Amino acid dipepetide frequency for Cohnella endophytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.503AlaAla: 8.503 ± 0.103
0.729AlaCys: 0.729 ± 0.019
4.692AlaAsp: 4.692 ± 0.055
5.61AlaGlu: 5.61 ± 0.071
3.511AlaPhe: 3.511 ± 0.044
6.771AlaGly: 6.771 ± 0.077
1.349AlaHis: 1.349 ± 0.028
5.866AlaIle: 5.866 ± 0.066
4.417AlaLys: 4.417 ± 0.057
8.444AlaLeu: 8.444 ± 0.074
2.404AlaMet: 2.404 ± 0.04
3.315AlaAsn: 3.315 ± 0.054
2.774AlaPro: 2.774 ± 0.05
2.679AlaGln: 2.679 ± 0.042
3.805AlaArg: 3.805 ± 0.054
5.962AlaSer: 5.962 ± 0.073
4.681AlaThr: 4.681 ± 0.101
6.32AlaVal: 6.32 ± 0.071
1.091AlaTrp: 1.091 ± 0.028
2.807AlaTyr: 2.807 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
0.534CysAla: 0.534 ± 0.019
0.099CysCys: 0.099 ± 0.008
0.392CysAsp: 0.392 ± 0.017
0.444CysGlu: 0.444 ± 0.016
0.277CysPhe: 0.277 ± 0.012
0.737CysGly: 0.737 ± 0.023
0.164CysHis: 0.164 ± 0.012
0.465CysIle: 0.465 ± 0.018
0.263CysLys: 0.263 ± 0.013
0.737CysLeu: 0.737 ± 0.023
0.184CysMet: 0.184 ± 0.01
0.258CysAsn: 0.258 ± 0.012
0.314CysPro: 0.314 ± 0.013
0.185CysGln: 0.185 ± 0.011
0.443CysArg: 0.443 ± 0.018
0.528CysSer: 0.528 ± 0.02
0.346CysThr: 0.346 ± 0.014
0.449CysVal: 0.449 ± 0.017
0.091CysTrp: 0.091 ± 0.008
0.258CysTyr: 0.258 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
4.268AspAla: 4.268 ± 0.058
0.376AspCys: 0.376 ± 0.016
2.652AspAsp: 2.652 ± 0.045
3.776AspGlu: 3.776 ± 0.053
2.17AspPhe: 2.17 ± 0.034
4.485AspGly: 4.485 ± 0.063
1.014AspHis: 1.014 ± 0.028
3.498AspIle: 3.498 ± 0.044
2.85AspLys: 2.85 ± 0.04
4.857AspLeu: 4.857 ± 0.057
1.255AspMet: 1.255 ± 0.025
2.157AspAsn: 2.157 ± 0.04
2.485AspPro: 2.485 ± 0.04
1.782AspGln: 1.782 ± 0.032
3.09AspArg: 3.09 ± 0.048
3.156AspSer: 3.156 ± 0.048
2.533AspThr: 2.533 ± 0.041
3.594AspVal: 3.594 ± 0.05
0.986AspTrp: 0.986 ± 0.028
2.08AspTyr: 2.08 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
5.879GluAla: 5.879 ± 0.077
0.375GluCys: 0.375 ± 0.018
2.993GluAsp: 2.993 ± 0.041
4.708GluGlu: 4.708 ± 0.07
2.075GluPhe: 2.075 ± 0.035
4.316GluGly: 4.316 ± 0.054
1.31GluHis: 1.31 ± 0.031
4.123GluIle: 4.123 ± 0.057
3.614GluLys: 3.614 ± 0.055
6.664GluLeu: 6.664 ± 0.088
1.913GluMet: 1.913 ± 0.036
2.319GluAsn: 2.319 ± 0.039
2.223GluPro: 2.223 ± 0.042
3.046GluGln: 3.046 ± 0.055
4.117GluArg: 4.117 ± 0.066
3.712GluSer: 3.712 ± 0.055
3.312GluThr: 3.312 ± 0.044
4.059GluVal: 4.059 ± 0.056
0.993GluTrp: 0.993 ± 0.024
1.892GluTyr: 1.892 ± 0.034
0.0GluXaa: 0.0 ± 0.0
Phe
3.537PheAla: 3.537 ± 0.052
0.333PheCys: 0.333 ± 0.014
2.461PheAsp: 2.461 ± 0.038
2.43PheGlu: 2.43 ± 0.031
1.739PhePhe: 1.739 ± 0.039
3.437PheGly: 3.437 ± 0.048
0.878PheHis: 0.878 ± 0.02
2.617PheIle: 2.617 ± 0.044
1.95PheLys: 1.95 ± 0.03
3.896PheLeu: 3.896 ± 0.059
1.083PheMet: 1.083 ± 0.024
1.653PheAsn: 1.653 ± 0.031
1.624PhePro: 1.624 ± 0.026
1.317PheGln: 1.317 ± 0.032
2.257PheArg: 2.257 ± 0.038
2.817PheSer: 2.817 ± 0.037
2.317PheThr: 2.317 ± 0.044
3.17PheVal: 3.17 ± 0.047
0.509PheTrp: 0.509 ± 0.019
1.477PheTyr: 1.477 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
5.92GlyAla: 5.92 ± 0.086
0.686GlyCys: 0.686 ± 0.022
3.817GlyAsp: 3.817 ± 0.059
4.464GlyGlu: 4.464 ± 0.066
3.31GlyPhe: 3.31 ± 0.043
5.876GlyGly: 5.876 ± 0.087
1.443GlyHis: 1.443 ± 0.028
5.699GlyIle: 5.699 ± 0.062
4.664GlyLys: 4.664 ± 0.054
7.378GlyLeu: 7.378 ± 0.08
2.342GlyMet: 2.342 ± 0.039
3.232GlyAsn: 3.232 ± 0.058
1.904GlyPro: 1.904 ± 0.039
2.649GlyGln: 2.649 ± 0.042
3.525GlyArg: 3.525 ± 0.053
5.008GlySer: 5.008 ± 0.074
5.08GlyThr: 5.08 ± 0.079
5.295GlyVal: 5.295 ± 0.055
1.257GlyTrp: 1.257 ± 0.028
3.037GlyTyr: 3.037 ± 0.042
0.0GlyXaa: 0.0 ± 0.0
His
1.5HisAla: 1.5 ± 0.031
0.174HisCys: 0.174 ± 0.01
0.981HisAsp: 0.981 ± 0.027
1.177HisGlu: 1.177 ± 0.027
0.951HisPhe: 0.951 ± 0.023
1.477HisGly: 1.477 ± 0.029
0.532HisHis: 0.532 ± 0.026
1.113HisIle: 1.113 ± 0.023
0.715HisLys: 0.715 ± 0.02
1.94HisLeu: 1.94 ± 0.038
0.481HisMet: 0.481 ± 0.015
0.619HisAsn: 0.619 ± 0.021
1.189HisPro: 1.189 ± 0.028
0.619HisGln: 0.619 ± 0.021
1.097HisArg: 1.097 ± 0.03
1.164HisSer: 1.164 ± 0.029
0.922HisThr: 0.922 ± 0.025
1.318HisVal: 1.318 ± 0.029
0.323HisTrp: 0.323 ± 0.012
0.818HisTyr: 0.818 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
6.169IleAla: 6.169 ± 0.063
0.524IleCys: 0.524 ± 0.018
3.759IleAsp: 3.759 ± 0.045
4.128IleGlu: 4.128 ± 0.055
2.269IlePhe: 2.269 ± 0.037
5.519IleGly: 5.519 ± 0.06
1.298IleHis: 1.298 ± 0.032
3.724IleIle: 3.724 ± 0.056
2.906IleLys: 2.906 ± 0.041
5.495IleLeu: 5.495 ± 0.068
1.476IleMet: 1.476 ± 0.029
2.374IleAsn: 2.374 ± 0.042
3.113IlePro: 3.113 ± 0.039
2.272IleGln: 2.272 ± 0.04
3.966IleArg: 3.966 ± 0.055
4.356IleSer: 4.356 ± 0.058
3.587IleThr: 3.587 ± 0.052
5.648IleVal: 5.648 ± 0.06
0.695IleTrp: 0.695 ± 0.019
1.991IleTyr: 1.991 ± 0.036
0.0IleXaa: 0.0 ± 0.0
Lys
4.353LysAla: 4.353 ± 0.052
0.215LysCys: 0.215 ± 0.012
2.887LysAsp: 2.887 ± 0.047
3.732LysGlu: 3.732 ± 0.058
1.727LysPhe: 1.727 ± 0.038
3.604LysGly: 3.604 ± 0.046
0.989LysHis: 0.989 ± 0.021
3.168LysIle: 3.168 ± 0.048
2.986LysLys: 2.986 ± 0.044
5.592LysLeu: 5.592 ± 0.061
1.477LysMet: 1.477 ± 0.028
2.035LysAsn: 2.035 ± 0.038
2.391LysPro: 2.391 ± 0.043
2.233LysGln: 2.233 ± 0.032
2.647LysArg: 2.647 ± 0.042
3.193LysSer: 3.193 ± 0.049
2.825LysThr: 2.825 ± 0.04
3.495LysVal: 3.495 ± 0.047
0.745LysTrp: 0.745 ± 0.021
1.768LysTyr: 1.768 ± 0.029
0.0LysXaa: 0.0 ± 0.0
Leu
8.557LeuAla: 8.557 ± 0.097
0.775LeuCys: 0.775 ± 0.025
5.043LeuAsp: 5.043 ± 0.054
5.893LeuGlu: 5.893 ± 0.076
4.658LeuPhe: 4.658 ± 0.059
6.63LeuGly: 6.63 ± 0.068
1.896LeuHis: 1.896 ± 0.034
6.328LeuIle: 6.328 ± 0.075
5.245LeuLys: 5.245 ± 0.059
10.69LeuLeu: 10.69 ± 0.121
2.432LeuMet: 2.432 ± 0.041
3.996LeuAsn: 3.996 ± 0.045
4.473LeuPro: 4.473 ± 0.055
3.654LeuGln: 3.654 ± 0.046
5.258LeuArg: 5.258 ± 0.065
7.307LeuSer: 7.307 ± 0.061
5.738LeuThr: 5.738 ± 0.056
6.38LeuVal: 6.38 ± 0.07
1.061LeuTrp: 1.061 ± 0.03
3.143LeuTyr: 3.143 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.235MetAla: 2.235 ± 0.035
0.151MetCys: 0.151 ± 0.008
1.451MetAsp: 1.451 ± 0.03
1.651MetGlu: 1.651 ± 0.036
1.003MetPhe: 1.003 ± 0.024
1.721MetGly: 1.721 ± 0.032
0.443MetHis: 0.443 ± 0.016
1.793MetIle: 1.793 ± 0.034
1.838MetLys: 1.838 ± 0.031
2.717MetLeu: 2.717 ± 0.036
0.79MetMet: 0.79 ± 0.021
1.438MetAsn: 1.438 ± 0.024
1.176MetPro: 1.176 ± 0.024
0.888MetGln: 0.888 ± 0.021
1.405MetArg: 1.405 ± 0.027
1.815MetSer: 1.815 ± 0.033
1.673MetThr: 1.673 ± 0.028
1.513MetVal: 1.513 ± 0.031
0.225MetTrp: 0.225 ± 0.012
0.697MetTyr: 0.697 ± 0.02
0.0MetXaa: 0.0 ± 0.0
Asn
3.497AsnAla: 3.497 ± 0.055
0.222AsnCys: 0.222 ± 0.012
2.202AsnAsp: 2.202 ± 0.045
2.543AsnGlu: 2.543 ± 0.035
1.388AsnPhe: 1.388 ± 0.031
3.873AsnGly: 3.873 ± 0.065
0.829AsnHis: 0.829 ± 0.023
2.287AsnIle: 2.287 ± 0.042
2.142AsnLys: 2.142 ± 0.038
3.409AsnLeu: 3.409 ± 0.052
0.951AsnMet: 0.951 ± 0.022
1.849AsnAsn: 1.849 ± 0.047
2.168AsnPro: 2.168 ± 0.038
1.305AsnGln: 1.305 ± 0.031
2.308AsnArg: 2.308 ± 0.037
2.425AsnSer: 2.425 ± 0.046
2.009AsnThr: 2.009 ± 0.042
2.976AsnVal: 2.976 ± 0.044
0.585AsnTrp: 0.585 ± 0.019
1.456AsnTyr: 1.456 ± 0.033
0.0AsnXaa: 0.0 ± 0.0
Pro
3.425ProAla: 3.425 ± 0.045
0.241ProCys: 0.241 ± 0.012
2.645ProAsp: 2.645 ± 0.041
3.194ProGlu: 3.194 ± 0.051
1.9ProPhe: 1.9 ± 0.035
2.968ProGly: 2.968 ± 0.047
0.845ProHis: 0.845 ± 0.024
2.637ProIle: 2.637 ± 0.038
1.801ProLys: 1.801 ± 0.031
3.92ProLeu: 3.92 ± 0.055
0.955ProMet: 0.955 ± 0.024
1.737ProAsn: 1.737 ± 0.036
1.305ProPro: 1.305 ± 0.03
1.307ProGln: 1.307 ± 0.025
1.545ProArg: 1.545 ± 0.03
2.918ProSer: 2.918 ± 0.044
2.196ProThr: 2.196 ± 0.054
3.105ProVal: 3.105 ± 0.042
0.552ProTrp: 0.552 ± 0.021
1.53ProTyr: 1.53 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
3.409GlnAla: 3.409 ± 0.052
0.18GlnCys: 0.18 ± 0.01
1.599GlnAsp: 1.599 ± 0.033
2.14GlnGlu: 2.14 ± 0.039
1.472GlnPhe: 1.472 ± 0.033
2.434GlnGly: 2.434 ± 0.044
0.609GlnHis: 0.609 ± 0.019
2.267GlnIle: 2.267 ± 0.039
1.605GlnLys: 1.605 ± 0.029
3.883GlnLeu: 3.883 ± 0.05
1.017GlnMet: 1.017 ± 0.025
1.199GlnAsn: 1.199 ± 0.026
1.462GlnPro: 1.462 ± 0.029
1.5GlnGln: 1.5 ± 0.035
1.731GlnArg: 1.731 ± 0.034
2.302GlnSer: 2.302 ± 0.037
1.979GlnThr: 1.979 ± 0.039
2.348GlnVal: 2.348 ± 0.039
0.586GlnTrp: 0.586 ± 0.021
1.252GlnTyr: 1.252 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
3.558ArgAla: 3.558 ± 0.053
0.339ArgCys: 0.339 ± 0.014
2.617ArgAsp: 2.617 ± 0.044
3.744ArgGlu: 3.744 ± 0.063
2.409ArgPhe: 2.409 ± 0.037
3.095ArgGly: 3.095 ± 0.049
1.046ArgHis: 1.046 ± 0.029
3.92ArgIle: 3.92 ± 0.046
3.174ArgLys: 3.174 ± 0.046
5.706ArgLeu: 5.706 ± 0.075
1.808ArgMet: 1.808 ± 0.037
2.251ArgAsn: 2.251 ± 0.038
1.76ArgPro: 1.76 ± 0.038
1.973ArgGln: 1.973 ± 0.036
2.863ArgArg: 2.863 ± 0.056
3.31ArgSer: 3.31 ± 0.046
2.807ArgThr: 2.807 ± 0.038
3.208ArgVal: 3.208 ± 0.045
0.721ArgTrp: 0.721 ± 0.022
1.912ArgTyr: 1.912 ± 0.038
0.0ArgXaa: 0.0 ± 0.0
Ser
5.736SerAla: 5.736 ± 0.077
0.436SerCys: 0.436 ± 0.018
3.515SerAsp: 3.515 ± 0.05
3.922SerGlu: 3.922 ± 0.053
3.021SerPhe: 3.021 ± 0.045
5.975SerGly: 5.975 ± 0.083
1.218SerHis: 1.218 ± 0.022
4.383SerIle: 4.383 ± 0.052
3.201SerLys: 3.201 ± 0.048
6.585SerLeu: 6.585 ± 0.063
1.709SerMet: 1.709 ± 0.032
2.576SerAsn: 2.576 ± 0.059
2.687SerPro: 2.687 ± 0.04
2.063SerGln: 2.063 ± 0.036
3.29SerArg: 3.29 ± 0.047
4.844SerSer: 4.844 ± 0.069
3.344SerThr: 3.344 ± 0.047
4.905SerVal: 4.905 ± 0.07
0.934SerTrp: 0.934 ± 0.024
2.363SerTyr: 2.363 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.87ThrAla: 4.87 ± 0.08
0.319ThrCys: 0.319 ± 0.013
3.074ThrAsp: 3.074 ± 0.052
3.108ThrGlu: 3.108 ± 0.048
2.432ThrPhe: 2.432 ± 0.045
4.853ThrGly: 4.853 ± 0.087
0.958ThrHis: 0.958 ± 0.023
4.038ThrIle: 4.038 ± 0.06
2.525ThrLys: 2.525 ± 0.039
5.56ThrLeu: 5.56 ± 0.064
1.326ThrMet: 1.326 ± 0.025
2.237ThrAsn: 2.237 ± 0.05
2.605ThrPro: 2.605 ± 0.058
1.556ThrGln: 1.556 ± 0.032
2.354ThrArg: 2.354 ± 0.037
3.623ThrSer: 3.623 ± 0.062
3.112ThrThr: 3.112 ± 0.065
4.72ThrVal: 4.72 ± 0.091
0.708ThrTrp: 0.708 ± 0.024
1.874ThrTyr: 1.874 ± 0.041
0.0ThrXaa: 0.0 ± 0.0
Val
5.939ValAla: 5.939 ± 0.064
0.591ValCys: 0.591 ± 0.019
3.688ValAsp: 3.688 ± 0.048
4.039ValGlu: 4.039 ± 0.062
2.983ValPhe: 2.983 ± 0.044
4.985ValGly: 4.985 ± 0.065
1.345ValHis: 1.345 ± 0.027
4.547ValIle: 4.547 ± 0.055
3.841ValLys: 3.841 ± 0.052
6.865ValLeu: 6.865 ± 0.081
1.774ValMet: 1.774 ± 0.034
2.962ValAsn: 2.962 ± 0.042
3.136ValPro: 3.136 ± 0.043
2.397ValGln: 2.397 ± 0.036
3.669ValArg: 3.669 ± 0.05
5.124ValSer: 5.124 ± 0.065
4.74ValThr: 4.74 ± 0.085
5.206ValVal: 5.206 ± 0.057
0.871ValTrp: 0.871 ± 0.026
2.321ValTyr: 2.321 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.944TrpAla: 0.944 ± 0.021
0.103TrpCys: 0.103 ± 0.008
0.729TrpAsp: 0.729 ± 0.021
0.774TrpGlu: 0.774 ± 0.024
0.589TrpPhe: 0.589 ± 0.02
0.945TrpGly: 0.945 ± 0.024
0.29TrpHis: 0.29 ± 0.014
0.951TrpIle: 0.951 ± 0.028
0.781TrpLys: 0.781 ± 0.02
1.419TrpLeu: 1.419 ± 0.033
0.42TrpMet: 0.42 ± 0.016
0.8TrpAsn: 0.8 ± 0.023
0.431TrpPro: 0.431 ± 0.018
0.477TrpGln: 0.477 ± 0.017
0.651TrpArg: 0.651 ± 0.02
0.945TrpSer: 0.945 ± 0.027
0.889TrpThr: 0.889 ± 0.029
0.843TrpVal: 0.843 ± 0.025
0.199TrpTrp: 0.199 ± 0.011
0.437TrpTyr: 0.437 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.897TyrAla: 2.897 ± 0.05
0.297TyrCys: 0.297 ± 0.015
1.867TyrAsp: 1.867 ± 0.034
2.168TyrGlu: 2.168 ± 0.037
1.616TyrPhe: 1.616 ± 0.03
2.884TyrGly: 2.884 ± 0.042
0.659TyrHis: 0.659 ± 0.023
1.847TyrIle: 1.847 ± 0.035
1.543TyrLys: 1.543 ± 0.033
3.4TyrLeu: 3.4 ± 0.052
0.827TyrMet: 0.827 ± 0.021
1.415TyrAsn: 1.415 ± 0.034
1.506TyrPro: 1.506 ± 0.031
1.073TyrGln: 1.073 ± 0.024
2.201TyrArg: 2.201 ± 0.039
2.199TyrSer: 2.199 ± 0.042
1.762TyrThr: 1.762 ± 0.045
2.469TyrVal: 2.469 ± 0.044
0.484TyrTrp: 0.484 ± 0.019
1.428TyrTyr: 1.428 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5255 proteins (1836382 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski