Amino acid dipepetide frequency for Roseospirillum parvum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.929AlaAla: 19.929 ± 0.244
1.17AlaCys: 1.17 ± 0.042
8.166AlaAsp: 8.166 ± 0.092
10.106AlaGlu: 10.106 ± 0.13
4.015AlaPhe: 4.015 ± 0.06
12.479AlaGly: 12.479 ± 0.133
2.871AlaHis: 2.871 ± 0.056
4.744AlaIle: 4.744 ± 0.078
2.767AlaLys: 2.767 ± 0.072
15.735AlaLeu: 15.735 ± 0.19
2.981AlaMet: 2.981 ± 0.058
2.608AlaAsn: 2.608 ± 0.062
7.259AlaPro: 7.259 ± 0.115
3.939AlaGln: 3.939 ± 0.065
11.303AlaArg: 11.303 ± 0.128
5.068AlaSer: 5.068 ± 0.075
6.323AlaThr: 6.323 ± 0.086
9.391AlaVal: 9.391 ± 0.11
1.758AlaTrp: 1.758 ± 0.047
2.396AlaTyr: 2.396 ± 0.043
0.0AlaXaa: 0.0 ± 0.0
Cys
0.958CysAla: 0.958 ± 0.034
0.091CysCys: 0.091 ± 0.008
0.517CysAsp: 0.517 ± 0.02
0.372CysGlu: 0.372 ± 0.018
0.245CysPhe: 0.245 ± 0.017
0.841CysGly: 0.841 ± 0.031
0.303CysHis: 0.303 ± 0.021
0.293CysIle: 0.293 ± 0.017
0.157CysLys: 0.157 ± 0.012
1.006CysLeu: 1.006 ± 0.034
0.106CysMet: 0.106 ± 0.008
0.17CysAsn: 0.17 ± 0.014
0.62CysPro: 0.62 ± 0.028
0.363CysGln: 0.363 ± 0.022
0.785CysArg: 0.785 ± 0.031
0.281CysSer: 0.281 ± 0.018
0.386CysThr: 0.386 ± 0.021
0.495CysVal: 0.495 ± 0.022
0.094CysTrp: 0.094 ± 0.009
0.18CysTyr: 0.18 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.446AspAla: 6.446 ± 0.088
0.485AspCys: 0.485 ± 0.022
3.874AspAsp: 3.874 ± 0.106
3.053AspGlu: 3.053 ± 0.073
1.951AspPhe: 1.951 ± 0.05
5.954AspGly: 5.954 ± 0.142
1.683AspHis: 1.683 ± 0.046
2.623AspIle: 2.623 ± 0.054
1.361AspLys: 1.361 ± 0.039
7.447AspLeu: 7.447 ± 0.108
1.341AspMet: 1.341 ± 0.035
1.286AspAsn: 1.286 ± 0.052
4.797AspPro: 4.797 ± 0.082
1.981AspGln: 1.981 ± 0.043
4.313AspArg: 4.313 ± 0.07
2.875AspSer: 2.875 ± 0.058
2.932AspThr: 2.932 ± 0.067
3.432AspVal: 3.432 ± 0.068
1.066AspTrp: 1.066 ± 0.033
1.282AspTyr: 1.282 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
9.25GluAla: 9.25 ± 0.119
0.308GluCys: 0.308 ± 0.016
3.097GluAsp: 3.097 ± 0.06
3.212GluGlu: 3.212 ± 0.076
1.302GluPhe: 1.302 ± 0.038
4.818GluGly: 4.818 ± 0.081
1.233GluHis: 1.233 ± 0.035
2.649GluIle: 2.649 ± 0.056
1.607GluLys: 1.607 ± 0.046
5.558GluLeu: 5.558 ± 0.073
1.664GluMet: 1.664 ± 0.044
1.24GluAsn: 1.24 ± 0.035
3.03GluPro: 3.03 ± 0.069
2.004GluGln: 2.004 ± 0.054
5.139GluArg: 5.139 ± 0.075
2.455GluSer: 2.455 ± 0.047
3.566GluThr: 3.566 ± 0.059
5.059GluVal: 5.059 ± 0.081
0.577GluTrp: 0.577 ± 0.022
0.797GluTyr: 0.797 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
3.916PheAla: 3.916 ± 0.064
0.338PheCys: 0.338 ± 0.017
2.233PheAsp: 2.233 ± 0.053
1.962PheGlu: 1.962 ± 0.046
1.147PhePhe: 1.147 ± 0.037
3.037PheGly: 3.037 ± 0.056
0.764PheHis: 0.764 ± 0.027
1.208PheIle: 1.208 ± 0.038
0.873PheLys: 0.873 ± 0.033
3.375PheLeu: 3.375 ± 0.067
0.637PheMet: 0.637 ± 0.026
0.843PheAsn: 0.843 ± 0.026
1.496PhePro: 1.496 ± 0.037
0.973PheGln: 0.973 ± 0.03
1.935PheArg: 1.935 ± 0.048
1.695PheSer: 1.695 ± 0.048
1.878PheThr: 1.878 ± 0.055
2.151PheVal: 2.151 ± 0.048
0.414PheTrp: 0.414 ± 0.022
0.725PheTyr: 0.725 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
10.262GlyAla: 10.262 ± 0.112
0.897GlyCys: 0.897 ± 0.035
5.019GlyAsp: 5.019 ± 0.097
5.072GlyGlu: 5.072 ± 0.083
3.041GlyPhe: 3.041 ± 0.056
8.544GlyGly: 8.544 ± 0.128
2.288GlyHis: 2.288 ± 0.056
3.584GlyIle: 3.584 ± 0.057
2.46GlyLys: 2.46 ± 0.057
11.167GlyLeu: 11.167 ± 0.145
2.339GlyMet: 2.339 ± 0.057
1.794GlyAsn: 1.794 ± 0.044
4.921GlyPro: 4.921 ± 0.085
3.357GlyGln: 3.357 ± 0.064
8.123GlyArg: 8.123 ± 0.097
3.94GlySer: 3.94 ± 0.076
4.583GlyThr: 4.583 ± 0.068
6.284GlyVal: 6.284 ± 0.088
1.482GlyTrp: 1.482 ± 0.043
1.935GlyTyr: 1.935 ± 0.044
0.0GlyXaa: 0.0 ± 0.0
His
2.568HisAla: 2.568 ± 0.052
0.223HisCys: 0.223 ± 0.015
1.363HisAsp: 1.363 ± 0.035
0.978HisGlu: 0.978 ± 0.03
0.799HisPhe: 0.799 ± 0.033
2.265HisGly: 2.265 ± 0.053
0.721HisHis: 0.721 ± 0.033
0.877HisIle: 0.877 ± 0.03
0.421HisLys: 0.421 ± 0.024
3.01HisLeu: 3.01 ± 0.061
0.441HisMet: 0.441 ± 0.021
0.46HisAsn: 0.46 ± 0.022
1.859HisPro: 1.859 ± 0.052
0.79HisGln: 0.79 ± 0.027
1.841HisArg: 1.841 ± 0.051
0.773HisSer: 0.773 ± 0.03
0.994HisThr: 0.994 ± 0.032
1.444HisVal: 1.444 ± 0.039
0.352HisTrp: 0.352 ± 0.019
0.553HisTyr: 0.553 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.605IleAla: 5.605 ± 0.082
0.356IleCys: 0.356 ± 0.019
3.321IleAsp: 3.321 ± 0.067
3.004IleGlu: 3.004 ± 0.057
1.06IlePhe: 1.06 ± 0.036
3.932IleGly: 3.932 ± 0.065
0.906IleHis: 0.906 ± 0.033
1.543IleIle: 1.543 ± 0.043
1.11IleLys: 1.11 ± 0.037
3.717IleLeu: 3.717 ± 0.066
0.659IleMet: 0.659 ± 0.03
1.156IleAsn: 1.156 ± 0.039
1.953IlePro: 1.953 ± 0.045
1.094IleGln: 1.094 ± 0.033
2.582IleArg: 2.582 ± 0.057
2.052IleSer: 2.052 ± 0.049
2.302IleThr: 2.302 ± 0.058
2.694IleVal: 2.694 ± 0.058
0.404IleTrp: 0.404 ± 0.017
0.763IleTyr: 0.763 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.884LysAla: 3.884 ± 0.082
0.132LysCys: 0.132 ± 0.011
1.347LysAsp: 1.347 ± 0.044
1.24LysGlu: 1.24 ± 0.042
0.56LysPhe: 0.56 ± 0.025
2.376LysGly: 2.376 ± 0.048
0.397LysHis: 0.397 ± 0.021
0.866LysIle: 0.866 ± 0.031
0.857LysLys: 0.857 ± 0.038
2.192LysLeu: 2.192 ± 0.06
0.518LysMet: 0.518 ± 0.023
0.558LysAsn: 0.558 ± 0.027
1.619LysPro: 1.619 ± 0.048
0.687LysGln: 0.687 ± 0.026
1.936LysArg: 1.936 ± 0.047
1.255LysSer: 1.255 ± 0.043
1.518LysThr: 1.518 ± 0.041
2.252LysVal: 2.252 ± 0.044
0.231LysTrp: 0.231 ± 0.016
0.394LysTyr: 0.394 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
18.013LeuAla: 18.013 ± 0.224
0.912LeuCys: 0.912 ± 0.026
7.407LeuAsp: 7.407 ± 0.108
6.352LeuGlu: 6.352 ± 0.077
3.631LeuPhe: 3.631 ± 0.064
10.34LeuGly: 10.34 ± 0.13
1.91LeuHis: 1.91 ± 0.051
5.13LeuIle: 5.13 ± 0.067
3.953LeuLys: 3.953 ± 0.069
11.303LeuLeu: 11.303 ± 0.161
2.453LeuMet: 2.453 ± 0.051
2.422LeuAsn: 2.422 ± 0.045
6.816LeuPro: 6.816 ± 0.097
2.006LeuGln: 2.006 ± 0.044
6.469LeuArg: 6.469 ± 0.091
6.216LeuSer: 6.216 ± 0.091
6.409LeuThr: 6.409 ± 0.085
7.893LeuVal: 7.893 ± 0.099
1.332LeuTrp: 1.332 ± 0.038
1.933LeuTyr: 1.933 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
3.307MetAla: 3.307 ± 0.058
0.144MetCys: 0.144 ± 0.012
1.122MetAsp: 1.122 ± 0.037
1.074MetGlu: 1.074 ± 0.037
0.572MetPhe: 0.572 ± 0.027
1.832MetGly: 1.832 ± 0.047
0.362MetHis: 0.362 ± 0.02
1.103MetIle: 1.103 ± 0.03
0.689MetLys: 0.689 ± 0.03
1.98MetLeu: 1.98 ± 0.051
0.522MetMet: 0.522 ± 0.027
0.558MetAsn: 0.558 ± 0.026
1.384MetPro: 1.384 ± 0.04
0.531MetGln: 0.531 ± 0.025
1.466MetArg: 1.466 ± 0.038
1.557MetSer: 1.557 ± 0.038
1.669MetThr: 1.669 ± 0.042
1.871MetVal: 1.871 ± 0.038
0.19MetTrp: 0.19 ± 0.014
0.276MetTyr: 0.276 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.502AsnAla: 2.502 ± 0.053
0.193AsnCys: 0.193 ± 0.014
1.178AsnAsp: 1.178 ± 0.041
0.922AsnGlu: 0.922 ± 0.032
0.622AsnPhe: 0.622 ± 0.025
1.919AsnGly: 1.919 ± 0.051
0.489AsnHis: 0.489 ± 0.022
0.926AsnIle: 0.926 ± 0.031
0.442AsnLys: 0.442 ± 0.021
2.507AsnLeu: 2.507 ± 0.048
0.496AsnMet: 0.496 ± 0.023
0.526AsnAsn: 0.526 ± 0.03
1.688AsnPro: 1.688 ± 0.038
0.783AsnGln: 0.783 ± 0.032
1.702AsnArg: 1.702 ± 0.041
0.839AsnSer: 0.839 ± 0.037
1.068AsnThr: 1.068 ± 0.036
1.441AsnVal: 1.441 ± 0.042
0.305AsnTrp: 0.305 ± 0.017
0.436AsnTyr: 0.436 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
8.62ProAla: 8.62 ± 0.118
0.412ProCys: 0.412 ± 0.022
4.522ProAsp: 4.522 ± 0.074
4.891ProGlu: 4.891 ± 0.09
1.913ProPhe: 1.913 ± 0.048
6.319ProGly: 6.319 ± 0.103
1.256ProHis: 1.256 ± 0.038
1.858ProIle: 1.858 ± 0.043
1.253ProLys: 1.253 ± 0.037
6.276ProLeu: 6.276 ± 0.096
1.284ProMet: 1.284 ± 0.04
1.017ProAsn: 1.017 ± 0.032
5.052ProPro: 5.052 ± 0.116
1.521ProGln: 1.521 ± 0.037
4.091ProArg: 4.091 ± 0.076
2.506ProSer: 2.506 ± 0.053
3.176ProThr: 3.176 ± 0.058
4.348ProVal: 4.348 ± 0.062
0.918ProTrp: 0.918 ± 0.031
1.081ProTyr: 1.081 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
4.896GlnAla: 4.896 ± 0.084
0.185GlnCys: 0.185 ± 0.014
1.29GlnAsp: 1.29 ± 0.044
1.55GlnGlu: 1.55 ± 0.046
0.787GlnPhe: 0.787 ± 0.027
2.896GlnGly: 2.896 ± 0.053
0.579GlnHis: 0.579 ± 0.025
1.248GlnIle: 1.248 ± 0.042
0.697GlnLys: 0.697 ± 0.03
2.431GlnLeu: 2.431 ± 0.046
0.783GlnMet: 0.783 ± 0.025
0.545GlnAsn: 0.545 ± 0.026
2.022GlnPro: 2.022 ± 0.041
0.965GlnGln: 0.965 ± 0.036
2.562GlnArg: 2.562 ± 0.052
1.331GlnSer: 1.331 ± 0.039
1.699GlnThr: 1.699 ± 0.038
2.771GlnVal: 2.771 ± 0.052
0.376GlnTrp: 0.376 ± 0.019
0.436GlnTyr: 0.436 ± 0.024
0.0GlnXaa: 0.0 ± 0.0
Arg
9.636ArgAla: 9.636 ± 0.125
0.577ArgCys: 0.577 ± 0.027
4.312ArgAsp: 4.312 ± 0.073
3.698ArgGlu: 3.698 ± 0.067
2.826ArgPhe: 2.826 ± 0.051
5.098ArgGly: 5.098 ± 0.065
2.335ArgHis: 2.335 ± 0.051
3.16ArgIle: 3.16 ± 0.062
1.685ArgLys: 1.685 ± 0.046
11.32ArgLeu: 11.32 ± 0.137
1.631ArgMet: 1.631 ± 0.04
1.334ArgAsn: 1.334 ± 0.037
5.101ArgPro: 5.101 ± 0.09
3.275ArgGln: 3.275 ± 0.066
7.822ArgArg: 7.822 ± 0.12
2.479ArgSer: 2.479 ± 0.057
3.285ArgThr: 3.285 ± 0.057
5.334ArgVal: 5.334 ± 0.078
1.012ArgTrp: 1.012 ± 0.034
1.398ArgTyr: 1.398 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.435SerAla: 5.435 ± 0.08
0.328SerCys: 0.328 ± 0.02
2.459SerAsp: 2.459 ± 0.063
2.273SerGlu: 2.273 ± 0.053
1.625SerPhe: 1.625 ± 0.041
5.017SerGly: 5.017 ± 0.077
1.142SerHis: 1.142 ± 0.036
1.629SerIle: 1.629 ± 0.046
0.953SerLys: 0.953 ± 0.032
5.16SerLeu: 5.16 ± 0.069
0.982SerMet: 0.982 ± 0.031
0.892SerAsn: 0.892 ± 0.03
2.944SerPro: 2.944 ± 0.054
1.534SerGln: 1.534 ± 0.043
3.446SerArg: 3.446 ± 0.062
1.881SerSer: 1.881 ± 0.052
2.148SerThr: 2.148 ± 0.047
3.171SerVal: 3.171 ± 0.064
0.582SerTrp: 0.582 ± 0.024
0.913SerTyr: 0.913 ± 0.03
0.0SerXaa: 0.0 ± 0.0
Thr
6.292ThrAla: 6.292 ± 0.082
0.472ThrCys: 0.472 ± 0.025
2.853ThrAsp: 2.853 ± 0.064
2.626ThrGlu: 2.626 ± 0.054
1.857ThrPhe: 1.857 ± 0.046
4.65ThrGly: 4.65 ± 0.075
1.105ThrHis: 1.105 ± 0.034
2.167ThrIle: 2.167 ± 0.054
0.965ThrLys: 0.965 ± 0.037
6.625ThrLeu: 6.625 ± 0.091
0.929ThrMet: 0.929 ± 0.032
1.087ThrAsn: 1.087 ± 0.035
4.094ThrPro: 4.094 ± 0.065
1.344ThrGln: 1.344 ± 0.037
3.593ThrArg: 3.593 ± 0.059
2.163ThrSer: 2.163 ± 0.055
2.949ThrThr: 2.949 ± 0.067
4.647ThrVal: 4.647 ± 0.097
0.675ThrTrp: 0.675 ± 0.025
1.157ThrTyr: 1.157 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
10.022ValAla: 10.022 ± 0.11
0.69ValCys: 0.69 ± 0.028
4.31ValAsp: 4.31 ± 0.072
4.638ValGlu: 4.638 ± 0.068
2.511ValPhe: 2.511 ± 0.054
6.13ValGly: 6.13 ± 0.082
1.5ValHis: 1.5 ± 0.043
3.499ValIle: 3.499 ± 0.069
1.816ValLys: 1.816 ± 0.045
8.03ValLeu: 8.03 ± 0.118
1.714ValMet: 1.714 ± 0.044
1.742ValAsn: 1.742 ± 0.047
3.869ValPro: 3.869 ± 0.061
1.598ValGln: 1.598 ± 0.046
5.195ValArg: 5.195 ± 0.067
3.682ValSer: 3.682 ± 0.067
3.804ValThr: 3.804 ± 0.07
6.448ValVal: 6.448 ± 0.096
0.838ValTrp: 0.838 ± 0.034
1.236ValTyr: 1.236 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.449TrpAla: 1.449 ± 0.042
0.131TrpCys: 0.131 ± 0.011
0.592TrpAsp: 0.592 ± 0.027
0.606TrpGlu: 0.606 ± 0.024
0.441TrpPhe: 0.441 ± 0.022
0.93TrpGly: 0.93 ± 0.031
0.357TrpHis: 0.357 ± 0.019
0.493TrpIle: 0.493 ± 0.02
0.288TrpLys: 0.288 ± 0.018
1.942TrpLeu: 1.942 ± 0.052
0.316TrpMet: 0.316 ± 0.018
0.296TrpAsn: 0.296 ± 0.018
0.785TrpPro: 0.785 ± 0.035
0.575TrpGln: 0.575 ± 0.026
1.346TrpArg: 1.346 ± 0.043
0.642TrpSer: 0.642 ± 0.026
0.659TrpThr: 0.659 ± 0.028
0.86TrpVal: 0.86 ± 0.035
0.221TrpTrp: 0.221 ± 0.017
0.211TrpTyr: 0.211 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.018TyrAla: 2.018 ± 0.049
0.219TyrCys: 0.219 ± 0.015
1.2TyrAsp: 1.2 ± 0.043
0.933TyrGlu: 0.933 ± 0.033
0.697TyrPhe: 0.697 ± 0.03
1.714TyrGly: 1.714 ± 0.045
0.533TyrHis: 0.533 ± 0.022
0.617TyrIle: 0.617 ± 0.022
0.464TyrLys: 0.464 ± 0.022
2.12TyrLeu: 2.12 ± 0.056
0.41TyrMet: 0.41 ± 0.022
0.449TyrAsn: 0.449 ± 0.02
1.005TyrPro: 1.005 ± 0.036
0.729TyrGln: 0.729 ± 0.027
1.67TyrArg: 1.67 ± 0.04
0.825TyrSer: 0.825 ± 0.031
0.898TyrThr: 0.898 ± 0.029
1.289TyrVal: 1.289 ± 0.033
0.31TyrTrp: 0.31 ± 0.019
0.475TyrTyr: 0.475 ± 0.025
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3067 proteins (1028483 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski