Amino acid dipepetide frequency for Fertoebacter nigrum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.639AlaAla: 21.639 ± 0.237
1.191AlaCys: 1.191 ± 0.031
7.964AlaAsp: 7.964 ± 0.09
8.657AlaGlu: 8.657 ± 0.113
4.783AlaPhe: 4.783 ± 0.074
12.769AlaGly: 12.769 ± 0.125
2.647AlaHis: 2.647 ± 0.055
5.731AlaIle: 5.731 ± 0.076
3.303AlaLys: 3.303 ± 0.067
16.232AlaLeu: 16.232 ± 0.168
4.344AlaMet: 4.344 ± 0.063
2.804AlaAsn: 2.804 ± 0.054
6.742AlaPro: 6.742 ± 0.115
4.948AlaGln: 4.948 ± 0.063
10.191AlaArg: 10.191 ± 0.117
5.614AlaSer: 5.614 ± 0.064
6.885AlaThr: 6.885 ± 0.082
9.777AlaVal: 9.777 ± 0.122
1.46AlaTrp: 1.46 ± 0.037
2.55AlaTyr: 2.55 ± 0.046
0.0AlaXaa: 0.0 ± 0.0
Cys
1.149CysAla: 1.149 ± 0.031
0.106CysCys: 0.106 ± 0.011
0.594CysAsp: 0.594 ± 0.021
0.366CysGlu: 0.366 ± 0.021
0.351CysPhe: 0.351 ± 0.018
1.0CysGly: 1.0 ± 0.028
0.283CysHis: 0.283 ± 0.018
0.372CysIle: 0.372 ± 0.018
0.166CysLys: 0.166 ± 0.013
0.884CysLeu: 0.884 ± 0.03
0.178CysMet: 0.178 ± 0.01
0.238CysAsn: 0.238 ± 0.016
0.509CysPro: 0.509 ± 0.024
0.233CysGln: 0.233 ± 0.014
0.58CysArg: 0.58 ± 0.023
0.399CysSer: 0.399 ± 0.02
0.478CysThr: 0.478 ± 0.02
0.588CysVal: 0.588 ± 0.028
0.13CysTrp: 0.13 ± 0.011
0.174CysTyr: 0.174 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.822AspAla: 7.822 ± 0.11
0.529AspCys: 0.529 ± 0.024
3.268AspAsp: 3.268 ± 0.069
2.878AspGlu: 2.878 ± 0.056
2.301AspPhe: 2.301 ± 0.042
5.369AspGly: 5.369 ± 0.09
1.323AspHis: 1.323 ± 0.044
2.684AspIle: 2.684 ± 0.048
1.167AspLys: 1.167 ± 0.031
6.483AspLeu: 6.483 ± 0.076
1.593AspMet: 1.593 ± 0.035
1.061AspAsn: 1.061 ± 0.033
3.619AspPro: 3.619 ± 0.053
1.824AspGln: 1.824 ± 0.038
4.405AspArg: 4.405 ± 0.071
2.001AspSer: 2.001 ± 0.048
2.928AspThr: 2.928 ± 0.07
4.082AspVal: 4.082 ± 0.063
1.194AspTrp: 1.194 ± 0.03
1.449AspTyr: 1.449 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
7.576GluAla: 7.576 ± 0.089
0.355GluCys: 0.355 ± 0.016
2.633GluAsp: 2.633 ± 0.043
2.358GluGlu: 2.358 ± 0.056
1.617GluPhe: 1.617 ± 0.037
4.601GluGly: 4.601 ± 0.079
0.957GluHis: 0.957 ± 0.031
2.765GluIle: 2.765 ± 0.05
1.562GluLys: 1.562 ± 0.046
4.358GluLeu: 4.358 ± 0.07
1.448GluMet: 1.448 ± 0.038
1.393GluAsn: 1.393 ± 0.034
2.538GluPro: 2.538 ± 0.06
1.621GluGln: 1.621 ± 0.041
3.693GluArg: 3.693 ± 0.062
1.926GluSer: 1.926 ± 0.046
3.08GluThr: 3.08 ± 0.058
3.943GluVal: 3.943 ± 0.06
0.701GluTrp: 0.701 ± 0.023
0.892GluTyr: 0.892 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
5.081PheAla: 5.081 ± 0.068
0.42PheCys: 0.42 ± 0.019
2.729PheAsp: 2.729 ± 0.048
1.712PheGlu: 1.712 ± 0.039
1.279PhePhe: 1.279 ± 0.034
3.779PheGly: 3.779 ± 0.06
0.82PheHis: 0.82 ± 0.027
1.55PheIle: 1.55 ± 0.038
0.753PheLys: 0.753 ± 0.03
3.424PheLeu: 3.424 ± 0.058
0.772PheMet: 0.772 ± 0.028
0.985PheAsn: 0.985 ± 0.033
1.637PhePro: 1.637 ± 0.032
0.989PheGln: 0.989 ± 0.028
2.366PheArg: 2.366 ± 0.049
1.921PheSer: 1.921 ± 0.049
2.201PheThr: 2.201 ± 0.042
2.578PheVal: 2.578 ± 0.051
0.56PheTrp: 0.56 ± 0.025
0.831PheTyr: 0.831 ± 0.027
0.0PheXaa: 0.0 ± 0.0
Gly
11.26GlyAla: 11.26 ± 0.114
0.907GlyCys: 0.907 ± 0.028
4.674GlyAsp: 4.674 ± 0.1
4.107GlyGlu: 4.107 ± 0.066
3.907GlyPhe: 3.907 ± 0.067
8.434GlyGly: 8.434 ± 0.157
2.149GlyHis: 2.149 ± 0.05
4.452GlyIle: 4.452 ± 0.07
2.694GlyLys: 2.694 ± 0.054
10.296GlyLeu: 10.296 ± 0.129
2.802GlyMet: 2.802 ± 0.05
2.288GlyAsn: 2.288 ± 0.088
4.284GlyPro: 4.284 ± 0.072
3.473GlyGln: 3.473 ± 0.053
6.403GlyArg: 6.403 ± 0.079
4.235GlySer: 4.235 ± 0.07
4.784GlyThr: 4.784 ± 0.085
6.636GlyVal: 6.636 ± 0.08
1.708GlyTrp: 1.708 ± 0.041
2.272GlyTyr: 2.272 ± 0.039
0.0GlyXaa: 0.0 ± 0.0
His
2.667HisAla: 2.667 ± 0.051
0.229HisCys: 0.229 ± 0.014
1.358HisAsp: 1.358 ± 0.037
0.958HisGlu: 0.958 ± 0.025
0.859HisPhe: 0.859 ± 0.028
2.095HisGly: 2.095 ± 0.059
0.571HisHis: 0.571 ± 0.026
0.886HisIle: 0.886 ± 0.025
0.405HisLys: 0.405 ± 0.018
2.292HisLeu: 2.292 ± 0.05
0.537HisMet: 0.537 ± 0.021
0.442HisAsn: 0.442 ± 0.018
1.452HisPro: 1.452 ± 0.039
0.575HisGln: 0.575 ± 0.023
1.47HisArg: 1.47 ± 0.035
0.922HisSer: 0.922 ± 0.028
0.802HisThr: 0.802 ± 0.027
1.599HisVal: 1.599 ± 0.037
0.372HisTrp: 0.372 ± 0.021
0.556HisTyr: 0.556 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.09IleAla: 7.09 ± 0.096
0.576IleCys: 0.576 ± 0.021
3.158IleAsp: 3.158 ± 0.058
2.712IleGlu: 2.712 ± 0.054
1.6IlePhe: 1.6 ± 0.038
4.845IleGly: 4.845 ± 0.073
0.866IleHis: 0.866 ± 0.028
2.035IleIle: 2.035 ± 0.048
0.957IleLys: 0.957 ± 0.029
4.396IleLeu: 4.396 ± 0.068
0.915IleMet: 0.915 ± 0.033
1.158IleAsn: 1.158 ± 0.035
2.167IlePro: 2.167 ± 0.042
0.898IleGln: 0.898 ± 0.028
3.249IleArg: 3.249 ± 0.056
2.525IleSer: 2.525 ± 0.049
2.989IleThr: 2.989 ± 0.056
3.393IleVal: 3.393 ± 0.059
0.666IleTrp: 0.666 ± 0.023
1.04IleTyr: 1.04 ± 0.032
0.0IleXaa: 0.0 ± 0.0
Lys
3.387LysAla: 3.387 ± 0.054
0.146LysCys: 0.146 ± 0.012
1.405LysAsp: 1.405 ± 0.039
0.957LysGlu: 0.957 ± 0.034
0.715LysPhe: 0.715 ± 0.027
2.372LysGly: 2.372 ± 0.047
0.525LysHis: 0.525 ± 0.021
1.253LysIle: 1.253 ± 0.038
0.782LysLys: 0.782 ± 0.031
2.388LysLeu: 2.388 ± 0.049
0.666LysMet: 0.666 ± 0.024
0.628LysAsn: 0.628 ± 0.025
1.582LysPro: 1.582 ± 0.041
0.669LysGln: 0.669 ± 0.027
1.698LysArg: 1.698 ± 0.043
1.37LysSer: 1.37 ± 0.032
1.59LysThr: 1.59 ± 0.036
1.865LysVal: 1.865 ± 0.043
0.293LysTrp: 0.293 ± 0.018
0.502LysTyr: 0.502 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
16.415LeuAla: 16.415 ± 0.173
1.0LeuCys: 1.0 ± 0.029
5.748LeuAsp: 5.748 ± 0.078
4.753LeuGlu: 4.753 ± 0.068
3.435LeuPhe: 3.435 ± 0.061
8.997LeuGly: 8.997 ± 0.095
2.193LeuHis: 2.193 ± 0.048
4.99LeuIle: 4.99 ± 0.079
2.508LeuLys: 2.508 ± 0.047
9.983LeuLeu: 9.983 ± 0.145
2.668LeuMet: 2.668 ± 0.053
2.631LeuAsn: 2.631 ± 0.053
6.502LeuPro: 6.502 ± 0.089
2.677LeuGln: 2.677 ± 0.049
7.98LeuArg: 7.98 ± 0.088
5.63LeuSer: 5.63 ± 0.086
6.35LeuThr: 6.35 ± 0.079
7.358LeuVal: 7.358 ± 0.095
1.478LeuTrp: 1.478 ± 0.044
2.042LeuTyr: 2.042 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.994MetAla: 3.994 ± 0.067
0.156MetCys: 0.156 ± 0.011
1.303MetAsp: 1.303 ± 0.034
1.192MetGlu: 1.192 ± 0.034
0.784MetPhe: 0.784 ± 0.023
2.27MetGly: 2.27 ± 0.045
0.415MetHis: 0.415 ± 0.02
1.455MetIle: 1.455 ± 0.041
0.884MetLys: 0.884 ± 0.026
2.729MetLeu: 2.729 ± 0.055
0.766MetMet: 0.766 ± 0.027
0.813MetAsn: 0.813 ± 0.027
1.593MetPro: 1.593 ± 0.037
1.07MetGln: 1.07 ± 0.028
1.84MetArg: 1.84 ± 0.035
1.311MetSer: 1.311 ± 0.033
2.12MetThr: 2.12 ± 0.039
2.023MetVal: 2.023 ± 0.04
0.232MetTrp: 0.232 ± 0.015
0.289MetTyr: 0.289 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.037AsnAla: 3.037 ± 0.051
0.233AsnCys: 0.233 ± 0.016
1.417AsnAsp: 1.417 ± 0.063
0.923AsnGlu: 0.923 ± 0.026
0.878AsnPhe: 0.878 ± 0.027
2.203AsnGly: 2.203 ± 0.059
0.5AsnHis: 0.5 ± 0.021
1.278AsnIle: 1.278 ± 0.037
0.486AsnLys: 0.486 ± 0.019
2.47AsnLeu: 2.47 ± 0.046
0.63AsnMet: 0.63 ± 0.023
0.604AsnAsn: 0.604 ± 0.024
1.876AsnPro: 1.876 ± 0.042
0.6AsnGln: 0.6 ± 0.025
1.729AsnArg: 1.729 ± 0.042
1.025AsnSer: 1.025 ± 0.03
1.224AsnThr: 1.224 ± 0.039
1.698AsnVal: 1.698 ± 0.044
0.4AsnTrp: 0.4 ± 0.017
0.589AsnTyr: 0.589 ± 0.022
0.0AsnXaa: 0.0 ± 0.0
Pro
7.546ProAla: 7.546 ± 0.12
0.394ProCys: 0.394 ± 0.02
4.174ProAsp: 4.174 ± 0.058
3.657ProGlu: 3.657 ± 0.071
1.967ProPhe: 1.967 ± 0.043
5.537ProGly: 5.537 ± 0.078
1.092ProHis: 1.092 ± 0.032
1.88ProIle: 1.88 ± 0.049
1.37ProLys: 1.37 ± 0.036
5.418ProLeu: 5.418 ± 0.076
1.352ProMet: 1.352 ± 0.033
1.128ProAsn: 1.128 ± 0.031
2.733ProPro: 2.733 ± 0.065
1.931ProGln: 1.931 ± 0.046
3.109ProArg: 3.109 ± 0.06
2.27ProSer: 2.27 ± 0.045
2.326ProThr: 2.326 ± 0.044
4.832ProVal: 4.832 ± 0.067
0.709ProTrp: 0.709 ± 0.028
1.156ProTyr: 1.156 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
4.697GlnAla: 4.697 ± 0.069
0.213GlnCys: 0.213 ± 0.015
1.6GlnAsp: 1.6 ± 0.041
1.233GlnGlu: 1.233 ± 0.037
0.979GlnPhe: 0.979 ± 0.029
3.011GlnGly: 3.011 ± 0.049
0.611GlnHis: 0.611 ± 0.026
1.826GlnIle: 1.826 ± 0.043
0.873GlnLys: 0.873 ± 0.027
2.588GlnLeu: 2.588 ± 0.044
1.077GlnMet: 1.077 ± 0.031
0.852GlnAsn: 0.852 ± 0.029
1.905GlnPro: 1.905 ± 0.04
1.058GlnGln: 1.058 ± 0.033
2.344GlnArg: 2.344 ± 0.045
1.526GlnSer: 1.526 ± 0.035
1.749GlnThr: 1.749 ± 0.039
2.589GlnVal: 2.589 ± 0.044
0.406GlnTrp: 0.406 ± 0.017
0.507GlnTyr: 0.507 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
9.432ArgAla: 9.432 ± 0.099
0.488ArgCys: 0.488 ± 0.023
4.269ArgAsp: 4.269 ± 0.068
3.265ArgGlu: 3.265 ± 0.054
2.753ArgPhe: 2.753 ± 0.055
5.092ArgGly: 5.092 ± 0.071
1.691ArgHis: 1.691 ± 0.042
3.882ArgIle: 3.882 ± 0.054
1.832ArgLys: 1.832 ± 0.04
8.26ArgLeu: 8.26 ± 0.111
2.118ArgMet: 2.118 ± 0.048
1.647ArgAsn: 1.647 ± 0.039
3.638ArgPro: 3.638 ± 0.064
2.433ArgGln: 2.433 ± 0.049
5.286ArgArg: 5.286 ± 0.074
3.158ArgSer: 3.158 ± 0.054
2.731ArgThr: 2.731 ± 0.05
5.141ArgVal: 5.141 ± 0.07
1.017ArgTrp: 1.017 ± 0.03
1.521ArgTyr: 1.521 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
5.638SerAla: 5.638 ± 0.07
0.395SerCys: 0.395 ± 0.021
2.668SerAsp: 2.668 ± 0.05
1.981SerGlu: 1.981 ± 0.048
1.986SerPhe: 1.986 ± 0.044
5.038SerGly: 5.038 ± 0.085
1.05SerHis: 1.05 ± 0.029
2.143SerIle: 2.143 ± 0.051
1.039SerLys: 1.039 ± 0.033
4.802SerLeu: 4.802 ± 0.075
1.067SerMet: 1.067 ± 0.029
1.101SerAsn: 1.101 ± 0.034
2.586SerPro: 2.586 ± 0.046
1.376SerGln: 1.376 ± 0.031
3.049SerArg: 3.049 ± 0.06
2.175SerSer: 2.175 ± 0.058
2.306SerThr: 2.306 ± 0.048
3.539SerVal: 3.539 ± 0.062
0.618SerTrp: 0.618 ± 0.023
1.173SerTyr: 1.173 ± 0.035
0.0SerXaa: 0.0 ± 0.0
Thr
6.948ThrAla: 6.948 ± 0.087
0.487ThrCys: 0.487 ± 0.02
3.004ThrAsp: 3.004 ± 0.05
2.628ThrGlu: 2.628 ± 0.047
1.957ThrPhe: 1.957 ± 0.05
5.842ThrGly: 5.842 ± 0.091
1.161ThrHis: 1.161 ± 0.031
2.501ThrIle: 2.501 ± 0.045
1.21ThrLys: 1.21 ± 0.033
6.301ThrLeu: 6.301 ± 0.085
1.246ThrMet: 1.246 ± 0.036
1.228ThrAsn: 1.228 ± 0.038
3.527ThrPro: 3.527 ± 0.061
1.466ThrGln: 1.466 ± 0.039
3.525ThrArg: 3.525 ± 0.058
2.286ThrSer: 2.286 ± 0.049
2.93ThrThr: 2.93 ± 0.069
4.254ThrVal: 4.254 ± 0.075
0.698ThrTrp: 0.698 ± 0.026
1.133ThrTyr: 1.133 ± 0.03
0.0ThrXaa: 0.0 ± 0.0
Val
10.551ValAla: 10.551 ± 0.107
0.599ValCys: 0.599 ± 0.021
3.798ValAsp: 3.798 ± 0.061
4.049ValGlu: 4.049 ± 0.061
2.887ValPhe: 2.887 ± 0.055
5.361ValGly: 5.361 ± 0.077
1.342ValHis: 1.342 ± 0.036
4.116ValIle: 4.116 ± 0.065
1.934ValLys: 1.934 ± 0.041
8.072ValLeu: 8.072 ± 0.096
2.215ValMet: 2.215 ± 0.048
1.86ValAsn: 1.86 ± 0.043
3.811ValPro: 3.811 ± 0.06
2.449ValGln: 2.449 ± 0.044
4.044ValArg: 4.044 ± 0.066
3.669ValSer: 3.669 ± 0.058
5.008ValThr: 5.008 ± 0.071
5.968ValVal: 5.968 ± 0.088
1.079ValTrp: 1.079 ± 0.028
1.428ValTyr: 1.428 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
1.62TrpAla: 1.62 ± 0.042
0.132TrpCys: 0.132 ± 0.011
0.771TrpAsp: 0.771 ± 0.032
0.605TrpGlu: 0.605 ± 0.026
0.552TrpPhe: 0.552 ± 0.025
1.091TrpGly: 1.091 ± 0.034
0.375TrpHis: 0.375 ± 0.019
0.577TrpIle: 0.577 ± 0.022
0.394TrpLys: 0.394 ± 0.02
1.765TrpLeu: 1.765 ± 0.042
0.38TrpMet: 0.38 ± 0.016
0.421TrpAsn: 0.421 ± 0.017
0.793TrpPro: 0.793 ± 0.025
0.742TrpGln: 0.742 ± 0.028
1.164TrpArg: 1.164 ± 0.037
0.731TrpSer: 0.731 ± 0.029
0.74TrpThr: 0.74 ± 0.027
0.944TrpVal: 0.944 ± 0.033
0.242TrpTrp: 0.242 ± 0.014
0.269TrpTyr: 0.269 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 0.051
0.221TyrCys: 0.221 ± 0.015
1.446TyrAsp: 1.446 ± 0.037
1.026TyrGlu: 1.026 ± 0.034
0.8TyrPhe: 0.8 ± 0.028
2.059TyrGly: 2.059 ± 0.043
0.475TyrHis: 0.475 ± 0.022
0.86TyrIle: 0.86 ± 0.027
0.473TyrLys: 0.473 ± 0.019
2.194TyrLeu: 2.194 ± 0.044
0.466TyrMet: 0.466 ± 0.021
0.517TyrAsn: 0.517 ± 0.021
1.084TyrPro: 1.084 ± 0.03
0.613TyrGln: 0.613 ± 0.023
1.53TyrArg: 1.53 ± 0.036
1.035TyrSer: 1.035 ± 0.032
1.109TyrThr: 1.109 ± 0.03
1.438TyrVal: 1.438 ± 0.034
0.345TyrTrp: 0.345 ± 0.02
0.527TyrTyr: 0.527 ± 0.022
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3609 proteins (1165447 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski