Amino acid dipepetide frequency for Equid gammaherpesvirus 2 (Equine herpesvirus 2)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.913AlaAla: 9.913 ± 1.001
1.888AlaCys: 1.888 ± 0.253
3.357AlaAsp: 3.357 ± 0.317
4.117AlaGlu: 4.117 ± 0.533
3.121AlaPhe: 3.121 ± 0.322
7.055AlaGly: 7.055 ± 0.553
2.203AlaHis: 2.203 ± 0.233
2.78AlaIle: 2.78 ± 0.313
3.042AlaLys: 3.042 ± 0.299
7.186AlaLeu: 7.186 ± 0.584
1.364AlaMet: 1.364 ± 0.17
2.308AlaAsn: 2.308 ± 0.297
6.006AlaPro: 6.006 ± 0.955
2.754AlaGln: 2.754 ± 0.367
5.271AlaArg: 5.271 ± 0.602
6.661AlaSer: 6.661 ± 0.515
4.065AlaThr: 4.065 ± 0.528
5.927AlaVal: 5.927 ± 0.48
0.787AlaTrp: 0.787 ± 0.157
1.836AlaTyr: 1.836 ± 0.231
0.0AlaXaa: 0.0 ± 0.0
Cys
1.888CysAla: 1.888 ± 0.345
0.498CysCys: 0.498 ± 0.104
0.997CysAsp: 0.997 ± 0.163
1.705CysGlu: 1.705 ± 0.217
1.154CysPhe: 1.154 ± 0.216
1.469CysGly: 1.469 ± 0.206
0.498CysHis: 0.498 ± 0.119
0.813CysIle: 0.813 ± 0.132
0.708CysLys: 0.708 ± 0.127
3.121CysLeu: 3.121 ± 0.343
0.551CysMet: 0.551 ± 0.14
0.761CysAsn: 0.761 ± 0.133
1.285CysPro: 1.285 ± 0.219
1.128CysGln: 1.128 ± 0.212
1.469CysArg: 1.469 ± 0.281
1.416CysSer: 1.416 ± 0.2
1.18CysThr: 1.18 ± 0.159
1.731CysVal: 1.731 ± 0.263
0.315CysTrp: 0.315 ± 0.099
0.682CysTyr: 0.682 ± 0.163
0.0CysXaa: 0.0 ± 0.0
Asp
3.934AspAla: 3.934 ± 0.404
0.944AspCys: 0.944 ± 0.163
2.754AspAsp: 2.754 ± 0.392
3.331AspGlu: 3.331 ± 0.45
2.439AspPhe: 2.439 ± 0.249
4.17AspGly: 4.17 ± 0.623
1.023AspHis: 1.023 ± 0.158
1.914AspIle: 1.914 ± 0.235
1.6AspLys: 1.6 ± 0.274
5.035AspLeu: 5.035 ± 0.417
1.18AspMet: 1.18 ± 0.163
1.469AspAsn: 1.469 ± 0.142
3.593AspPro: 3.593 ± 0.896
1.233AspGln: 1.233 ± 0.191
2.754AspArg: 2.754 ± 0.252
3.462AspSer: 3.462 ± 0.358
2.177AspThr: 2.177 ± 0.233
3.331AspVal: 3.331 ± 0.265
0.656AspTrp: 0.656 ± 0.135
1.416AspTyr: 1.416 ± 0.192
0.0AspXaa: 0.0 ± 0.0
Glu
5.927GluAla: 5.927 ± 0.576
1.311GluCys: 1.311 ± 0.228
3.908GluAsp: 3.908 ± 0.466
5.376GluGlu: 5.376 ± 0.71
2.413GluPhe: 2.413 ± 0.29
6.189GluGly: 6.189 ± 0.921
0.839GluHis: 0.839 ± 0.135
2.439GluIle: 2.439 ± 0.294
2.387GluLys: 2.387 ± 0.275
4.825GluLeu: 4.825 ± 0.388
1.285GluMet: 1.285 ± 0.176
2.229GluAsn: 2.229 ± 0.262
4.196GluPro: 4.196 ± 1.827
1.547GluGln: 1.547 ± 0.229
3.776GluArg: 3.776 ± 0.376
4.196GluSer: 4.196 ± 0.556
3.278GluThr: 3.278 ± 0.288
4.065GluVal: 4.065 ± 0.291
0.393GluTrp: 0.393 ± 0.105
1.442GluTyr: 1.442 ± 0.198
0.0GluXaa: 0.0 ± 0.0
Phe
2.937PheAla: 2.937 ± 0.246
0.97PheCys: 0.97 ± 0.176
1.757PheAsp: 1.757 ± 0.182
2.177PheGlu: 2.177 ± 0.235
2.439PhePhe: 2.439 ± 0.376
2.596PheGly: 2.596 ± 0.286
0.892PheHis: 0.892 ± 0.138
2.413PheIle: 2.413 ± 0.281
2.754PheLys: 2.754 ± 0.331
5.429PheLeu: 5.429 ± 0.453
1.075PheMet: 1.075 ± 0.174
1.888PheAsn: 1.888 ± 0.238
2.203PhePro: 2.203 ± 0.253
1.547PheGln: 1.547 ± 0.19
1.914PheArg: 1.914 ± 0.261
3.698PheSer: 3.698 ± 0.378
2.177PheThr: 2.177 ± 0.291
2.885PheVal: 2.885 ± 0.359
0.708PheTrp: 0.708 ± 0.146
2.072PheTyr: 2.072 ± 0.237
0.0PheXaa: 0.0 ± 0.0
Gly
7.107GlyAla: 7.107 ± 0.63
1.678GlyCys: 1.678 ± 0.244
5.481GlyAsp: 5.481 ± 0.57
6.53GlyGlu: 6.53 ± 0.707
2.203GlyPhe: 2.203 ± 0.269
10.674GlyGly: 10.674 ± 1.235
1.39GlyHis: 1.39 ± 0.19
1.914GlyIle: 1.914 ± 0.187
2.15GlyLys: 2.15 ± 0.23
5.874GlyLeu: 5.874 ± 0.471
1.39GlyMet: 1.39 ± 0.173
1.993GlyAsn: 1.993 ± 0.178
5.166GlyPro: 5.166 ± 1.306
2.439GlyGln: 2.439 ± 0.227
5.481GlyArg: 5.481 ± 0.57
4.694GlySer: 4.694 ± 0.475
3.357GlyThr: 3.357 ± 0.27
5.848GlyVal: 5.848 ± 0.455
0.551GlyTrp: 0.551 ± 0.117
2.124GlyTyr: 2.124 ± 0.211
0.0GlyXaa: 0.0 ± 0.0
His
1.914HisAla: 1.914 ± 0.222
0.367HisCys: 0.367 ± 0.097
0.656HisAsp: 0.656 ± 0.164
1.18HisGlu: 1.18 ± 0.182
1.18HisPhe: 1.18 ± 0.18
1.705HisGly: 1.705 ± 0.247
0.498HisHis: 0.498 ± 0.113
0.997HisIle: 0.997 ± 0.208
0.944HisLys: 0.944 ± 0.136
2.623HisLeu: 2.623 ± 0.336
0.629HisMet: 0.629 ± 0.123
0.865HisAsn: 0.865 ± 0.183
1.705HisPro: 1.705 ± 0.242
0.577HisGln: 0.577 ± 0.133
1.442HisArg: 1.442 ± 0.182
1.469HisSer: 1.469 ± 0.198
1.311HisThr: 1.311 ± 0.164
2.019HisVal: 2.019 ± 0.227
0.236HisTrp: 0.236 ± 0.081
0.787HisTyr: 0.787 ± 0.145
0.0HisXaa: 0.0 ± 0.0
Ile
2.518IleAla: 2.518 ± 0.271
1.128IleCys: 1.128 ± 0.197
1.81IleAsp: 1.81 ± 0.217
1.941IleGlu: 1.941 ± 0.204
2.229IlePhe: 2.229 ± 0.273
1.416IleGly: 1.416 ± 0.173
1.075IleHis: 1.075 ± 0.16
1.941IleIle: 1.941 ± 0.269
1.678IleLys: 1.678 ± 0.257
4.511IleLeu: 4.511 ± 0.421
0.865IleMet: 0.865 ± 0.158
1.941IleAsn: 1.941 ± 0.257
2.019IlePro: 2.019 ± 0.267
1.364IleGln: 1.364 ± 0.21
1.888IleArg: 1.888 ± 0.191
2.99IleSer: 2.99 ± 0.304
2.255IleThr: 2.255 ± 0.318
2.177IleVal: 2.177 ± 0.246
0.525IleTrp: 0.525 ± 0.115
1.783IleTyr: 1.783 ± 0.235
0.0IleXaa: 0.0 ± 0.0
Lys
1.993LysAla: 1.993 ± 0.236
0.656LysCys: 0.656 ± 0.157
2.019LysAsp: 2.019 ± 0.204
2.229LysGlu: 2.229 ± 0.257
1.705LysPhe: 1.705 ± 0.221
2.282LysGly: 2.282 ± 0.265
1.364LysHis: 1.364 ± 0.237
2.072LysIle: 2.072 ± 0.217
3.173LysLys: 3.173 ± 0.405
4.144LysLeu: 4.144 ± 0.341
1.128LysMet: 1.128 ± 0.175
2.255LysAsn: 2.255 ± 0.319
3.278LysPro: 3.278 ± 1.32
1.416LysGln: 1.416 ± 0.166
2.623LysArg: 2.623 ± 0.309
3.147LysSer: 3.147 ± 0.33
3.042LysThr: 3.042 ± 0.261
2.544LysVal: 2.544 ± 0.302
0.315LysTrp: 0.315 ± 0.1
1.416LysTyr: 1.416 ± 0.204
0.0LysXaa: 0.0 ± 0.0
Leu
7.789LeuAla: 7.789 ± 0.53
2.649LeuCys: 2.649 ± 0.32
4.353LeuAsp: 4.353 ± 0.306
5.77LeuGlu: 5.77 ± 0.337
4.668LeuPhe: 4.668 ± 0.442
6.556LeuGly: 6.556 ± 0.487
2.439LeuHis: 2.439 ± 0.258
3.698LeuIle: 3.698 ± 0.397
4.668LeuLys: 4.668 ± 0.342
9.258LeuLeu: 9.258 ± 0.633
1.941LeuMet: 1.941 ± 0.231
4.17LeuAsn: 4.17 ± 0.404
5.376LeuPro: 5.376 ± 0.491
3.226LeuGln: 3.226 ± 0.391
6.687LeuArg: 6.687 ± 0.531
7.736LeuSer: 7.736 ± 0.567
5.324LeuThr: 5.324 ± 0.38
5.979LeuVal: 5.979 ± 0.599
1.233LeuTrp: 1.233 ± 0.202
3.619LeuTyr: 3.619 ± 0.356
0.0LeuXaa: 0.0 ± 0.0
Met
2.465MetAla: 2.465 ± 0.251
0.472MetCys: 0.472 ± 0.151
0.813MetAsp: 0.813 ± 0.127
1.495MetGlu: 1.495 ± 0.219
1.233MetPhe: 1.233 ± 0.217
1.442MetGly: 1.442 ± 0.167
0.367MetHis: 0.367 ± 0.092
0.918MetIle: 0.918 ± 0.152
0.682MetLys: 0.682 ± 0.166
2.334MetLeu: 2.334 ± 0.256
0.525MetMet: 0.525 ± 0.113
0.498MetAsn: 0.498 ± 0.104
0.708MetPro: 0.708 ± 0.146
0.577MetGln: 0.577 ± 0.157
1.075MetArg: 1.075 ± 0.15
1.364MetSer: 1.364 ± 0.203
1.6MetThr: 1.6 ± 0.232
1.18MetVal: 1.18 ± 0.219
0.184MetTrp: 0.184 ± 0.078
0.865MetTyr: 0.865 ± 0.144
0.0MetXaa: 0.0 ± 0.0
Asn
2.124AsnAla: 2.124 ± 0.226
0.708AsnCys: 0.708 ± 0.152
0.787AsnAsp: 0.787 ± 0.121
1.364AsnGlu: 1.364 ± 0.183
1.337AsnPhe: 1.337 ± 0.212
2.203AsnGly: 2.203 ± 0.324
0.708AsnHis: 0.708 ± 0.156
2.177AsnIle: 2.177 ± 0.246
1.6AsnLys: 1.6 ± 0.253
4.117AsnLeu: 4.117 ± 0.435
0.865AsnMet: 0.865 ± 0.141
1.075AsnAsn: 1.075 ± 0.211
2.334AsnPro: 2.334 ± 0.231
1.18AsnGln: 1.18 ± 0.177
1.967AsnArg: 1.967 ± 0.245
2.963AsnSer: 2.963 ± 0.294
1.967AsnThr: 1.967 ± 0.206
2.859AsnVal: 2.859 ± 0.372
0.42AsnTrp: 0.42 ± 0.097
1.469AsnTyr: 1.469 ± 0.215
0.0AsnXaa: 0.0 ± 0.0
Pro
5.481ProAla: 5.481 ± 0.725
1.337ProCys: 1.337 ± 0.24
3.042ProAsp: 3.042 ± 0.758
5.796ProGlu: 5.796 ± 1.872
2.177ProPhe: 2.177 ± 0.274
6.792ProGly: 6.792 ± 1.303
1.416ProHis: 1.416 ± 0.152
1.836ProIle: 1.836 ± 0.235
3.278ProLys: 3.278 ± 1.319
5.245ProLeu: 5.245 ± 0.405
0.997ProMet: 0.997 ± 0.164
1.311ProAsn: 1.311 ± 0.287
8.497ProPro: 8.497 ± 3.075
3.121ProGln: 3.121 ± 0.874
4.196ProArg: 4.196 ± 0.575
4.458ProSer: 4.458 ± 0.444
3.331ProThr: 3.331 ± 0.495
4.904ProVal: 4.904 ± 0.334
0.761ProTrp: 0.761 ± 0.155
1.521ProTyr: 1.521 ± 0.168
0.0ProXaa: 0.0 ± 0.0
Gln
3.016GlnAla: 3.016 ± 0.457
0.734GlnCys: 0.734 ± 0.16
1.206GlnAsp: 1.206 ± 0.208
1.81GlnGlu: 1.81 ± 0.211
1.678GlnPhe: 1.678 ± 0.266
2.727GlnGly: 2.727 ± 0.281
0.918GlnHis: 0.918 ± 0.207
1.574GlnIle: 1.574 ± 0.181
1.6GlnLys: 1.6 ± 0.19
3.121GlnLeu: 3.121 ± 0.297
0.577GlnMet: 0.577 ± 0.129
1.311GlnAsn: 1.311 ± 0.2
2.885GlnPro: 2.885 ± 0.725
3.121GlnGln: 3.121 ± 0.99
1.941GlnArg: 1.941 ± 0.245
2.019GlnSer: 2.019 ± 0.223
2.046GlnThr: 2.046 ± 0.293
2.046GlnVal: 2.046 ± 0.223
0.367GlnTrp: 0.367 ± 0.085
1.049GlnTyr: 1.049 ± 0.225
0.0GlnXaa: 0.0 ± 0.0
Arg
5.979ArgAla: 5.979 ± 0.451
1.836ArgCys: 1.836 ± 0.267
4.012ArgAsp: 4.012 ± 0.304
4.773ArgGlu: 4.773 ± 0.617
2.177ArgPhe: 2.177 ± 0.223
5.56ArgGly: 5.56 ± 0.545
1.6ArgHis: 1.6 ± 0.205
1.678ArgIle: 1.678 ± 0.162
2.255ArgLys: 2.255 ± 0.245
4.825ArgLeu: 4.825 ± 0.39
0.944ArgMet: 0.944 ± 0.182
1.574ArgAsn: 1.574 ± 0.231
3.96ArgPro: 3.96 ± 0.476
2.413ArgGln: 2.413 ± 0.289
4.432ArgArg: 4.432 ± 0.403
3.803ArgSer: 3.803 ± 0.354
2.072ArgThr: 2.072 ± 0.183
4.432ArgVal: 4.432 ± 0.471
0.551ArgTrp: 0.551 ± 0.116
1.81ArgTyr: 1.81 ± 0.222
0.0ArgXaa: 0.0 ± 0.0
Ser
4.668SerAla: 4.668 ± 0.399
1.783SerCys: 1.783 ± 0.309
4.196SerAsp: 4.196 ± 0.417
4.039SerGlu: 4.039 ± 0.502
3.304SerPhe: 3.304 ± 0.334
4.983SerGly: 4.983 ± 0.448
1.705SerHis: 1.705 ± 0.21
2.36SerIle: 2.36 ± 0.251
3.567SerLys: 3.567 ± 0.33
8.287SerLeu: 8.287 ± 0.51
1.678SerMet: 1.678 ± 0.259
2.177SerAsn: 2.177 ± 0.237
5.376SerPro: 5.376 ± 0.366
2.911SerGln: 2.911 ± 0.352
4.589SerArg: 4.589 ± 0.464
6.504SerSer: 6.504 ± 0.746
3.934SerThr: 3.934 ± 0.491
5.193SerVal: 5.193 ± 0.504
0.682SerTrp: 0.682 ± 0.144
1.914SerTyr: 1.914 ± 0.299
0.0SerXaa: 0.0 ± 0.0
Thr
3.881ThrAla: 3.881 ± 0.346
1.311ThrCys: 1.311 ± 0.242
2.518ThrAsp: 2.518 ± 0.284
2.754ThrGlu: 2.754 ± 0.239
2.806ThrPhe: 2.806 ± 0.379
3.488ThrGly: 3.488 ± 0.291
1.39ThrHis: 1.39 ± 0.205
2.124ThrIle: 2.124 ± 0.315
1.678ThrLys: 1.678 ± 0.204
5.796ThrLeu: 5.796 ± 0.435
1.128ThrMet: 1.128 ± 0.203
1.678ThrAsn: 1.678 ± 0.268
3.75ThrPro: 3.75 ± 0.296
1.81ThrGln: 1.81 ± 0.225
2.937ThrArg: 2.937 ± 0.326
4.642ThrSer: 4.642 ± 0.498
4.589ThrThr: 4.589 ± 1.15
4.353ThrVal: 4.353 ± 0.898
0.42ThrTrp: 0.42 ± 0.108
1.547ThrTyr: 1.547 ± 0.208
0.0ThrXaa: 0.0 ± 0.0
Val
5.193ValAla: 5.193 ± 0.489
1.81ValCys: 1.81 ± 0.255
3.016ValAsp: 3.016 ± 0.234
3.724ValGlu: 3.724 ± 0.368
4.17ValPhe: 4.17 ± 0.421
4.38ValGly: 4.38 ± 0.359
1.678ValHis: 1.678 ± 0.265
2.623ValIle: 2.623 ± 0.287
3.068ValLys: 3.068 ± 0.268
6.635ValLeu: 6.635 ± 0.577
1.574ValMet: 1.574 ± 0.208
2.491ValAsn: 2.491 ± 0.256
4.93ValPro: 4.93 ± 0.676
2.098ValGln: 2.098 ± 0.252
3.776ValArg: 3.776 ± 0.293
5.507ValSer: 5.507 ± 0.489
4.38ValThr: 4.38 ± 0.409
4.957ValVal: 4.957 ± 0.563
0.629ValTrp: 0.629 ± 0.151
2.832ValTyr: 2.832 ± 0.377
0.0ValXaa: 0.0 ± 0.0
Trp
0.865TrpAla: 0.865 ± 0.159
0.315TrpCys: 0.315 ± 0.114
0.367TrpAsp: 0.367 ± 0.095
0.629TrpGlu: 0.629 ± 0.13
0.472TrpPhe: 0.472 ± 0.114
0.734TrpGly: 0.734 ± 0.19
0.288TrpHis: 0.288 ± 0.073
0.341TrpIle: 0.341 ± 0.085
0.525TrpLys: 0.525 ± 0.132
1.233TrpLeu: 1.233 ± 0.246
0.131TrpMet: 0.131 ± 0.055
0.472TrpAsn: 0.472 ± 0.112
0.734TrpPro: 0.734 ± 0.167
0.367TrpGln: 0.367 ± 0.108
0.629TrpArg: 0.629 ± 0.139
0.577TrpSer: 0.577 ± 0.114
0.682TrpThr: 0.682 ± 0.138
0.551TrpVal: 0.551 ± 0.112
0.079TrpTrp: 0.079 ± 0.041
0.236TrpTyr: 0.236 ± 0.082
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.046TyrAla: 2.046 ± 0.236
0.97TyrCys: 0.97 ± 0.176
1.364TyrAsp: 1.364 ± 0.21
1.285TyrGlu: 1.285 ± 0.176
1.626TyrPhe: 1.626 ± 0.235
1.626TyrGly: 1.626 ± 0.2
0.813TyrHis: 0.813 ± 0.156
1.442TyrIle: 1.442 ± 0.205
1.442TyrLys: 1.442 ± 0.225
3.54TyrLeu: 3.54 ± 0.299
0.944TyrMet: 0.944 ± 0.186
1.757TyrAsn: 1.757 ± 0.294
1.521TyrPro: 1.521 ± 0.204
0.918TyrGln: 0.918 ± 0.158
1.836TyrArg: 1.836 ± 0.247
2.544TyrSer: 2.544 ± 0.303
1.836TyrThr: 1.836 ± 0.203
2.491TyrVal: 2.491 ± 0.288
0.42TyrTrp: 0.42 ± 0.105
1.364TyrTyr: 1.364 ± 0.226
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 78 proteins (38132 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski