4.661 ± 0.091
2.49ValPhe: 2.49 ± 0.071
6.757ValGly: 6.757 ± 0.107
1.483ValHis: 1.483 ± 0.049
4.139ValIle: 4.139 ± 0.089
2.906ValLys: 2.906 ± 0.071
7.682ValLeu: 7.682 ± 0.112
1.7ValMet: 1.7 ± 0.052
2.144ValAsn: 2.144 ± 0.065
4.092ValPro: 4.092 ± 0.085
2.556ValGln: 2.556 ± 0.061
4.878ValArg: 4.878 ± 0.097
5.299ValSer: 5.299 ± 0.096
4.621ValThr: 4.621 ± 0.081
7.137ValVal: 7.137 ± 0.12
0.941ValTrp: 0.941 ± 0.037
1.583ValTyr: 1.583 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
1.655TrpAla: 1.655 ± 0.055
0.131TrpCys: 0.131 ± 0.014
0.819TrpAsp: 0.819 ± 0.037
0.712TrpGlu: 0.712 ± 0.032
0.523TrpPhe: 0.523 ± 0.025
0.987TrpGly: 0.987 ± 0.035
0.321TrpHis: 0.321 ± 0.023
0.739TrpIle: 0.739 ± 0.036
0.584TrpLys: 0.584 ± 0.033
1.417TrpLeu: 1.417 ± 0.054
0.389TrpMet: 0.389 ± 0.024
0.45TrpAsn: 0.45 ± 0.031
0.604TrpPro: 0.604 ± 0.032
0.675TrpGln: 0.675 ± 0.035
0.85TrpArg: 0.85 ± 0.042
0.662TrpSer: 0.662 ± 0.032
0.69TrpThr: 0.69 ± 0.032
1.114TrpVal: 1.114 ± 0.039
0.286TrpTrp: 0.286 ± 0.023
0.335TrpTyr: 0.335 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.433TyrAla: 2.433 ± 0.057
0.249TyrCys: 0.249 ± 0.021
1.335TyrAsp: 1.335 ± 0.048
1.357TyrGlu: 1.357 ± 0.047
0.954TyrPhe: 0.954 ± 0.038
2.025TyrGly: 2.025 ± 0.055
0.381TyrHis: 0.381 ± 0.022
0.911TyrIle: 0.911 ± 0.042
0.967TyrLys: 0.967 ± 0.039
2.602TyrLeu: 2.602 ± 0.065
0.453TyrMet: 0.453 ± 0.025
0.625TyrAsn: 0.625 ± 0.032
1.285TyrPro: 1.285 ± 0.054
1.008TyrGln: 1.008 ± 0.042
1.495TyrArg: 1.495 ± 0.055
1.506TyrSer: 1.506 ± 0.05
1.251TyrThr: 1.251 ± 0.054
1.778TyrVal: 1.778 ± 0.049
0.357TyrTrp: 0.357 ± 0.024
0.639TyrTyr: 0.639 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1934 proteins (650714 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski