Amino acid dipepetide frequency for Rickettsiella grylli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.621AlaAla: 5.621 ± 0.147
1.175AlaCys: 1.175 ± 0.066
3.096AlaAsp: 3.096 ± 0.091
4.156AlaGlu: 4.156 ± 0.097
3.311AlaPhe: 3.311 ± 0.103
4.238AlaGly: 4.238 ± 0.137
2.075AlaHis: 2.075 ± 0.07
6.012AlaIle: 6.012 ± 0.122
4.367AlaLys: 4.367 ± 0.112
9.373AlaLeu: 9.373 ± 0.158
1.734AlaMet: 1.734 ± 0.074
2.827AlaAsn: 2.827 ± 0.084
2.066AlaPro: 2.066 ± 0.074
3.218AlaGln: 3.218 ± 0.09
3.277AlaArg: 3.277 ± 0.096
4.152AlaSer: 4.152 ± 0.09
3.63AlaThr: 3.63 ± 0.093
4.1AlaVal: 4.1 ± 0.106
0.947AlaTrp: 0.947 ± 0.048
2.617AlaTyr: 2.617 ± 0.078
0.0AlaXaa: 0.0 ± 0.0
Cys
0.852CysAla: 0.852 ± 0.044
0.194CysCys: 0.194 ± 0.021
0.527CysAsp: 0.527 ± 0.034
0.565CysGlu: 0.565 ± 0.035
0.739CysPhe: 0.739 ± 0.045
0.868CysGly: 0.868 ± 0.048
0.405CysHis: 0.405 ± 0.028
0.942CysIle: 0.942 ± 0.064
0.603CysLys: 0.603 ± 0.041
1.526CysLeu: 1.526 ± 0.068
0.233CysMet: 0.233 ± 0.025
0.371CysAsn: 0.371 ± 0.032
0.579CysPro: 0.579 ± 0.044
0.574CysGln: 0.574 ± 0.042
0.581CysArg: 0.581 ± 0.04
0.725CysSer: 0.725 ± 0.041
0.57CysThr: 0.57 ± 0.034
0.73CysVal: 0.73 ± 0.037
0.104CysTrp: 0.104 ± 0.015
0.463CysTyr: 0.463 ± 0.033
0.0CysXaa: 0.0 ± 0.0
Asp
3.338AspAla: 3.338 ± 0.163
0.506AspCys: 0.506 ± 0.036
1.856AspAsp: 1.856 ± 0.074
2.678AspGlu: 2.678 ± 0.076
2.276AspPhe: 2.276 ± 0.069
2.106AspGly: 2.106 ± 0.089
1.153AspHis: 1.153 ± 0.048
3.363AspIle: 3.363 ± 0.101
2.981AspLys: 2.981 ± 0.086
5.088AspLeu: 5.088 ± 0.105
0.89AspMet: 0.89 ± 0.05
1.937AspAsn: 1.937 ± 0.082
2.1AspPro: 2.1 ± 0.068
1.6AspGln: 1.6 ± 0.075
2.077AspArg: 2.077 ± 0.076
2.409AspSer: 2.409 ± 0.076
2.109AspThr: 2.109 ± 0.073
2.595AspVal: 2.595 ± 0.077
0.567AspTrp: 0.567 ± 0.039
2.059AspTyr: 2.059 ± 0.077
0.0AspXaa: 0.0 ± 0.0
Glu
3.998GluAla: 3.998 ± 0.104
0.576GluCys: 0.576 ± 0.033
2.021GluAsp: 2.021 ± 0.069
3.203GluGlu: 3.203 ± 0.1
2.077GluPhe: 2.077 ± 0.078
2.999GluGly: 2.999 ± 0.102
1.25GluHis: 1.25 ± 0.056
4.665GluIle: 4.665 ± 0.103
5.616GluLys: 5.616 ± 0.12
5.571GluLeu: 5.571 ± 0.124
1.313GluMet: 1.313 ± 0.061
3.27GluAsn: 3.27 ± 0.1
1.569GluPro: 1.569 ± 0.063
2.54GluGln: 2.54 ± 0.085
2.904GluArg: 2.904 ± 0.083
2.798GluSer: 2.798 ± 0.078
3.085GluThr: 3.085 ± 0.084
3.081GluVal: 3.081 ± 0.101
0.531GluTrp: 0.531 ± 0.041
1.428GluTyr: 1.428 ± 0.059
0.0GluXaa: 0.0 ± 0.0
Phe
2.769PheAla: 2.769 ± 0.083
0.617PheCys: 0.617 ± 0.04
2.269PheAsp: 2.269 ± 0.081
2.204PheGlu: 2.204 ± 0.074
3.119PhePhe: 3.119 ± 0.126
2.427PheGly: 2.427 ± 0.077
1.162PheHis: 1.162 ± 0.054
4.208PheIle: 4.208 ± 0.117
2.778PheLys: 2.778 ± 0.089
5.562PheLeu: 5.562 ± 0.174
1.06PheMet: 1.06 ± 0.051
2.694PheAsn: 2.694 ± 0.09
2.093PhePro: 2.093 ± 0.067
1.756PheGln: 1.756 ± 0.068
1.885PheArg: 1.885 ± 0.065
4.353PheSer: 4.353 ± 0.127
2.457PheThr: 2.457 ± 0.081
2.375PheVal: 2.375 ± 0.08
0.545PheTrp: 0.545 ± 0.034
1.964PheTyr: 1.964 ± 0.074
0.0PheXaa: 0.0 ± 0.0
Gly
4.021GlyAla: 4.021 ± 0.134
0.816GlyCys: 0.816 ± 0.048
2.497GlyAsp: 2.497 ± 0.088
3.022GlyGlu: 3.022 ± 0.087
3.108GlyPhe: 3.108 ± 0.087
3.967GlyGly: 3.967 ± 0.152
1.688GlyHis: 1.688 ± 0.064
4.986GlyIle: 4.986 ± 0.114
3.621GlyLys: 3.621 ± 0.111
7.002GlyLeu: 7.002 ± 0.146
1.365GlyMet: 1.365 ± 0.063
2.253GlyAsn: 2.253 ± 0.078
1.858GlyPro: 1.858 ± 0.074
2.391GlyGln: 2.391 ± 0.09
2.773GlyArg: 2.773 ± 0.093
3.533GlySer: 3.533 ± 0.15
2.8GlyThr: 2.8 ± 0.11
3.729GlyVal: 3.729 ± 0.096
0.755GlyTrp: 0.755 ± 0.05
2.283GlyTyr: 2.283 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
2.208HisAla: 2.208 ± 0.078
0.47HisCys: 0.47 ± 0.034
1.184HisAsp: 1.184 ± 0.054
1.266HisGlu: 1.266 ± 0.053
1.691HisPhe: 1.691 ± 0.066
1.442HisGly: 1.442 ± 0.058
1.128HisHis: 1.128 ± 0.049
1.919HisIle: 1.919 ± 0.065
1.148HisLys: 1.148 ± 0.056
3.431HisLeu: 3.431 ± 0.089
0.434HisMet: 0.434 ± 0.03
0.974HisAsn: 0.974 ± 0.044
1.483HisPro: 1.483 ± 0.058
1.354HisGln: 1.354 ± 0.048
1.467HisArg: 1.467 ± 0.057
1.743HisSer: 1.743 ± 0.06
1.32HisThr: 1.32 ± 0.055
1.702HisVal: 1.702 ± 0.072
0.515HisTrp: 0.515 ± 0.037
1.575HisTyr: 1.575 ± 0.067
0.0HisXaa: 0.0 ± 0.0
Ile
6.224IleAla: 6.224 ± 0.121
0.823IleCys: 0.823 ± 0.045
4.091IleAsp: 4.091 ± 0.096
4.525IleGlu: 4.525 ± 0.122
3.331IlePhe: 3.331 ± 0.118
4.676IleGly: 4.676 ± 0.132
2.233IleHis: 2.233 ± 0.073
5.639IleIle: 5.639 ± 0.137
5.169IleLys: 5.169 ± 0.12
7.682IleLeu: 7.682 ± 0.162
1.3IleMet: 1.3 ± 0.056
4.251IleAsn: 4.251 ± 0.106
3.666IlePro: 3.666 ± 0.098
3.557IleGln: 3.557 ± 0.093
3.318IleArg: 3.318 ± 0.094
5.022IleSer: 5.022 ± 0.112
4.272IleThr: 4.272 ± 0.098
4.419IleVal: 4.419 ± 0.116
0.669IleTrp: 0.669 ± 0.04
2.477IleTyr: 2.477 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
4.19LysAla: 4.19 ± 0.114
0.472LysCys: 0.472 ± 0.036
2.344LysAsp: 2.344 ± 0.094
4.306LysGlu: 4.306 ± 0.118
2.014LysPhe: 2.014 ± 0.082
3.25LysGly: 3.25 ± 0.083
1.48LysHis: 1.48 ± 0.056
5.693LysIle: 5.693 ± 0.124
7.434LysLys: 7.434 ± 0.187
6.416LysLeu: 6.416 ± 0.124
1.596LysMet: 1.596 ± 0.065
4.855LysAsn: 4.855 ± 0.136
2.638LysPro: 2.638 ± 0.087
3.526LysGln: 3.526 ± 0.099
3.49LysArg: 3.49 ± 0.083
3.481LysSer: 3.481 ± 0.098
4.095LysThr: 4.095 ± 0.103
2.888LysVal: 2.888 ± 0.082
0.617LysTrp: 0.617 ± 0.051
1.575LysTyr: 1.575 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
9.031LeuAla: 9.031 ± 0.162
1.27LeuCys: 1.27 ± 0.048
4.984LeuAsp: 4.984 ± 0.127
6.193LeuGlu: 6.193 ± 0.139
5.761LeuPhe: 5.761 ± 0.151
6.972LeuGly: 6.972 ± 0.15
2.916LeuHis: 2.916 ± 0.107
8.851LeuIle: 8.851 ± 0.17
8.453LeuLys: 8.453 ± 0.152
13.443LeuLeu: 13.443 ± 0.274
2.586LeuMet: 2.586 ± 0.084
6.462LeuAsn: 6.462 ± 0.14
5.002LeuPro: 5.002 ± 0.119
4.753LeuGln: 4.753 ± 0.112
4.909LeuArg: 4.909 ± 0.115
8.638LeuSer: 8.638 ± 0.151
6.81LeuThr: 6.81 ± 0.14
5.612LeuVal: 5.612 ± 0.123
1.218LeuTrp: 1.218 ± 0.068
3.182LeuTyr: 3.182 ± 0.082
0.0LeuXaa: 0.0 ± 0.0
Met
1.84MetAla: 1.84 ± 0.072
0.192MetCys: 0.192 ± 0.021
1.051MetAsp: 1.051 ± 0.054
0.949MetGlu: 0.949 ± 0.045
0.579MetPhe: 0.579 ± 0.037
1.385MetGly: 1.385 ± 0.063
0.606MetHis: 0.606 ± 0.037
1.523MetIle: 1.523 ± 0.056
1.381MetLys: 1.381 ± 0.058
2.136MetLeu: 2.136 ± 0.081
0.601MetMet: 0.601 ± 0.041
1.27MetAsn: 1.27 ± 0.054
0.879MetPro: 0.879 ± 0.051
0.988MetGln: 0.988 ± 0.053
1.065MetArg: 1.065 ± 0.052
1.48MetSer: 1.48 ± 0.054
1.453MetThr: 1.453 ± 0.064
1.116MetVal: 1.116 ± 0.047
0.14MetTrp: 0.14 ± 0.017
0.405MetTyr: 0.405 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.605AsnAla: 3.605 ± 0.102
0.531AsnCys: 0.531 ± 0.039
2.131AsnAsp: 2.131 ± 0.08
2.631AsnGlu: 2.631 ± 0.082
2.335AsnPhe: 2.335 ± 0.09
2.339AsnGly: 2.339 ± 0.089
1.431AsnHis: 1.431 ± 0.057
3.345AsnIle: 3.345 ± 0.098
3.539AsnLys: 3.539 ± 0.109
5.038AsnLeu: 5.038 ± 0.121
0.746AsnMet: 0.746 ± 0.035
2.751AsnAsn: 2.751 ± 0.109
2.699AsnPro: 2.699 ± 0.087
2.583AsnGln: 2.583 ± 0.073
2.47AsnArg: 2.47 ± 0.069
2.696AsnSer: 2.696 ± 0.094
2.855AsnThr: 2.855 ± 0.094
2.723AsnVal: 2.723 ± 0.096
0.533AsnTrp: 0.533 ± 0.036
1.966AsnTyr: 1.966 ± 0.086
0.0AsnXaa: 0.0 ± 0.0
Pro
2.425ProAla: 2.425 ± 0.089
0.511ProCys: 0.511 ± 0.037
1.962ProAsp: 1.962 ± 0.069
2.561ProGlu: 2.561 ± 0.083
2.314ProPhe: 2.314 ± 0.085
2.4ProGly: 2.4 ± 0.082
1.413ProHis: 1.413 ± 0.054
3.27ProIle: 3.27 ± 0.092
2.07ProLys: 2.07 ± 0.076
5.277ProLeu: 5.277 ± 0.11
0.764ProMet: 0.764 ± 0.042
1.822ProAsn: 1.822 ± 0.072
1.575ProPro: 1.575 ± 0.054
1.837ProGln: 1.837 ± 0.08
1.67ProArg: 1.67 ± 0.07
2.626ProSer: 2.626 ± 0.071
2.122ProThr: 2.122 ± 0.075
2.452ProVal: 2.452 ± 0.077
0.49ProTrp: 0.49 ± 0.041
1.548ProTyr: 1.548 ± 0.062
0.0ProXaa: 0.0 ± 0.0
Gln
3.438GlnAla: 3.438 ± 0.097
0.628GlnCys: 0.628 ± 0.054
1.46GlnAsp: 1.46 ± 0.06
2.432GlnGlu: 2.432 ± 0.076
2.145GlnPhe: 2.145 ± 0.064
2.766GlnGly: 2.766 ± 0.086
1.557GlnHis: 1.557 ± 0.067
2.938GlnIle: 2.938 ± 0.101
3.042GlnLys: 3.042 ± 0.105
6.053GlnLeu: 6.053 ± 0.124
0.909GlnMet: 0.909 ± 0.035
1.898GlnAsn: 1.898 ± 0.07
1.555GlnPro: 1.555 ± 0.061
2.823GlnGln: 2.823 ± 0.119
2.699GlnArg: 2.699 ± 0.104
2.701GlnSer: 2.701 ± 0.081
2.649GlnThr: 2.649 ± 0.093
2.344GlnVal: 2.344 ± 0.085
0.671GlnTrp: 0.671 ± 0.045
1.18GlnTyr: 1.18 ± 0.057
0.0GlnXaa: 0.0 ± 0.0
Arg
3.105ArgAla: 3.105 ± 0.1
0.617ArgCys: 0.617 ± 0.037
2.093ArgAsp: 2.093 ± 0.076
2.748ArgGlu: 2.748 ± 0.09
2.687ArgPhe: 2.687 ± 0.085
2.66ArgGly: 2.66 ± 0.089
1.392ArgHis: 1.392 ± 0.061
3.6ArgIle: 3.6 ± 0.106
2.708ArgLys: 2.708 ± 0.076
6.322ArgLeu: 6.322 ± 0.142
0.963ArgMet: 0.963 ± 0.042
1.853ArgAsn: 1.853 ± 0.071
1.654ArgPro: 1.654 ± 0.058
2.224ArgGln: 2.224 ± 0.087
2.464ArgArg: 2.464 ± 0.101
2.712ArgSer: 2.712 ± 0.08
2.034ArgThr: 2.034 ± 0.068
2.64ArgVal: 2.64 ± 0.091
0.714ArgTrp: 0.714 ± 0.039
2.163ArgTyr: 2.163 ± 0.077
0.0ArgXaa: 0.0 ± 0.0
Ser
4.353SerAla: 4.353 ± 0.114
0.735SerCys: 0.735 ± 0.047
2.746SerAsp: 2.746 ± 0.079
3.194SerGlu: 3.194 ± 0.098
3.331SerPhe: 3.331 ± 0.11
4.032SerGly: 4.032 ± 0.146
1.795SerHis: 1.795 ± 0.063
4.904SerIle: 4.904 ± 0.101
3.417SerLys: 3.417 ± 0.096
7.96SerLeu: 7.96 ± 0.136
1.333SerMet: 1.333 ± 0.057
2.821SerAsn: 2.821 ± 0.089
2.547SerPro: 2.547 ± 0.078
2.861SerGln: 2.861 ± 0.085
2.929SerArg: 2.929 ± 0.081
4.009SerSer: 4.009 ± 0.118
3.553SerThr: 3.553 ± 0.096
3.576SerVal: 3.576 ± 0.097
0.576SerTrp: 0.576 ± 0.037
2.007SerTyr: 2.007 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
3.768ThrAla: 3.768 ± 0.09
0.644ThrCys: 0.644 ± 0.04
2.371ThrAsp: 2.371 ± 0.09
2.992ThrGlu: 2.992 ± 0.095
2.249ThrPhe: 2.249 ± 0.074
3.657ThrGly: 3.657 ± 0.129
1.894ThrHis: 1.894 ± 0.074
3.989ThrIle: 3.989 ± 0.093
2.629ThrLys: 2.629 ± 0.09
7.217ThrLeu: 7.217 ± 0.152
1.132ThrMet: 1.132 ± 0.055
1.894ThrAsn: 1.894 ± 0.068
2.931ThrPro: 2.931 ± 0.089
2.791ThrGln: 2.791 ± 0.096
2.427ThrArg: 2.427 ± 0.084
3.27ThrSer: 3.27 ± 0.113
3.017ThrThr: 3.017 ± 0.103
3.13ThrVal: 3.13 ± 0.088
0.601ThrTrp: 0.601 ± 0.037
1.596ThrTyr: 1.596 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.131ValAla: 4.131 ± 0.111
0.694ValCys: 0.694 ± 0.037
3.026ValAsp: 3.026 ± 0.09
2.83ValGlu: 2.83 ± 0.096
2.545ValPhe: 2.545 ± 0.085
3.657ValGly: 3.657 ± 0.117
1.374ValHis: 1.374 ± 0.066
4.577ValIle: 4.577 ± 0.098
3.221ValLys: 3.221 ± 0.098
6.046ValLeu: 6.046 ± 0.132
1.284ValMet: 1.284 ± 0.064
2.816ValAsn: 2.816 ± 0.096
2.188ValPro: 2.188 ± 0.07
1.804ValGln: 1.804 ± 0.065
2.341ValArg: 2.341 ± 0.079
3.58ValSer: 3.58 ± 0.094
3.074ValThr: 3.074 ± 0.091
3.496ValVal: 3.496 ± 0.105
0.581ValTrp: 0.581 ± 0.038
1.813ValTyr: 1.813 ± 0.066
0.0ValXaa: 0.0 ± 0.0
Trp
0.671TrpAla: 0.671 ± 0.034
0.149TrpCys: 0.149 ± 0.019
0.533TrpAsp: 0.533 ± 0.038
0.585TrpGlu: 0.585 ± 0.042
0.545TrpPhe: 0.545 ± 0.037
0.685TrpGly: 0.685 ± 0.044
0.332TrpHis: 0.332 ± 0.029
1.013TrpIle: 1.013 ± 0.052
0.563TrpLys: 0.563 ± 0.037
1.465TrpLeu: 1.465 ± 0.061
0.262TrpMet: 0.262 ± 0.028
0.547TrpAsn: 0.547 ± 0.04
0.522TrpPro: 0.522 ± 0.035
0.626TrpGln: 0.626 ± 0.04
0.592TrpArg: 0.592 ± 0.044
0.649TrpSer: 0.649 ± 0.045
0.488TrpThr: 0.488 ± 0.034
0.737TrpVal: 0.737 ± 0.045
0.163TrpTrp: 0.163 ± 0.021
0.301TrpTyr: 0.301 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.403TyrAla: 2.403 ± 0.075
0.529TyrCys: 0.529 ± 0.039
1.446TyrAsp: 1.446 ± 0.111
1.458TyrGlu: 1.458 ± 0.053
2.14TyrPhe: 2.14 ± 0.074
1.939TyrGly: 1.939 ± 0.06
1.171TyrHis: 1.171 ± 0.058
1.905TyrIle: 1.905 ± 0.071
1.621TyrLys: 1.621 ± 0.059
4.439TyrLeu: 4.439 ± 0.112
0.533TyrMet: 0.533 ± 0.041
1.383TyrAsn: 1.383 ± 0.069
1.51TyrPro: 1.51 ± 0.064
2.079TyrGln: 2.079 ± 0.073
2.016TyrArg: 2.016 ± 0.076
2.102TyrSer: 2.102 ± 0.065
1.808TyrThr: 1.808 ± 0.058
1.632TyrVal: 1.632 ± 0.056
0.488TyrTrp: 0.488 ± 0.033
1.385TyrTyr: 1.385 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1372 proteins (442456 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski