Amino acid dipepetide frequency for Catabacter hongkongensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	9.087AlaAla: 9.087 ± 0.127	1.345AlaCys: 1.345 ± 0.037	5.075AlaAsp: 5.075 ± 0.086	5.722AlaGlu: 5.722 ± 0.096	3.405AlaPhe: 3.405 ± 0.067	7.381AlaGly: 7.381 ± 0.097	1.331AlaHis: 1.331 ± 0.036	5.639AlaIle: 5.639 ± 0.092	5.534AlaLys: 5.534 ± 0.083	7.817AlaLeu: 7.817 ± 0.12	2.53AlaMet: 2.53 ± 0.049	2.945AlaAsn: 2.945 ± 0.067	2.665AlaPro: 2.665 ± 0.086	3.655AlaGln: 3.655 ± 0.075	3.714AlaArg: 3.714 ± 0.067	4.331AlaSer: 4.331 ± 0.077	3.714AlaThr: 3.714 ± 0.074	7.088AlaVal: 7.088 ± 0.104	0.628AlaTrp: 0.628 ± 0.029	2.711AlaTyr: 2.711 ± 0.064	0.002AlaXaa: 0.002 ± 0.001
Cys	1.416CysAla: 1.416 ± 0.046	0.286CysCys: 0.286 ± 0.018	0.848CysAsp: 0.848 ± 0.035	0.943CysGlu: 0.943 ± 0.035	0.629CysPhe: 0.629 ± 0.024	1.683CysGly: 1.683 ± 0.047	0.255CysHis: 0.255 ± 0.017	1.022CysIle: 1.022 ± 0.038	0.724CysLys: 0.724 ± 0.033	0.967CysLeu: 0.967 ± 0.032	0.449CysMet: 0.449 ± 0.021	0.486CysAsn: 0.486 ± 0.023	0.657CysPro: 0.657 ± 0.032	0.263CysGln: 0.263 ± 0.017	0.673CysArg: 0.673 ± 0.032	0.848CysSer: 0.848 ± 0.034	0.673CysThr: 0.673 ± 0.026	1.189CysVal: 1.189 ± 0.04	0.097CysTrp: 0.097 ± 0.009	0.445CysTyr: 0.445 ± 0.021	0.001CysXaa: 0.001 ± 0.001
Asp	5.127AspAla: 5.127 ± 0.068	0.767AspCys: 0.767 ± 0.03	2.938AspAsp: 2.938 ± 0.065	4.621AspGlu: 4.621 ± 0.083	2.754AspPhe: 2.754 ± 0.06	4.921AspGly: 4.921 ± 0.122	0.83AspHis: 0.83 ± 0.033	4.778AspIle: 4.778 ± 0.076	3.279AspLys: 3.279 ± 0.063	4.419AspLeu: 4.419 ± 0.063	2.011AspMet: 2.011 ± 0.05	2.034AspAsn: 2.034 ± 0.045	1.869AspPro: 1.869 ± 0.053	1.388AspGln: 1.388 ± 0.041	2.272AspArg: 2.272 ± 0.054	2.757AspSer: 2.757 ± 0.058	3.077AspThr: 3.077 ± 0.061	4.32AspVal: 4.32 ± 0.067	0.567AspTrp: 0.567 ± 0.027	2.431AspTyr: 2.431 ± 0.062	0.001AspXaa: 0.001 ± 0.001
Glu	5.645GluAla: 5.645 ± 0.099	0.82GluCys: 0.82 ± 0.029	3.518GluAsp: 3.518 ± 0.077	5.76GluGlu: 5.76 ± 0.088	2.526GluPhe: 2.526 ± 0.058	4.431GluGly: 4.431 ± 0.089	1.182GluHis: 1.182 ± 0.039	5.443GluIle: 5.443 ± 0.08	5.851GluLys: 5.851 ± 0.084	6.361GluLeu: 6.361 ± 0.085	2.415GluMet: 2.415 ± 0.05	3.711GluAsn: 3.711 ± 0.073	2.214GluPro: 2.214 ± 0.058	3.214GluGln: 3.214 ± 0.073	3.372GluArg: 3.372 ± 0.082	3.074GluSer: 3.074 ± 0.064	3.761GluThr: 3.761 ± 0.073	4.146GluVal: 4.146 ± 0.073	0.593GluTrp: 0.593 ± 0.027	2.98GluTyr: 2.98 ± 0.066	0.002GluXaa: 0.002 ± 0.001
Phe	3.562PheAla: 3.562 ± 0.067	0.715PheCys: 0.715 ± 0.032	2.755PheAsp: 2.755 ± 0.055	2.797PheGlu: 2.797 ± 0.072	1.892PhePhe: 1.892 ± 0.056	3.19PheGly: 3.19 ± 0.066	0.734PheHis: 0.734 ± 0.031	2.661PheIle: 2.661 ± 0.069	1.702PheLys: 1.702 ± 0.037	3.72PheLeu: 3.72 ± 0.077	1.157PheMet: 1.157 ± 0.042	1.391PheAsn: 1.391 ± 0.041	1.402PhePro: 1.402 ± 0.039	1.074PheGln: 1.074 ± 0.033	1.6PheArg: 1.6 ± 0.044	2.888PheSer: 2.888 ± 0.057	2.428PheThr: 2.428 ± 0.093	2.953PheVal: 2.953 ± 0.065	0.357PheTrp: 0.357 ± 0.022	1.486PheTyr: 1.486 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	6.446GlyAla: 6.446 ± 0.107	1.291GlyCys: 1.291 ± 0.042	3.899GlyAsp: 3.899 ± 0.083	5.168GlyGlu: 5.168 ± 0.085	3.238GlyPhe: 3.238 ± 0.061	6.186GlyGly: 6.186 ± 0.131	1.215GlyHis: 1.215 ± 0.037	6.579GlyIle: 6.579 ± 0.091	5.578GlyLys: 5.578 ± 0.073	6.279GlyLeu: 6.279 ± 0.084	2.706GlyMet: 2.706 ± 0.057	3.256GlyAsn: 3.256 ± 0.071	1.42GlyPro: 1.42 ± 0.044	2.319GlyGln: 2.319 ± 0.054	3.434GlyArg: 3.434 ± 0.06	4.143GlySer: 4.143 ± 0.091	4.67GlyThr: 4.67 ± 0.097	5.8GlyVal: 5.8 ± 0.101	0.641GlyTrp: 0.641 ± 0.026	3.124GlyTyr: 3.124 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	1.264HisAla: 1.264 ± 0.041	0.288HisCys: 0.288 ± 0.019	0.877HisAsp: 0.877 ± 0.032	1.031HisGlu: 1.031 ± 0.032	0.751HisPhe: 0.751 ± 0.03	1.283HisGly: 1.283 ± 0.041	0.322HisHis: 0.322 ± 0.019	1.292HisIle: 1.292 ± 0.044	0.969HisLys: 0.969 ± 0.034	1.324HisLeu: 1.324 ± 0.038	0.533HisMet: 0.533 ± 0.023	0.632HisAsn: 0.632 ± 0.025	0.821HisPro: 0.821 ± 0.033	0.422HisGln: 0.422 ± 0.02	0.716HisArg: 0.716 ± 0.029	0.927HisSer: 0.927 ± 0.032	0.963HisThr: 0.963 ± 0.03	0.971HisVal: 0.971 ± 0.031	0.139HisTrp: 0.139 ± 0.011	0.622HisTyr: 0.622 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	6.713IleAla: 6.713 ± 0.097	1.135IleCys: 1.135 ± 0.041	4.606IleAsp: 4.606 ± 0.082	4.633IleGlu: 4.633 ± 0.082	2.816IlePhe: 2.816 ± 0.063	5.428IleGly: 5.428 ± 0.083	1.08IleHis: 1.08 ± 0.036	5.068IleIle: 5.068 ± 0.107	4.062IleLys: 4.062 ± 0.069	6.496IleLeu: 6.496 ± 0.107	2.12IleMet: 2.12 ± 0.047	2.795IleAsn: 2.795 ± 0.056	3.097IlePro: 3.097 ± 0.058	1.74IleGln: 1.74 ± 0.051	3.391IleArg: 3.391 ± 0.066	4.76IleSer: 4.76 ± 0.079	4.288IleThr: 4.288 ± 0.071	5.272IleVal: 5.272 ± 0.077	0.533IleTrp: 0.533 ± 0.024	2.332IleTyr: 2.332 ± 0.058	0.0IleXaa: 0.0 ± 0.0
Lys	5.138LysAla: 5.138 ± 0.073	0.714LysCys: 0.714 ± 0.03	3.649LysAsp: 3.649 ± 0.068	5.371LysGlu: 5.371 ± 0.082	1.721LysPhe: 1.721 ± 0.043	4.19LysGly: 4.19 ± 0.067	1.01LysHis: 1.01 ± 0.033	4.564LysIle: 4.564 ± 0.084	5.894LysLys: 5.894 ± 0.084	5.19LysLeu: 5.19 ± 0.08	2.263LysMet: 2.263 ± 0.048	3.454LysAsn: 3.454 ± 0.064	2.175LysPro: 2.175 ± 0.056	2.539LysGln: 2.539 ± 0.058	3.3LysArg: 3.3 ± 0.07	3.151LysSer: 3.151 ± 0.058	3.824LysThr: 3.824 ± 0.061	3.691LysVal: 3.691 ± 0.073	0.552LysTrp: 0.552 ± 0.019	2.363LysTyr: 2.363 ± 0.055	0.003LysXaa: 0.003 ± 0.002
Leu	7.365LeuAla: 7.365 ± 0.1	1.571LeuCys: 1.571 ± 0.043	4.783LeuAsp: 4.783 ± 0.076	5.637LeuGlu: 5.637 ± 0.088	3.686LeuPhe: 3.686 ± 0.075	6.119LeuGly: 6.119 ± 0.102	1.488LeuHis: 1.488 ± 0.045	5.716LeuIle: 5.716 ± 0.098	5.736LeuLys: 5.736 ± 0.077	7.98LeuLeu: 7.98 ± 0.143	2.686LeuMet: 2.686 ± 0.065	3.446LeuAsn: 3.446 ± 0.076	3.546LeuPro: 3.546 ± 0.065	2.738LeuGln: 2.738 ± 0.061	4.16LeuArg: 4.16 ± 0.081	6.005LeuSer: 6.005 ± 0.097	4.81LeuThr: 4.81 ± 0.074	5.604LeuVal: 5.604 ± 0.085	0.682LeuTrp: 0.682 ± 0.028	3.018LeuTyr: 3.018 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	2.551MetAla: 2.551 ± 0.058	0.425MetCys: 0.425 ± 0.023	2.036MetAsp: 2.036 ± 0.05	2.337MetGlu: 2.337 ± 0.054	0.964MetPhe: 0.964 ± 0.033	2.36MetGly: 2.36 ± 0.049	0.448MetHis: 0.448 ± 0.022	2.174MetIle: 2.174 ± 0.053	2.389MetLys: 2.389 ± 0.051	2.913MetLeu: 2.913 ± 0.055	1.025MetMet: 1.025 ± 0.04	1.45MetAsn: 1.45 ± 0.044	1.335MetPro: 1.335 ± 0.042	1.298MetGln: 1.298 ± 0.033	1.511MetArg: 1.511 ± 0.042	1.747MetSer: 1.747 ± 0.051	1.739MetThr: 1.739 ± 0.045	1.959MetVal: 1.959 ± 0.054	0.204MetTrp: 0.204 ± 0.015	0.801MetTyr: 0.801 ± 0.032	0.001MetXaa: 0.001 ± 0.001
Asn	3.483AsnAla: 3.483 ± 0.063	0.521AsnCys: 0.521 ± 0.025	2.103AsnAsp: 2.103 ± 0.049	2.692AsnGlu: 2.692 ± 0.055	1.467AsnPhe: 1.467 ± 0.039	3.679AsnGly: 3.679 ± 0.094	0.638AsnHis: 0.638 ± 0.027	3.323AsnIle: 3.323 ± 0.059	2.241AsnLys: 2.241 ± 0.046	3.392AsnLeu: 3.392 ± 0.064	1.334AsnMet: 1.334 ± 0.038	1.712AsnAsn: 1.712 ± 0.055	1.989AsnPro: 1.989 ± 0.044	1.253AsnGln: 1.253 ± 0.042	1.777AsnArg: 1.777 ± 0.047	2.098AsnSer: 2.098 ± 0.061	2.29AsnThr: 2.29 ± 0.058	2.949AsnVal: 2.949 ± 0.061	0.339AsnTrp: 0.339 ± 0.02	1.485AsnTyr: 1.485 ± 0.052	0.0AsnXaa: 0.0 ± 0.0
Pro	3.184ProAla: 3.184 ± 0.076	0.476ProCys: 0.476 ± 0.023	2.62ProAsp: 2.62 ± 0.063	3.29ProGlu: 3.29 ± 0.072	1.568ProPhe: 1.568 ± 0.046	2.56ProGly: 2.56 ± 0.061	0.657ProHis: 0.657 ± 0.028	2.042ProIle: 2.042 ± 0.047	1.908ProLys: 1.908 ± 0.043	2.882ProLeu: 2.882 ± 0.059	0.957ProMet: 0.957 ± 0.029	1.187ProAsn: 1.187 ± 0.04	1.049ProPro: 1.049 ± 0.038	1.629ProGln: 1.629 ± 0.039	1.124ProArg: 1.124 ± 0.033	1.91ProSer: 1.91 ± 0.047	1.857ProThr: 1.857 ± 0.054	3.316ProVal: 3.316 ± 0.071	0.24ProTrp: 0.24 ± 0.017	1.411ProTyr: 1.411 ± 0.041	0.001ProXaa: 0.001 ± 0.001
Gln	3.043GlnAla: 3.043 ± 0.072	0.318GlnCys: 0.318 ± 0.019	1.825GlnAsp: 1.825 ± 0.042	2.776GlnGlu: 2.776 ± 0.072	1.147GlnPhe: 1.147 ± 0.03	2.294GlnGly: 2.294 ± 0.057	0.425GlnHis: 0.425 ± 0.022	2.482GlnIle: 2.482 ± 0.05	2.869GlnLys: 2.869 ± 0.06	2.679GlnLeu: 2.679 ± 0.057	1.185GlnMet: 1.185 ± 0.034	1.738GlnAsn: 1.738 ± 0.05	1.26GlnPro: 1.26 ± 0.038	1.62GlnGln: 1.62 ± 0.057	1.521GlnArg: 1.521 ± 0.046	1.751GlnSer: 1.751 ± 0.046	1.804GlnThr: 1.804 ± 0.05	2.044GlnVal: 2.044 ± 0.044	0.303GlnTrp: 0.303 ± 0.02	1.312GlnTyr: 1.312 ± 0.042	0.001GlnXaa: 0.001 ± 0.001
Arg	3.281ArgAla: 3.281 ± 0.059	0.548ArgCys: 0.548 ± 0.029	2.402ArgAsp: 2.402 ± 0.053	3.995ArgGlu: 3.995 ± 0.071	1.95ArgPhe: 1.95 ± 0.047	2.837ArgGly: 2.837 ± 0.054	0.776ArgHis: 0.776 ± 0.034	3.481ArgIle: 3.481 ± 0.073	3.129ArgLys: 3.129 ± 0.063	4.054ArgLeu: 4.054 ± 0.075	1.565ArgMet: 1.565 ± 0.047	1.854ArgAsn: 1.854 ± 0.042	1.376ArgPro: 1.376 ± 0.04	1.759ArgGln: 1.759 ± 0.049	2.372ArgArg: 2.372 ± 0.067	2.126ArgSer: 2.126 ± 0.054	2.194ArgThr: 2.194 ± 0.048	2.872ArgVal: 2.872 ± 0.055	0.363ArgTrp: 0.363 ± 0.019	1.752ArgTyr: 1.752 ± 0.044	0.001ArgXaa: 0.001 ± 0.001
Ser	4.933SerAla: 4.933 ± 0.081	0.76SerCys: 0.76 ± 0.027	3.005SerAsp: 3.005 ± 0.057	3.334SerGlu: 3.334 ± 0.066	2.541SerPhe: 2.541 ± 0.054	5.549SerGly: 5.549 ± 0.086	0.944SerHis: 0.944 ± 0.036	3.951SerIle: 3.951 ± 0.063	2.994SerLys: 2.994 ± 0.067	4.676SerLeu: 4.676 ± 0.073	1.718SerMet: 1.718 ± 0.049	2.0SerAsn: 2.0 ± 0.047	1.987SerPro: 1.987 ± 0.05	1.796SerGln: 1.796 ± 0.046	2.452SerArg: 2.452 ± 0.058	3.26SerSer: 3.26 ± 0.08	2.736SerThr: 2.736 ± 0.067	4.435SerVal: 4.435 ± 0.072	0.428SerTrp: 0.428 ± 0.022	2.021SerTyr: 2.021 ± 0.051	0.001SerXaa: 0.001 ± 0.001
Thr	4.865ThrAla: 4.865 ± 0.113	0.598ThrCys: 0.598 ± 0.027	3.304ThrAsp: 3.304 ± 0.081	3.383ThrGlu: 3.383 ± 0.073	2.173ThrPhe: 2.173 ± 0.053	5.103ThrGly: 5.103 ± 0.095	0.897ThrHis: 0.897 ± 0.036	3.773ThrIle: 3.773 ± 0.066	3.073ThrLys: 3.073 ± 0.063	5.02ThrLeu: 5.02 ± 0.082	1.482ThrMet: 1.482 ± 0.044	1.973ThrAsn: 1.973 ± 0.064	2.612ThrPro: 2.612 ± 0.061	2.001ThrGln: 2.001 ± 0.05	1.996ThrArg: 1.996 ± 0.053	2.704ThrSer: 2.704 ± 0.07	2.666ThrThr: 2.666 ± 0.073	4.561ThrVal: 4.561 ± 0.123	0.408ThrTrp: 0.408 ± 0.024	1.691ThrTyr: 1.691 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	5.699ValAla: 5.699 ± 0.079	1.272ValCys: 1.272 ± 0.046	3.916ValAsp: 3.916 ± 0.07	4.455ValGlu: 4.455 ± 0.069	3.2ValPhe: 3.2 ± 0.07	4.74ValGly: 4.74 ± 0.078	1.068ValHis: 1.068 ± 0.033	5.379ValIle: 5.379 ± 0.092	4.406ValLys: 4.406 ± 0.067	6.669ValLeu: 6.669 ± 0.106	2.253ValMet: 2.253 ± 0.043	2.911ValAsn: 2.911 ± 0.065	2.783ValPro: 2.783 ± 0.059	2.147ValGln: 2.147 ± 0.052	3.163ValArg: 3.163 ± 0.06	4.566ValSer: 4.566 ± 0.074	4.286ValThr: 4.286 ± 0.138	5.473ValVal: 5.473 ± 0.092	0.628ValTrp: 0.628 ± 0.028	2.469ValTyr: 2.469 ± 0.053	0.001ValXaa: 0.001 ± 0.001
Trp	0.563TrpAla: 0.563 ± 0.023	0.122TrpCys: 0.122 ± 0.012	0.532TrpAsp: 0.532 ± 0.023	0.562TrpGlu: 0.562 ± 0.029	0.385TrpPhe: 0.385 ± 0.019	0.587TrpGly: 0.587 ± 0.026	0.151TrpHis: 0.151 ± 0.011	0.583TrpIle: 0.583 ± 0.028	0.591TrpLys: 0.591 ± 0.023	0.832TrpLeu: 0.832 ± 0.026	0.269TrpMet: 0.269 ± 0.016	0.418TrpAsn: 0.418 ± 0.024	0.189TrpPro: 0.189 ± 0.016	0.351TrpGln: 0.351 ± 0.018	0.325TrpArg: 0.325 ± 0.02	0.408TrpSer: 0.408 ± 0.02	0.4TrpThr: 0.4 ± 0.024	0.455TrpVal: 0.455 ± 0.024	0.091TrpTrp: 0.091 ± 0.01	0.298TrpTyr: 0.298 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.954TyrAla: 2.954 ± 0.068	0.58TyrCys: 0.58 ± 0.023	2.47TyrAsp: 2.47 ± 0.052	2.512TyrGlu: 2.512 ± 0.068	1.652TyrPhe: 1.652 ± 0.043	2.87TyrGly: 2.87 ± 0.069	0.696TyrHis: 0.696 ± 0.028	2.416TyrIle: 2.416 ± 0.053	1.824TyrLys: 1.824 ± 0.054	3.103TyrLeu: 3.103 ± 0.07	1.008TyrMet: 1.008 ± 0.033	1.373TyrAsn: 1.373 ± 0.043	1.423TyrPro: 1.423 ± 0.043	1.192TyrGln: 1.192 ± 0.039	1.812TyrArg: 1.812 ± 0.052	2.064TyrSer: 2.064 ± 0.047	2.102TyrThr: 2.102 ± 0.073	2.386TyrVal: 2.386 ± 0.056	0.319TyrTrp: 0.319 ± 0.019	1.485TyrTyr: 1.485 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.001XaaPhe: 0.001 ± 0.001	0.002XaaGly: 0.002 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.0XaaIle: 0.0 ± 0.0	0.004XaaLys: 0.004 ± 0.002	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.001	0.001XaaXaa: 0.001 ± 0.001

Statistics based on 3148 proteins (940206 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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