Amino acid dipepetide frequency for Devosia sp. DBB001

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.102AlaAla: 16.102 ± 0.173	0.734AlaCys: 0.734 ± 0.027	6.944AlaAsp: 6.944 ± 0.08	7.446AlaGlu: 7.446 ± 0.088	4.665AlaPhe: 4.665 ± 0.062	10.356AlaGly: 10.356 ± 0.118	2.042AlaHis: 2.042 ± 0.04	7.039AlaIle: 7.039 ± 0.092	4.003AlaLys: 4.003 ± 0.067	13.421AlaLeu: 13.421 ± 0.127	3.613AlaMet: 3.613 ± 0.054	3.422AlaAsn: 3.422 ± 0.061	5.477AlaPro: 5.477 ± 0.087	4.169AlaGln: 4.169 ± 0.059	8.131AlaArg: 8.131 ± 0.09	6.289AlaSer: 6.289 ± 0.066	6.223AlaThr: 6.223 ± 0.076	8.784AlaVal: 8.784 ± 0.083	1.421AlaTrp: 1.421 ± 0.033	2.639AlaTyr: 2.639 ± 0.04	0.0AlaXaa: 0.0 ± 0.0
Cys	0.719CysAla: 0.719 ± 0.026	0.083CysCys: 0.083 ± 0.008	0.442CysAsp: 0.442 ± 0.02	0.342CysGlu: 0.342 ± 0.016	0.258CysPhe: 0.258 ± 0.013	0.708CysGly: 0.708 ± 0.023	0.205CysHis: 0.205 ± 0.013	0.325CysIle: 0.325 ± 0.016	0.149CysLys: 0.149 ± 0.012	0.639CysLeu: 0.639 ± 0.021	0.116CysMet: 0.116 ± 0.01	0.178CysAsn: 0.178 ± 0.011	0.364CysPro: 0.364 ± 0.018	0.172CysGln: 0.172 ± 0.011	0.457CysArg: 0.457 ± 0.019	0.375CysSer: 0.375 ± 0.016	0.335CysThr: 0.335 ± 0.016	0.474CysVal: 0.474 ± 0.018	0.074CysTrp: 0.074 ± 0.008	0.16CysTyr: 0.16 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.753AspAla: 6.753 ± 0.074	0.396AspCys: 0.396 ± 0.018	2.968AspAsp: 2.968 ± 0.048	3.573AspGlu: 3.573 ± 0.059	2.325AspPhe: 2.325 ± 0.041	5.19AspGly: 5.19 ± 0.086	1.127AspHis: 1.127 ± 0.03	3.244AspIle: 3.244 ± 0.051	1.945AspLys: 1.945 ± 0.045	5.919AspLeu: 5.919 ± 0.067	1.329AspMet: 1.329 ± 0.034	1.484AspAsn: 1.484 ± 0.037	3.45AspPro: 3.45 ± 0.051	1.695AspGln: 1.695 ± 0.036	3.898AspArg: 3.898 ± 0.058	2.102AspSer: 2.102 ± 0.046	2.629AspThr: 2.629 ± 0.05	4.173AspVal: 4.173 ± 0.059	1.023AspTrp: 1.023 ± 0.031	1.569AspTyr: 1.569 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	7.841GluAla: 7.841 ± 0.09	0.27GluCys: 0.27 ± 0.014	2.814GluAsp: 2.814 ± 0.05	3.291GluGlu: 3.291 ± 0.064	1.876GluPhe: 1.876 ± 0.043	4.407GluGly: 4.407 ± 0.062	1.206GluHis: 1.206 ± 0.03	3.43GluIle: 3.43 ± 0.062	2.253GluLys: 2.253 ± 0.047	5.44GluLeu: 5.44 ± 0.071	1.505GluMet: 1.505 ± 0.036	1.636GluAsn: 1.636 ± 0.038	2.899GluPro: 2.899 ± 0.059	2.078GluGln: 2.078 ± 0.052	4.567GluArg: 4.567 ± 0.073	2.378GluSer: 2.378 ± 0.038	3.455GluThr: 3.455 ± 0.05	4.035GluVal: 4.035 ± 0.061	0.693GluTrp: 0.693 ± 0.023	1.081GluTyr: 1.081 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	4.74PheAla: 4.74 ± 0.066	0.351PheCys: 0.351 ± 0.017	2.723PheAsp: 2.723 ± 0.047	2.258PheGlu: 2.258 ± 0.045	1.454PhePhe: 1.454 ± 0.039	3.763PheGly: 3.763 ± 0.058	0.743PheHis: 0.743 ± 0.025	1.896PheIle: 1.896 ± 0.044	1.121PheLys: 1.121 ± 0.027	3.502PheLeu: 3.502 ± 0.057	0.815PheMet: 0.815 ± 0.027	1.195PheAsn: 1.195 ± 0.033	1.625PhePro: 1.625 ± 0.037	1.067PheGln: 1.067 ± 0.028	2.092PheArg: 2.092 ± 0.043	2.361PheSer: 2.361 ± 0.043	2.11PheThr: 2.11 ± 0.039	3.1PheVal: 3.1 ± 0.051	0.634PheTrp: 0.634 ± 0.023	1.0PheTyr: 1.0 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	9.093GlyAla: 9.093 ± 0.095	0.656GlyCys: 0.656 ± 0.023	4.36GlyAsp: 4.36 ± 0.07	5.025GlyGlu: 5.025 ± 0.072	3.633GlyPhe: 3.633 ± 0.051	7.366GlyGly: 7.366 ± 0.1	1.77GlyHis: 1.77 ± 0.038	4.875GlyIle: 4.875 ± 0.061	3.658GlyLys: 3.658 ± 0.058	8.857GlyLeu: 8.857 ± 0.084	2.246GlyMet: 2.246 ± 0.041	2.561GlyAsn: 2.561 ± 0.045	3.505GlyPro: 3.505 ± 0.051	3.028GlyGln: 3.028 ± 0.051	5.505GlyArg: 5.505 ± 0.077	4.682GlySer: 4.682 ± 0.07	4.778GlyThr: 4.778 ± 0.07	6.336GlyVal: 6.336 ± 0.073	1.363GlyTrp: 1.363 ± 0.033	2.37GlyTyr: 2.37 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.998HisAla: 1.998 ± 0.039	0.171HisCys: 0.171 ± 0.014	1.198HisAsp: 1.198 ± 0.031	1.077HisGlu: 1.077 ± 0.031	0.874HisPhe: 0.874 ± 0.025	1.796HisGly: 1.796 ± 0.043	0.537HisHis: 0.537 ± 0.023	0.969HisIle: 0.969 ± 0.027	0.554HisLys: 0.554 ± 0.022	1.96HisLeu: 1.96 ± 0.04	0.486HisMet: 0.486 ± 0.017	0.515HisAsn: 0.515 ± 0.019	1.24HisPro: 1.24 ± 0.033	0.557HisGln: 0.557 ± 0.02	1.275HisArg: 1.275 ± 0.035	0.851HisSer: 0.851 ± 0.025	0.877HisThr: 0.877 ± 0.028	1.422HisVal: 1.422 ± 0.037	0.303HisTrp: 0.303 ± 0.016	0.516HisTyr: 0.516 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	7.738IleAla: 7.738 ± 0.081	0.433IleCys: 0.433 ± 0.018	3.794IleAsp: 3.794 ± 0.052	3.651IleGlu: 3.651 ± 0.055	1.894IlePhe: 1.894 ± 0.043	5.232IleGly: 5.232 ± 0.07	0.887IleHis: 0.887 ± 0.023	2.614IleIle: 2.614 ± 0.047	1.606IleLys: 1.606 ± 0.034	4.717IleLeu: 4.717 ± 0.07	1.061IleMet: 1.061 ± 0.033	1.587IleAsn: 1.587 ± 0.042	2.428IlePro: 2.428 ± 0.04	1.247IleGln: 1.247 ± 0.029	3.033IleArg: 3.033 ± 0.045	3.037IleSer: 3.037 ± 0.056	2.869IleThr: 2.869 ± 0.043	4.804IleVal: 4.804 ± 0.065	0.654IleTrp: 0.654 ± 0.022	1.247IleTyr: 1.247 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	4.665LysAla: 4.665 ± 0.072	0.127LysCys: 0.127 ± 0.01	1.809LysAsp: 1.809 ± 0.043	1.548LysGlu: 1.548 ± 0.038	1.006LysPhe: 1.006 ± 0.028	2.703LysGly: 2.703 ± 0.051	0.587LysHis: 0.587 ± 0.024	1.668LysIle: 1.668 ± 0.041	1.126LysLys: 1.126 ± 0.039	3.473LysLeu: 3.473 ± 0.051	0.723LysMet: 0.723 ± 0.024	0.759LysAsn: 0.759 ± 0.027	2.065LysPro: 2.065 ± 0.046	1.012LysGln: 1.012 ± 0.028	2.295LysArg: 2.295 ± 0.048	1.922LysSer: 1.922 ± 0.037	2.04LysThr: 2.04 ± 0.044	2.71LysVal: 2.71 ± 0.054	0.39LysTrp: 0.39 ± 0.019	0.63LysTyr: 0.63 ± 0.024	0.0LysXaa: 0.0 ± 0.0
Leu	13.736LeuAla: 13.736 ± 0.146	0.698LeuCys: 0.698 ± 0.023	6.158LeuAsp: 6.158 ± 0.062	5.366LeuGlu: 5.366 ± 0.069	3.652LeuPhe: 3.652 ± 0.063	8.546LeuGly: 8.546 ± 0.084	1.717LeuHis: 1.717 ± 0.035	5.175LeuIle: 5.175 ± 0.07	3.664LeuLys: 3.664 ± 0.063	9.54LeuLeu: 9.54 ± 0.124	2.366LeuMet: 2.366 ± 0.041	2.91LeuAsn: 2.91 ± 0.049	5.551LeuPro: 5.551 ± 0.073	2.644LeuGln: 2.644 ± 0.047	6.422LeuArg: 6.422 ± 0.072	6.359LeuSer: 6.359 ± 0.087	5.748LeuThr: 5.748 ± 0.061	8.063LeuVal: 8.063 ± 0.078	1.16LeuTrp: 1.16 ± 0.035	2.107LeuTyr: 2.107 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	3.213MetAla: 3.213 ± 0.049	0.124MetCys: 0.124 ± 0.009	1.098MetAsp: 1.098 ± 0.025	1.07MetGlu: 1.07 ± 0.032	0.79MetPhe: 0.79 ± 0.025	1.831MetGly: 1.831 ± 0.034	0.439MetHis: 0.439 ± 0.02	1.332MetIle: 1.332 ± 0.034	0.851MetLys: 0.851 ± 0.031	2.564MetLeu: 2.564 ± 0.051	0.587MetMet: 0.587 ± 0.023	0.765MetAsn: 0.765 ± 0.025	1.455MetPro: 1.455 ± 0.033	0.84MetGln: 0.84 ± 0.025	1.661MetArg: 1.661 ± 0.027	1.665MetSer: 1.665 ± 0.038	1.929MetThr: 1.929 ± 0.034	1.822MetVal: 1.822 ± 0.039	0.212MetTrp: 0.212 ± 0.013	0.307MetTyr: 0.307 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.51AsnAla: 3.51 ± 0.056	0.208AsnCys: 0.208 ± 0.012	1.468AsnAsp: 1.468 ± 0.042	1.32AsnGlu: 1.32 ± 0.031	1.148AsnPhe: 1.148 ± 0.031	2.733AsnGly: 2.733 ± 0.06	0.506AsnHis: 0.506 ± 0.02	1.488AsnIle: 1.488 ± 0.036	0.829AsnLys: 0.829 ± 0.024	2.857AsnLeu: 2.857 ± 0.047	0.665AsnMet: 0.665 ± 0.021	0.803AsnAsn: 0.803 ± 0.028	2.079AsnPro: 2.079 ± 0.043	0.87AsnGln: 0.87 ± 0.024	1.825AsnArg: 1.825 ± 0.039	1.442AsnSer: 1.442 ± 0.03	1.418AsnThr: 1.418 ± 0.042	2.136AsnVal: 2.136 ± 0.042	0.518AsnTrp: 0.518 ± 0.021	0.825AsnTyr: 0.825 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	6.225ProAla: 6.225 ± 0.091	0.253ProCys: 0.253 ± 0.014	3.54ProAsp: 3.54 ± 0.056	3.737ProGlu: 3.737 ± 0.06	2.03ProPhe: 2.03 ± 0.041	4.388ProGly: 4.388 ± 0.06	1.073ProHis: 1.073 ± 0.029	2.53ProIle: 2.53 ± 0.048	1.687ProLys: 1.687 ± 0.036	4.727ProLeu: 4.727 ± 0.067	1.175ProMet: 1.175 ± 0.033	1.601ProAsn: 1.601 ± 0.038	2.334ProPro: 2.334 ± 0.055	1.711ProGln: 1.711 ± 0.035	2.805ProArg: 2.805 ± 0.048	2.808ProSer: 2.808 ± 0.049	2.627ProThr: 2.627 ± 0.044	4.218ProVal: 4.218 ± 0.062	0.661ProTrp: 0.661 ± 0.019	1.272ProTyr: 1.272 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.946GlnAla: 3.946 ± 0.056	0.176GlnCys: 0.176 ± 0.011	1.458GlnAsp: 1.458 ± 0.035	1.373GlnGlu: 1.373 ± 0.033	1.229GlnPhe: 1.229 ± 0.035	2.337GlnGly: 2.337 ± 0.041	0.618GlnHis: 0.618 ± 0.022	1.84GlnIle: 1.84 ± 0.038	1.042GlnLys: 1.042 ± 0.029	3.153GlnLeu: 3.153 ± 0.043	0.981GlnMet: 0.981 ± 0.027	0.869GlnAsn: 0.869 ± 0.027	1.799GlnPro: 1.799 ± 0.041	1.278GlnGln: 1.278 ± 0.039	2.4GlnArg: 2.4 ± 0.046	1.816GlnSer: 1.816 ± 0.03	1.75GlnThr: 1.75 ± 0.039	2.483GlnVal: 2.483 ± 0.047	0.418GlnTrp: 0.418 ± 0.019	0.702GlnTyr: 0.702 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	7.102ArgAla: 7.102 ± 0.1	0.406ArgCys: 0.406 ± 0.019	3.707ArgAsp: 3.707 ± 0.048	3.872ArgGlu: 3.872 ± 0.059	2.7ArgPhe: 2.7 ± 0.042	4.478ArgGly: 4.478 ± 0.057	1.506ArgHis: 1.506 ± 0.037	3.838ArgIle: 3.838 ± 0.059	2.297ArgLys: 2.297 ± 0.045	7.275ArgLeu: 7.275 ± 0.09	1.735ArgMet: 1.735 ± 0.035	1.995ArgAsn: 1.995 ± 0.041	3.218ArgPro: 3.218 ± 0.054	2.58ArgGln: 2.58 ± 0.043	4.932ArgArg: 4.932 ± 0.071	3.466ArgSer: 3.466 ± 0.049	3.266ArgThr: 3.266 ± 0.052	4.532ArgVal: 4.532 ± 0.056	0.887ArgTrp: 0.887 ± 0.027	1.675ArgTyr: 1.675 ± 0.036	0.0ArgXaa: 0.0 ± 0.0
Ser	6.043SerAla: 6.043 ± 0.068	0.327SerCys: 0.327 ± 0.014	2.892SerAsp: 2.892 ± 0.045	2.786SerGlu: 2.786 ± 0.048	2.361SerPhe: 2.361 ± 0.048	5.481SerGly: 5.481 ± 0.078	1.018SerHis: 1.018 ± 0.027	3.063SerIle: 3.063 ± 0.046	1.58SerLys: 1.58 ± 0.038	5.625SerLeu: 5.625 ± 0.064	1.316SerMet: 1.316 ± 0.034	1.498SerAsn: 1.498 ± 0.037	2.796SerPro: 2.796 ± 0.048	1.702SerGln: 1.702 ± 0.033	3.502SerArg: 3.502 ± 0.055	2.875SerSer: 2.875 ± 0.053	2.806SerThr: 2.806 ± 0.047	4.217SerVal: 4.217 ± 0.059	0.772SerTrp: 0.772 ± 0.025	1.332SerTyr: 1.332 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.121ThrAla: 6.121 ± 0.079	0.308ThrCys: 0.308 ± 0.016	2.937ThrAsp: 2.937 ± 0.057	2.808ThrGlu: 2.808 ± 0.045	2.177ThrPhe: 2.177 ± 0.04	5.16ThrGly: 5.16 ± 0.082	1.117ThrHis: 1.117 ± 0.029	3.353ThrIle: 3.353 ± 0.05	1.495ThrLys: 1.495 ± 0.034	6.078ThrLeu: 6.078 ± 0.071	1.195ThrMet: 1.195 ± 0.033	1.521ThrAsn: 1.521 ± 0.036	3.241ThrPro: 3.241 ± 0.052	1.561ThrGln: 1.561 ± 0.034	3.298ThrArg: 3.298 ± 0.046	2.923ThrSer: 2.923 ± 0.047	3.027ThrThr: 3.027 ± 0.056	4.248ThrVal: 4.248 ± 0.059	0.682ThrTrp: 0.682 ± 0.024	1.338ThrTyr: 1.338 ± 0.034	0.0ThrXaa: 0.0 ± 0.0
Val	9.499ValAla: 9.499 ± 0.077	0.523ValCys: 0.523 ± 0.018	4.321ValAsp: 4.321 ± 0.052	4.677ValGlu: 4.677 ± 0.062	2.93ValPhe: 2.93 ± 0.051	6.078ValGly: 6.078 ± 0.078	1.305ValHis: 1.305 ± 0.03	4.226ValIle: 4.226 ± 0.059	2.33ValLys: 2.33 ± 0.052	7.883ValLeu: 7.883 ± 0.093	1.839ValMet: 1.839 ± 0.043	2.14ValAsn: 2.14 ± 0.05	3.993ValPro: 3.993 ± 0.056	2.072ValGln: 2.072 ± 0.042	4.669ValArg: 4.669 ± 0.056	4.522ValSer: 4.522 ± 0.066	4.79ValThr: 4.79 ± 0.069	6.367ValVal: 6.367 ± 0.082	0.913ValTrp: 0.913 ± 0.026	1.606ValTyr: 1.606 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.267TrpAla: 1.267 ± 0.033	0.121TrpCys: 0.121 ± 0.008	0.679TrpAsp: 0.679 ± 0.023	0.576TrpGlu: 0.576 ± 0.019	0.543TrpPhe: 0.543 ± 0.021	0.94TrpGly: 0.94 ± 0.029	0.299TrpHis: 0.299 ± 0.016	0.675TrpIle: 0.675 ± 0.025	0.429TrpLys: 0.429 ± 0.018	1.598TrpLeu: 1.598 ± 0.039	0.34TrpMet: 0.34 ± 0.016	0.524TrpAsn: 0.524 ± 0.021	0.686TrpPro: 0.686 ± 0.023	0.634TrpGln: 0.634 ± 0.023	1.023TrpArg: 1.023 ± 0.025	0.838TrpSer: 0.838 ± 0.027	0.768TrpThr: 0.768 ± 0.022	0.946TrpVal: 0.946 ± 0.03	0.241TrpTrp: 0.241 ± 0.014	0.307TrpTyr: 0.307 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.606TyrAla: 2.606 ± 0.052	0.211TyrCys: 0.211 ± 0.013	1.481TyrAsp: 1.481 ± 0.035	1.358TyrGlu: 1.358 ± 0.029	1.007TyrPhe: 1.007 ± 0.03	2.172TyrGly: 2.172 ± 0.046	0.473TyrHis: 0.473 ± 0.02	0.955TyrIle: 0.955 ± 0.023	0.64TyrLys: 0.64 ± 0.021	2.353TyrLeu: 2.353 ± 0.041	0.46TyrMet: 0.46 ± 0.018	0.689TyrAsn: 0.689 ± 0.025	1.198TyrPro: 1.198 ± 0.032	0.749TyrGln: 0.749 ± 0.022	1.678TyrArg: 1.678 ± 0.038	1.278TyrSer: 1.278 ± 0.03	1.141TyrThr: 1.141 ± 0.032	1.815TyrVal: 1.815 ± 0.035	0.417TyrTrp: 0.417 ± 0.017	0.662TyrTyr: 0.662 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4502 proteins (1360218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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